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1. Full Text Natural products on demand
by Hamann, Lawrence G
Nature Chemistry, ISSN 1755-4330, 2014, Volume 6, Issue 6, pp. 460 - 461
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2. Full Text SYNTHETIC STRATEGY Natural products on demand
by Hamann, LG
NATURE CHEMISTRY, ISSN 1755-4330, 06/2014, Volume 6, Issue 6, pp. 460 - 461
CHEMISTRY, MULTIDISCIPLINARY | BUILDING-BLOCKS | ACID | Polyenes - chemistry | Biological Products - chemical synthesis | Glucosides - chemical synthesis | Carotenoids - chemical synthesis
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3. Full Text Expedient access to saturated nitrogen heterocycles by photoredox cyclization of imino-tethered dihydropyridinesElectronic supplementary information (ESI) available: Supplementary substrate scope. Supplementary optimizations table. BDFE calculations. Detailed experimental procedures and compound characterization. See DOI: 10.1039/c9sc03429c
by Bissonnette, Noah B and Ellis, J. Michael and Hamann, Lawrence G and Romanov-Michailidis, Fedor
ISSN 2041-6520, 10/2019, Volume 1, Issue 41, pp. 9591 - 9596
A large proportion of medicinally relevant molecules bear nitrogen and sp 3 -hybridized carbon functionalities. Overwhelmingly, these atoms are found as part... 
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4. Expedient access to saturated nitrogen heterocycles by photoredox cyclization of imino-tethered dihydropyridines (Electronic supplementary information (ESI) available: Supplementary substrate scope. Supplementary optimizations table. BDFE calculations. Detailed experimental procedures and compound characterization. See DOI: 10.1039/c9sc03429c)
by Noah B Bissonnette and J Michael Ellis and Lawrence G Hamann and Fedor Romanov-Michailidis
Chemical Science, ISSN 2041-6520, 01/2019, Volume 10, Issue 41, pp. 9591 - 9596
A large proportion of medicinally relevant molecules bear nitrogen and sp3-hybridized carbon functionalities. Overwhelmingly, these atoms are found as part of... 
Hydrogen bonds | Imines | Lithium | Iridium | Aldehydes | Nitrogen | Carbon | Substrates | Alkylation
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5. Full Text Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
by Gao, Min and Nettles, Richard E and Belema, Makonen and Snyder, Lawrence B and Nguyen, Van N and Fridell, Robert A and Serrano-Wu, Michael H and Langley, David R and Sun, Jin-Hua and O'Boyle Ii, Donald R and Lemm, Julie A and Wang, Chunfu and Knipe, Jay O and Chien, Caly and Colonno, Richard J and Grasela, Dennis M and Meanwell, Nicholas A and Hamann, Lawrence G
Nature, ISSN 0028-0836, 05/2010, Volume 465, Issue 7294, pp. 96 - 100
The worldwide prevalence of chronic hepatitis C virus (HCV) infection is estimated to be approaching 200 million people(1). Current therapy relies upon a... 
DOMAIN | REPLICATION | HEPATITIS-C VIRUS | RNA | MULTIDISCIPLINARY SCIENCES | CELL | NONSTRUCTURAL PROTEINS | Hepatitis C - drug therapy | Humans | Middle Aged | Drug Resistance, Viral | Imidazoles - chemistry | Cercopithecus aethiops | Male | Young Adult | Time Factors | Antiviral Agents - chemistry | Inhibitory Concentration 50 | Adult | Female | Vero Cells | Hepacivirus - drug effects | Cell Line | Antiviral Agents - pharmacology | Antiviral Agents - blood | Antiviral Agents - therapeutic use | Genotype | Imidazoles - pharmacology | Imidazoles - blood | Animals | Adolescent | Hepatitis C - virology | HeLa Cells | Viral Load - drug effects | Viral Nonstructural Proteins - antagonists & inhibitors | Biochemical genetics | Genetic aspects | Research | Hepatitis C virus | RNA polymerases | Genotype & phenotype | Amino acids
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6. Full Text A scalable synthesis of -2-azabicyclo[3.1.0]hexane-3-carboxylic acid
by Wang, Gan and James, Clint A and Meanwell, Nicholas A and Hamann, Lawrence G and Belema, Makonen
Tetrahedron Letters, ISSN 0040-4039, 12/2013, Volume 54, Issue 49, p. 6722
Telomerase
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7. Full Text Development of targeted protein degradation therapeutics
by Chamberlain, PP and Hamann, LG
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 10/2019, Volume 15, Issue 10, pp. 937 - 944
Targeted protein degradation as a therapeutic modality has seen dramatic progress and massive investment in recent years because of the convergence of two key... 
COMPLEX | SELECTIVE DEGRADATION | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUTAMINE-SYNTHETASE | LENALIDOMIDE | OKIHIRO-SYNDROME | THALIDOMIDE | CEREBLON | PROTAC DESIGN | E3 UBIQUITIN LIGASE | Proteins | Degradation | Ubiquitin | Binding | Proteolysis | Chimeras | Binders | Ubiquitin-protein ligase | Optimization | Substrates
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8. Full Text SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice
by Palacino, James and Swalley, Susanne E and Song, Cheng and Cheung, Atwood K and Shu, Lei and Zhang, Xiaolu and Van Hoosear, Mailin and Shin, Youngah and Chin, Donovan N and Keller, Caroline Gubser and Beibel, Martin and Renaud, Nicole A and Smith, Thomas M and Salcius, Michael and Shi, Xiaoying and Hild, Marc and Servais, Rebecca and Jain, Monish and Deng, Lin and Bullock, Caroline and McLellan, Michael and Schuierer, Sven and Murphy, Leo and Blommers, Marcel J J and Blaustein, Cecile and Berenshteyn, Frada and Lacoste, Arnaud and Thomas, Jason R and Roma, Guglielmo and Michaud, Gregory A and Tseng, Brian S and Porter, Jeffery A and Myer, Vic E and Tallarico, John A and Hamann, Lawrence G and Curtis, Daniel and Fishman, Mark C and Dietrich, William F and Dales, Natalie A and Sivasankaran, Rajeev
Nature Chemical Biology, ISSN 1552-4450, 07/2015, Volume 11, Issue 7, pp. 511 - 517
Spinal muscular atrophy (SMA), which results from the loss of expression of the survival of motor neuron-1 (SMN1) gene, represents the most common genetic... 
SURVIVAL | SYSTEM | PROTEIN | SPINAL MUSCULAR-ATROPHY | MESSENGER-RNA | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | EXPRESSION | BINDING | SINGLE NUCLEOTIDE | RNA Precursors - chemistry | Ribonucleoprotein, U1 Small Nuclear - metabolism | Small Molecule Libraries - pharmacology | Alternative Splicing | Humans | Small Molecule Libraries - metabolism | Survival of Motor Neuron 2 Protein - metabolism | Proteolysis | Survival of Motor Neuron 2 Protein - chemistry | Protein Binding - drug effects | Survival of Motor Neuron 2 Protein - genetics | Ribonucleoprotein, U1 Small Nuclear - chemistry | Female | RNA Precursors - metabolism | RNA, Double-Stranded - metabolism | Binding Sites | RNA, Double-Stranded - chemistry | Disease Models, Animal | RNA, Double-Stranded - agonists | Muscular Atrophy, Spinal - mortality | Gene Expression | Muscular Atrophy, Spinal - metabolism | Ribonucleoprotein, U1 Small Nuclear - agonists | Models, Molecular | Small Molecule Libraries - chemical synthesis | Mice, Transgenic | RNA Precursors - agonists | Muscular Atrophy, Spinal - pathology | Animals | Protein Stability - drug effects | Survival Analysis | Muscular Atrophy, Spinal - drug therapy | Mice | Molecular biology | Rodents | Neurological disorders
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9. Full Text Accessing Drug Metabolites via Transition‐Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration
by Genovino, Julien and Sames, Dalibor and Hamann, Lawrence G and Touré, B. Barry
Angewandte Chemie International Edition, ISSN 1433-7851, 11/2016, Volume 55, Issue 46, pp. 14218 - 14238
Can classical and modern chemical C−H oxidation reactions complement biotransformation in the synthesis of drug metabolites? We have surveyed the literature in... 
C−H functionalization | biotransformation | chemotransformation | drug discovery | drug metabolites | HYDROXYLATED ARENES | LEAD DIVERSIFICATION | UDENFRIEND SYSTEM | FUNGAL PEROXYGENASES | C-H functionalization | TERT-BUTYL HYDROPEROXIDE | CHEMISTRY, MULTIDISCIPLINARY | BENZYLIC OXIDATION | CYTOCHROME-P450 ENZYMES | ORGANIC-COMPOUNDS | LATE-STAGE FUNCTIONALIZATION | ACTIVE METABOLITE | Microfluidic Analytical Techniques | Transition Elements - chemistry | Biological Products - chemistry | Pharmaceutical Preparations - metabolism | Electrochemical Techniques | Oxidation-Reduction | Pharmaceutical Preparations - chemistry | Biological Products - metabolism | Catalysis | Hydrogen - chemistry | Carbon - chemistry | Electrochemical reactions | Metabolites | Liver | Electrochemistry | Oxidation-reduction reaction | Drug discovery | Pharmaceutical industry | Microfluidics | Oxidation
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10. Full Text Late-stage C-H functionalization of complex alkaloids and drug molecules via intermolecular rhodium-carbenoid insertion
by He, Jing and Hamann, Lawrence G and Davies, Huw M. L and Beckwith, Rohan E. J
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 5943
Alkaloids constitute a large family of natural products possessing diverse biological properties. Their unique and complex structures have inspired numerous... 
ORGANIC-SYNTHESIS | ACTIVATION | ASYMMETRIC-SYNTHESIS | DIVERSIFICATION | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | BOND FUNCTIONALIZATION | CHEMISTRY | ALPHA-AMINO-ACID | HETEROARENES SCOPE | DISCOVERY | Amines - chemistry | Biological Products - chemistry | Chemistry, Pharmaceutical - methods | Magnetic Resonance Spectroscopy | Strychnine - chemistry | Drug Design | Catalysis | Hydrogen - chemistry | Alkaloids - chemistry | Carbon - chemistry | Rhodium - chemistry | Strychnine - analogs & derivatives
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11. Full Text Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
by Dowdle, William E and Nyfeler, Beat and Nagel, Jane and Elling, Robert A and Liu, Shanming and Triantafellow, Ellen and Menon, Suchithra and Wang, Zuncai and Honda, Ayako and Pardee, Gwynn and Cantwell, John and Luu, Catherine and Cornella-Taracido, Ivan and Harrington, Edmund and Fekkes, Peter and Lei, Hong and Fang, Qing and Digan, Mary Ellen and Burdick, Debra and Powers, Andrew F and Helliwell, Stephen B and Daquin, Simon and Bastien, Julie and Wang, Henry and Wiederschain, Dmitri and Kuerth, Jenny and Bergman, Philip and Schwalb, David and Thomas, Jason and Ugwonali, Savuth and Harbinski, Fred and Tallarico, John and Wilson, Christopher J and Myer, Vic E and Porter, Jeffery A and Bussiere, Dirksen E and Finan, Peter M and Labow, Mark A and Mao, Xiaohong and Hamann, Lawrence G and Manning, Brendan D and Valdez, Reginald A and Nicholson, Thomas and Schirle, Markus and Knapp, Mark S and Keaney, Erin P and Murphy, Leon O
Nature Cell Biology, ISSN 1465-7392, 10/2014, Volume 16, Issue 11, pp. 1069 - 1079
Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain cellular homeostasis. In this study we use the new autophagy inhibitor... 
SYSTEM | LYSOSOMES | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | CROHN-DISEASE | UBIQUITIN | KINASE | RECEPTOR | IDENTIFICATION | GENOME-WIDE ASSOCIATION | DELETION | CELL BIOLOGY | Nuclear Receptor Coactivators - metabolism | Humans | Phagosomes - metabolism | Cells, Cultured | Autophagy - physiology | Iron - metabolism | Autophagy - drug effects | Animals | Ferritins - metabolism | Lysosomes - metabolism | Homeostasis - physiology | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Mice | Homeostasis | Autophagy (Cytology) | Genetic aspects | Properties | Ferritin
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12. Full Text Sustainable Practices in Medicinal Chemistry: Current State and Future Directions
by Bryan, Marian C and Dillon, Barry and Hamann, Lawrence G and Hughes, Gregory J and Kopach, Michael E and Peterson, Emily A and Pourashraf, Mehrnaz and Raheem, Izzat and Richardson, Paul and Richter, Daniel and Sneddon, Helen F
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2013, Volume 56, Issue 15, pp. 6007 - 6021
The medicinal chemistry subgroup of the American Chemical Society’s Green Chemistry Institute Pharmaceutical Roundtable (ACS GCI PR) offers a perspective on... 
REPLACEMENT | ORGANIC-SYNTHESIS | ROOM-TEMPERATURE | CHEMISTRY, MEDICINAL | CROSS-COUPLINGS | PERSPECTIVE | ENZYMATIC REDUCTION | GREEN CHEMISTRY | DRUG DISCOVERY | PHARMACEUTICAL-INDUSTRY | SOLVENT | Chemistry, Pharmaceutical - methods | Green Chemistry Technology - methods | Chemical Engineering - trends | Green Chemistry Technology - trends | Drug Discovery - trends | Drug Discovery - methods | Chemical Engineering - methods | Chemistry, Pharmaceutical - trends
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13. Die Erschließung von Wirkstoffmetaboliten durch ubergangsmetallkatalysierte C-H-Oxidation: die Leber als Inspiration fur die Synthese
by Julien Genovino and Dalibor Sames and Lawrence G Hamann and B Barry Toure
Angewandte Chemie, ISSN 0044-8249, 11/2016, Volume 128, Issue 46, p. 14430
  Können klassische und moderne C-H-Oxidationsreaktionen Biotransformationen bei der Synthese von Wirkstoffmetaboliten ergänzen? Wir haben versucht, bei einer... 
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14. Full Text Expedient access to saturated nitrogen heterocycles by photoredox cyclization of imino-tethered dihydropyridines
by Bissonnette, NB and Ellis, JM and Hamann, LG and Romanov-Michailidis, F
CHEMICAL SCIENCE, ISSN 2041-6520, 11/2019, Volume 10, Issue 41, pp. 9591 - 9596
A large proportion of medicinally relevant molecules bear nitrogen and sp(3)-hybridized carbon functionalities. Overwhelmingly, these atoms are found as part... 
MEDICINAL CHEMISTS TOOLBOX | NATURAL-PRODUCT | SUBSTITUTION | THIOMORPHOLINES | VOLTAMMETRIC OXIDATION | HANTZSCH 1,4-DIHYDROPYRIDINES | COUPLED ELECTRON-TRANSFER | SINGLE-LAYER | SNAP REAGENTS | EFFICIENT | CHEMISTRY, MULTIDISCIPLINARY
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15. Full Text SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate
by Matyskiela, Mary E and Couto, Suzana and Zheng, Xinde and Lu, Gang and Hui, Julia and Stamp, Katie and Drew, Clifton and Ren, Yan and Wang, Maria and Carpenter, Aaron and Lee, Chung-Wein and Clayton, Thomas and Fang, Wei and Lu, Chin-Chun and Riley, Mariko and Abdubek, Polat and Blease, Kate and Hartke, James and Kumar, Gondi and Vessey, Rupert and Rolfe, Mark and Hamann, Lawrence G and Chamberlain, Philip P
Nature Chemical Biology, ISSN 1552-4450, 10/2018, Volume 14, Issue 10, pp. 981 - 987
Targeted protein degradation via small-molecule modulation of cereblon offers vast potential for the development of new therapeutics. Cereblon-binding... 
MULTIPLE-MYELOMA | CONGENITAL-ABNORMALITIES | GENE | RADIAL RAY SYNDROME | PROTEIN-DEGRADATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LENALIDOMIDE | OKIHIRO-SYNDROME | MUTATIONS | RENAL-OCULAR SYNDROME | E3 UBIQUITIN LIGASE | Binding | Epidemics | Rabbits | Congenital defects | Transgenic mice | Birth defects | Birth | Phocomelia | Drug development | Substrates | Zinc | Teratogenicity | Mice | Zinc finger proteins | Mutation | Thalidomide | Index Medicus
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