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1. Full Text Bacterial diversity and community structure in polygonal tundra soils from Samoylov Island, Lena Delta, Siberia
by Liebner, Susanne and Harder, Jens and Wagner, Dirk
International Microbiology, ISSN 1139-6709, 2008, Volume 11, Issue 3, pp. 195 - 202
During the Arctic summer, bacteria are active above the permafrost in an environment with sharp temperature and oxygen gradients. The present study addressed... 
Active layer | Siberian Arctic | Clone libraries | Bacterial diversity | Nutrient gradients | Tundra | PHYLOGENETIC DIVERSITY | PERMAFROST | active layer | IN-SITU DETECTION | MICROBIOLOGY | FATTY-ACIDS | SP NOV | GRADIENT GEL-ELECTROPHORESIS | bacterial diversity | tundra | GRAM-POSITIVE BACTERIA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HIGH ARCTIC WETLANDS | nutrient gradients | clone libraries | TARGETED OLIGONUCLEOTIDE PROBES | 16S RIBOSOMAL-RNA | Bacteroidetes - isolation & purification | DNA, Bacterial - isolation & purification | DNA, Ribosomal - analysis | Gene Library | Soil Microbiology | Molecular Sequence Data | In Situ Hybridization, Fluorescence | Actinobacteria - classification | Ice | Soil - analysis | Bacteroidetes - classification | Bacteria - genetics | Sequence Analysis, DNA | Bacteria - isolation & purification | Arctic Regions | Ecosystem | Actinobacteria - genetics | Cloning, Molecular - methods | Siberia | Bacteria - classification | RNA, Ribosomal, 16S - genetics | DNA, Bacterial - analysis | Actinobacteria - isolation & purification | Bacteroidetes - genetics | bacterial diversity · clone libraries · nutrient gradients · active layer · tundra · Siberian Arctic
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2. Full Text Infection of keratinocytes with trichophytum rubrum induces epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression
by Firat, Yasemin Helene and Simanski, Maren and Rademacher, Franziska and Schrod̈er, Lena and Brasch, Jochen and Harder, Jürgen
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e93941
Human keratinocytes are able to express various antimicrobial peptides (AMP) to protect the skin from exaggerated microbial colonization and infection.... 
DEFENSE | PATTERN-RECOGNITION RECEPTOR | MULTIDISCIPLINARY SCIENCES | DECTIN-2 | ANTIMICROBIAL PEPTIDES | SKIN | DERMATOPHYTES | Ribonucleases - genetics | beta-Defensins - genetics | ErbB Receptors - metabolism | Humans | Epidermal Growth Factor - metabolism | Interleukin-17 - pharmacology | Immunity, Innate | Keratinocytes - immunology | Trichophyton - physiology | Gene Expression Regulation - drug effects | Keratinocytes - drug effects | Keratinocytes - metabolism | Trichophyton - growth & development | Keratinocytes - microbiology | Interferon-gamma - pharmacology | Infectious skin diseases | Care and treatment | Epidermal growth factor | Analysis | Ribonuclease | Diagnosis | Gene expression | Health aspects | Risk factors | Ribonuclease A | Peptides | Blocking antibodies | Infections | Mycelia | Microorganisms | Ribonuclease T | Antimicrobial peptides | Inhibition | Cytokines | Epidermal growth factor receptors | Dermatology | Secretion | Germination | Keratinocytes | Antimicrobial agents | Pattern recognition | Defensins | γ-Interferon | Skin | Interferon | Ribonuclease 7 | Colonization | Conidia
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3. Full Text The Pattern Recognition Receptor NOD2 Mediates Staphylococcus aureus–Induced IL-17C Expression in Keratinocytes
by Roth, Sarah A and Simanski, Maren and Rademacher, Franziska and Schröder, Lena and Harder, Jürgen
Journal of Investigative Dermatology, ISSN 0022-202X, 02/2014, Volume 134, Issue 2, pp. 374 - 380
IL-17C is an important epithelial cell-derived cytokine activating innate immunity by the induction of antimicrobial peptides and cytokines. Here, we... 
ATOPIC-DERMATITIS | ACTIVATION | POLYMORPHISMS | CROHNS-DISEASE | IMMUNE-RESPONSES | INNATE | INFECTION | KAPPA-B | SKIN | PSORIATIC-ARTHRITIS | DERMATOLOGY | RNA, Small Interfering - genetics | Staphylococcal Infections - immunology | Humans | Interleukin-17 - immunology | Interleukin-17 - genetics | Nod2 Signaling Adaptor Protein - immunology | Nod2 Signaling Adaptor Protein - genetics | Dermatitis, Atopic - microbiology | Keratinocytes - cytology | Keratinocytes - immunology | Immunity, Innate - immunology | Dermatitis, Atopic - immunology | Gene Expression - immunology | HEK293 Cells | Staphylococcus aureus - immunology | Primary Cell Culture | Promoter Regions, Genetic - immunology | Keratinocytes - microbiology
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4. Full Text Luminescence Properties of C‐Diazaborolyl‐ortho‐Carboranes as Donor–Acceptor Systems
by Weber, Lothar and Kahlert, Jan and Brockhinke, Regina and Böhling, Lena and Brockhinke, Andreas and Stammler, Hans‐Georg and Neumann, Beate and Harder, Rachel A and Fox, Mark A
Chemistry – A European Journal, ISSN 0947-6539, 07/2012, Volume 18, Issue 27, pp. 8347 - 8357
Seven derivatives of 1,2‐dicarbadodecaborane (ortho‐carborane, 1,2‐C2B10H12) with a 1,3‐diethyl‐ or 1,3‐diphenyl‐1,3,2‐benzodiazaborolyl group on one cage... 
donor–acceptor systems | luminescence | diazaboroles | charge transfer | carboranes | donor-acceptor systems | CHARGE-TRANSFER EMISSION | CRYSTAL-STRUCTURES | AMORPHOUS MOLECULAR MATERIALS | CHEMICAL-SHIFT CALCULATIONS | CHEMISTRY, MULTIDISCIPLINARY | AGGREGATION-INDUCED EMISSION | PI-ELECTRON SYSTEMS | 2-PHOTON-EXCITED FLUORESCENCE | SET MODEL CHEMISTRY | 3-COORDINATE ORGANOBORON COMPOUNDS | NONLINEAR-OPTICAL-PROPERTIES | Emissions | Low energy | Bands | Cage | Computation | Fluid flow | Fluorescence | Excitation | Orientation
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5. Full Text Electrochemical and spectroelectrochemical studies of C-benzodiazaborolyl-ortho-carboranes
by Weber, Lothar and Kahlert, Jan and Böhling, Lena and Brockhinke, Andreas and Stammler, Hans-Georg and Neumann, Beate and Harder, Rachel A and Low, Paul J and Fox, Mark A
Journal of the Chemical Society. Dalton Transactions, ISSN 1477-9226, 11/2013, Volume 42, Issue 2, pp. 2266 - 2281
Fifteen C-diazaborolyl-ortho-carboranes, 1-R'-2-R''-1,2-C sub(2)B sub(10)H sub(10), where R' represents the groups 2-(1,3-Et sub(2)-1,3,2-N sub(2)BC sub(6)H... 
Cage | Infrared | X-rays | Voltammetry | Oxidation | Counting | Radicals
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6. Full Text Microconstriction Arrays for High-Throughput Quantitative Measurements of Cell Mechanical Properties
by Lange, Janina R and Steinwachs, Julian and Kolb, Thorsten and Lautscham, Lena A and Harder, Irina and Whyte, Graeme and Fabry, Ben
Biophysical Journal, ISSN 0006-3495, 07/2015, Volume 109, Issue 1, pp. 26 - 34
We describe a method for quantifying the mechanical properties of cells in suspension with a microfluidic device consisting of a parallel array of micron-sized... 
DEFORMABILITY | SMOOTH-MUSCLE | BIOPHYSICS | ACTIN NETWORKS | CYTOSKELETON | MICRORHEOLOGY | BEHAVIOR | FLUCTUATIONS | CHROMATIN DECONDENSATION | CANCER | LIVING CELLS | Microfluidic Analytical Techniques - methods | Models, Theoretical | Rheology | Humans | Microfluidic Analytical Techniques - instrumentation | Lab-On-A-Chip Devices | Glass - chemistry | Equipment Design | Pressure | Cell Nucleus - physiology | Cell Physiological Phenomena - drug effects | Cell Line, Tumor | Cytoskeleton - physiology | Mechanical Phenomena | Microtechnology - instrumentation | Cell Nucleus - drug effects | Cytoskeleton - drug effects | Cell Biophysics
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7. Full Text The role of RNase 7 in innate cutaneous defense against Pseudomonas aeruginosa
by Rademacher, Franziska and Simanski, Maren and Schröder, Lena and Mildner, Michael and Harder, Jürgen
Experimental Dermatology, ISSN 0906-6705, 03/2017, Volume 26, Issue 3, pp. 227 - 233
The ribonuclease RNase 7 is a major skin‐derived human antimicrobial protein expressed in keratinocytes. Here we show that the gram‐negative pathogen... 
cutaneous innate defense | keratinocytes | epidermal growth factor receptor | antimicrobial peptides | ACTIVATION | DIFFERENTIAL EXPRESSION | CHRONIC WOUNDS | EGFR | DERMATOLOGY | EPITHELIAL-CELLS | IMMUNE-RESPONSES | SKIN | SIGNALING CASCADE | Ribonucleases - genetics | Gene Expression - drug effects | Skin - metabolism | Humans | Receptor, Epidermal Growth Factor - drug effects | Ribonucleases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Organoids | Pseudomonas aeruginosa - metabolism | Hydroxamic Acids - pharmacology | Skin - immunology | Toll-Like Receptor 5 - metabolism | Signal Transduction | Epidermis - drug effects | RNA, Small Interfering - pharmacology | Cells, Cultured | Gene Silencing | Keratinocytes | Antibodies, Neutralizing - pharmacology | Cetuximab - pharmacology | Tyrphostins - pharmacology | ADAM17 Protein - genetics | Epidermis - immunology | Ribonucleases - immunology | Quinazolines - pharmacology | Viral antibodies | Epidermal growth factor | Analysis | Antibodies | Pseudomonas aeruginosa | Skin | Ribonuclease | Gene expression | Enzyme-linked immunosorbent assay | Ribonuclease A | Pathogens | Antimicrobial activity | Stratum corneum | TLR5 protein | Epidermal growth factor receptors | Antimicrobial agents | siRNA | Pattern recognition | Ribonuclease P | Ribonuclease S | Toll-like receptors | Ligands | Ribonuclease 7 | Metalloproteinase
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8. Full Text IL-17A and IFN-γ Synergistically Induce RNase 7 Expression via STAT3 in Primary Keratinocytes
by Simanski, Maren and Rademacher, Franziska and Schröder, Lena and Schumacher, Hanna Maria and Gläser, Regine and Harder, Jürgen
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e59531
Human keratinocytes produce several antimicrobial peptides and proteins (AMP) which contribute to the protection of human skin against infection. RNase 7 is a... 
INVASIVE BACTERIAL-INFECTION | HYPER-IGE SYNDROME | ATOPIC-DERMATITIS | HUMAN SKIN | MULTIDISCIPLINARY SCIENCES | MECHANISMS | ANTIMICROBIAL PEPTIDES | PROTEINS | IMMUNE DEFENSE | PSORIASIS | PROTECTS | S100 Calcium Binding Protein A7 | Gene Expression Regulation, Enzymologic - drug effects | Ribonucleases - genetics | beta-Defensins - genetics | Staphylococcus aureus - physiology | Humans | Interleukin-17 - pharmacology | Ribonucleases - metabolism | Dose-Response Relationship, Drug | Drug Synergism | S100 Proteins - genetics | Keratinocytes - drug effects | Keratinocytes - metabolism | Staphylococcus aureus - drug effects | Keratinocytes - microbiology | Interferon-gamma - pharmacology | STAT3 Transcription Factor - metabolism | Ribonuclease A | Antimicrobial activity | Immune response | Bacterial infections | Psoriasis | Cytokines | Peptides | Dermatology | Stat3 protein | Keratinocytes | Staphylococcus infections | Antimicrobial agents | siRNA | Tumor necrosis factor-α | Gene expression | Dermatitis | Antiinfectives and antibacterials | Proteins | S100 protein | γ-Interferon | Antimicrobial peptides | Skin | Ribonuclease 7 | Immune system
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9. Full Text Comparison of two prototypes of a magnetically adjustable glaucoma implant in rabbits
by Schwerk, B and Harder, L and Windhovel, C and Hewicker-Trautwein, M and Wagner, A and Bach, JP and Voigt, LC and Hinze, U and Chichkov, B and Haferkamp, H and Lubatschowski, H and Nikolic, S and Nolte, I
PLOS ONE, ISSN 1932-6203, 04/2019, Volume 14, Issue 4, p. e0215316
Glaucoma drainage devices are used in surgical glaucoma therapy. Success of controlling the intraocular pressure is limited due to fibrous implant... 
FIBROSIS | BIOCOMPATIBILITY | MULTIDISCIPLINARY SCIENCES | AQUEOUS-HUMOR | VALVE | DRAINAGE DEVICES | INTRAOCULAR-PRESSURE | OUTCOMES | DEEP SCLERECTOMY | DIFFERENT BIOMATERIALS | CLINICAL-EXPERIENCE | Glaucoma | Trabeculectomy | Rabbits | Lasers in surgery | Physiological aspects | Diagnosis | Comparative analysis | Transplants & implants | Drainage control | Drainage facilities | Adhesion tests | Flow characteristics | Macrophages | Veterinary medicine | Eye | Design | Biomedical materials | Obstructions | Lymphocytes | Surgery | Prototypes | Cell adhesion | Outflow | Biocompatibility | Statistical analysis | Aqueous humour | Mechanical properties | Inflammation | Humour | Pressure | Low level | Drainage | Fibrin | Fibrosis | Intraocular pressure
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10. Full Text The Inflammasome and the Epidermal Growth Factor Receptor (EGFR) Are Involved in the Staphylococcus aureus-Mediated Induction of IL-1alpha and IL-1beta in Human Keratinocytes
by Simanski, Maren and Rademacher, Franziska and Schröder, Lena and Gläser, Regine and Harder, Jürgen
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 1, p. e0147118
Staphylococcus (S.) aureus is an important pathogen causing various infections including those of the skin. Keratinocytes are able to sense invading S. aureus... 
INTERLEUKIN-1-ALPHA SECRETION | ACTIVATION | ADAM17 | PRECURSOR | HUMAN BETA-DEFENSIN-2 | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | KAPPA-B | SKIN | RNASE 7 | EXPRESSION | ADAM17 Protein | RNA, Small Interfering - genetics | ErbB Receptors - antagonists & inhibitors | ADAM Proteins - physiology | Staphylococcus aureus - physiology | Humans | Cells, Cultured | Gene Expression Regulation | Interleukin-1alpha - metabolism | Interleukin-1beta - genetics | Protein Precursors - metabolism | ErbB Receptors - physiology | Inflammasomes - physiology | RNA Interference | Interleukin-1beta - metabolism | Keratinocytes - metabolism | CARD Signaling Adaptor Proteins | Interleukin-1alpha - biosynthesis | Interleukin-1alpha - genetics | Interleukin-1beta - biosynthesis | Protein Processing, Post-Translational | Caspase 1 - physiology | Cytoskeletal Proteins - physiology | Keratinocytes - microbiology | Shedding | Peptides | Blocking antibodies | Infections | Interleukin 1 receptors | Inactivation | Caspase-1 | Proteins | Epidermal growth factor | Rodents | Interleukin 1 | Antimicrobial peptides | Bacteria | Deactivation | Cytokines | Epidermal growth factor receptors | Dermatology | Secretion | Keratinocytes | Caspase | Staphylococcus infections | Antimicrobial agents | siRNA | Gene expression | Speck | Skin | Cancer | Apoptosis
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11. Full Text IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis
by Bilsborough, Janine and Leung, Donald Y.M and Maurer, Mark and Howell, Michael and Boguniewcz, Mark and Yao, Lena and Storey, Harold and LeCiel, Cosette and Harder, Brandon and Gross, Jane A
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 2006, Volume 117, Issue 2, pp. 418 - 425
IL-31 is a newly discovered T-cell cytokine that, when overexpressed in mice, results in pruritus and skin dermatitis resembling human atopic dermatitis (AD).... 
pruritus | macrophages | Atopic dermatitis | IL-31 receptor A | keratinocytes | IL-31 | skin-homing T cells | Skin-homing T cells | Keratinocytes | Pruritus | Macrophages | MACROPHAGE-DERIVED CHEMOKINE | atopic dermatitis | IMMUNOLOGY | ACTIVATION-REGULATED CHEMOKINE | THYMUS | ALLERGY | CYTOKINE RECEPTOR | TARC | ALLERGIC DISEASES | EXPRESSION | Membrane Glycoproteins - analysis | Psoriasis - immunology | Antigens, Neoplasm | Lymphocyte Activation | Humans | Middle Aged | Male | Receptors, Interleukin | Receptors, Lymphocyte Homing - metabolism | Dermatitis, Atopic - physiopathology | Antigens, Differentiation, T-Lymphocyte | Interleukins - metabolism | Interleukins - genetics | Psoriasis - physiopathology | Dermatitis, Atopic - immunology | Adult | Female | T-Lymphocytes - immunology | Skin - immunology | Immunohistochemistry | Autoimmunity | Antigens | T cells | Proteins | Human subjects | Flow cytometry | Cytokines | Psoriasis | Disease | Pathogenesis | Lymphocytes | Rodents | T cell receptors | Chemokines
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12. Full Text The role of RNase 7 in innate cutaneous defense againstPseudomonas aeruginosa
by Rademacher, Franziska and Simanski, Maren and Schröder, Lena and Mildner, Michael and Harder, Jürgen
Experimental Dermatology, ISSN 0906-6705, 03/2017, Volume 26, Issue 3, pp. 227 - 233
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13. Full Text A stomatin-domain protein essential for touch sensation in the mouse
by Wetzel, Christiane and Hu, Jing and Riethmacher, Dieter and Benckendorff, Anne and Harder, Lena and Eilers, Andreas and Moshourab, Rabih and Kozlenkov, Alexey and Labuz, Dominika and Caspani, Ombretta and Erdmann, Bettina and Machelska, Halina and Heppenstall, Paul A and Lewin, Gary R
Nature, ISSN 0028-0836, 01/2007, Volume 445, Issue 7124, pp. 206 - 209
Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located... 
LOCALIZATION | PAIN | RAT | MULTIDISCIPLINARY SCIENCES | RECEPTOR NEURONS | SENSING ION CHANNELS | MEMBRANE-PROTEIN | MECHANOSENSATION | C-ELEGANS | MECHANORECEPTOR | SENSORY NEURONS | Protein Structure, Tertiary | Acid Sensing Ion Channels | Membrane Proteins - genetics | Nerve Tissue Proteins - deficiency | Rats | Male | Electric Conductivity | Ganglia, Spinal - cytology | Mutation - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Membrane Proteins - deficiency | Nerve Tissue Proteins - chemistry | Animals | Membrane Proteins - chemistry | Sodium Channels - metabolism | Female | Membrane Proteins - metabolism | Mice | Touch - physiology | Mechanoreceptors - metabolism | Afferent Pathways | Ganglia, Spinal - metabolism | Proteins | Neurology | Pain | Touch | Sensory perception | Rodents
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