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Journal Article
British Journal of Cancer, ISSN 0007-0920, 09/2017, Volume 117, Issue 6, pp. 791 - 800
Background: The use of clinical MRI scanners to conduct pre-clinical research facilitates comparisons with clinical studies. Here the utility and sensitivity... 
CONTRAST-ENHANCED MRI | 1.5 T | MRI | clinical platform | cancer imaging | neuroblastoma | RELAXATION | murine model | pre-clinical | BREAST-CANCER | MYCN | ONCOLOGY | GROWTH | INFORMATICS | INHIBITOR | CARCINOMA | BLOOD | Anilides - therapeutic use | Magnetic Resonance Imaging - methods | Male | Stomach Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Magnets | Cyclophosphamide - therapeutic use | Female | Neuroblastoma - pathology | Disease Models, Animal | Pyridines - therapeutic use | Stomach Neoplasms - genetics | Stomach Neoplasms - diagnostic imaging | Neuroblastoma - genetics | Signal-To-Noise Ratio | Mice, Transgenic | Neuroblastoma - diagnostic imaging | Stomach Neoplasms - drug therapy | Phenotype | Animals | Contrast Media | Magnetic Resonance Imaging - instrumentation | Receptor Protein-Tyrosine Kinases - genetics | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Mice | Mutation | Phantoms, Imaging | Coils | Medical research | Animal models | Data acquisition | Transgenic mice | Scanners | Delineation | Clinical trials | Neuroblastoma | Quantitation | Lymphoma | Relaxation time | Radio frequency | Cyclophosphamide | Magnetic resonance imaging | Perfusion | Transgenic animals | Rodents | Functional magnetic resonance imaging | Biomarkers | Protein-tyrosine kinase | Tumors | Image contrast | Translational Therapeutics
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0119834
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. While the pathways that are deregulated in MB remain to be fully characterized,... 
DIVISION SYMMETRY | STEM-CELLS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | N-MYC | NEURONAL PRECURSORS | CENTRAL-NERVOUS-SYSTEM | NEURAL PRECURSORS | IDENTIFICATION | EXPRESSION | BRAIN-TUMORS | Neoplasm Transplantation | Neoplastic Stem Cells - drug effects | Humans | Cerebellum - drug effects | Spheroids, Cellular - pathology | Medulloblastoma - mortality | Aurora Kinase A - antagonists & inhibitors | Aurora Kinase A - metabolism | Allografts | Neoplastic Stem Cells - metabolism | Medulloblastoma - pathology | Neoplastic Stem Cells - pathology | Female | Antineoplastic Agents - pharmacology | N-Myc Proto-Oncogene Protein | Spheroids, Cellular - drug effects | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Principal Component Analysis | Aurora Kinase A - genetics | Proto-Oncogene Proteins - metabolism | Cerebellar Neoplasms - drug therapy | Gene Expression | Cerebellum - metabolism | Spheroids, Cellular - metabolism | Cerebellar Neoplasms - mortality | Neural Stem Cells - drug effects | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Cerebellar Neoplasms - genetics | Pyrimidines - pharmacology | Neural Stem Cells - pathology | Cerebellum - pathology | Azepines - pharmacology | Animals | Survival Analysis | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Medulloblastoma - drug therapy | Neural Stem Cells - metabolism | Brain | Medulloblastoma | Brain tumors | Stem cells | Genetically modified organisms | Genetic engineering | Chemical properties | Cancer | Cerebellum | Bone grafts | Surgical implants | Deregulation | Stem cell transplantation | Drug development | Kinases | Subgroups | MYCN gene | Cell fate | Transgenic animals | Rodents | Cell cycle | Neurospheres | Growth factors | Medical research | Cell survival | Cell division | Tumor cell lines | Gene expression | Ribonucleic acid--RNA | Survival | Progenitor cells | Pathology | Medical prognosis | Cell lines | Neural stem cells | Aberration | Tumors | RNA | Ribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, p. e28356
Journal Article
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2012, Volume 22, Issue 1, pp. 117 - 130
The mutation is associated with intrinsic and acquired resistance to crizotinib and cosegregates with in neuroblastoma. In this study, we generated a mouse... 
Journal Article
Cancer Cell, ISSN 1535-6108, 01/2015, Volume 27, Issue 1, pp. 72 - 84
We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined family... 
AMPLIFICATION | ONCOLOGY | OUTCOME PREDICTION | ANAPLASTIC MEDULLOBLASTOMA | TP53 MUTATION | CHILDHOOD MEDULLOBLASTOMA | N-MYC | CENTRAL-NERVOUS-SYSTEM | NEUROBLASTOMA | SUBGROUPS | CHILDRENS-CANCER | CELL BIOLOGY | Oncogene Proteins - genetics | Humans | Child, Preschool | Molecular Sequence Data | Neoplasm Recurrence, Local - drug therapy | Infant | Male | Antineoplastic Agents - therapeutic use | Tumor Suppressor Protein p53 - genetics | Young Adult | Medulloblastoma - pathology | Neoplasms, Experimental | Adult | Female | N-Myc Proto-Oncogene Protein | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Nuclear Proteins - genetics | Child | Cerebellar Neoplasms - drug therapy | Signal Transduction | Oncogene Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Cerebellar Neoplasms - genetics | Proto-Oncogene Proteins c-myc - metabolism | Animals | Gene Amplification | Adolescent | Neoplasm Recurrence, Local - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Mutation | Medulloblastoma - drug therapy | Neurosciences | Genetic engineering | Tumor proteins | Medulloblastoma | Children's hospitals | Brain tumors | Clinical Medicine | Neurology | Neurologi | Medical and Health Sciences | Medicin och hälsovetenskap | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 10/2019, Volume 79, Issue 20, pp. 5382 - 5393
Neuroblastoma is a pediatric cancer that is frequently metastatic and resistant to conventional treatment. In part, a lack of natively metastatic,... 
EPITHELIAL-MESENCHYMAL TRANSITION | THYMIDINE KINASE | ONCOLOGY | STAT3 | GROWTH | GUIDELINES | DRUG-RESISTANCE | INTERLEUKIN-6 | CANCER | EXPRESSION | PROMOTES
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 491 - 491
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2012, Volume 18, Issue 20, pp. 5650 - 5661
Journal Article
Journal of Virology, ISSN 0022-538X, 08/1997, Volume 71, Issue 8, pp. 5894 - 5904
Journal Article