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ISSN 1359-7345, 1/2018, Volume 54, Issue 7, pp. 833 - 836
The neuronal protein α-synuclein (αS) plays a key role in Parkinson's disease, forming inclusions termed Lewy bodies and Lewy neurites. Recent improvements in... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 32, pp. 13482 - 13497
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2015, Volume 108, Issue 2, pp. 64a - 64a
Journal Article
ISSN 1477-0520, 3/2015, Volume 13, Issue 14, pp. 4183 - 4189
We report here a chemoselective peptide "stapling" method that can be performed on ligand-receptor complexes in situ . An appropriately structured macrocyclic... 
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2015, Volume 108, Issue 2, p. 64
Journal Article
Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 7, pp. 833 - 836
Journal Article
ISSN 1477-0520, 6/2016, Volume 14, Issue 24, pp. 5768 - 5773
Peptide cross-linking has been widely explored as a means of constraining short sequences into stable folded conformations, most commonly α-helices. The... 
Journal Article
Journal of Peptide Science, ISSN 1075-2617, 02/2014, Volume 20, Issue 2, pp. 108 - 114
Journal Article
Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 7, pp. 833 - 836
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2018, Volume 114, Issue 3, pp. 586a - 587a
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 02/2019, Volume 141, Issue 5, pp. 1893 - 1897
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2017, Volume 292, Issue 32, pp. 13482 - 13497
Direct cell-to-cell transmission of proteopathic alpha-synuclein (alpha-syn) aggregates is thought to underlie the progression of neuro-degenerative... 
CELLS | FIBRILS | LEWY BODY | SPECTROSCOPIC PROPERTIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | DNA TRANSFECTION | AXONAL-TRANSPORT | CHLOROQUINE | NEURODEGENERATIVE DISEASES | PARKINSONS-DISEASE | Neurons - pathology | Humans | Fluorescent Dyes - analysis | Trypan Blue - analysis | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Endocytosis | Lysosomes - metabolism | Neurons - ultrastructure | Protein Aggregation, Pathological - pathology | Endosomes - ultrastructure | Hippocampus - ultrastructure | Lysosomes - pathology | Neurons - metabolism | Porphobilinogen - analogs & derivatives | alpha-Synuclein - genetics | Rhodamines - chemistry | Green Fluorescent Proteins - chemistry | Fluorescent Dyes - chemistry | Green Fluorescent Proteins - metabolism | Microscopy, Electron, Transmission | Cells, Cultured | Hippocampus - pathology | Endosomes - pathology | Recombinant Fusion Proteins - chemistry | Porphobilinogen - analysis | Porphobilinogen - chemistry | alpha-Synuclein - chemistry | Lysosomes - ultrastructure | Hippocampus - metabolism | Coloring Agents - analysis | Animals | Embryo, Mammalian - cytology | Mice | Mutation | alpha-Synuclein - metabolism | Protein Aggregation, Pathological - metabolism | Amino Acid Substitution | Hydrogen-Ion Concentration | Rhodamines - analysis | Editors' Picks | fibril | amyloid | neurodegenerative disease | transmission | confocal microscopy | alpha-synuclein | lysosome | synucleinopathies
Journal Article
ISSN 1359-7345, 10/2017, Volume 53, Issue 8, pp. 1172 - 1175
Site-specific fluorescence probes can be used to measure distances within proteins when used as part of a Förster resonance energy transfer (FRET) pair. Here... 
Journal Article
Chemical Communications, ISSN 1359-7345, 10/2011, Volume 47, Issue 39, pp. 10915 - 10917
Covalent side-chain cross-linking has been shown to be a viable strategy to control peptide folding. We report here that an oxime side-chain linkage can elicit... 
CATALYSIS | PROTEIN | SOLID-PHASE SYNTHESIS | HYDRAZONE | BUILDING-BLOCKS | AMINO-ACIDS | STABILIZATION | STABILITY | UNPROTECTED PEPTIDES | CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | Oximes - chemistry | Amino Acid Sequence | Peptides - chemistry | Protein Structure, Secondary | Water - chemistry | Molecular Sequence Data | Protein Folding
Journal Article
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