X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chemistry (128) 128
heterocyclic compounds (127) 127
metallurgy (127) 127
organic chemistry (127) 127
human necessities (121) 121
hygiene (121) 121
medical or veterinary science (121) 121
preparations for medical, dental, or toilet purposes (121) 121
specific therapeutic activity of chemical compounds ormedicinal preparations (111) 111
acyclic or carbocyclic compounds (39) 39
index medicus (16) 16
chemistry, organic (13) 13
animals (10) 10
chemistry, medicinal (9) 9
mice (8) 8
humans (7) 7
inflammation (7) 7
derivatives (6) 6
receptors, glucocorticoid - agonists (6) 6
structure-activity relationship (6) 6
corticosteroids (5) 5
lactones (5) 5
letter (5) 5
steroids (5) 5
a-ring mimetics (4) 4
antigens (4) 4
asymmetric synthesis (4) 4
crohn's disease (4) 4
cytokines (4) 4
discovery (4) 4
glucocorticoids (4) 4
immunology (4) 4
inhibition (4) 4
mechanisms (4) 4
rats (4) 4
receptors, glucocorticoid - metabolism (4) 4
responses (4) 4
activation (3) 3
analysis (3) 3
anti-inflammatory agents - pharmacology (3) 3
antígens (3) 3
arthritis (3) 3
azaindoles (3) 3
binding (3) 3
binding sites (3) 3
biology and life sciences (3) 3
blockade (3) 3
butenolides (3) 3
chemistry, multidisciplinary (3) 3
chemokine receptors (3) 3
cèl·lules t (3) 3
dihydroxylations (3) 3
disease (3) 3
drug discovery (3) 3
female (3) 3
gamma-lactones (3) 3
glucocorticoid receptor (3) 3
glucocorticoids - chemistry (3) 3
hydrogen bonding (3) 3
inflammatory diseases (3) 3
inhibició (3) 3
ligand-binding domain (3) 3
ligands (3) 3
malaltia de crohn (3) 3
medicine and health sciences (3) 3
models, molecular (3) 3
modulators (3) 3
molecular-mechanisms (3) 3
natural-products (3) 3
other natural products (3) 3
pathogenesis (3) 3
potent (3) 3
prednisolone (3) 3
protein binding - drug effects (3) 3
rats, sprague-dawley (3) 3
rodents (3) 3
science (3) 3
stereoisomerism (3) 3
stereoselective synthesis (3) 3
t cells (3) 3
transcription (3) 3
transrepression (3) 3
7-azaindoles (2) 2
acid (2) 2
acids (2) 2
agriculture (2) 2
animal husbandry (2) 2
anti-inflammatory agents - chemistry (2) 2
anti-inflammatory agents - therapeutic use (2) 2
arthritis - drug therapy (2) 2
arylsulfonamide (2) 2
asymmetric dihydroxylation (2) 2
biocides, e.g. as disinfectants, as pesticides, as herbicides (2) 2
bruton's tyrosine kinase (2) 2
ccr1 (2) 2
cell biology (2) 2
chemokines (2) 2
cho cells (2) 2
clinical immunology (2) 2
cricetulus (2) 2
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (148) 148
French (26) 26
Spanish (23) 23
German (11) 11
Chinese (9) 9
Portuguese (5) 5
Arabic (4) 4
Norwegian (4) 4
Russian (3) 3
Serbian (3) 3
Korean (2) 2
Croatian (1) 1
Danish (1) 1
Greek (1) 1
Polish (1) 1
Slovenian (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


ACS Symposium Series, ISSN 0097-6156, 2016, Volume 1240, pp. 171 - 183
Conference Proceeding
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 05/2019, Volume 28, Issue 5, pp. 489 - 496
Background: An efficacious anti-inflammatory corticosteroid with reduced side effects has been long sought. We report the pooled results from three clinical... 
corticosteroid | glucocorticoid receptor | prednisolone | BI 653048 | Anti-inflammatory | SEGRA | MANAGEMENT | PHARMACOLOGY & PHARMACY | IDENTIFICATION | Index Medicus
Journal Article
Expert opinion on investigational drugs, 03/2019, p. 1
An efficacious anti-inflammatory corticosteroid with reduced side effects has been long sought. We report the pooled results from three clinical... 
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e100883
GPBAR1 is a G protein-coupled receptor that is activated by certain bile acids and plays an important role in the regulation of bile acid synthesis, lipid... 
Cricetulus | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Receptors, G-Protein-Coupled - agonists | Lipopolysaccharides - immunology | Myeloid Cells - immunology | Inflammation Mediators - metabolism | Female | Myeloid Cells - drug effects | Macrophages - immunology | CHO Cells | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Cyclic AMP | Monocytes - drug effects | Macrophages - metabolism | Animals | Myeloid Cells - metabolism | Macrophages - drug effects | Mice | Receptors, G-Protein-Coupled - genetics | Cytokines - biosynthesis | Cluster Analysis | Encephalitis | Inflammation | B cells | G proteins | RNA | Membrane proteins | Energy metabolism | Multiple sclerosis | Encephalomyelitis | Disease | Trafficking | Central nervous system | Homeostasis | Inflammatory response | Nervous system | Lymphocytes T | Activation | Kinases | Macrophages | Inflammatory diseases | Gene sequencing | Lipopolysaccharides | Proteins | Cell activation | Immunology | Lymphocytes | Rodents | Tumor necrosis factor-TNF | Lipid metabolism | Pharmaceutical sciences | Antigens | Bile acids | Cytokines | Medical treatment | Metabolism | Ribonucleic acid--RNA | Experimental allergic encephalomyelitis | Energy balance | Monocytes | Brain research | Acids | Correlation analysis | Bile | Ribonucleic acid
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e105883 - e105883
Inflammation is associated with immune cells infiltrating into the inflammatory site and pain. CC chemokine receptor 1 (CCR1) mediates trafficking of... 
RHEUMATOID-ARTHRITIS | PATHOGENESIS | NEUROPATHIC PAIN | RECRUITMENT | MULTIDISCIPLINARY SCIENCES | NEUTROPHILS | OPIOID RECEPTORS | MICE | CHEMOKINE RECEPTORS | BLOCKADE | INFILTRATION | Hyperalgesia - chemically induced | Arthritis, Experimental - genetics | Pain - immunology | Pain - chemically induced | Bone Marrow Transplantation - methods | Cell Movement - genetics | Cell Movement - immunology | Leukocytes - immunology | Acetic Acid | Flow Cytometry | Pain - genetics | Myeloid Cells - immunology | Peritonitis - genetics | Bone Marrow Cells - immunology | Receptors, CCR1 - immunology | Neutrophils - metabolism | Neutrophil Infiltration - immunology | Mice, Inbred C57BL | Peritonitis - metabolism | Neutrophils - immunology | Arthritis, Experimental - immunology | Peritonitis - immunology | Neutrophil Infiltration - genetics | Freund's Adjuvant | Mice, Knockout | Hyperalgesia - immunology | Pain Measurement - methods | Receptors, CCR1 - genetics | Animals | Hyperalgesia - genetics | Myeloid Cells - metabolism | Leukocytes - metabolism | Bone Marrow Cells - metabolism | Receptors, CCR1 - antagonists & inhibitors | CC chemokine receptors | Animal models | Disease | Leukocyte migration | Trafficking | Leukocytes | Inflammatory diseases | CCR1 protein | Immunology | Pain | Rodents | Protein transport | Pharmaceutical sciences | Immune system | Adenosine | Myeloid cells | Pain perception | Dopamine | Cytokines | Narcotics | Neutrophils | Leukocytes (neutrophilic) | Pharmacology | Inflammation | Hemopoiesis | White blood cells | Acids | Freund's adjuvant | Rheumatoid arthritis | Ligands | Acetic acid | Potassium | Chemokines | Peritoneum | Index Medicus
Journal Article
Clinical Immunology, ISSN 1521-6616, 12/2018, Volume 197, pp. 205 - 218
Lupus nephritis is a common disease manifestation of SLE, in which immune complex deposition and macrophage activation are important contributors to disease... 
Systemic lupus erythematosus | Lupus nephritis | NZB/W | MRL/lpr | Bruton's tyrosine kinase | PATHOGENESIS | BRUTONS TYROSINE KINASE | ACTIVATION | PROTEIN | IMMUNOLOGY | Lupus | Tyrosine | Medical research | Nephritis | Analysis | Medicine, Experimental | Bruton’s tyrosine kinase | MRL | NZB | lpr
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 3, pp. 441 - 448
Exploring various cyclization strategies, using a submicromolar pyrazole HTS screening hit as a starting point, a novel indazole based CCR1 antagonist core was... 
CCR1 | Scaffold hopping | Clinical compound | Chemokine receptors | Indazole | MLN3897 | CHEMISTRY, MEDICINAL | EFFICACY | SAFETY | CHEMISTRY, ORGANIC | ARTHRITIS | DISCOVERY | PHARMACOKINETICS | PLUS METHOTREXATE | TARGETS | BLOCKADE | Medicine, Experimental | Medical research | Respiratory tract diseases | Drug discovery
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 3, pp. 435 - 440
A HTS screen for CCR1 antagonists afforded a novel sub-micromolar hit containing a pyrazole core. In this report the design, optimization, and SAR of novel... 
CCR1 | Development candidate | HTS hit | Chemokine receptors | Pyrazole | MLN3897 | CHEMISTRY, MEDICINAL | EFFICACY | SAFETY | CHEMISTRY, ORGANIC | ARTHRITIS | POTENT | PHARMACOKINETICS | PLUS METHOTREXATE | TARGETS | BLOCKADE | Respiratory tract diseases | Amides | Drug discovery
Journal Article
Synlett, ISSN 0936-5214, 12/2005, Volume 2005, Issue 20, pp. 3121 - 3125
Abstract The DBU-mediated cyclization of ORTHO-(Boc-amino)alkynyl pyridines, -pyridazines, -pyrimidines and -pyrazines ­efficiently generates azaindoles and... 
letter | Heterocycles | Cyclization | Azaindole | Alkynes | Diazaindoles | SERIES | alkynes | CHEMISTRY, ORGANIC | diazaindoles | cyclization | azaindole | heterocycles | CESIUM | SYSTEMS | PALLADIUM-CATALYZED HETEROANNULATION | 7-AZAINDOLES | POTASSIUM | DERIVATIVES
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 03/2014, Volume 348, Issue 3, pp. 421 - 431
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2013, Volume 23, Issue 24, pp. 6640 - 6644
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2010, Volume 53, Issue 18, pp. 6681 - 6698
Syntheses and structure−activity relationships (SAR) of nonsteroidal glucocorticoid receptor (GR) agonists are described. These compounds contain azaindole... 
RESPONSES | SIDE | CHEMISTRY, MEDICINAL | REPRESSION |