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1. Full Text Lifespan Catch-up growth and obesity in male mice
by Ozanne, Susan E and Hales, C. Nicholas
Nature, ISSN 0028-0836, 01/2004, Volume 427, Issue 6973, pp. 411 - 412
Poor fetal growth is linked with long-term detrimental effects on health in adulthood. Here we investigate whether the lifespan of male mice is affected by... 
RATS | LONGEVITY | MULTIDISCIPLINARY SCIENCES | Prenatal Nutritional Physiological Phenomena | Nutritional Physiological Phenomena | Male | Obesity - physiopathology | Animals, Suckling - physiology | Animals, Suckling - growth & development | Growth - physiology | Animals | Animals, Newborn - growth & development | Animals, Newborn - physiology | Diet | Obesity - etiology | Mice | Longevity - physiology
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2. Full Text Catch-up growth and obesity in male mice
by Ozanne, Susan E and Hales, C. Nicholas
Nature, ISSN 0028-0836, 01/2004, Volume 427, Issue 6973, pp. 411 - 412
Poor fetal growth is linked with long-term detrimental effects on health in adulthood. Here we investigate whether the lifespan of male mice is affected by... 
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3. Full Text Proinsulin is an independent predictor of coronary heart disease: Report from a 27-year follow-up study
by Zethelius, Björn and Byberg, Liisa and Hales, C. Nicholas and Lithell, Hans and Berne, Christian and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper and Institutionen för folkhälso- och vårdvetenskap
Circulation, ISSN 0009-7322, 05/2002, Volume 105, Issue 18, pp. 2153 - 2158
Background-Some, but not all, studies have reported a relationship between plasma insulin and coronary heart disease (CHD). Conventional nonspecific insulin... 
Myocardial infarction | Coronary heart disease | Epidemiology | Insulin | Risk factors | risk factors | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | insulin | MYOCARDIAL-INFARCTION | SPLIT PROINSULIN | myocardial infarction | ACTIVATOR INHIBITOR TYPE-1 | HYPERINSULINEMIA | epidemiology | MEN | INSULIN-RESISTANCE ATHEROSCLEROSIS | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | coronary heart disease | HEMATOLOGY | ARTERY DISEASE | GLUCOSE-TOLERANCE | Coronary Disease - blood | Proinsulin - blood | Prospective Studies | Follow-Up Studies | Humans | Insulin - immunology | Middle Aged | Risk Factors | Male | Survival Rate | Biomarkers - blood | Coronary Disease - diagnosis | Insulin - blood | Coronary Disease - mortality | Radioimmunoassay | Proinsulin - immunology | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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4. Full Text The thrifty phenotype hypothesis
by Hales, C. Nicholas and Barker, David J. P
British Medical Bulletin, ISSN 0007-1420, 2001, Volume 60, Issue 1, pp. 5 - 20
The thrifty phenotype hypothesis proposes that the epidemiological associations between poor fetal and infant growth and the subsequent development of type 2... 
DEPENDENT DIABETES-MELLITUS | INFANT GROWTH | MEDICINE, GENERAL & INTERNAL | METABOLIC SYNDROME | INDIAN CHILDREN | LOW-BIRTH-WEIGHT | FETAL GROWTH | INSULIN-RESISTANCE | IMPAIRED GLUCOSE-TOLERANCE | 7-YEAR-OLD CHILDREN | CARDIOVASCULAR RISK-FACTORS | Birth Weight | Phenotype | Diabetes Mellitus, Type 2 - physiopathology | Growth | Humans | Diabetes Mellitus, Type 2 - embryology | Diabetes Mellitus, Type 2 - etiology | Embryonic and Fetal Development | Infant, Newborn
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5. Full Text Do different dimensions of the metabolic syndrome change together over time?: Evidence supporting obesity as the central feature
by Maison, Patrick and Byrne, Christopher D and Hales, C. Nicholas and Day, Nicholas E and Wareham, Nicholas J
Diabetes Care, ISSN 0149-5992, 2001, Volume 24, Issue 10, pp. 1758 - 1763
OBJECTIVE - The Metabolic syndrome is a loosely defined Cluster of cardiovascular risk factors including low HDL cholesterol, hypertriglyceridemia, glucose... 
DIAGNOSIS | ENDOCRINOLOGY & METABOLISM | CONSULTATION | ASSAYS | PROVISIONAL REPORT | PROINSULIN | INSULIN-RESISTANCE SYNDROME | Blood Pressure | Body Constitution | Body Mass Index | Glucose Tolerance Test | Fasting | Prospective Studies | Metabolic Syndrome - physiology | Obesity - complications | Humans | Middle Aged | Male | Insulin - blood | Triglycerides - blood | Cholesterol, HDL - blood | Adult | Female | Aged | Blood Glucose - metabolism | Cohort Studies | Food | Obesity | Diabetes | Metabolism | Health risk assessment
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6. Full Text Poor fetal growth followed by rapid postnatal catch-up growth leads to premature death
by Ozanne, Susan E and Nicholas Hales, C
Mechanisms of Ageing and Development, ISSN 0047-6374, 2005, Volume 126, Issue 8, pp. 852 - 854
It is widely accepted that individuals with a low birth weight are at increased risk of developing type 2 diabetes, insulin resistance and cardiovascular... 
Early nutrition | Catch-up growth | Lifespan | Fetal programming | INSULIN | OBESITY | DIET | lifespan | fetal programming | MICE | catch-up growth | early nutrition | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | Body Weight | Signal Transduction | Mice, Inbred C57BL | Fetal Growth Retardation | Insulin Resistance | Nutritional Physiological Phenomena | Male | Longevity | Insulin - metabolism | Animals | Time Factors | Sensitivity and Specificity | Aging | Mice | Animal Feed | Type 2 diabetes | Growth | Insulin resistance
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7. Full Text Loss of Proliferative Capacity and Induction of Senescence in Oxidatively Stressed Human Fibroblasts
by Jian-Hua Chen and Kai Stoeber and Sarah Kingsbury and Susan E. Ozanne and Gareth H. Williams and C. Nicholas Hales
Journal of Biological Chemistry, ISSN 0021-9258, 11/2004, Volume 279, Issue 47, pp. 49439 - 49446
Cellular senescence can result from short, dysfunctional telomeres, oxidative stress, or oncogene expression, and may contribute to aging. To investigate the... 
PREMATURE SENESCENCE | ONCOGENIC RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | CELL-FREE SYSTEM | CATCH-UP GROWTH | S-PHASE | HYDROGEN-PEROXIDE | REPLICATIVE LIFE-SPAN | DNA-REPLICATION | P53 | Phosphorylation | Cell Proliferation | Oxidative Stress | Humans | Oxygen - metabolism | Cell Nucleus - metabolism | Time Factors | Cellular Senescence | Fibroblasts - metabolism | Cell Line | Down-Regulation | Retinoblastoma Protein - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | DNA - metabolism | Fibroblasts - pathology | Blotting, Western | Microscopy, Confocal | Phenotype | Bromodeoxyuridine - pharmacology | Saccharomyces cerevisiae Proteins - metabolism | Cytosol - metabolism | Fibroblasts - cytology
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8. Full Text Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet
by Ozanne, Susan E and Lewis, Rohan and Jennings, Bridget J and Hales, C. Nicholas
Clinical Science, ISSN 0143-5221, 02/2004, Volume 106, Issue 2, pp. 141 - 145
Poor early growth is associated with Type 11 diabetes, hypertension and other features of the metabolic syndrome in adulthood. It has been suggested that this... 
Appetite | Type II diabetes | Obesity | Growth restriction | Catch-up growth | Diet | MEDICINE, RESEARCH & EXPERIMENTAL | growth restriction | RATS | RESTRICTION | catch-up growth | CHILDHOOD | BLOOD-PRESSURE | HYPERCALORIC NUTRITION | UTERO | OVERWEIGHT | appetite | diet | HYPERTENSION | obesity | LIFE | Dietary Proteins - administration & dosage | Maternal Nutritional Physiological Phenomena | Lactation | Obesity - embryology | Weaning | Mice, Inbred C57BL | Male | Animals | Female | Models, Animal | Obesity - etiology | Mice
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9. Full Text Strong Correlation Between Experiment and Simulation for Two-Photon Absorption Induced Carrier Generation
by Hales, Joel M and Roche, Nicolas J.-H and Khachatrian, Ani and Mcmorrow, Dale and Buchner, Stephen and Warner, Jeffrey and Turowski, Marek and Lilja, Klas and Hooten, Nicholas C and En Xia Zhang and Reed, Robert A and Schrimpf, Ronald D
IEEE Transactions on Nuclear Science, ISSN 0018-9499, 05/2017, Volume 64, Issue 5, pp. 1133 - 1136
This correspondence comments on the correlation between measured and simulated charge collection in two diode structures presented in [1]. In [1], results from... 
Meters | Correlation | Pulse measurements | Energy measurement | Measurement by laser beam | single-event effect (SEE) | Silicon | Calibration | Photodiodes | two-photon absorption (TPA) | single-event upset (SEU) | NUCLEAR SCIENCE & TECHNOLOGY | ENGINEERING, ELECTRICAL & ELECTRONIC | Research | Chemical properties | Laser beams | Computer simulation | Propagation | Photon absorption | Charge simulation | Absorption | Charge deposition | Energy | Simulation | Correlation analysis | Numerical prediction | Deposition
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10. Full Text Fasting proinsulin concentrations predict the development of type 2 diabetes
by N J Wareham and C D Byrne and R Williams and N E Day and C N Hales
Diabetes Care, ISSN 0149-5992, 02/1999, Volume 22, Issue 2, pp. 262 - 270
Fasting proinsulin concentrations predict the development of type 2 diabetes. N J Wareham , C D Byrne , R Williams , N E Day and C N Hales Department of... 
POPULATION | COMMUNITY | CONVERSION | MEN | ENDOCRINOLOGY & METABOLISM | IMPAIRED GLUCOSE-TOLERANCE | FOLLOW-UP | HUMAN INSULIN | MELLITUS | PREVALENCE | NIDDM | Body Mass Index | Predictive Value of Tests | Proinsulin - blood | Glucose Tolerance Test | Fasting | Protein Precursors - blood | Humans | Middle Aged | England | Male | Biomarkers - blood | Insulin - blood | Disease Progression | Glucose Intolerance - blood | Glucose Intolerance - diagnosis | Diabetes Mellitus, Type 2 - diagnosis | Regression Analysis | Diabetes Mellitus, Type 2 - blood | Adult | Female | Longitudinal Studies | Cohort Studies
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11. Full Text Two-Photon Absorption Induced Single-Event Effects: Correlation Between Experiment and Simulation
by Hales, Joel M and Roche, Nicolas J.-H and Khachatrian, Ani and McMorrow, Dale and Buchner, Stephen and Warner, Jeffrey and Turowski, Marek and Lilja, Klas and Hooten, Nicholas C and Zhang, En Xia and Reed, Robert A and Schrimpf, Ronald D
IEEE Transactions on Nuclear Science, ISSN 0018-9499, 12/2015, Volume 62, Issue 6, pp. 2867 - 2873
Carrier-density distributions generated via two-photon absorption from pulsed laser excitation are simulated using nonlinear-optical beam propagation software.... 
Kerr effect | CMOS | optical kerr effect | free-carrier absorption | Single event upsets | single-event effect (SEE) | two-photon absorption | CMOS technology | Silicon | free-carrier refraction | Nonlinear optics | single-event upset (SEU) | nonlinear optics | silicon | DAMAGE | PULSES | ENGINEERING, ELECTRICAL & ELECTRONIC | NUCLEAR SCIENCE & TECHNOLOGY | TRANSIENT-RESPONSE | Research
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12. Full Text Fetal growth and adult diseases
by Ozanne, Susan E and Fernandez-Twinn, Denise and Hales, C.Nicholas
Seminars in Perinatology, ISSN 0146-0005, 2004, Volume 28, Issue 1, pp. 81 - 87
Evidence that the quality of fetal growth and development has strong and, in widely varying populations, reproducible effects on susceptibility to many common... 
BREAST-CANCER | OBESITY | ROAD | RISK | PEDIATRICS | COHORT | WEIGHT | GLUCOSE-TOLERANCE | LIFE | OBSTETRICS & GYNECOLOGY | Pregnancy | Cardiovascular Diseases - etiology | Cardiovascular Diseases - prevention & control | Humans | Adult | Female | Fetal Growth Retardation - complications
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13. Full Text Methods of cellular senescence induction using oxidative stress
by Chen, Jian-Hua and Ozanne, Susan E and Hales, C. Nicholas
Methods in Molecular Biology, ISSN 1064-3745, 04/2007, Volume 371, pp. 179 - 189
Normal human fibroblasts cultured in vitro only have a limited proliferation potential. They eventually become senescent as a result of serial passage, which... 
Cell cycle arrest | Oxidative stress | SA-β-gal | Senescence | Double-strand break | DNA damage | Oxidants - pharmacology | Animals | Models, Biological | Humans | Aging - drug effects | Cells, Cultured | Hydrogen Peroxide - pharmacology | Rodentia | Cellular Senescence - drug effects | Fibroblasts - cytology | Oxidative Stress - drug effects | Fibroblasts - metabolism
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14. Full Text Scenario archetypes: Converging rather than diverging themes
by Hunt, Dexter V. L and Lombardi, D. Rachel and Atkinson, Stuart and Barber, Austin R.G and Barnes, Matthew and Boyko, Christopher T and Brown, Julie and Bryson, John and Butler, David and Caputo, Silvio and Caserio, Maria and Coles, Richard and Cooper, Rachel F.D and Farmani, Raziyeh and Gaterell, Mark and Hale, James and Hales, Chantal and Hewitt, C. Nicholas and Jankovic, Lubo and Jefferson, I and Leach, J and MacKenzie, A. Rob and Memon, Fayyaz Ali and Sadler, Jon P and Weingaertner, Carina and Whyatt, J. Duncan and Rogers, Christopher D. F
Sustainability, ISSN 2071-1050, 2012, Volume 4, Issue 4, pp. 740 - 772
Future scenarios provide challenging, plausible and relevant stories about how the future could unfold. Urban Futures (UF) research has identified a... 
Scenario archetypes | Sustainability | Future scenarios | GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | ENVIRONMENTAL SCIENCES | future scenarios | ENERGY | VISIONS | FUTURE | ENVIRONMENTAL STUDIES | scenario archetypes | sustainability | WORLD | sustainability; future scenarios; scenario archetypes | Economics
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15. Full Text Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp
by Zethelius, B and Lithell, H and Hales, C N and Berne, C and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper and Institutionen för folkhälso- och vårdvetenskap
Diabetologia, ISSN 0012-186X, 5/2005, Volume 48, Issue 5, pp. 862 - 867
The association between CHD and insulin sensitivity (Si) measured by the euglycaemic insulin clamp has not been examined previously. Earlier studies found a... 
Medicine | Proinsulin | Predictor | Coronary heart disease | Insulin | Risk factors | risk factors | insulin | MYOCARDIAL-INFARCTION | ACTIVATOR INHIBITOR TYPE-1 | RISK FACTOR | HYPERINSULINEMIA | RESISTANCE ATHEROSCLEROSIS | proinsulin | NONDIABETIC POPULATION | MIDDLE-AGED MEN | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | coronary heart disease | predictor | ASSOCIATION | ARTERY-DISEASE | Body Mass Index | Insulin - pharmacology | Proinsulin - blood | Follow-Up Studies | Humans | Proportional Hazards Models | Coronary Disease - epidemiology | Insulin - administration & dosage | Male | Biomarkers - blood | Insulin - blood | Coronary Disease - mortality | Sweden | Health Surveys | Survival Analysis | Aged | Glucose Clamp Technique | Blood Glucose - metabolism | Medical research | Glucose metabolism | Analysis | Medicine, Experimental | Glucose | Dextrose | Proinsulin/blood | Medical and Health Sciences | Medicin och hälsovetenskap | Blood Glucose/metabolism | Insulin/administration & dosage/blood/pharmacology | MEDICINE | Biological Markers/blood | MEDICIN | Coronary Disease/epidemiology/mortality | Research Support; Non-U.S. Gov't
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16. Full Text Benchmarking sustainability in cities: The role of indicators and future scenarios
by Boyko, Christopher T and Gaterell, Mark R and Barber, Austin R.G and Brown, Julie and Bryson, John R and Butler, David and Caputo, Silvio and Caserio, Maria and Coles, Richard and Cooper, Rachel and Davies, Gemma and Farmani, Raziyeh and Hale, James and Hales, A. Chantal and Hewitt, C. Nicholas and Hunt, Dexter V.L and Jankovic, Lubo and Jefferson, Ian and Leach, Joanne M and Lombardi, D. Rachel and MacKenzie, A. Robert and Memon, Fayyaz A and Pugh, Thomas A.M and Sadler, John P and Weingaertner, Carina and Whyatt, J. Duncan and Rogers, Christopher D.F
Global Environmental Change, ISSN 0959-3780, 02/2012, Volume 22, Issue 1, pp. 245 - 254
â–º Scenarios are useful for exploring the effects of current decisions on future plans. â–º The toolkit allows new scenarios, characteristics and indicators to be... 
Scenarios | Regeneration | Toolkit | Urban Futures | Indicators | Sustainability | SWEDEN | INTERDISCIPLINARITY | AGRICULTURE | URBAN REGENERATION PERFORMANCE | ISSUES | ENVIRONMENTAL SCIENCES | POLICY | DECISION-MAKING | CITY | FRAMEWORK | SCALE | ENVIRONMENTAL STUDIES | GEOGRAPHY | Modernism (Art) | Benchmarks | School construction | Art, Modern | Sustainable development
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17. Full Text Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity
by Jane L. Tarry-Adkins and Susan E. Ozanne and Anthony Norden and Hanane Cherif and C. Nicholas Hales
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 02/2006, Volume 290, Issue 2, pp. 509 - 516
It is well documented that females live longer than males and more renal damage occurs in males. However, the underlying mechanisms are not fully understood.... 
Telomeres | Senescence | CELLS | OXIDATIVE STRESS | PHYSIOLOGY | RAT | telomeres | EXCRETION | GLOMERULAR INJURY | DAMAGE | senescence | OXYGEN | ESTROGEN | UROLOGY & NEPHROLOGY | MALES | AGE | Sulfotransferases | Glutathione Peroxidase - metabolism | Calcium-Binding Proteins | Kidney Medulla - enzymology | Rats, Wistar | Glutathione Reductase - metabolism | Kidney Cortex - metabolism | Tumor Suppressor Protein p53 - metabolism | Rats | Male | Longevity | Animals | Cellular Senescence | Kidney Medulla - metabolism | Sex Factors | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Telomere - physiology | Albuminuria - metabolism | Kidney Cortex - enzymology | Superoxide Dismutase - metabolism
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