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Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7693, pp. 544 - 548
Therapeutic antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients... 
METASTATIC MELANOMA | CTLA-4 BLOCKADE | BLADDER-CANCER | THERAPY | LANDSCAPE | SUBTYPES | UROTHELIAL CARCINOMA | MULTIDISCIPLINARY SCIENCES | GENES | ADAPTIVE IMMUNE RESISTANCE | MPDL3280A | CD8-Positive T-Lymphocytes - cytology | Humans | Antibodies, Monoclonal - therapeutic use | Urothelium - pathology | Urologic Neoplasms - pathology | Neoplasm Metastasis | Urologic Neoplasms - drug therapy | Urologic Neoplasms - genetics | Immunotherapy | Antibodies - immunology | Antigens, Neoplasm - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Antigens, Neoplasm - analysis | Disease Models, Animal | Fibroblasts - metabolism | Antibodies - therapeutic use | Antigens, Neoplasm - immunology | Antibodies, Monoclonal - pharmacology | Treatment Outcome | B7-H1 Antigen - immunology | Urologic Neoplasms - immunology | Antibodies - pharmacology | Tumor Microenvironment - immunology | Collagen - metabolism | Phenotype | Animals | B7-H1 Antigen - antagonists & inhibitors | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | CD8-Positive T-Lymphocytes - drug effects | Urothelium - immunology | Mice | Mutation | CD8-Positive T-Lymphocytes - immunology | Urothelium - drug effects | Transforming Growth Factor beta - metabolism | Cohort Studies | Drug Resistance, Neoplasm - drug effects | PD-1 protein | CD8 antigen | Transforming growth factor-a | Antibodies | Parenchyma | Lymphocytes T | Metastasis | Immunity | Metastases | Genotype & phenotype | Signal transduction | Lymphocytes | Cell cycle | Fibroblasts | Growth factors | Urothelial cancer | Phenotypes | Cytokines | Melanoma | Blocking | Gene expression | Patients | Generalized linear models | Signaling | Stromal cells | Medical prognosis | Collagen | PD-L1 protein | Ligands | Determinants | Infiltration | Cancer | Tumors | Apoptosis | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Genetics, ISSN 0016-6731, 04/2014, Volume 196, Issue 4, pp. 1131 - 1131
The causes of the large effect of the X chromosome in reproductive isolation and speciation have long been debated. The faster-X hypothesis predicts that... 
Journal Article
by Clark, Andrew G and Eisen, Michael B and Smith, Douglas R and Bergman, Casey M and Oliver, Brian and Markow, Therese A and Kaufman, Thomas C and Kellis, Manolis and Gelbart, William and Iyer, Venky N and Pollard, Daniel A and Sackton, Timothy B and Larracuente, Amanda M and Singh, Nadia D and Abad, Jose P and Abt, Dawn N and Adryan, Boris and Aguade, Montserrat and Akashi, Hiroshi and Anderson, Wyatt W and Aquadro, Charles F and Ardell, David H and Arguello, Roman and Artieri, Carlo G and Barbash, Daniel A and Barker, Daniel and Barsanti, Paolo and Batterham, Phil and Batzoglou, Serafim and Begun, Dave and Bhutkar, Arjun and Blanco, Enrico and Bosak, Stephanie A and Bradley, Robert K and Brand, Adrianne D and Brent, Michael R and Brooks, Angela N and Brown, Randall H and Butlin, Roger K and Caggese, Corrado and Calvi, Brian R and Bernardo De Carvalho, A and Caspi, Anat and Castrezana, Sergio and Celniker, Susan E and Chang, Jean L and Chapple, Charles and Chatterji, Sourav and Chinwalla, Asif and Civetta, Alberto and Clifton, Sandra W and Comeron, Josep M and Costello, James C and Coyne, Jerry A and Daub, Jennifer and David, Robert G and Delcher, Arthur L and Delehaunty, Kim and Do, Chuong B and Ebling, Heather and Edwards, Kevin and Eickbush, Thomas and Evans, Jay D and Filipski, Alan and Findeiß, Sven and Freyhult, Eva and Fulton, Lucinda and Fulton, Robert and Garcia, Ana C. L and Gardiner, Anastasia and Garfield, David A and Garvin, Barry E and Gibson, Greg and Gilbert, Don and Gnerre, Sante and Godfrey, Jennifer and Good, Robert and Gotea, Valer and Gravely, Brenton and Greenberg, Anthony J and Griffiths-Jones, Sam and Gross, Samuel and Guigo, Roderic and Gustafson, Erik A and Haerty, Wilfried and Hahn, Matthew W and Halligan, Daniel L and Halpern, Aaron L and Halter, Gillian M and Han, Mira V and Heger, Andreas and Hillier, LaDeana and Hinrichs, Angie S and Holmes, Ian and Hoskins, Roger A and Hubisz, Melissa J and Hultmark, Dan and Huntley, Melanie A and Jaffe, David B and Jagadeeshan, Santosh and ... and Drosophila 12 Genomes Consor and Broad Inst Whole Genome Ass and Broad Inst Genome Sequencing and Drosophila 12 Genomes Consortium and Medicinska fakulteten and Umeå centrum för molekylär patogenes (UCMP) (Medicinska fakulteten) and Umeå universitet
Nature, ISSN 0028-0836, 11/2007, Volume 450, Issue 7167, pp. 203 - 218
Journal Article
Molecular Biology and Evolution, ISSN 0737-4038, 10/2015, Volume 32, Issue 10, p. 2547
  The brown rat, Rattus norvegicus, is both a notorious pest and a frequently used model in biomedical research. By analyzing genome sequences of 12... 
Proteins | Biological variation | Evolutionary biology | Rodents | Genomes | Mutation
Journal Article
Genetics, ISSN 0016-6731, 01/2014, Volume 196, Issue 1, pp. 313 - 320
Journal Article
Molecular Biology and Evolution, ISSN 0737-4038, 04/2014, Volume 31, Issue 4, p. 1010
  Genetic recombination associated with sexual reproduction increases the efficiency of natural selection by reducing the strength of Hill-Robertson... 
Proteins | Insects | Genomics | Genomes | Chromosomes | Deoxyribonucleic acid--DNA | Polymorphism
Journal Article
Genetics, ISSN 0016-6731, 01/2014, Volume 196, Issue 1, pp. 313 - 313
We employed deep genome sequencing of two parents and 12 of their offspring to estimate the mutation rate per site per generation in a full-sib family of... 
Journal Article
PLoS Genetics, ISSN 1553-7390, 12/2013, Volume 9, Issue 12
  The contribution of regulatory versus protein change to adaptive evolution has long been controversial. In principle, the rate and strength of adaptation... 
Proteins | Genomics | Genomes | Mutation | Mammals | Gene expression | Experiments | Estimates | Evolution & development | Deoxyribonucleic acid--DNA
Journal Article
Forensic Science International: Genetics Supplement Series, ISSN 1875-1768, 12/2017, Volume 6, pp. e62 - e64
Age related tissue-specific DNA methylation markers have been identified in many studies, which can be used to estimate the chronological age of an unknown... 
HM450 | DNA methylation | Epigenetics | Aging | Microarray | CpG sites | Forensic genetics | DNA testing | Methylation | Observations | Methods
Journal Article
BMJ Open Respiratory Research, ISSN 2052-4439, 01/2018, Volume 5, Issue 1, p. e000240
IntroductionAccurate prognostication is difficult in malignant pleural mesothelioma (MPM). We developed a set of robust computational models to quantify the... 
Prediction models | mesothelioma | pleural disease | Studies | Variables | Chemotherapy | Comorbidity | Lymphocytes | Socioeconomic factors | Medical prognosis | Lung cancer | Genomics | Neutrophils | Mesothelioma | Systematic review
Journal Article