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Cancer Discovery, ISSN 2159-8274, 04/2019, Volume 9, Issue 4, pp. 482 - 491
The PI3K pathway is mutated and aberrantly activated in many cancers and plays a central role in tumor cell proliferation and survival, making it a rational... 
DOSE-ESCALATION | ONCOLOGY | PHASE IB | PATHWAY | METASTATIC BREAST-CANCER | DOUBLE-BLIND | RESISTANCE | MOUSE-MODEL | GENOMIC CHARACTERIZATION | ACTIVATING MUTATIONS | PLUS
Journal Article
Oncology Times, ISSN 0276-2234, 11/2017, Volume 39, Issue 22, pp. 36 - 37
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 69, pp. 114371 - 114392
The ERBB family of receptor tyrosine kinases has been implicated in carcinogenesis for over three decades with rigorous attention to EGFR and HER2. ERBB... 
Mutation | HER2 | EGFR | HER4 | HER3 | HUMAN-BREAST-CANCER | ACQUIRED-RESISTANCE | EGFR MUTATIONS | DOMAIN MUTATIONS | SOMATIC MUTATIONS | CELL BIOLOGY | CELL LUNG-CANCER | mutation | TARGETED THERAPIES | EPIDERMAL-GROWTH-FACTOR | TYROSINE KINASE INHIBITOR | ACTIVATING MUTATIONS
Journal Article
Journal Article
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 12/2016, Volume 160, Issue 3, p. 457
Purpose Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in human breast cancer. Furthermore, PIK3CA mutations are commonly associated... 
Epidermal growth factor | RNA | Analysis | Genomics | Estrogen | Genetic research | Breast cancer | Genetic aspects | Genomes | Gene expression | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 06/2017, Volume 77, Issue 12, pp. 3280 - 3292
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2013, Volume 4, Issue 11, pp. 1866 - 1867
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4323 - 4334
Purpose: Dual blockade of HER2 with trastuzumab and lapatinib or pertuzumab has been shown to be superior to single-agent trastuzumab. However, a significant... 
CELLS | ONCOGENE | SOLID TUMORS | TRASTUZUMAB | ONCOLOGY | CCND1 AMPLIFICATION | GROWTH | ACQUIRED-RESISTANCE | OPEN-LABEL | KINASE INHIBITOR LAPATINIB | ERBB RECEPTORS | Receptor, ErbB-2 - genetics | Humans | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Antibodies, Monoclonal, Humanized - administration & dosage | Female | Quinazolines - administration & dosage | Receptor, ErbB-2 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Lapatinib | Fibroblast Growth Factor 3 - antagonists & inhibitors | Fibroblast Growth Factor 3 - genetics | Antineoplastic Combined Chemotherapy Protocols | Trastuzumab - administration & dosage | Breast Neoplasms - drug therapy | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Neoadjuvant Therapy - adverse effects | Mice | Drug Resistance, Neoplasm - drug effects | Phosphorylation | Copy number | Statistical methods | Kinases | Xenografts | Fibroblast growth factor receptor 1 | Protein-tyrosine kinase | Tyrosine | Fibroblast growth factor 3 | Statistical analysis | Breast cancer | Gene expression | Patients | ErbB-2 protein | Fibroblast growth factor 4 | Amplification | Signaling | Gene amplification | Inhibitors | Experimental design | Breast | Trastuzumab | Tumors | Cancer | Fibroblast growth factor receptors | trastuzumab | breast cancer | drug resistance | HER2 | FGFR
Journal Article
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