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index medicus (17) 17
humans (15) 15
biomarkers (12) 12
proteins (11) 11
male (10) 10
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cerebrospinal fluid (7) 7
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parasitic diseases (5) 5
proteomics - methods (5) 5
stroke (5) 5
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biological markers (4) 4
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diagnosis (4) 4
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human african trypanosomiasis (4) 4
identification (4) 4
medicin och hälsovetenskap (4) 4
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patients (4) 4
santé publique et épidémiologie (4) 4
science (4) 4
stage determination (4) 4
trypanosomiasis, african (4) 4
young adult (4) 4
aged, 80 and over (3) 3
analysis (3) 3
biochemistry (3) 3
cerebrospinal-fluid (3) 3
combination of biomarkers (3) 3
disease (3) 3
h-fabp (3) 3
infectious diseases (3) 3
markers (3) 3
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medicinska och farmaceutiska grundvetenskaper (3) 3
neglected tropical diseases (3) 3
nervous-system involvement (3) 3
panel (3) 3
parasitology (3) 3
peptides (3) 3
physiological aspects (3) 3
proteome - metabolism (3) 3
quantitative proteomics (3) 3
research article (3) 3
sleeping sickness (3) 3
software (3) 3
tropical medicine (3) 3
trypanosoma brucei gambiense (3) 3
trypanosomiasis (3) 3
usage (3) 3
[ sdv.spee ] life sciences [q-bio]/santé publique et épidémiologie (2) 2
acid-binding protein (2) 2
adolescent (2) 2
african trypanosomiasis (2) 2
algorithms (2) 2
base sequence (2) 2
basic medicine (2) 2
binding (2) 2
bioindicators (2) 2
biological markers/analysis (2) 2
biomarker (2) 2
biomarkers - analysis (2) 2
biomarkers - metabolism (2) 2
blood-brain-barrier (2) 2
carrier proteins - metabolism (2) 2
central-nervous-system (2) 2
cerebrospinal fluid proteins - analysis (2) 2
clinical study (2) 2
computational biology - methods (2) 2
computational biology/methods (2) 2
creutzfeldt-jakob-disease (2) 2
data interpretation, statistical (2) 2
diagnostic medicine (2) 2
diagnostic systems (2) 2
evaluation (2) 2
exhibitions (2) 2
field diagnosis (2) 2
fluid (2) 2
follow-up (2) 2
general pathology (2) 2
glutathione transferase (2) 2
identification and classification (2) 2
infektionsmedicin (2) 2
kinetics (2) 2
klinisk medicin (2) 2
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1. Full Text pROC: An open-source package for R and S+ to analyze and compare ROC curves
by Robin, Xavier and Turck, Natacha and Hainard, Alexandre and Tiberti, Natalia and Lisacek, Frédérique and Sanchez, Jean-Charles and Müller, Markus
BMC Bioinformatics, ISSN 1471-2105, 03/2011, Volume 12, Issue 1, pp. 77 - 77
Receiver operating characteristic (ROC) curves are useful tools to evaluate classifiers in biomedical and bioinformatics applications. However, conclusions are... 
Computational Biology - methods | Confidence Intervals | Data Interpretation, Statistical | Humans | Biomarkers - analysis | Programming Languages | ROC Curve | Software | Confidence intervals | Usage | Public software | Mathematical statistics | Analysis | Science | Research | Computer programs | Studies | User interface | Biomarkers | Data mining | Bioinformatics | Manuscripts | Programming languages | Methods
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2. Full Text A multiparameter panel method for outcome prediction following aneurysmal subarachnoid hemorrhage
by Turck, Natacha and Turck, Natacha and Vutskits, Laszlo and Vutskits, Laszlo and Sanchez-Pena, Paola and Sanchez-Pena, Paola and Robin, Xavier and Robin, Xavier and Hainard, Alexandre and Hainard, Alexandre and Gex-Fabry, Marianne and Gex-Fabry, Marianne and Fouda, Catherine and Fouda, Catherine and Bassem, Hadiji and Bassem, Hadiji and Mueller, Markus and Mueller, Markus and Lisacek, Frédérique and Lisacek, Frédérique and Puybasset, Louis and Puybasset, Louis and Sanchez, Jean-Charles and Sanchez, Jean-Charles
Intensive Care Medicine, ISSN 0342-4642, 1/2010, Volume 36, Issue 1, pp. 107 - 115
Accurate early anticipation of long-term irreversible brain damage during the acute phase of patients with aneurysmal subarachnoid hemorrhage (aSAH) remains... 
Pediatrics | Pain Medicine | Pneumology/Respiratory System | Emergency Medicine | Prognosis | Medicine & Public Health | Intensive / Critical Care Medicine | NDKA | H-FABP | Anesthesiology | S100β | Aneurysmal subarachnoid hemorrhage | EARLY-DIAGNOSIS | PROGNOSTIC-FACTORS | POSTMORTEM CEREBROSPINAL-FLUID | SERUM | IDENTIFICATION | TROPONIN-I | STROKE | BIOMARKERS | ACID-BINDING PROTEIN | S100 beta | CRITICAL CARE MEDICINE | Predictive Value of Tests | Prospective Studies | Outcome Assessment (Health Care) | Heart - physiology | Humans | Middle Aged | Male | NM23 Nucleoside Diphosphate Kinases - metabolism | Troponin I - blood | Neurosurgical Procedures | S100 Proteins - blood | Female | Nerve Growth Factors - blood | Subarachnoid Hemorrhage - diagnosis | France | Fatty Acids - metabolism | Subarachnoid Hemorrhage - surgery | Acute Disease | Enzyme-Linked Immunosorbent Assay | S100 Calcium Binding Protein beta Subunit | Subarachnoid Hemorrhage - complications | Brain Damage, Chronic - etiology | Carrier Proteins - metabolism | Proteins - metabolism | Aged | Brain Damage, Chronic - epidemiology | Diagnosis | Research | Subarachnoid hemorrhage | Patient outcomes
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3. Full Text Human Proteinpedia enables sharing of human protein data
by Lefevre, Michael and Molina, Henrik and Mehrle, Alexander and Jung, Peter and Muddiman, David C and Hochstrasser, Denis F and Nalli, Anuradha and Mann, Matthias and Zhou, Ming and Fenselau, Catherine and Cagney, Gerard and DeSouza, Leroi V and Sirdeshmukh, Ravi and Björling, Erik and Pepperkok, Rainer and Rice, Robert H and Zurbig, Petra and Chaerkady, Raghothama and Purvine, Samuel O and Pandey, Akhilesh and Sullivan, Matthew and Balgley, Brian M and Bantscheff, Marcus and Figeys, Daniel and Michael Siu, K W and Vidal-Taboada, José-Manuel and Gimble, Jeffrey M and Hjernø, Karin and Cantin, Greg T and Hanash, Samir M and Petricoin, Emanuel F and Crockett, David and Dunn, Michael J and Lim, Megan S and Drewes, Gerard and Gromov, Pavel and Costello, Catherine E and Deutsch, Eric W and Gnad, Florian and Takatalo, Maarit and Alexandre, Hainard and Celis, Julio E and Vihinen, Mauno and Morgan, James D and Andrews, Philip C and Ahn, Natalie G and Korf, Ulrike and Kwon, Min-Seok and James, Peter and Wiemann, Stefan and Veenstra, Timothy D and Helsens, Kenny and Menon, Rajasree and Sheng, Shi Jun and Gelfi, Cecilia and Kheterpal, Indu and Lee, Young-Jin and Zhu, Yunping and Chu, Feixia and Mathivanan, Suresh and Horn, David M and Bennett, Keiryn L and Hofmann, Oliver and Pennington, Kyla and Ramachandran, Prasanna and Jensen, Pia Hønnerup and Löbke, Christian and Zhong, Jun and Moritz, Robert and Loo, Joseph A and Ohara, Osamu and Martinez-Heredia, Juan and Seshi, Beerelli and Hancock, William S and Simpson, Richard J and Shivakumar, K and Neubert, Thomas A and Goel, Renu and Rick, Jens and Ewing, Rob M and Sayd, Thierry and Oliva, Rafael and Thongboonkerd, Visith and Bustelo, Xosé R and Sanchez, Jean-Charles and De Marzo, Angelo M and Dransfield, Eric and Paik, Young-Ki and Hruban, Ralph H and Harsha, HC and He, Fuchu and Fang, Xiangming and Amanchy, Ramars and Hermeking, Heiko and Gagné, Pierre and Kikuno, Reiko F and Smith, Jeffrey C and Xu, Tao and Oyama, Masaaki and Gevaert, Kris and ... and Pacific Northwest National Lab. (PNNL), Richland, WA (United States) and Skolan för bioteknologi (BIO) and KTH and Proteomik (stängd 20130101)
Nature Biotechnology, ISSN 1087-0156, 02/2008, Volume 26, Issue 2, pp. 164 - 167
Proteomic technologies, such as yeast twohybrid, mass spectrometry (MS), protein/ peptide arrays and fluorescence microscopy, yield multi-dimensional data... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | User-Computer Interface | Information Storage and Retrieval - methods | Magnetic Resonance Spectroscopy - methods | Gene Expression Profiling - methods | Proteome - classification | Peptide Mapping - methods | Proteome - chemistry | Internationality | Database Management Systems | Databases, Protein | Software | Internet | Proteomics - methods | Proteome - metabolism | Evaluation | Online services | Web sites | Online information services | Information services | STANDARDIZATION | PEPTIDES | FLUORESCENCE | BASIC BIOLOGICAL SCIENCES | YEASTS | MASS SPECTROSCOPY | MICROSCOPY | OWNERSHIP | PROTEINS
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4. Full Text Single cell immuno-laser microdissection coupled to label-free proteomics to reveal the proteotypes of human brain cells after ischemia
by García-Berrocoso, Teresa and Llombart, Víctor and Colàs-Campàs, Laura and Hainard, Alexandre and Licker, Virginie and Penalba, Anna and Ramiro, Laura and Simats, Alba and Bustamante, Alejandro and Martínez-Saez, Elena and Canals, Francesc and Sanchez, Jean-Charles and Montaner, Joan
Molecular and Cellular Proteomics, ISSN 1535-9476, 01/2018, Volume 17, Issue 1, pp. 175 - 189
Cerebral ischemia entails rapid tissue damage in the affected brain area causing devastating neurological dysfunction. How each component of the neurovascular... 
STROKE | GLUTAMATE TRANSPORTERS | HYPOXIA-ISCHEMIA | PROTEIN ARRAY | GAS-PHASE FRACTIONATION | FOCAL CEREBRAL-ISCHEMIA | DISEASE | BIOCHEMICAL RESEARCH METHODS | UP-REGULATION | EXPRESSION | MASS-SPECTROMETRY | Humans | Middle Aged | Brain Ischemia - metabolism | Laser Capture Microdissection | Male | Proteome | Blood-Brain Barrier - metabolism | Phenotype | Proteomics | Aged, 80 and over | Female | Aged | Neurons - metabolism | Brain | Stroke | Neurons | Brain slice preparation | Patients | Proteins | Molecular modelling | Plasticity (synaptic) | Ischemia | Blood-brain barrier | Autopsy | Neurological complications | Biomarkers | Brain damage | Bioinformatics | Brain injury | Research
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5. Full Text Relative Quantification of Proteins in Human Cerebrospinal Fluids by MS/MS Using 6-Plex Isobaric Tags
by Dayon, Loïc and Hainard, Alexandre and Licker, Virginie and Turck, Natacha and Kuhn, Karsten and Hochstrasser, Denis F and Burkhard, Pierre R and Sanchez, Jean-Charles
Analytical Chemistry, ISSN 0003-2700, 04/2008, Volume 80, Issue 8, pp. 2921 - 2931
A new 6-plex isobaric mass tagging technology is presented, and proof of principle studies are carried out using standard protein mixtures and human... 
STROKE | S-100 PROTEIN | CHEMISTRY, ANALYTICAL | CARDIAC-ARREST | QUANTITATIVE PROTEOMICS | NEURON-SPECIFIC ENOLASE | FIBRILLARY ACIDIC PROTEIN | SERUM-CREATINE-KINASE | INJURY | BRAIN-DAMAGE | DJ-1 | Lactoglobulins - analysis | Milk - chemistry | S100 Calcium Binding Protein beta Subunit | Humans | S100 Proteins - cerebrospinal fluid | Trypsin - analysis | Creatine Kinase, BB Form - cerebrospinal fluid | Glial Fibrillary Acidic Protein - cerebrospinal fluid | Animals | Brain Injuries - cerebrospinal fluid | Cerebrospinal Fluid - chemistry | Cattle | Spectrometry, Mass, Electrospray Ionization - methods | Swine | Horses | Nerve Growth Factors - cerebrospinal fluid | Cerebrospinal Fluid Proteins - analysis | Myoglobin - analysis | Tandem Mass Spectrometry - methods | Proteins | Measurement | Cerebrospinal fluid | Chemical properties | Identification and classification | Mass spectrometry | Methods
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6. Full Text Exploring the human tear fluid: Discovery of new biomarkers in multiple sclerosis
by Salvisberg, Cindy and Tajouri, Nadja and Hainard, Alexandre and Burkhard, Pierre R and Lalive, Patrice H and Turck, Natacha
PROTEOMICS – Clinical Applications, ISSN 1862-8346, 04/2014, Volume 8, Issue 3-4, pp. 185 - 194
Purpose Multiple sclerosis is the first cause of progressive neurological disability among young adults living in Western countries. Its diagnosis is mostly... 
Biomarkers | Multiple sclerosis | Isobaric labeling | Tears | OLIGOCLONAL BANDS | TRYPTIC PEPTIDES | PROTEOME | BIOCHEMICAL RESEARCH METHODS | MARKERS | CEREBROSPINAL-FLUID | IDENTIFICATION | ALPHA-1-ANTICHYMOTRYPSIN | DISEASE | CYSTATIN-C | PROTEINS | Biomarkers - metabolism | Multiple Sclerosis - diagnosis | Multiple Sclerosis - cerebrospinal fluid | Humans | Middle Aged | Tears - metabolism | Male | Young Adult | Body Fluids - metabolism | Proteomics | Adult | Female | Aged | Biomarkers - cerebrospinal fluid | Eye Proteins - biosynthesis | Multiple Sclerosis - metabolism | Proteins | Discovery and exploration | Biological markers | Analysis | Enzyme-linked immunosorbent assay
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7. Full Text Cerebrospinal fluid neopterin as marker of the meningo-encephalitic stage of trypanosoma brucei gambiense sleeping sickness
by Tiberti, Natalia and Hainard, Alexandre and Lejon, Veerle and Courtioux, Bertrand and Matovu, Enock and Enyaru, John Charles and Robin, Xavier and Turck, Natacha and Kristensson, Krister and Ngoyi, Dieudonné Mumba and Vatunga, Gedeão M. L and Krishna, Sanjeev and Büscher, Philippe and Bisser, Sylvie and Ndung'u, Joseph Mathu and Sanchez, Jean-Charles
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e40909
Background: Sleeping sickness, or human African trypanosomiasis (HAT), is a protozoan disease that affects rural communities in sub-Saharan Africa.... 
BIOMARKERS | NERVOUS-SYSTEM INVOLVEMENT | FIELD DIAGNOSIS | ACTIVATION | HUMAN AFRICAN TRYPANOSOMIASIS | MULTIDISCIPLINARY SCIENCES | FOLLOW-UP | IGM | DIAGNOSTIC-ACCURACY | Reproducibility of Results | Neopterin - cerebrospinal fluid | Meningoencephalitis - cerebrospinal fluid | Meningoencephalitis - parasitology | Humans | Male | Trypanosomiasis, African - parasitology | Immunoglobulin M - cerebrospinal fluid | Trypanosomiasis, African - blood | Adult | Female | Leukocyte Count | Biomarkers - cerebrospinal fluid | Trypanosomiasis, African - cerebrospinal fluid | Cohort Studies | Trypanosoma brucei gambiense - physiology | Medicine, Experimental | Medical research | Care and treatment | Trypanosomiasis | Blood cell count | Immunoglobulin M | Vascular cell adhesion molecule 1 | Rural communities | CXCL13 protein | Erythrocytes | Nervous system | Infections | Cerebrospinal fluid | Parasites | Leukocytes | Veterinary medicine | Proteins | Acquired immune deficiency syndrome--AIDS | Parasitic diseases | Human immunodeficiency virus--HIV | Bioindicators | African trypanosomiasis | Vector-borne diseases | Parasitology | Cytokines | Intercellular adhesion molecule 1 | Rural areas | Medical treatment | Blood cells | Patients | Gelatinase B | White blood cells | Tuberculosis | CXCL10 protein | Proteomics | Biomarkers | Diagnostic systems | Neopterin | Biological Markers | Trypanosomiasis, African | Trypanosoma brucei gambiense | Meningoencephalitis | Life Sciences | Santé publique et épidémiologie | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
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8. Full Text Blood Glutathione S-Transferase-π as a Time Indicator of Stroke Onset
by Turck, Natacha and Robin, Xavier and Walter, Nadia and Fouda, Catherine and Hainard, Alexandre and Sztajzel, Roman and Wagner, Ghislaine and Hochstrasser, Denis F and Montaner, Joan and Burkhard, Pierre R and Sanchez, Jean-Charles
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e43830
Ability to accurately determine time of stroke onset remains challenging. We hypothesized that an early biomarker characterized by a rapid increase in blood... 
Prognosis | Humans | Middle Aged | Stroke - diagnosis | Male | Stroke - drug therapy | Tissue Plasminogen Activator - therapeutic use | Biomarkers - blood | Case-Control Studies | Stroke - blood | Time Factors | Aged, 80 and over | Adult | Female | Aged | Glutathione S-Transferase pi - blood | Neurosciences | Stroke | Intravenous administration | Kinases | Patients | Thrombolysis | Blood | Proteins | Medicine | Neurology | Windows (intervals) | Brain research | Hospitals | Glutathione transferase | Rodents | Proteomics | Biomarkers | Tumor necrosis factor-TNF | Bioindicators | Diagnostic systems | Bioinformatics | Immunoassays | Glutathione
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9. Full Text STAT6 promotes bi-directional modulation of PKM2 in liver and adipose inflammatory cells in Rosiglitazone-treated mice
by Sajic, Tatjana and Hainard, Alexandre and Scherl, Alexander and Wohlwend, Annelise and Negro, Francesco and Sanchez, Jean-Charles and Szanto, Ildiko
Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, p. 2350
STAT6 interacts with PPAR gamma to elicit macrophage polarization towards an anti-inflammatory, insulin-sensitizing phenotype. Mice deficient in STAT6 display... 
OBESITY | METABOLISM | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | ZUCKER FATTY RATS | ACTIVATED-RECEPTOR-GAMMA | MUSCLE TRIGLYCERIDE | HEPATIC STEATOSIS | MACROPHAGE ACTIVATION | T-CELLS | FACTOR-ALPHA | Liver - metabolism | Adipose Tissue - cytology | STAT6 Transcription Factor - metabolism | Mice, Knockout | Adipose Tissue - metabolism | Animals | Carrier Proteins - metabolism | Liver - drug effects | Signal Transduction - drug effects | Thyroid Hormones - metabolism | Signal Transduction - physiology | Liver - cytology | Membrane Proteins - metabolism | Mice | Thiazolidinediones - pharmacology | Adipose Tissue - drug effects | Proteome - metabolism | Oxidative stress | Polarization | Adipose tissue | Pyruvate kinase | Liver | Pyruvic acid | Inflammation | Macrophages | Insulin | Hepatocytes | Rodents | Stat6 protein | Glycolysis | Rosiglitazone
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10. Full Text Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola
by Bonnet, Julien and Vignoles, Philippe and Tiberti, Natalia and Gedeão, Vatunga and Hainard, Alexandre and Turck, Natacha and Josenando, Theophile and Ndung’u, Joseph M and Sanchez, Jean-Charles and Courtioux, Bertrand and Bisser, Sylvie
BioMed Research International, ISSN 2314-6133, 11/2019, Volume 2019, pp. 1 - 9
Human African Trypanosomiasis may become manageable in the next decade with fexinidazole. However, currently stage diagnosis remains difficult to implement in... 
Life Sciences | Santé publique et épidémiologie
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11. Full Text General Statistical Modeling of Data from Protein Relative Expression Isobaric Tags
by Breitwieser, Florian P and Müller, André and Dayon, Loïc and Köcher, Thomas and Hainard, Alexandre and Pichler, Peter and Schmidt-Erfurth, Ursula and Superti-Furga, Giulio and Sanchez, Jean-Charles and Mechtler, Karl and Bennett, Keiryn L and Colinge, Jacques
Journal of Proteome Research, ISSN 1535-3893, 06/2011, Volume 10, Issue 6, pp. 2758 - 2766
Quantitative comparison of the protein content of biological samples is a fundamental tool of research. The TMT and iTRAQ isobaric labeling technologies allow... 
iTRAQ | TMT | quantitative proteomics | bioinformatics | statistics | MASS-SPECTROMETRY DATA | QUANTIFICATION | STRATEGY | BIOCHEMICAL RESEARCH METHODS | IDENTIFICATION | MIXTURES | PEPTIDES | TOOL | REVEALS | Data Interpretation, Statistical | Algorithms | Animals | Ceruloplasmin - chemistry | Humans | Rats | Mice | Software | Blood Proteins - chemistry | Models, Statistical | Proteomics - methods
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12. Full Text Neopterin Is a Cerebrospinal Fluid Marker for Treatment Outcome Evaluation in Patients Affected by Trypanosoma brucei gambiense Sleeping Sickness
by Tiberti, Natalia and Lejon, Veerle and Hainard, Alexandre and Courtioux, Bertrand and Robin, Xavier and Turck, Natacha and Kristensson, Krister and Matovu, Enock and Enyaru, John Charles and Mumba Ngoyi, Dieudonné and Krishna, Sanjeev and Bisser, Sylvie and Ndungu, Joseph Mathu and Büscher, Philippe and Sanchez, Jean-Charles
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 2013, Volume 7, Issue 2, p. e2088
Background: Post-therapeutic follow-up is essential to confirm cure and to detect early treatment failures in patients affected by sleeping sickness (HAT).... 
NERVOUS-SYSTEM INVOLVEMENT | HUMAN AFRICAN TRYPANOSOMIASIS | STAGE | POSTTREATMENT FOLLOW-UP | IMMUNOGLOBULINS | DIAGNOSTIC-TESTS | PARASITOLOGY | TROPICAL MEDICINE | CONGO | Young Adult | Trypanosomiasis, African - drug therapy | Neopterin - cerebrospinal fluid | Humans | Middle Aged | Trypanosoma brucei gambiense - pathogenicity | Adult | Female | Male | Treatment Outcome | Biomarkers - cerebrospinal fluid | Drug Monitoring - methods | Diagnosis | Cerebrospinal fluid | Trypanosoma brucei | Properties | Biological markers | Health aspects | Identification and classification | African trypanosomiasis | Accuracy | Parasites | Medical treatment | Failure | Blood | Biological Markers | Trypanosomiasis, African | Trypanosoma brucei gambiense | Life Sciences | Santé publique et épidémiologie | Neopterin | Drug Monitoring | Klinisk medicin | Medicin och hälsovetenskap | Infektionsmedicin | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
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