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1. Full Text Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease
by Wang, Qian and Cobo-Stark, Patricia and Patel, Vishal and Somlo, Stefan and Han, Pyung-Lim and Igarashi, Peter
Kidney international, ISSN 0085-2538, 02/2018, Volume 93, Issue 2, pp. 403 - 415
polycystin-2 | adenylyl cyclase | cyclic AMP | cilia | knockout mice | polycystic kidney disease | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Kidney - pathology | Kidney - enzymology | Polycystic Kidney, Autosomal Dominant - pathology | Male | Polycystic Kidney, Autosomal Dominant - genetics | RNA Interference | Female | Cilia - enzymology | Polycystic Kidney, Autosomal Dominant - enzymology | Cyclic AMP - metabolism | Kidney - physiopathology | Second Messenger Systems | Disease Models, Animal | Adenylyl Cyclases - deficiency | Cilia - pathology | Down-Regulation | Mice, Inbred C57BL | Polycystic Kidney, Autosomal Dominant - prevention & control | TRPP Cation Channels - deficiency | Epithelial Cells - pathology | Adenylyl Cyclases - metabolism | Disease Progression | TRPP Cation Channels - genetics | Mice, Knockout | Animals | Epithelial Cells - enzymology | Protein kinase A | Cell proliferation | Kidneys | Polycystic kidney | Epithelial cells | Secretion | Cyclic AMP | siRNA | Polycystin-2 | Collecting duct | A kinase-anchoring protein | Cilia | Phosphodiesterase | Index Medicus | Polycystic kidney disease
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2. Full Text Hyperoxygenation revitalizes Alzheimer’s disease pathology through the upregulation of neurotrophic factors
by Choi, Juli and Kwon, Hye‐Jin and Lee, Jung‐Eun and Lee, Yunjin and Seoh, Ju‐Young and Han, Pyung‐Lim
Aging cell, ISSN 1474-9718, 04/2019, Volume 18, Issue 2, pp. e12888 - n/a
MeCP2 | cognition | BDNF | hyperoxygenation | Alzheimer | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Cell Biology | Cell Line | Age Factors | Peroxides - pharmacology | Mice, Transgenic | Hippocampus - pathology | Hippocampus - drug effects | Oxygen - metabolism | Alzheimer Disease - pathology | Up-Regulation - drug effects | Hippocampus - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Mice | Disease Models, Animal | Alzheimer's disease | Neurodegenerative diseases | Cognitive ability | siRNA | Neurotrophin 3 | Cyclic AMP response element-binding protein | Neurotrophic factors | Neurogenesis | Neurotrophin 4 | Vascularization | Neurotrophin receptors | Atrophy | Pathology | Brain-derived neurotrophic factor | Methyl-CpG binding protein | MeCP2 protein | Presenilin 1 | Aging | TrkB receptors | Hippocampus | Index Medicus | Original Papers | Original Paper
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3. Full Text Intranasal Delivery of HMGB1 siRNA Confers Target Gene Knockdown and Robust Neuroprotection in the Postischemic Brain
by Kim, Il-Doo and Shin, Joo-Hyun and Kim, Seung-Woo and Choi, Sunghyun and Ahn, Junseong and Han, Pyung-Lim and Park, Jong-Sang and Lee, Ja-Kyeong
Molecular therapy, ISSN 1525-0016, 04/2012, Volume 20, Issue 4, pp. 829 - 839
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Immunohistochemistry | Neuroprotective Agents - therapeutic use | Brain Ischemia - metabolism | Rats | Immunoblotting | Male | Brain Ischemia - prevention & control | Administration, Intranasal | Rats, Sprague-Dawley | HMGB1 Protein - genetics | Animals | RNA, Small Interfering - therapeutic use | Brain Ischemia - drug therapy | Neuroprotective Agents - administration & dosage | RNA, Small Interfering - administration & dosage | HMGB1 Protein - antagonists & inhibitors | Real-Time Polymerase Chain Reaction | Index Medicus | Original
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4. Full Text Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress
by Lee, Kang‐Woo and Kim, Jung‐Bin and Seo, Ji‐Seon and Kim, Tae‐Kyung and Im, Joo‐Young and Baek, In‐Sun and Kim, Kyoung‐Shim and Lee, Ja‐Kyeong and Han, Pyung‐Lim
Journal of neurochemistry, ISSN 0022-3042, 01/2009, Volume 108, Issue 1, pp. 165 - 175
matrix metalloproteinase‐2 | Alzheimer’s disease | plaque pathogenesis | behavioral stress | reactive oxygen species | Plaque pathogenesis | Reactive oxygen species | Behavioral stress | Alzheimer's disease | Matrix metalloproteinase-2 | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Organic mental disorders. Neuropsychology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Reactive Oxygen Species - metabolism | Embryo, Mammalian | Aniline Compounds | Humans | Oxidative Stress - physiology | Male | Protein Carbonylation - drug effects | Cerebral Cortex - cytology | Alzheimer Disease - pathology | Brain - metabolism | Pyrimidines | Time Factors | Amyloid beta-Peptides - metabolism | Lipid Peroxidation - drug effects | Female | Neurons - metabolism | Corticosterone - blood | Neurons - drug effects | Disease Models, Animal | Stress, Psychological - chemically induced | Enzyme-Linked Immunosorbent Assay | Plaque, Amyloid - pathology | Matrix Metalloproteinase 2 - metabolism | Cells, Cultured | Mice, Transgenic | Mice, Inbred ICR | Lipid Peroxidation - physiology | Protein Carbonylation - physiology | Gene Expression Regulation - drug effects | Matrix Metalloproteinase 2 - genetics | Amyloid beta-Protein Precursor - genetics | Animals | Brain - pathology | Plaque, Amyloid - metabolism | Mice | Oxidative Stress - drug effects | Alzheimer Disease - genetics | Stress, Psychological - physiopathology | Corticotropin releasing hormone | Oxidative stress | Medical colleges | Enzymes | Corticosteroids | Animal behavior | Neurons | Analysis | Physiological aspects | Rodents | Biochemistry | Oxidation | Alzheimers disease | Metabolism | Stress | Index Medicus
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5. Full Text Alarmin HMGB1 induces systemic and brain inflammatory exacerbation in post-stroke infection rat model
by Kim, Il-Doo and Lee, Hahnbie and Kim, Seung-Woo and Lee, Hye-Kyung and Choi, Juli and Han, Pyung-Lim and Lee, Ja-Kyeong
Cell death & disease, ISSN 2041-4889, 01/2018, Volume 9, Issue 4, pp. 426 - 14
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Inflammation - pathology | Bacterial Infections - etiology | Male | Infarction, Middle Cerebral Artery - metabolism | Brain - metabolism | Inflammation - metabolism | HMGB1 Protein - metabolism | Behavior, Animal - drug effects | Toll-Like Receptor 4 - antagonists & inhibitors | HMGB1 Protein - antagonists & inhibitors | Disease Models, Animal | Lipopolysaccharides - toxicity | Rats | Infarction, Middle Cerebral Artery - pathology | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Peptides - pharmacology | Brain - drug effects | Animals | Cyclooxygenase 2 - metabolism | Brain - pathology | Ketamine - pharmacology | HMGB1 Protein - blood | Bacterial Infections - metabolism | Nitric Oxide Synthase Type II - metabolism | Potentiation | Stroke | Therapeutic applications | Neurobiology | Infections | Inflammation | Glutamic acid receptors | TLR4 protein | HMGB1 protein | Lipopolysaccharides | Ischemia | Cerebral blood flow | Rodents | Toll-like receptors | Aspartic acid | D-aspartic acid | N-Methyl-D-aspartic acid | Brain injury | Apoptosis | Index Medicus
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6. Full Text NADPH oxidase mediates depressive behavior induced by chronic stress in mice
by Seo, Ji-Seon and Park, Jin-Young and Choi, Juli and Kim, Tae-Kyung and Shin, Joo-Hyun and Lee, Ja-Kyeong and Han, Pyung-Lim
The Journal of neuroscience, ISSN 0270-6474, 07/2012, Volume 32, Issue 28, pp. 9690 - 9699
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Gene Expression Regulation, Enzymologic - drug effects | Corticosterone - pharmacology | Reactive Oxygen Species - metabolism | Humans | NADPH Oxidases - metabolism | Male | Green Fluorescent Proteins - genetics | Hippocampus - drug effects | Depressive Disorder - etiology | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Imipramine - administration & dosage | Brain - metabolism | Acetophenones - administration & dosage | Swimming - psychology | Time Factors | Social Behavior | Depressive Disorder - enzymology | Lipid Peroxidation - drug effects | Superoxides - metabolism | NADPH Oxidases - genetics | Restraint, Physical - adverse effects | Neurons - metabolism | Neurons - drug effects | Antidepressive Agents, Tricyclic - administration & dosage | Neuroblastoma - pathology | Disease Models, Animal | Depressive Disorder - genetics | Cell Line | Green Fluorescent Proteins - metabolism | Drug Administration Schedule | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Hydrogen Peroxide - pharmacology | Ascorbic Acid - administration & dosage | Mice, Transgenic | Hippocampus - pathology | Phosphoproteins - genetics | Hindlimb Suspension | Animals | Analysis of Variance | Gene Expression Regulation, Enzymologic - genetics | Antioxidants - administration & dosage | Depressive Disorder - prevention & control | Corticosterone - metabolism | Mice | Lipid Peroxidation - genetics | RNA, Small Interfering - metabolism | Index Medicus
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7. Full Text Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours
by Sim, Hye-Ri and Choi, Tae-Yong and Lee, Hyo Jin and Kang, Eun Young and Yoon, Sehyoun and Han, Pyung-Lim and Choi, Se-Young and Baik, Ja-Hyun
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1579 - 1579
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Electric Stimulation | Receptors, Dopamine D2 - deficiency | Neuronal Plasticity - drug effects | Behavior, Addictive - etiology | Receptors, Dopamine D2 - metabolism | Behavior, Addictive - metabolism | Gene Knockdown Techniques | Lentivirus - metabolism | Stress, Psychological - metabolism | Anxiety - complications | Behavior, Animal - drug effects | Restraint, Physical | Central Nervous System Sensitization - drug effects | Behavior, Addictive - physiopathology | Anxiety - metabolism | Nucleus Accumbens - pathology | Nucleus Accumbens - physiopathology | Conditioning (Psychology) - drug effects | Anxiety - physiopathology | Maze Learning - drug effects | Cocaine - pharmacology | Animals | Mice | In Vitro Techniques | Nucleus Accumbens - drug effects | Stress, Psychological - complications | Stress, Psychological - physiopathology | Index Medicus
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8. Full Text Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum
by Lee, Yunjin and Han, Pyung-Lim
Experimental neurobiology, ISSN 1226-2560, 06/2019, Volume 28, Issue 3, pp. 337 - 351
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | dorsal striatum | dopamine receptors | TrkB receptor | early-life stress | Original | Autism spectrum disorder | 뇌과학
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9. Full Text Excessive D1 Dopamine Receptor Activation in the Dorsal Striatum Promotes Autistic-Like Behaviors
by Lee, Yunjin and Lee, Yunjin and Kim, Hannah and Kim, Hannah and Kim, Ji-Eun and Kim, Ji-Eun and Park, Jin-Young and Park, Jin-Young and Choi, Juli and Choi, Juli and Lee, Jung-Eun and Lee, Jung-Eun and Lee, Eun-Hwa and Lee, Eun-Hwa and Han, Pyung-Lim and Han, Pyung-Lim
Molecular neurobiology, ISSN 0893-7648, 7/2018, Volume 55, Issue 7, pp. 5658 - 5671
Neurology | Neurosciences | Biomedicine | Dopamine | D1 receptor | Neurobiology | Autism spectrum disorder | Dorsal striatum | Cell Biology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Autistic Disorder - pathology | Phosphorylation | Autistic Disorder - metabolism | Mice, Inbred C57BL | Receptors, N-Methyl-D-Aspartate - metabolism | Optogenetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Substantia Nigra - metabolism | Receptor, Metabotropic Glutamate 5 - metabolism | Corpus Striatum - metabolism | Mice, Knockout | Receptors, Dopamine D1 - metabolism | Behavior, Animal | Animals | Social Behavior | Corpus Striatum - pathology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Autism | Medical research | Brain research | Animal behavior | Neurons | Analysis | Medicine, Experimental | Phenols | Dopamine receptors | Animal models | Phenotypes | Substantia nigra | siRNA | Caudate-putamen | Dopamine D1 receptors | Rodents | Neostriatum | Amphetamines | Dopamine transporter | Mice | Receptor mechanisms | Dopamine D2 receptors | Index Medicus
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