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Nature Medicine, ISSN 1078-8956, 10/2012, Volume 18, Issue 10, pp. 1570 - 1574
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57479 - e57479
Journal Article
Nature Biotechnology, ISSN 1087-0156, 11/2010, Volume 28, Issue 11, pp. 1203 - 1207
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, pp. e0209509 - e0209509
Modulating the complement system is a promising strategy in drug discovery for disorders with uncontrolled complement activation. Although some of these... 
SERUM HALF-LIFE | IMMUNOGENICITY | PHARMACOKINETICS | COMPLEMENT INHIBITOR ECULIZUMAB | MULTIDISCIPLINARY SCIENCES | IN-VIVO | HEMOPHILIA-A | MONOCLONAL-ANTIBODY | EMICIZUMAB PROPHYLAXIS | DEPENDENT ANTIGEN-BINDING | THERAPEUTIC ANTIBODY | Endosomes - immunology | Protein Engineering - methods | Humans | Macaca fascicularis | Antibodies, Monoclonal - therapeutic use | Drug Discovery - methods | Complement Activation - immunology | Complement C5 - isolation & purification | Recombinant Proteins - isolation & purification | Time Factors | Complement C5 - immunology | Computer Simulation | Antibodies, Monoclonal - immunology | Complement Activation - drug effects | Histocompatibility Antigens Class I - immunology | Immune System Diseases - immunology | Antibody Affinity | Immune System Diseases - drug therapy | Mice, Transgenic | Histocompatibility Antigens Class I - genetics | Antibodies, Monoclonal - genetics | Animals | Receptors, Fc - immunology | Mutagenesis | Recombinant Proteins - immunology | Receptors, Fc - genetics | Mice | Complement C5 - antagonists & inhibitors | Hydrogen-Ion Concentration | Viral antibodies | Protein engineering | Usage | Physiological aspects | Antibodies | Genetic aspects | Research | Complement (Immunology) | Neonates | Plasma | Intravenous administration | Immune clearance | Disorders | Complement | Monkeys | Dosage | pH effects | Accumulation | Engineering | Salvage | Hemophilia | Recycling | Drug dosages | Binding | Antigens | Surface charge | Immunoglobulins | Fc receptors | Complement activation | Complement component C5 | Mutation | Endosomes | Neutralization | Pharmaceuticals | Polymorphism | Index Medicus | pH
Journal Article
Journal Article
Journal Article
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 12/2017, Volume 32, Issue 6, pp. 277 - 285
Journal Article