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1. Development of High Efficiency MHD Power Generation and Related Technologies
by Nobuhiro Harada
Denki Gakkai Ronbunshi. B, Enerugi, Denki Kiki, Denryoku, ISSN 0385-4213, 10/2016, Volume 136, Issue 10, p. 768
Electric power generation | Power efficiency
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2. Full Text Post‐translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation
by Hayashi, Takanori and Harada, Nobuhiro
FEBS Journal, ISSN 1742-464X, 11/2014, Volume 281, Issue 21, pp. 4830 - 4840
The post‐translational regulation of aromatase has not been well characterized as compared with transcriptional regulation. Several studies of... 
calcium/calmodulin kinase II | aromatase | calcineurin | phosphorylation | post‐translational regulation | Phosphorylation | Post-translational regulation | Calcium/calmodulin kinase II | Aromatase | Calcineurin | OVARY | QUAIL BRAIN | calcium/calmodulin kinase II | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE | RAPID CONTROL | HUMAN PLACENTAL AROMATASE | ENZYME | BRAIN AROMATASE | post-translational regulation | ESTRADIOL | GENE-EXPRESSION | Cyclosporine - pharmacology | Humans | Aromatase - metabolism | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Adenosine Triphosphate - pharmacology | Cytosol - enzymology | Proteolysis - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology | Tacrolimus - pharmacology | Female | Phosphorylation - drug effects | Calcium - pharmacology | RNA, Small Interfering - pharmacology | Alkaline Phosphatase - pharmacology | Microsomes - enzymology | Magnesium - pharmacology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Catalysis - drug effects | Alkaline Phosphatase - antagonists & inhibitors | Choriocarcinoma - pathology | Cell-Free System | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Proteolysis | Proteins | Enzymes | Catalysis | Cellular biology | Index Medicus
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3. Full Text Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis
by Ubuka, Takayoshi and Haraguchi, Shogo and Tobari, Yasuko and Narihiro, Misato and Ishikawa, Kei and Hayashi, Takanori and Harada, Nobuhiro and Tsutsui, Kazuyoshi
Nature Communications, ISSN 2041-1723, 01/2014, Volume 5, Issue 1, pp. 3061 - 3061
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion and socio-sexual behaviours. Oestrogen... 
QUAIL COTURNIX-JAPONICA | MALE SEXUAL-BEHAVIOR | AGGRESSIVE-BEHAVIOR | MALE JAPANESE-QUAIL | BRAIN AROMATASE-ACTIVITY | FINCH TAENIOPYGIA-GUTTATA | MULTIDISCIPLINARY SCIENCES | HORMONE GNIH | LOCOMOTOR-ACTIVITY | RAPID CONTROL | CDNA CLONING | Hypothalamus - physiology | Hypothalamic Hormones - administration & dosage | Aromatase - metabolism | Behavior, Animal - physiology | Male | Circadian Rhythm - physiology | Preoptic Area - metabolism | Glycoproteins - pharmacology | Glycoproteins - administration & dosage | Hypothalamic Hormones - pharmacology | Dose-Response Relationship, Drug | Sexual Behavior, Animal - physiology | Animals | Behavior, Animal - drug effects | Models, Animal | Coturnix - physiology | Androgens - metabolism | Estrogens - metabolism | Infusions, Intraventricular | Sexual Behavior, Animal - drug effects | Estradiol - pharmacology | Index Medicus
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4. Full Text X-ray and Electron Spectroscopy of Water
by Fransson, Thomas and Harada, Yoshihisa and Kosugi, Nobuhiro and Besley, Nicholas A and Winter, Bernd and Rehr, John J and Pettersson, Lars G. M and Nilsson, Anders and Institutionen för fysik, kemi och biologi and Linköpings universitet and Teoretisk kemi and Tekniska fakulteten
Chemical Reviews, ISSN 0009-2665, 07/2016, Volume 116, Issue 13, pp. 7551 - 7569
Here we present an overview of recent developments of X-ray and electron spectroscopy to probe water at different temperatures. Photon-induced ionization... 
HYDROGEN-BOND-NETWORK | SELF-CONSISTENT-FIELD | ABSORPTION FINE-STRUCTURE | OXYGEN K-EDGE | CORE-LEVEL SPECTROSCOPY | LIQUID WATER | 1ST COORDINATION SHELL | DENSITY-FUNCTIONAL THEORY | CHEMISTRY, MULTIDISCIPLINARY | STATIC-EXCHANGE CALCULATIONS | EMISSION SPECTROSCOPY | Hydrogen bonds | Simulation | Spectrum analysis | Electrons | Electronic structure | Phases | Absorption | Computer simulation | Ionization | X-rays | Electron spectroscopy | Hydrogen bonding | Fysik | Atom and Molecular Physics and Optics | Physical Sciences | Naturvetenskap | Natural Sciences | Atom- och molekylfysik och optik
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5. Full Text Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines
by Kong, Il Gyu and Tokuhara, Daisuke and Kurokawa, Shiho and Sato, Ayuko and Kohda, Tomoko and Harada, Norihiro and Mejima, Mio and Kozaki, Shunji and Yuki, Yoshikazu and Takahashi, Yuko and Kiyono, Hiroshi and Kataoka, Nobuhiro and Akiyoshi, Kazunari and Takahashi, Haruko and Sawada, Shin-ichi and Nochi, Tomonori and Tsukada, Hideo
Nature Materials, ISSN 1476-1122, 07/2010, Volume 9, Issue 7, pp. 572 - 578
Nanotechnology is an innovative method of freely controlling nanometre-sized materials. Recent outbreaks of mucosal infectious diseases have increased the... 
PHYSICS, CONDENSED MATTER | HUMORAL IMMUNE-RESPONSES | PHYSICS, APPLIED | DENDRITIC CELLS | MUCOSAL IMMUNITY | STABILIZATION | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | ASSEMBLED HYDROGEL NANOPARTICLE | MOLECULAR CHAPERONE | GENERATION | HYDROPHOBIZED POLYSACCHARIDES | CHOLERA-TOXIN | PULLULAN | Nanoparticles - chemistry | Nanotechnology - methods | Botulinum Toxins, Type A - chemistry | Materials Testing | Olfactory Bulb - metabolism | Administration, Intranasal | Drug Delivery Systems | Brain - metabolism | Clostridium botulinum - metabolism | Animals | Immune System | Vaccines - chemistry | Female | Mice | Mice, Inbred BALB C | Gels - chemistry | Proteins | Nanomaterials | Materials science | Biomedical materials | Vaccines | Index Medicus
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6. Full Text USP19-mediated deubiquitination facilitates the stabilization of HRD1 ubiquitin ligase
by Harada, Kumi and Kato, Masako and Nakamura, Nobuhiro
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1829 - 1829
In the endoplasmic reticulum (ER), misfolded and unfolded proteins are eliminated by a process called ER-associated protein degradation (ERAD) in order to... 
ERAD | Deubiquitinating enzyme | Membrane protein | Ubiquitin ligase | Endoplasmic reticulum | ubiquitin ligase | ENDOPLASMIC-RETICULUM UBIQUITIN | UNFOLDED-PROTEIN RESPONSE | deubiquitinating enzyme | MUSCLE ATROPHY | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, MULTIDISCIPLINARY | USP19 | PROTEASOME | membrane protein | DEGRADATION | endoplasmic reticulum | Endoplasmic Reticulum-Associated Degradation | Endopeptidases - metabolism | RNA, Small Interfering - genetics | Humans | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Ubiquitin - genetics | Ubiquitination | Animals | Endopeptidases - genetics | Proteolysis | HEK293 Cells | Proteasome Endopeptidase Complex - metabolism | Protein Stability | Ubiquitin-Protein Ligases - genetics | COS Cells | RNA, Small Interfering - metabolism | Proteins | Enzymes | Protein folding | Proteases | Index Medicus
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7. Full Text The proportion of chromatin graded between closed and open states determines the level of transcripts derived from distinct promoters in the CYP19 gene
by Kotomura, Naoe and Harada, Nobuhiro and Ishihara, Satoru
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0128282 - e0128282
The human CYP19 gene encodes aromatase, which converts androgens to estrogens. CYP19 mRNA variants are transcribed mainly from three promoters. Quantitative... 
TARGET | METHYLATION | HUMAN GENOME | RECOGNITION | MULTIDISCIPLINARY SCIENCES | TISSUES | AROMATASE | MAMMALIAN-CELLS | EXPRESSION | BINDING | Chromatin - metabolism | Aromatase - genetics | Transcription, Genetic - physiology | Promoter Regions, Genetic - physiology | Humans | Aromatase - biosynthesis | Gene Expression Regulation, Enzymologic - physiology | HeLa Cells | Chromatin - genetics | Chromatin Assembly and Disassembly - physiology | Hep G2 Cells | Physiological aspects | Chromatin | Hormones, Sex | Research | Cytochrome P-450 | Cytochrome | Enzymes | Fractionation | Transcription factors | Transcription | Estrogens | Biochemistry | Genomes | Breast cancer | Gene expression | Loci | Promoters | Dispersion | Polymerase chain reaction | Proteins | Androgens | Antibiotics | Aromatase | DNA methylation | Nucleosomes | Deoxyribonucleic acid--DNA | Index Medicus | Deoxyribonucleic acid | DNA
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8. Full Text The Androgen Receptor Governs the Execution, but Not Programming, of Male Sexual and Territorial Behaviors
by Juntti, Scott A and Tollkuhn, Jessica and Wu, Melody V and Fraser, Eleanor J and Soderborg, Taylor and Tan, Stella and Honda, Shin-Ichiro and Harada, Nobuhiro and Shah, Nirao M
Neuron, ISSN 0896-6273, 2010, Volume 66, Issue 2, pp. 260 - 272
Testosterone and estrogen are essential for male behaviors in vertebrates. How these two signaling pathways interact to control masculinization of the brain... 
SYSNEURO | EVO_ECOL | MOLNEURO | Sysneuro | Evo_Ecol | Molneuro | MESSENGER-RIBONUCLEIC-ACID | FEMALE MOUSE-BRAIN | STRIA TERMINALIS | AROMATASE GENE CYP19 | TESTICULAR FEMINIZATION MUTATION | CENTRAL-NERVOUS-SYSTEM | PREOPTIC AREA | RAT FOREBRAIN | NEUROSCIENCES | MICE LACKING | BED NUCLEUS | Brain - metabolism | Sexual Behavior, Animal - physiology | Testosterone - metabolism | Territoriality | Animals | Receptors, Androgen - genetics | Receptors, Androgen - metabolism | Male | Mice, Transgenic | Mice | Neurons - metabolism | Estrogens - metabolism | Testosterone | Neurosciences | Neurons | Estrogen | Executions and executioners | Genotype & phenotype | Behavior | Gene expression | Index Medicus
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9. Full Text Characterization of a novel reassortant H7N3 highly pathogenic avian influenza virus isolated from a poultry meat product taken on a passenger flight to Japan
by SHIBATA, Akihiro and HARADA, Rieko and OKAMATSU, Masatoshi and MATSUNO, Keita and ARITA, Tomoko and SUZUKI, Yasushi and SHIRAKURA, Masayuki and ODAGIRI, Takato and TAKEMAE, Nobuhiro and UCHIDA, Yuko and SAITO, Takehiko and SAKODA, Yoshihiro and OSAKA, Hiroyuki
Journal of Veterinary Medical Science, ISSN 0916-7250, 2019, Volume 81, Issue 3, pp. 444 - 448
A new reassortant H7N3 avian influenza virus (AIV) was isolated from a duck meat product that was illegally taken on board a passenger flight from China to... 
reassortant virus | highly pathogenic avian influenza virus | H7N3 subtype | E627K | VETERINARY SCIENCES | HUMAN INFECTION | Epidemics | Passengers | Antigenicity | Flight | Influenza | Biological evolution | Viruses | Aquatic birds | Avian flu | Evolution & development | Meat products | Meat | Index Medicus | Virology
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10. Full Text Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6
by Nakamura, Nobuhiro and Harada, Kumi and Kato, Masako and Hirose, Shigehisa
Experimental Cell Research, ISSN 0014-4827, 10/2014, Volume 328, Issue 1, pp. 207 - 216
Ubiquitin-specific protease (USP)19 is a recently identified deubiquitinating enzyme (DUB) having multiple splice variants and cellular functions. One variant... 
Proteasomal degradation | Endoproteolytic processing | Deubiquitinating enzyme | E3 ubiquitin ligase | ER-associated degradation | RECOGNITION | RETROTRANSLOCATION | QUALITY-CONTROL | USP19 | CELL BIOLOGY | ONCOLOGY | DISLOCATION | DEGRADATION | ENDOPLASMIC-RETICULUM | PROTEINS | Endopeptidases - metabolism | RNA, Small Interfering - genetics | Immunoprecipitation | Humans | Cells, Cultured | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Endoplasmic Reticulum - metabolism | Ubiquitin-Protein Ligases - chemistry | Blotting, Western | Endopeptidases - chemistry | Ubiquitination | Animals | Endopeptidases - genetics | Membrane Proteins - chemistry | ATP Binding Cassette Subfamily B Member 11 | HEK293 Cells | ATP-Binding Cassette Transporters - metabolism | Membrane Proteins - metabolism | Mice | Protein Processing, Post-Translational | Protein Stability | Proteins | Proteases | Ligases | Enzymes | Membranes | Index Medicus
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11. Full Text Visualization of subcapsular hepatic malignancy by indocyanine-green fluorescence imaging during laparoscopic hepatectomy
by Kudo, Hiroki and Ishizawa, Takeaki and Tani, Keigo and Harada, Nobuhiro and Ichida, Akihiko and Shimizu, Atsushi and Kaneko, Junichi and Aoki, Taku and Sakamoto, Yoshihiro and Sugawara, Yasuhiko and Hasegawa, Kiyoshi and Kokudo, Norihiro
Surgical Endoscopy, ISSN 0930-2794, 8/2014, Volume 28, Issue 8, pp. 2504 - 2508
Although laparoscopic hepatectomy has increasingly been used to treat cancers in the liver, the accuracy of intraoperative diagnosis may be inferior to that of... 
Fluorescence imaging | Medicine & Public Health | Surgery | Gynecology | Hepatology | Gastroenterology | Abdominal Surgery | Hepatocellular carcinoma | Indocyanine green | Laparoscopic hepatectomy | Liver metastasis | Proctology | SURGERY | HEPATOCELLULAR-CARCINOMA | INTRAOPERATIVE ULTRASONOGRAPHY | COLORECTAL LIVER METASTASES | Carcinoma, Hepatocellular - diagnosis | Coloring Agents | Humans | Middle Aged | Indocyanine Green | Fluorescence | Carcinoma, Hepatocellular - surgery | Liver Neoplasms - surgery | Male | Laparoscopy | Hepatectomy | Liver Neoplasms - diagnosis | Intraoperative Care | Female | Liver Neoplasms - secondary | Liver cancer | Laparoscopic surgery | Index Medicus
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12. Full Text Steroid hormone action and sex differences in brain function
by Harada, Nobuhiro
Neuroscience Research, ISSN 0168-0102, 09/2011, Volume 71, pp. e45 - e45
NEUROSCIENCES
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13. Full Text Adult Male Rat Hippocampus Synthesizes Estradiol from Pregnenolone by Cytochromes P45017α and P450 Aromatase Localized in Neurons
by Yasushi Hojo and Taka-aki Hattori and Taihei Enami and Aizo Furukawa and Kumiko Suzuki and Hiro-taka Ishii and Hideo Mukai and John H. Morrison and William G. M. Janssen and Shiro Kominami and Nobuhiro Harada and Tetsuya Kimoto and Suguru Kawato
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2004, Volume 101, Issue 3, pp. 865 - 870
In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol has been doubted because of the inability to detect... 
Brain | Solvents | Testosterone | Biological Sciences | Messenger RNA | Neurons | Pyramidal cells | Neuroglia | Cytochromes | Hippocampus | Steroids | DEHYDROEPIANDROSTERONE-SULFATE | MESSENGER-RNA | DENDRITIC SPINE DENSITY | MULTIDISCIPLINARY SCIENCES | NEUROSTEROIDS | STEROIDOGENIC ENZYMES | RECEPTOR | CENTRAL-NERVOUS-SYSTEM | EXPRESSION | BRAIN | METHYL-D-ASPARTATE
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14. Full Text Brain Estrogen Deficiency Accelerates Aβ Plaque Formation in an Alzheimer's Disease Animal Model
by Xu Yue and Melissa Lu and Techie Lancaster and Phillip Cao and Shin-Ichiro Honda and Matthias Staufenbiel and Nobuhiro Harada and Zhenyu Zhong and Yong Shen and Rena Li
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2005, Volume 102, Issue 52, pp. 19198 - 19203
Much evidence indicates that women have a higher risk of developing Alzheimer's disease (AD) than do men. The reason for this gender difference is unclear. We... 
Proteins | Brain | Biological Sciences | Messenger RNA | Transgenic animals | Neurons | Neuropathology | Estrogens | Mice | Amyloids | Microglia | Transgenic animal | Amyloid deposition | Aromatase | SECRETASE | NEPRILYSIN | aromatase | INSULIN-DEGRADING ENZYME | MULTIDISCIPLINARY SCIENCES | CYP19 GENE | AMYLOID PRECURSOR PROTEIN | PATHOLOGY | PREVALENCE | MOUSE MODELS | transgenic animal | RAT-BRAIN | amyloid deposition | TRANSGENIC MICE
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15. Full Text A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis in Heart and Kidney Transplant Recipients in Japan
by Owada, Yohei and Oshiro, Yukio and Inagaki, Yuki and Harada, Hiroshi and Fujiyama, Nobuhiro and Kawagishi, Naoki and Yagisawa, Takashi and Usui, Joichi and Akutsu, Naotake and Itabashi, Yoshihiro and Saito, Kazuhide and Watarai, Yoshihiko and Ichimaru, Naotsugu and Imamura, Ryoichi and Kyakuno, Miyaji and Ide, Kentaro and Shibuya, Yuichi and Okabe, Yasuhiro and Ono, Minoru and Sasaki, Konosuke and Shiose, Akira and Yamagishi, Kazumasa and Ohnishi, Hiroshi and Nagashima, Shigeo and Takahashi, Masaharu and Yuzawa, Kenji and Okamoto, Hiroaki and Ohkohchi, Nobuhiro
Transplantation, ISSN 0041-1337, 05/2019, p. 1
BACKGROUND.Recently, chronic hepatitis E has been reported in solid-organ transplant (SOT) recipients in European countries. Previously, we clarified the... 
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16. Full Text Visualization of volatile substances in different organelles with an atmospheric-pressure mass microscope
by Harada, Takahiro and Yuba-Kubo, Akiko and Sugiura, Yuki and Zaima, Nobuhiro and Hayasaka, Takahiro and Goto-Inoue, Naoko and Wakui, Masatoshi and Suematsu, Makoto and Takeshita, Kengo and Ogawa, Kiyoshi and Yoshida, Yoshikazu and Setou, Mitsutoshi
Analytical Chemistry, ISSN 0003-2700, 11/2009, Volume 81, Issue 21, pp. 9153 - 9157
We have developed a mass microscope (mass spectrometry imager with spatial resolution higher than the naked eye) equipped with an atmospheric pressure... 
GINGER ZINGIBER-OFFICINALE | HIGH-SPATIAL-RESOLUTION | CHEMISTRY, ANALYTICAL | METABOLITES | METABOLOMICS | SMALL MOLECULES | DESORPTION/IONIZATION | RAT-BRAIN | IDENTIFICATION | SPECTROMETRY | TISSUE-SECTIONS | Tandem Mass Spectrometry - instrumentation | Ginger - chemistry | Monoterpenes - analysis | Volatile Organic Compounds - analysis | Fatty Alcohols - analysis | Volatile Organic Compounds - chemistry | Catechols - analysis | Tandem Mass Spectrometry - methods | Atmospheric Pressure | Usage | Cell organelles | Chemical properties | Observations | Mass spectrometry | Methods | Analytical chemistry | Volatile organic compounds--VOCs | Atmospheric pressure | Microscopes | Index Medicus
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