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1. Full Text Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial
by Saito, Haruhiro and Fukuhara, Tatsuro and Furuya, Naoki and Watanabe, Kana and Sugawara, Shunichi and Iwasawa, Shunichiro and Tsunezuka, Yoshio and Yamaguchi, Ou and Okada, Morihito and Yoshimori, Kozo and Nakachi, Ichiro and Gemma, Akihiko and Azuma, Koichi and Kurimoto, Futoshi and Tsubata, Yukari and Fujita, Yuka and Nagashima, Hiromi and Asai, Gyo and Watanabe, Satoshi and Miyazaki, Masaki and Hagiwara, Koichi and Nukiwa, Toshihiro and Morita, Satoshi and Kobayashi, Kunihiko and Maemondo, Makoto
The lancet oncology, ISSN 1470-2045, 05/2019, Volume 20, Issue 5, pp. 625 - 635
Life Sciences & Biomedicine | Oncology | Science & Technology | Care and treatment | Product development | Erlotinib | Lung cancer, Non-small cell | Analysis | Index Medicus
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2. Full Text First-Line Gefitinib for Patients With Advanced Non–Small-Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Mutations Without Indication for Chemotherapy
by Akira Inoue and Kunihiko Kobayashi and Kazuhiro Usui and Makoto Maemondo and Shoji Okinaga and Iwao Mikami and Masahiro Ando and Koichi Yamazaki and Yasuo Saijo and Akihiko Gemma and Hitoshi Miyazawa and Tomoaki Tanaka and Kenji Ikebuchi and Toshihiro Nukiwa and Satoshi Morita and Koichi Hagiwara and North East Japan Gefitinib Study Group
Journal of clinical oncology, ISSN 0732-183X, 03/2009, Volume 27, Issue 9, pp. 1394 - 1400
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the respiratory system and mediastinum | Biological and medical sciences | Medical sciences | Tumors | Pneumology | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Lung Neoplasms - enzymology | Prospective Studies | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | Young Adult | Aged, 80 and over | Adult | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Mutation | Index Medicus
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3. Full Text Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease
by Yasuda, Satoshi and Kaikita, Koichi and Akao, Masaharu and Ako, Junya and Matoba, Tetsuya and Nakamura, Masato and Miyauchi, Katsumi and Hagiwara, Nobuhisa and Kimura, Kazuo and Hirayama, Atsushi and Matsui, Kunihiko and Ogawa, Hisao and AFIRE Investigators
The New England journal of medicine, ISSN 0028-4793, 09/2019, Volume 381, Issue 12, pp. 1103 - 1113
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Atrial Fibrillation - drug therapy | Humans | Atrial Fibrillation - complications | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Drug Therapy, Combination - adverse effects | Factor Xa Inhibitors - therapeutic use | Rivaroxaban - adverse effects | Atrial Fibrillation - mortality | Coronary Disease - complications | Factor Xa Inhibitors - adverse effects | Coronary Disease - therapy | Coronary Artery Bypass | Female | Aged | Aspirin - therapeutic use | Platelet Aggregation Inhibitors - therapeutic use | Percutaneous Coronary Intervention | Purinergic P2Y Receptor Antagonists - therapeutic use | Rivaroxaban - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Rivaroxaban | Treatment outcome | Usage | Safety and security measures | Atrial fibrillation | Analysis | Thrombolytic drugs | Drug therapy | Myocardial infarction | Hypertension | Cerebral infarction | Anticoagulants | Cardiac arrhythmia | Stroke | Coronary artery | Clinical trials | Cardiovascular disease | Angina | Thrombosis | Embolism | Fibrillation | Hemostasis | Coronary vessels | Safety | Heart diseases | Age | Vitamin K | Index Medicus | Abridged Index Medicus
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4. Full Text Combined Survival Analysis of Prospective Clinical Trials of Gefitinib for Non–Small Cell Lung Cancer with EGFR Mutations
by Satoshi Morita and Isamu Okamoto and Kunihiko Kobayashi and Koichi Yamazaki and Hajime Asahina and Akira Inoue and Koichi Hagiwara and Noriaki Sunaga and Noriko Yanagitani and Toyoaki Hida and Kimihide Yoshida and Tomonori Hirashima and Kosei Yasumoto and Kenji Sugio and Tetsuya Mitsudomi and Masahiro Fukuoka and Toshihiro Nukiwa
Clinical cancer research, ISSN 1078-0432, 07/2009, Volume 15, Issue 13, pp. 4493 - 4498
non–small cell lung cancer | mutation | EGF receptor | gefitinib | Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the respiratory system and mediastinum | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Pneumology | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | Male | Treatment Outcome | Antineoplastic Agents - therapeutic use | Mutation - physiology | Genes, erbB-1 | Quinazolines - therapeutic use | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Clinical Trials, Phase II as Topic | Index Medicus
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5. Full Text Epidermal growth factor receptor (EGFR) mutation and personalized therapy in advanced nonsmall cell lung cancer (NSCLC)
by Kobayashi, Kunihiko and Hagiwara, Koichi
Targeted oncology, ISSN 1776-2596, 3/2013, Volume 8, Issue 1, pp. 27 - 33
EGFR mutation | Nonsmall cell lung cancer (NSCLC) | Medicine & Public Health | Erlotinib | Oncology | EGFR-TKI | Gefitinib | Biomedicine general | Life Sciences & Biomedicine | Science & Technology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Lung Neoplasms - pathology | Randomized Controlled Trials as Topic | Protein Kinase Inhibitors - administration & dosage | Clinical Trials, Phase III as Topic | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Mutation | Precision Medicine - methods | Chemotherapy | Genetic aspects | Epidermal growth factor | Algorithms | Lung cancer, Non-small cell | Cancer | Index Medicus | Review
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6. Full Text Safety and Efficacy of Autologous Skeletal Myoblast Sheets (TCD-51073) for the Treatment of Severe Chronic Heart Failure Due to Ischemic Heart Disease
by Sawa, Yoshiki and Yoshikawa, Yasushi and Toda, Koichi and Fukushima, Satsuki and Yamazaki, Kenji and Ono, Minoru and Sakata, Yasushi and Hagiwara, Nobuhisa and Kinugawa, Koichiro and Miyagawa, Shigeru
Circulation journal : official journal of the Japanese Circulation Society, ISSN 1346-9843, 2015, Volume 79, Issue 5, pp. 991 - 999
Heart failure | Myoblast sheets | Regenerative therapy | Multicenter study | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Heart Failure - surgery | Autografts | Follow-Up Studies | Humans | Middle Aged | Heart Failure - physiopathology | Male | Stroke Volume | Myoblasts, Skeletal - transplantation | Myocardial Ischemia - complications | Myocardial Ischemia - physiopathology | Adult | Female | Aged | Chronic Disease | Heart Failure - etiology | Myocardial Ischemia - surgery | Index Medicus
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7. Full Text Total Synthesis of Talatisamine
by Kamakura, Daiki and Todoroki, Hidenori and Urabe, Daisuke and Hagiwara, Koichi and Inoue, Masayuki
Angewandte Chemie (International ed.), ISSN 1433-7851, 01/2020, Volume 59, Issue 1, pp. 479 - 486
terpenoids | total synthesis | cyclization | rearrangement | alkaloids | Aconitine - chemical synthesis | Aconitine - chemistry | Molecular Structure | Aconitine - analogs & derivatives | Humans | Aconitum - chemistry | Diterpenes | Forging | Synthesis | Potassium channels | Ring structures | Mercury | Index Medicus
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8. Full Text Importance of the cytological samples for the epidermal growth factor receptor gene mutation test for non‐small cell lung cancer
by Hagiwara, Koichi and Kobayashi, Kunihiko
Cancer science, ISSN 1347-9032, 03/2013, Volume 104, Issue 3, pp. 291 - 297
Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - genetics | Specimen Handling | Histocytological Preparation Techniques | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Reagent Kits, Diagnostic - standards | Mutation | DNA Mutational Analysis - methods | Mutagenicity Tests - methods | Epidermal growth factor | Gene mutations | Genes | Lung cancer, Small cell | Genetic aspects | Lung cancer, Non-small cell | Cancer | Index Medicus | Review
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9. Full Text Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR
by Maemondo, Makoto and Inoue, Akira and Kobayashi, Kunihiko and Sugawara, Shunichi and Oizumi, Satoshi and Isobe, Hiroshi and Gemma, Akihiko and Harada, Masao and Harada, Toshiyuki and Yoshizawa, Hirohisa and Kinoshita, Ichiro and Fujita, Yuka and Okinaga, Shoji and Hirano, Haruto and Yoshimori, Kozo and Ogura, Takashi and Ando, Masahiro and Miyazawa, Hitoshi and Tanaka, Tomoaki and Saijo, Yasuo and Hagiwara, Koichi and Morita, Satoshi and Nukiwa, Toshihiro and NE Japan Study Grp and North-East Japan Study Group
The New England journal of medicine, ISSN 0028-4793, 06/2010, Volume 362, Issue 25, pp. 2380 - 2388
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Tumors of the respiratory system and mediastinum | Biological and medical sciences | General aspects | Medical sciences | Pneumology | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | Carboplatin - administration & dosage | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Genes, erbB-1 | Carcinoma, Non-Small-Cell Lung - secondary | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Survival Analysis | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Female | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Paclitaxel - administration & dosage | Chemotherapy | Patient outcomes | Dosage and administration | Gefitinib | Lung cancer, Non-small cell | Drug therapy | Cancer | Studies | Peptides | Pharmaceutical industry | Cancer therapies | Lung cancer | Index Medicus | Abridged Index Medicus
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10. Full Text Elucidation of Degradation Behavior of Tricyclic Antidepressant Amoxapine in Artificial Gastric Juice
by Koichi Saitoa and Nami Hagiwaraa and Miho Sakamotob and Daigo Wakanac and Rie Itoa and Tomoo Hosoec and Hoshi University and cDepartment of Bioregulatory Science and Faculty of Pharmaceutical Sciences and Tokyo Metropolitan Institute of Public Health and aDepartment of Analytical Chemistry and bDepartment of Pharmaceutical Sciences
Chemical & pharmaceutical bulletin, ISSN 0009-2363, 2020, Volume 68, Issue 9, pp. 848 - 854
Drug addiction | Amitriptyline | Degradation products | Forensic science | Desipramine | Entropy | Clomipramine | Degradation | Imipramine | Antidepressants | Tricyclic antidepressants | Juices | Pharmacokinetics | Activation energy | Gastric juice | Entropy of activation | Structural analysis | Index Medicus
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11. Full Text Mutations of optineurin in amyotrophic lateral sclerosis
by Maruyama, Hirofumi and Morino, Hiroyuki and Ito, Hidefumi and Izumi, Yuishin and Kato, Hidemasa and Watanabe, Yasuhito and Kinoshita, Yoshimi and Kamada, Masaki and Nodera, Hiroyuki and Suzuki, Hidenori and Ko