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1. Full Text Thomas Moran's Chasm of the Colorado: heritage or mediation?
by Harding, Wedny and Martin, Jacky
Revue française d'études americaines, ISSN 0397-7870, 01/2014, Volume 137, pp. 9 - 22
//ABSTRACT IN FRENCH: Cet article analyse le tableau de Thomas Moran, « Chasm of Colorado », envisagé comme le trait d'union entre divers héritages en mutation... 
Moran, Thomas
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2. Full Text Thomas Moran's “Chasm of the Colorado”: Heritage or Mediation?
by Harding, Wendy and Martin, Jacky
Revue française d’études américaines, ISSN 0397-7870, 2013, Volume 137, Issue 3, pp. 9 - 22
Cet article analyse le tableau de Thomas Moran, « Chasm of Colorado », envisagé comme le trait d'union entre divers héritages en mutation plutôt que comme un... 
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3. Full Text Thomas Moran's “Chasm of the Colorado”: Heritage or Mediation?
by Harding, Wendy and Martin, Jacky
Revue Française d Etudes Américaines, ISSN 0397-7870, 2013, Volume 137, Issue 3, p. 9
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4. Ecosystems at the land-sea margin
: drainage basin to coastal sea
by Malone, Thomas C
1999, Coastal and estuarine studies., ISBN 9780875902692, Volume 55, ix, 381
Coastal ecology | Estuarine ecology | Nutrient cycles
Book
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5. Full Text Abstract 2476: Preclinical assessment of the PARP inhibitor rucaparib in homologous recombination deficient prostate cancer models
by Nguyen, Minh and Simmons, Andrew D and Harding, Thomas C
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 2476 - 2476
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6. Full Text Severity of obstructive sleep apnea is related to aldosterone status in subjects with resistant hypertension
by Gonzaga, Carolina C and Gaddam, Krishna K and Ahmed, Mustafa I and Pimenta, Eduardo and Thomas, S. Justin and Harding, Susan M and Oparil, Suzanne and Cofield, Stacey S and Calhoun, David A
Journal of Clinical Sleep Medicine, ISSN 1550-9389, 08/2010, Volume 6, Issue 4, pp. 363 - 368
Background: We previously described a significant correlation between plasma aldosterone concentration (PAC) and severity of obstructive sleep apnea (OSA) in... 
Sleep disorder | Cardiovascular disease | Resistant hypertension | Aldosterone | Obstructive sleep apnea | cardiovascular disease | DIAGNOSIS | HYPERALDOSTERONISM | aldosterone | HEART-FAILURE | PREVALENCE | resistant hypertension | SCIENTIFIC STATEMENT | CLINICAL NEUROLOGY | PROFESSIONAL-EDUCATION-COMMITTEE | sleep disorder | VENTILATION | CARDIOVASCULAR-DISEASE | BLOOD-PRESSURE-RESEARCH | ASSOCIATION | Prospective Studies | Cross-Sectional Studies | Comorbidity | Humans | Middle Aged | Risk Factors | Hypertension - drug therapy | Male | Reference Values | Polysomnography | Renin - blood | Aldosterone - urine | Hyperaldosteronism - diagnosis | Sleep Apnea, Obstructive - urine | Adult | Female | Aged | Sleep Apnea, Obstructive - epidemiology | Hypertension - epidemiology | Hyperaldosteronism - epidemiology | Hypertension - urine | Drug Resistance | Hyperaldosteronism - urine | Index Medicus | New Research
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7. Full Text Abstract 1716: The PARP inhibitor rucaparib activates the STING pathway and enhances antitumor responses of immune checkpoint inhibitors inBRCAdeficient syngeneic models
by Nguyen, Minh and Robillard, Liliane and Lin, Kevin K and Harding, Thomas C and Simmons, Andrew D
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 1716 - 1716
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8. Full Text Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients
by Chabon, Jacob J and Simmons, Andrew D and Lovejoy, Alexander F and Esfahani, Mohammad S and Newman, Aaron M and Haringsma, Henry J and Kurtz, David M and Stehr, Henning and Scherer, Florian and Karlovich, Chris A and Harding, Thomas C and Durkin, Kathleen A and Otterson, Gregory A and Purcell, W. Thomas and Camidge, D. Ross and Goldman, Jonathan W and Sequist, Lecia V and Piotrowska, Zofia and Wakelee, Heather A and Neal, Joel W and Alizadeh, Ash A and Diehn, Maximilian
Nature Communications, ISSN 2041-1723, 06/2016, Volume 7, Issue 1, pp. 11815 - 11815
Circulating tumour DNA (ctDNA) analysis facilitates studies of tumour heterogeneity. Here we employ CAPP-Seq ctDNA analysis to study resistance mechanisms in... 
TYROSINE KINASE INHIBITORS | RECEPTOR GENE-MUTATIONS | KRAS MUTATIONS | MET AMPLIFICATION | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | INTRATUMOR HETEROGENEITY | PLASMA DNA | ACQUIRED-RESISTANCE | GEFITINIB SENSITIVITY | NSCLC PATIENTS | Index Medicus
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9. Full Text Abstract 3595:In vivoacquired resistance to the mutant EGFR inhibitor Rociletinib (CO-1686) is associated with activation of the c-MET pathway
by Haringsma, Henry J and Allen, Andrew and Harding, Thomas C and Simmons, Andrew D
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 3595 - 3595
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10. Full Text Abstract 1009: Comprehensive ctDNA sequencing reveals mechanisms of resistance to rociletinib in EGFR T790M-mutated NSCLC
by Helman, Elena and Simmons, Andrew D and Karlovich, Chris A and Harding, Thomas C and Raponi, Mitch and Chudova, Darya I and Simon, Daniel A and Lanman, Richard B and Talasaz, AmirAli
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 1009 - 1009
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11. Full Text Rapid responses of British butterflies to opposing forces of climate and habitat change
by Asher, J and Willis, S. G and Hill, J. K and Fox, R and Jeffcoate, G and Harding, P and Thomas, C. D and Greatorex-Davies, J. N and Huntley, B and Warren, M. S and Thomas, J. A and Jeffcoate, S and Moss, D and Telfer, M. G and Roy, D. B
Nature, ISSN 0028-0836, 11/2001, Volume 414, Issue 6859, pp. 65 - 69
Habitat degradation and climate change are thought to be altering the distributions and abundances of animals and plants throughout the world, but their... 
AVAILABILITY | MULTIDISCIPLINARY SCIENCES | RANGES | Adaptation, Physiological | Climate | Animals | Species Specificity | Butterflies - physiology | Environment | United Kingdom | Seasons | Population Dynamics | Butterflies & moths | Climate change | Habitats | Animal behavior | Index Medicus
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12. Full Text Abstract C199: PI3K/AKT/mTOR inhibitors enhance the anti-tumor activity of the FGFR, VEGFR and PDGFR inhibitor lucitanib in FGF-dependent breast cancer models
by Nguyen, Minh and Robillard, Liliane and Simmons, Andrew D and Haringsma, Henry J and Harding, Thomas C
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. C199 - C199
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13. Full Text Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial
by Swisher, Elizabeth M, Dr Prof and Lin, Kevin K, PhD and Oza, Amit M, Prof and Scott, Clare L, PhD and Giordano, Heidi, MA and Sun, James, PhD and Konecny, Gottfried E, MD and Coleman, Robert L, Prof and Tinker, Anna V, MD and O'Malley, David M, MD and Kristeleit, Rebecca S, MD and Ma, Ling, MD and Bell-McGuinn, Katherine M, MD and Brenton, James D, Prof and Cragun, Janiel M, MD and Oaknin, Ana, MD and Ray-Coquard, Isabelle, Prof and Harrell, Maria I, PhD and Mann, Elaina, MS and Kaufmann, Scott H, Prof and Floquet, Anne, MD and Leary, Alexandra, MD and Harding, Thomas C, PhD and Goble, Sandra, MS and Maloney, Lara, BA and Isaacson, Jeff, PhD and Allen, Andrew R, MD and Rolfe, Lindsey, MBChB and Yelensky, Roman, PhD and Raponi, Mitch, PhD and McNeish, Iain A, Prof
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 18, Issue 1, pp. 75 - 87
Summary Background Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1... 
Hematology, Oncology and Palliative Medicine | BRCA MUTATION | POLY(ADP-RIBOSE) POLYMERASE | RANDOMIZED PHASE-2 | ONCOLOGY | HOMOLOGOUS RECOMBINATION DEFICIENCY | MUTANT-CELLS | PROSTATE-CANCER | INHIBITORS | DNA-REPAIR | NEGATIVE BREAST-CANCER | GENOMIC LOSS | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Ovarian Neoplasms - pathology | Salvage Therapy | Neoplasm Recurrence, Local - drug therapy | Germ-Line Mutation - genetics | Neoplasm Recurrence, Local - pathology | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Peritoneal Neoplasms - drug therapy | Fallopian Tube Neoplasms - genetics | Female | Antineoplastic Agents - pharmacology | Poly(ADP-ribose) Polymerases - chemistry | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Fallopian Tube Neoplasms - drug therapy | Peritoneal Neoplasms - pathology | Neoplasms, Glandular and Epithelial - pathology | Fallopian Tube Neoplasms - pathology | Survival Rate | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | BRCA1 Protein - genetics | International Agencies | Peritoneal Neoplasms - genetics | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Indoles - therapeutic use | Neoplasm Recurrence, Local - genetics | Aged | Neoplasm Staging | BRCA2 Protein - genetics | Drug Resistance, Neoplasm - drug effects | Sugars | Monosaccharides | Ovarian cancer | Analysis | Carcinoma | Cancer | Index Medicus
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14. Full Text Abstract 4676: DNA repair protein expression and response of homologous recombination deficient ovarian cancer to the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib in the ARIEL2 Part 1 study
by Hendrickson, Andrea E. Wahner and Lin, Kevin K and Visscher, Daniel W and Hurley, Rachel M and Raponi, Mitch and Harding, Thomas C and Murphy, Linda M and Wagner, Jill M and Giordano, Heidi and McNeish, Iain and Swisher, Elizabeth M and Kaufmann, Scott
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 4676 - 4676
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15. The letters and speeches, with elucidations by Thomas Carlyle
: edited with notes, supplement and enl. index
by Cromwell, Oliver, 1599-1658 and Carlyle, Thomas, 1795-1881 and Lomas, Sophia Crawford and Firth, C. H. 1857-1936. (Charles Harding)
1904, 3 v.
Book
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16. The letters and speeches
: with elucidations by Thomas Carlyle
by Cromwell, Oliver, 1599-1658 and Carlyle, Thomas, 1795-1881 and Lomas, Sophia Crawford and Firth, C. H. 1857-1936. (Charles Harding)
1904, 3 v.
Book
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17. Full Text Abstract B50: Antineoplastic activity of Top I inhibitor etirinotecan pegol (NKTR-102) and PARP inhibitor rucaparib (CO-388) in platinum-resistant high-grade serous BRCA WT ovarian cancer PDX models
by Nitschmann, Caroline C and Hurley, Rachel M and Becker, Marc A and Hou, Xiaonan and Hoch, Ute and Harding, Thomas C and Charych, Deborah H and Kaufmann, Scott H and Haluska, Paul and Weroha, Saravut J
Clinical Cancer Research, ISSN 1078-0432, 01/2016, Volume 22, Issue 2 Supplement, pp. B50 - B50
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18. Full Text Deficiency in type i interferon signaling prevents the early interferon-induced gene signature in pancreatic islets but not type 1 diabetes in NOD mice
by Quah, Hong Sheng and Miranda-Hernandez, Socorro and Khoo, Aimee and Harding, Ashley and Fynch, Stacey and Elkerbout, Lorraine and Brodnicki, Thomas C and Baxter, Alan G and Kay, Thomas W. H and Thomas, Helen E and Graham, Kate L
Diabetes, ISSN 0012-1797, 03/2014, Volume 63, Issue 3, pp. 1032 - 1040
Type I interferons (IFNs) have been implicated in the initiation of islet autoimmunity and development of type 1 diabetes. To directly test their involvement,... 
PLASMACYTOID DENDRITIC CELLS | DESTRUCTION | INITIATION | MACROPHAGES | BETA-CELLS | MOUSE | ENDOCRINOLOGY & METABOLISM | ALPHA | INSULITIS | EXPRESSION | MOLECULES | Gene Expression | Mice, Inbred C57BL | Receptor, Interferon alpha-beta - physiology | Toll-Like Receptor 9 - physiology | Animals | Diabetes Mellitus, Type 1 - etiology | Islets of Langerhans - metabolism | Toll-Like Receptor 2 - physiology | Mice, Inbred NOD | Signal Transduction - physiology | Histocompatibility Antigens Class I - biosynthesis | Interferon Type I - physiology | Mice | Genetic aspects | Interferon | Research | Gene expression | Type 1 diabetes | Identification and classification | Signal transduction | Immunology | Rodents | Diabetes | Insulin | Index Medicus | Abridged Index Medicus
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19. Full Text Abstract 3349: Preclinical efficacyof the PARP inhibitor rucaparib (AG014699/PF-01367338) as a monotherapy and incombination with PI3K inhibition
by Robillard, Liliane and Harding, Thomas C and Walter, Annette O
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 3349 - 3349
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20. Full Text Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial
by Coleman, Robert L and Coleman, R L and Oza, Amit M and Oza, A M and Lorusso, D and Lorusso, Domenica and Aghajanian, C and Aghajanian, Carol and Oaknin, A and Oaknin, Ana and Dean, A and Dean, Andrew and Colombo, N and Colombo, Nicoletta and Weberpals, Johanne I and Weberpals, J I and Clamp, Andrew and Clamp, A and Scambia, Giovanni and Scambia, G and Leary, A and Leary, Alexandra and Holloway, Robert W and Holloway, R W and Gancedo, M Amenedo and Gancedo, Margarita Amenedo and Fong, Peter C and Fong, P C and Goh, Jeffrey C and Goh, J C and O'Malley, David M and O'Malley, D M and Armstrong, Deborah K and Armstrong, D K and Garcia-Donas, Jesus and Garcia-Donas, J and Swisher, E M and Swisher, Elizabeth M and Floquet, A and Floquet, Anne and Konecny, Gottfried E and Konecny, G E and McNeish, I A and McNeish, Iain A and Scott, C L and Scott, Clare L and Cameron, Terri and Maloney, Lara and Isaacson, Jeff and Goble, Sandra and Grace, Caroline and Harding, Thomas C and Raponi, Mitch and Sun, James and Lin, Kevin K and Giordano, Heidi and Ledermann, J A and Ledermann, Jonathan A and Buck, M and Friedlander, M L and Harnett, P and Kichenadasse, G and Denys, H and Dirix, L and Vergote, I and Elit, L and Ghatage, P and Plante, M and Provencher, D and Welch, S and Gladieff, L and Joly, F and Lortholary, A and Lotz, J and Medioni, J and Tredan, O and You, B and El-Balat, A and Hänle, C and Krabisch, P and Neunhöffer, T and Pölcher, M and Wimberger, P and Amit, A and Kovel, S and Leviov, M and Safra, T and Shapira-Frommer, R and Stemmer, S and Bologna, A and Pignata, S and Sabbatini, R F and Tamberi, S and Zamagni, C and O'Donnell, A and Herraez, A Casado and Guerra, E M and Palacio, I and Romero, I and Sanchez, A and ... and ARIEL3 Investigators and ARIEL3 investigators
The Lancet, ISSN 0140-6736, 10/2017, Volume 390, Issue 10106, pp. 1949 - 1961
Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a mutation or high percentage of... 
MEDICINE, GENERAL & INTERNAL | MULTICENTER | SOLID TUMORS | BEVACIZUMAB | OPEN-LABEL | CANCER | HETEROZYGOSITY | EPITHELIAL OVARIAN | CHEMOTHERAPY | Double-Blind Method | Follow-Up Studies | Risk Assessment | Humans | Middle Aged | Ovarian Neoplasms - pathology | Neoplasm Recurrence, Local - drug therapy | Survival Rate | Treatment Outcome | Ovarian Neoplasms - mortality | Neoplasm Recurrence, Local - mortality | Indoles - administration & dosage | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Neoplasm Recurrence, Local - pathology | Disease-Free Survival | Maintenance Chemotherapy - methods | Internationality | Ovarian Neoplasms - therapy | Female | Aged | Molecular Targeted Therapy - methods | Clinical trials | Care and treatment | Carcinoma | Drug therapy | Ovarian cancer | Cancer | Analysis | Chemotherapy | Ovarian carcinoma | Platinum | Biomarkers | Mutation | Cancer therapies | Tumors | Homologous recombination | Central nervous system | Poly(ADP-ribose) | Homology | Genomes | Fallopian tube | ADP | Anticancer properties | Metastases | Homologous recombination repair | Randomization | Pain | Motivation | Ribose | Hemoglobin | Alanine | Anemia | Poly(ADP-ribose) polymerase | Breast cancer | Patients | Survival | Heterozygosity | Abdomen | Polymerase | Inhibitors | Point mutation | Loss of heterozygosity | Antitumor activity | Aspartate aminotransferase | Peritoneum | Index Medicus | Abridged Index Medicus
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