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1. Full Text Both lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype-dependent manner
by Nordgren, Johan and Sharma, Sumit and Bucardo, Filemon and Nasir, Waqas and Günaydin, Gökçe and Ouermi, Djeneba and Nitiema, Leon W and Becker-Dreps, Sylvia and Simpore, Jacques and Hammarström, Lennart and Larson, Göran and Svensson, Lennart and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Hälsouniversitetet and Avdelningen för mikrobiologi och molekylär medicin
Clinical Infectious Diseases, ISSN 1058-4838, 12/2014, Volume 59, Issue 11, pp. 1567 - 1573
Background. The live oral rotavirus (RV) vaccines have shown a reduced efficacy in Africa. Recent in vitro studies have shown binding of the RV surface protein... 
Vaccine | Rotavirus | Susceptibility | Histo-blood group antigen | Lewis | MOLECULAR CHARACTERIZATION | INFECTIOUS DISEASES | susceptibility | ABO-PHENOTYPE | BURKINA-FASO | BLOOD-GROUP ANTIGENS | SMALL-INTESTINE | MICROBIOLOGY | CELL-SURFACE ANTIGENS | IMMUNOLOGY | histo-blood group antigen | CHILDREN | FETAL TISSUE | vaccine | EPITHELIAL-CELLS | rotavirus | HELICOBACTER-PYLORI | Genetic Predisposition to Disease | Rotavirus Infections - epidemiology | Humans | Child, Preschool | Rotavirus - genetics | Infant | Nicaragua - epidemiology | Rotavirus Infections - genetics | ABO Blood-Group System - genetics | Burkina Faso - epidemiology | Lewis Blood-Group System - genetics | Rotavirus Infections - virology | Infant, Newborn | Treatment outcome | Care and treatment | Rotavirus infections | Rotaviruses | Analysis | Genotype | Genetic aspects | Dosage and administration | Research | Vaccines | Risk factors | Proteins | Diarrhea | Genotype & phenotype | Antigens | Viral infections | Index Medicus | and Commentaries | histo–blood group antigen | Clinical Medicine | rotavirus; histo-blood group antigen; Lewis; susceptibility; vaccine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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2. Full Text B-Cell Activating Factor Receptor Deficiency Is Associated with an Adult-Onset Antibody Deficiency Syndrome in Humans
by Klaus Warnatz and Ulrich Salzer and Marta Rizzi and Beate Fischer and Sylvia Gutenberger and Joachim Böhm and Anne-Kathrin Kienzler and Qiang Pan-Hammarström and Lennart Hammarström and Mirzokhid Rakhmanov and Michael Schlesier and Bodo Grimbacher and Hans-Hartmut Peter and Hermann Eibel and Klaus Rajewsky
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 33, pp. 13945 - 13950
B-cell survival depends on signals induced by B-cell activating factor (BAFF) binding to its receptor (BAFF-R). In mice, mutations in BAFF or BAFF-R cause... 
T lymphocytes | Phenotypes | Receptors | Common variable immunodeficiency | Immunology | B lymphocytes | Memory | Plasma cells | Antibodies | Genetic mutation | B lymphopenia | Recessive mutation | Primary immunodeficiency | SURVIVAL | MATURATION ANTIGEN | MARGINAL ZONE | MULTIDISCIPLINARY SCIENCES | COMMON VARIABLE IMMUNODEFICIENCY | T-CELL | CUTTING EDGE | FAMILY | BAFF-R | primary immunodeficiency | DIFFERENTIATION | MUTATIONS | recessive mutation | Amino Acid Sequence | Humans | Middle Aged | Molecular Sequence Data | Family Health | Male | B-Cell Activation Factor Receptor - physiology | Homozygote | Age of Onset | Aged, 80 and over | B-Cell Activation Factor Receptor - deficiency | Immunologic Deficiency Syndromes - genetics | Adult | Female | Aged | B-Cell Activation Factor Receptor - genetics | B-Lymphocytes - metabolism | Cohort Studies | Development and progression | Genetic aspects | B cells | Health aspects | Immunodeficiency | Genotype & phenotype | Immunoglobulins | Mutation | Gene expression | Rodents | Binding sites | Index Medicus | Biological Sciences
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3. Full Text A hypomorphic recombination-activating gene 1 ( RAG1 ) mutation resulting in a phenotype resembling common variable immunodeficiency
by Abolhassani, Hassan, MD|Wang, Ning, PhD|Aghamohammadi, Asghar, MD, PhD|Rezaei, Nima, MD, PhD|Lee, Yu Nee, PhD|Frugoni, Francesco, PhD|Notarangelo, Luigi D., MD|Pan-Hammarström, Qiang, MD, PhD|Hammarström, Lennart, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 6, pp. 1375 - 1380
Background Recombination-activating gene 1 (RAG1) deficiency presents with a varied spectrum of combined immunodeficiency, ranging from a T− B− NK+ type of... 
Allergy and Immunology | differential diagnosis | Common variable immunodeficiency | recombination activation genes | mismanagement | granulomatous lesion | READ ALIGNMENT | TOLERANCE | COMBINED IMMUNE-DEFICIENCY | CLINICAL PHENOTYPES | V(D)J RECOMBINATION | OMENN-SYNDROME | IMMUNOLOGY | GRANULOMATOUS-DISEASE | ALLERGY | AUTOIMMUNITY | GENETIC-HETEROGENEITY | T-CELLS | Liver Diseases - immunology | Common Variable Immunodeficiency - immunology | Granuloma - genetics | Liver Diseases - genetics | Humans | Common Variable Immunodeficiency - genetics | Male | Homeodomain Proteins - immunology | Lymphoma, B-Cell - genetics | Homeodomain Proteins - genetics | Phenotype | Adolescent | Lymphoma, B-Cell - immunology | Granuloma - immunology | Mutation | Neutropenia - genetics | Neutropenia - immunology | Genetic research | Medical colleges | Genetic aspects | Genes | Stem cells | Anopheles | Analysis | Liver | Immunological deficiency syndromes | Lymphomas | Single nucleotide polymorphisms | Nucleotide sequencing | DNA sequencing | Genotype & phenotype | Lymphocytes | Chicken pox | Software | Infections | Genomes | Patients | Viral infections | Deoxyribonucleic acid--DNA | Immune system | Index Medicus | Abridged Index Medicus
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4. Full Text International Consensus Document (ICON): Common Variable Immunodeficiency Disorders
by Bonilla, Francisco A., MD, PhD|Barlan, Isil, MD|Chapel, Helen, MD|Costa-Carvalho, Beatriz T., MD|Cunningham-Rundles, Charlotte, MD, PhD|de la Morena, M. Teresa, MD|Espinosa-Rosales, Francisco J., MD|Hammarström, Lennart, MD, PhD|Nonoyama, Shigeaki, MD|Quinti, Isabella, MD, PhD|Routes, John M., MD|Tang, Mimi L.K., MD, PhD|Warnatz, Klaus, MD
Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, 2015, Volume 4, Issue 1, pp. 38 - 59
  The phenotype is very broad, ranging from only bacterial infections, to progression from a CVID-like condition to severe disease similar to a combined... 
Internal Medicine | Allergy and Immunology | INFLAMMATORY-BOWEL-DISEASE | NODULAR REGENERATIVE HYPERPLASIA | B-CELL | ALLERGY | CYSTIC FIBROSIS BRONCHIECTASIS | INTRAVENOUS IMMUNOGLOBULIN | IMMUNOGLOBULIN REPLACEMENT THERAPY | T-CELL-RECEPTOR | ANTIBODY-DEFICIENCY | QUALITY-OF-LIFE | IMMUNOLOGY | SELECTIVE IGA DEFICIENCY | Common Variable Immunodeficiency - immunology | Agammaglobulinemia - immunology | Diagnosis, Differential | Age Factors | Agammaglobulinemia - therapy | Humans | Agammaglobulinemia - diagnosis | Immunophenotyping | International Cooperation | Common Variable Immunodeficiency - diagnosis | Algorithms | B-Lymphocytes - immunology | Common Variable Immunodeficiency - therapy | Expert Testimony | Immunology | Bacterial infections | Laboratories | Committees | Infections | Vaccines | Patients | Age | Asthma | Index Medicus
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5. Full Text Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity
by Lopez-Herrera, Gabriela and Tampella, Giacomo and Pan-Hammarström, Qiang and Herholz, Peer and Trujillo-Vargas, Claudia M and Phadwal, Kanchan and Simon, Anna Katharina and Moutschen, Michel and Etzioni, Amos and Mory, Adi and Srugo, Izhak and Melamed, Doron and Hultenby, Kjell and Liu, Chonghai and Baronio, Manuela and Vitali, Massimiliano and Philippet, Pierre and Dideberg, Vinciane and Aghamohammadi, Asghar and Rezaei, Nima and Enright, Victoria and Du, Likun and Salzer, Ulrich and Eibel, Hermann and Pfeifer, Dietmar and Veelken, Hendrik and Stauss, Hans and Lougaris, Vassilios and Plebani, Alessandro and Gertz, E. Michael and Schäffer, Alejandro A and Hammarström, Lennart and Grimbacher, Bodo
The American Journal of Human Genetics, ISSN 0002-9297, 06/2012, Volume 90, Issue 6, pp. 986 - 1001
Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently not well understood. Most affected individuals are simplex cases, but both... 
B-LYMPHOCYTES | AUTOPHAGY GENE | PROTEIN | GRAY PLATELET SYNDROME | DISEASE | GENETICS & HEREDITY | X-LINKED AGAMMAGLOBULINEMIA | COMMON VARIABLE IMMUNODEFICIENCY | ENDOPLASMIC-RETICULUM | SELECTIVE IGA DEFICIENCY | LARGE COHORT | B-Lymphocytes - cytology | Cell Proliferation | Agammaglobulinemia - genetics | Microscopy, Electron, Transmission - methods | Humans | Autoimmunity - genetics | Child, Preschool | Genotype | Immunophenotyping | Male | Chromosome Mapping | Autophagy | Homozygote | Phenotype | Pedigree | Adaptor Proteins, Signal Transducing - genetics | Immunologic Deficiency Syndromes - genetics | Female | Models, Genetic | Mutation | Child | Apoptosis | Genetic Linkage | Autoimmunity | Gene mutations | Genetic susceptibility | Agammaglobulinemia | Causes of | Genetic aspects | Research | Immunoglobulins | Analysis | Immunodeficiency | Genetic research | Mitogens | Genotype & phenotype | Genetic disorders | Autoimmune diseases | Childrens health | Immune system | Index Medicus | Heredity | Hypogammaglobulinemia | Lipopolysaccharides | chromosome 4 | Cell activation | Lymphocytes B | Development | Genotypes | Phagocytosis | Linkage analysis
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6. Full Text Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
by Bacchelli, Chiara and Björkander, Janne and Hammarström, Lennart and Cunningham-Rundles, Charlotte and Nelson, David L and Salzer, Ulrich and Du, Likun and Offer, Steven and Pan-Hammarström, Qiang and Behrens, Timothy W and Grimbacher, Bodo and Gaspar, H Bobby and Institutionen för molekylär och klinisk medicin and Allergicentrum and Linköpings universitet and Hälsouniversitetet
Nature Genetics, ISSN 1061-4036, 04/2007, Volume 39, Issue 4, pp. 429 - 430
GENETICS & HEREDITY | Transmembrane Activator and CAML Interactor Protein - genetics | Genetic Testing | IgA Deficiency - genetics | Polymorphism, Genetic - physiology | Gene Frequency | Humans | Common Variable Immunodeficiency - genetics | Family | Female | Male | Transmembrane Activator and CAML Interactor Protein - physiology | Case-Control Studies | Genetic variation | Immunological deficiency syndromes | Development and progression | Diagnosis | Research | Immunoglobulin A | Health aspects | Risk factors | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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7. Full Text Placental transfer of maternally-derived iga precludes the use of guthrie card eluates as a screening tool for primary immunodeficiency diseases
by Borte, Stephan and Janzi, Magdalena and Pan-Hammarström, Qiang and von Döbeln, Ulrika and Nordvall, Lennart and Winiarski, Jacek and Fasth, Anders and Hammarström, Lennart and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för kvinnors och barns hälsa and Pediatrik and Uppsala universitet
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e43419 - e43419
There is a need for neonatal screening tools to improve the long-term clinical outcome of patients with primary immunodeficiency diseases (PID). Recently, a... 
ATAXIA-TELANGIECTASIA PATIENTS | BONE-MARROW-TRANSPLANTATION | PRE-B-CELLS | MULTIDISCIPLINARY SCIENCES | COMBINED IMMUNE-DEFICIENCY | ACUTE LYMPHOBLASTIC-LEUKEMIA | X-LINKED AGAMMAGLOBULINEMIA | COMPLETE DIGEORGE-SYNDROME | ADENOSINE-DEAMINASE DEFICIENCY | STEM-CELL TRANSPLANTATION | EPSTEIN-BARR-VIRUS | Immunoglobulin A - metabolism | Enzyme-Linked Immunosorbent Assay | Humans | Neonatal Screening - methods | IgA Deficiency - blood | Placenta - metabolism | Pregnancy | Animals | Immunoglobulin A - blood | Female | Immunologic Deficiency Syndromes - blood | Immunologic Deficiency Syndromes - diagnosis | Infant, Newborn | Infants (Newborn) | Medical tests | Immunological deficiency syndromes | B cells | Medical screening | Immunoglobulin A | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap | Neonates | Pediatrics | Severe combined immunodeficiency | Transplants & implants | Laboratories | Placental transfer | Blood | Defects | Immunology | Lymphocytes | Health and safety screening | Bone marrow | Children | Adenosine | Fetuses | Immunodeficiency | Metabolism | Patients | Diseases | Medicine | Placenta | Lymphocytes B | Lymphopenia | Mutation
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8. Full Text Effective prophylaxis against rotavirus diarrhea using a combination of Lactobacillus rhamnosus GG and antibodies
by Pant, Neha and Marcotte, Harold and Brüssow, Harald and Svensson, Lennart and Hammarström, Lennart and Molekylär virologi and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Hälsouniversitetet
BMC Microbiology, ISSN 1471-2180, 2007, Volume 7, Issue 1, pp. 86 - 86
Background: Rotavirus is a worldwide cause of infectious infantile diarrhea that claims over 600,000 lives annually. Recently, two new vaccine candidates have... 
TRIAL | CELLS | INFANT MICE | IMMUNOGLOBULIN | REUTERI | PASSIVE-IMMUNITY | MICROBIOLOGY | BACTERIOTHERAPY | INFECTION | GASTROENTERITIS | CHILDREN | Diarrhea - physiopathology | Humans | Rotavirus - immunology | Rotavirus - genetics | Diarrhea - epidemiology | Diarrhea - prevention & control | Lactobacillus - classification | Cattle | Female | Rotavirus - isolation & purification | Rotavirus Infections - virology | Immunoglobulins - biosynthesis | Colostrum - chemistry | Antibodies, Viral - biosynthesis | Rotavirus Infections - physiopathology | Antibodies, Viral - therapeutic use | Rotavirus Infections - epidemiology | Diarrhea - virology | Treatment Outcome | Combined Modality Therapy | Intestine, Small - virology | Pregnancy | Animals | Immunization, Passive | Probiotics - therapeutic use | Mice | Mice, Inbred BALB C | Immunoglobulins - therapeutic use | Rotavirus Infections - prevention & control | Care and treatment | Diarrhea in children | Rotaviruses | Fluid therapy | Research | Health aspects | Risk factors | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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9. Full Text Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins
by Hensvold, Aase Haj and Magnusson, Patrik K E and Joshua, Vijay and Hansson, Monika and Israelsson, Lena and Ferreira, Ricardo and Jakobsson, Per-Johan and Holmdahl, Rikard and Hammarström, Lennart and Malmström, Vivianne and Askling, Johan and Klareskog, Lars and Catrina, Anca Irinel
Annals of the Rheumatic Diseases, ISSN 0003-4967, 02/2015, Volume 74, Issue 2, pp. 375 - 380
Objective To investigate the role of genetic and environmental factors in the development of anticitrullinated protein antibodies (ACPA) and ACPA-positive... 
AUTOANTIBODIES | IGA | FINE SPECIFICITY | RISK-FACTORS | CYCLIC CITRULLINATED PEPTIDE | DETERMINANTS | AUTOIMMUNITY | DISEASE | 1ST-DEGREE RELATIVES | SMOKING | RHEUMATOLOGY | Genetic Predisposition to Disease | Genome-Wide Association Study | Enzyme-Linked Immunosorbent Assay | HLA-DRB1 Chains - genetics | Smoking - immunology | Humans | Middle Aged | Genotype | Male | Socioeconomic Factors | Citrulline - immunology | Epitopes - immunology | Arthritis, Rheumatoid - genetics | Autoantibodies - immunology | Aged, 80 and over | Female | Aged | Arthritis, Rheumatoid - immunology | Autoantibodies - genetics | Care and treatment | Autoantibodies | Analysis | Rheumatoid arthritis | Genetic aspects | Epidemiology | Risk factors | Studies | Population | Hospitals | Peptides | Twins | Smoking | Index Medicus
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