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Molecular Psychiatry, ISSN 1359-4184, 11/2013, Volume 18, Issue 11, pp. 1225 - 1234
Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer's... 
Brain | Tau | BIN1 | Alzheimer | Drosophila | COMMON VARIANTS | PHOSPHORYLATION | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | brain | ENDOCYTOSIS | NEUROSCIENCES | IDENTIFIES VARIANTS | DISEASE | AMPHIPHYSIN-II | GENOME-WIDE ASSOCIATION | Endophenotypes | Gene Expression - genetics | Humans | Transcription Factors - deficiency | Nerve Degeneration - genetics | tau Proteins - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Case-Control Studies | Alzheimer Disease - pathology | Brain - metabolism | Drosophila melanogaster - metabolism | Synaptosomes - pathology | Nuclear Proteins - biosynthesis | Tumor Suppressor Proteins - genetics | Nuclear Proteins - genetics | tau Proteins - antagonists & inhibitors | Genetic Predisposition to Disease - genetics | Plaque, Amyloid - pathology | Cells, Cultured | Transcription Factors - genetics | Nerve Degeneration - pathology | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Alzheimer Disease - metabolism | Drosophila Proteins - deficiency | Brain - pathology | Polymorphism, Single Nucleotide - genetics | Adaptor Proteins, Signal Transducing - biosynthesis | Mice | Drosophila Proteins - genetics | Alzheimer Disease - genetics | Tumor Suppressor Proteins - biosynthesis | Physiological aspects | Complications and side effects | Genetic aspects | Alzheimer's disease | Risk factors | Amyloid beta-protein | Index Medicus | Original
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 11/2009, Volume 14, Issue 11, pp. 1004 - 1016
The only recognized genetic determinant of the common forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). To... 
CAA | Brain expression | Alzheimer | IL-33 | Polymorphism | CEREBRAL AMYLOID ANGIOPATHY | IMMUNE CELLS | PROTEIN | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAST-CELLS | RISK | polymorphism | APOLIPOPROTEIN-E GENOTYPE | NEUROSCIENCES | VASCULAR DEMENTIA | brain expression | A-BETA | SMOOTH-MUSCLE-CELLS | ASSOCIATION | Apolipoprotein E4 - genetics | Follow-Up Studies | Humans | Cercopithecus aethiops | Male | Neuroblastoma | Cerebral Amyloid Angiopathy - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Interleukins - metabolism | Alzheimer Disease - pathology | Alzheimer Disease - diagnosis | Brain - metabolism | Interleukins - genetics | Transfection - methods | Genetic Load | Amyloid beta-Peptides - metabolism | Female | Retrospective Studies | Cerebral Amyloid Angiopathy - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Peptide Fragments - metabolism | Interleukin-33 | Oligonucleotide Array Sequence Analysis - methods | Proportional Hazards Models | Genotype | International Cooperation | Cerebral Amyloid Angiopathy - pathology | Animals | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | COS Cells | Cell Line, Transformed | Immunohistochemistry | Interleukins | Amyloid beta-protein | Genetic aspects | Research | Apolipoproteins | Health aspects | Alzheimer's disease | Risk factors
Journal Article
EBioMedicine, ISSN 2352-3964, 07/2016, Volume 9, Issue C, pp. 278 - 292
Journal Article
Journal Article
Journal Article
Carcinogenesis, ISSN 0143-3334, 12/2017, Volume 38, Issue 12, pp. 1157 - 1166
Evolution led to an essential symbiotic relationship between the host and commensal microbiota, regulating physiological functions including inflammation and... 
INTESTINAL INFLAMMATION | FUSOBACTERIUM-NUCLEATUM | POLYMERASE-CHAIN-REACTION | ONCOLOGY | GASTRIC-CANCER | COLORECTAL-CANCER | ESCHERICHIA-COLI | REGULATORY T-CELLS | ENTEROTOXIGENIC BACTEROIDES-FRAGILIS | GUT MICROBIOTA | TUMOR MICROENVIRONMENT
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2006, Volume 399, Issue 2, pp. 275 - 283
The transcription activator SREBP-1c (sterol-regulatory-element-binding protein-1c) is induced by insulin in the liver and is considered a master regulator of... 
Fatty acid synthase | Glycogen synthase kinase-3 | Insulin | Glucokinase | Liver | TRANSCRIPTION FACTORS | ACTIVATION | LIPID-METABOLISM | insulin | liver | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUTRITIONAL REGULATION | SREBP FAMILY | KINASE B/CAKT | LIPOGENIC ENZYME GENES | glycogen synthase kinase-3 | fatty acid synthase | GLUCOSE | EXPRESSION | glucokinase | DEPENDENT DEGRADATION | Gene Expression Regulation, Enzymologic - drug effects | Fatty Acid Synthases - metabolism | Rats, Wistar | Male | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Liver X Receptors | Protein Binding - drug effects | Orphan Nuclear Receptors | Fatty Acid Synthases - genetics | Hepatocytes - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Insulin - pharmacology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | RNA, Messenger - genetics | Rats | Glucokinase - genetics | Glucokinase - metabolism | Hydrocarbons, Fluorinated | Sulfonamides - pharmacology | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Hepatocytes - enzymology | Receptors, Cytoplasmic and Nuclear - metabolism | CYP7A1, cytochrome P450, family 7, subfamily A, polypeptide 1 | SRE, sterol-regulatory element | ACC, acetyl-CoA carboxylase | LXRE1, LXR binding element 1 | FAK, focal adhesion kinase | GCK, glucokinase | GSK-3, glycogen synthase kinase-3 | RT, reverse transcription | FASN, fatty acid synthase | SREBP-1c, sterol-regulatory-element-binding protein 1c | ChIP, chromatin immunoprecipitation | ECL, enhanced chemiluminescence | CAT, chloramphenicol acetyltransferase | LXR, liver X receptor | FBS, foetal bovine serum | qPCR, quantitative PCR
Journal Article
Molecular psychiatry, ISSN 1359-4184, 11/2009, Volume 14, Issue 11, pp. 1004 - 1016
The only recognised genetic determinant of the common forms of Alzheimer’s disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). To identify new... 
brain expression | CAA | polymorphism | Alzheimer | IL-33
Journal Article
Digestive and Liver Disease, ISSN 1590-8658, 2012, Volume 45, Issue 3, pp. 195 - 199
Journal Article