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1. Full Text Nuclear Receptors as New Perspective for the Management of Liver Diseases
by Trauner, Michael and Halilbasic, Emina
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2011, Volume 140, Issue 4, pp. 1120 - 1125.e12
Gastroenterology and Hepatology | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver Diseases - therapy | Receptors, Cytoplasmic and Nuclear - physiology | Liver Diseases - physiopathology | Humans | Index Medicus | Abridged Index Medicus
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2. Full Text Bile acid transporters and regulatory nuclear receptors in the liver and beyond
by Halilbasic, Emina and Claudel, Thierry and Trauner, Michael
Journal of hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | Index Medicus | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
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3. Full Text New therapeutic concepts in bile acid transport and signaling for management of cholestasis
by Trauner, Michael and Fuchs, Claudia Daniela and Halilbasic, Emina and Paumgartner, Gustav
Hepatology (Baltimore, Md.), ISSN 0270-9139, 04/2017, Volume 65, Issue 4, pp. 1393 - 1404
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver Circulation - physiology | Severity of Illness Index | Signal Transduction | Humans | Bile Acids and Salts - metabolism | Treatment Outcome | Cholestasis - physiopathology | Animals | Taurocholic Acid - administration & dosage | Biological Transport - drug effects | Cholestasis - drug therapy | Cohort Studies | Disease Models, Animal | Liver diseases | Bile | Index Medicus
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4. Full Text Pathogenesis of primary sclerosing cholangitis
by Pollheimer, Marion J., MD and Halilbasic, Emina, MD and Fickert, Peter, MD and Trauner, Michael, MD
Baillière's best practice & research. Clinical gastroenterology, ISSN 1521-6918, 2011, Volume 25, Issue 6, pp. 727 - 739
Gastroenterology and Hepatology | Inflammatory bowel diseases | Primary sclerosing cholangitis (PSC) | Immunology | Pathogenesis | Aetiology | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Animals | Major Histocompatibility Complex - genetics | Cholangitis, Sclerosing - immunology | Bile - chemistry | Humans | Inflammatory Bowel Diseases - immunology | Cholangitis, Sclerosing - genetics | Cholangitis, Sclerosing - complications | Mice | Inflammatory Bowel Diseases - complications | Disease Models, Animal | Autoimmunity | Autoantibodies | Histocompatibility antigens | Liver diseases | Analysis | Gastrointestinal diseases | HLA histocompatibility antigens | Index Medicus
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5. Full Text norUrsodeoxycholic acid improves cholestasis in primary sclerosing cholangitis
by Fickert, Peter and Hirschfield, Gideon M and Denk, Gerald and Marschall, Hanns-Ulrich and Altorjay, Istvan and Färkkilä, Martti and Schramm, Christoph and Spengler, Ulrich and Chapman, Roger and Bergquist, Annika and Schrumpf, Erik and Nevens, Frederik and Trivedi, Palak and Reiter, Florian P and Tornai, Istvan and Halilbasic, Emina and Greinwald, Roland and Pröls, Markus and Manns, Michael P and Trauner, Michael and European PSC norUDCA Study Group and European PSC norUDCA Study Grp and Sahlgrenska akademin and Institute of Medicine and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institutionen för medicin
Journal of hepatology, ISSN 0168-8278, 09/2017, Volume 67, Issue 3, pp. 549 - 558
Bile acid treatment | Alkaline phosphatase | Side chain-shortened bile acids | Sclerosing cholangitis | Cholehepatic shunting | Cholestasis | Ursodeoxycholic acid | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Cholangitis, Sclerosing - drug therapy | Double-Blind Method | Ursodeoxycholic Acid - analogs & derivatives | Humans | Middle Aged | Male | Ursodeoxycholic Acid - adverse effects | Ursodeoxycholic Acid - therapeutic use | Dose-Response Relationship, Drug | Adult | Female | Cholestasis - drug therapy | Alkaline Phosphatase - blood | Inflammation | Bile duct | Cholangitis | Bile | Gallbladder diseases | Clinical trials | Pruritus | Patients | Index Medicus | Klinisk medicin | p120 | primary biliary-cirrhosis | inflammation | v11 | bile-acids | azouilleres o | knockout mice | survival | controlled-trial | 1990 | Clinical Medicine | liver fibrosis | alkaline-phosphatase | journal of hepatology | quality-of-life | dose ursodeoxycholic acid | Medicin och hälsovetenskap
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