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1. Full Text A SYSTEMS BIOLOGY APPROACH TOWARD UNDERSTANDING SCHIZOPHRENIA
by Haroutunian, Vahram
Schizophrenia research, ISSN 0920-9964, 2014, Volume 153, pp. S10 - S10
Psychiatry
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2. Full Text Schizophrenia: Susceptibility genes and oligodendroglial and myelin related abnormalities
by Roussos, Panos and Haroutunian, Vahram
Frontiers in cellular neuroscience, ISSN 1662-5102, 01/2014, Volume 8, pp. 5 - 5
Node of Ranvier | Disconnectivity | GWAS | Polygenic | Systems biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain architecture | Medical imaging | Mental disorders | Myelin | Neurons | Schizophrenia | Bipolar disorder | Glycoproteins | Genomes | Gene expression | Neuronal-glial interactions | Social research | Oligodendrocytes | Psychiatry | Neuroimaging | GWAS (genome-wide association study) | Gene Expression | Systems Biology | node of Ranvier | polygenic
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3. Full Text Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
by Readhead, Ben and Haure-Mirande, Jean-Vianney and Funk, Cory C and Richards, Matthew A and Shannon, Paul and Haroutunian, Vahram and Sano, Mary and Liang, Winnie S and Beckmann, Noam D and Price, Nathan D and Reiman, Eric M and Schadt, Eric E and Ehrlich, Michelle E and Gandy, Sam and Dudley, Joel T
Neuron (Cambridge, Mass.), ISSN 0896-6273, 07/2018, Volume 99, Issue 1, pp. 64 - 82.e7
systems biology | Roseolovirus | integrative genomics | human herpesvirus | multiscale networks | HHV-6B | HHV-7 | HHV-6A | network biology | Alzheimer's disease | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Amyloid Precursor Protein Secretases - genetics | Encephalitis, Viral - genetics | Encephalitis, Viral - virology | Genomics | Humans | Brain - virology | Gene Expression Profiling | Aspartic Acid Endopeptidases - genetics | Gene Regulatory Networks | Herpesvirus 7, Human | Case-Control Studies | Herpesvirus 6, Human | Viral Load | Alzheimer Disease - pathology | Brain - metabolism | Microbiota | Monomeric Clathrin Assembly Proteins - genetics | Tumor Suppressor Proteins - genetics | Amyloid beta-Protein Precursor - metabolism | Encephalitis, Viral - metabolism | Nuclear Proteins - genetics | Roseolovirus Infections - pathology | Clusterin - genetics | Roseolovirus Infections - genetics | Presenilin-1 - genetics | Mice, Transgenic | Roseolovirus Infections - metabolism | Mice, Knockout | Alzheimer Disease - virology | Animals | Adaptor Proteins, Signal Transducing - genetics | Alzheimer Disease - metabolism | Proteomics | Brain - pathology | Roseolovirus Infections - virology | Encephalitis, Viral - pathology | Mice | MicroRNAs - genetics | Alzheimer Disease - genetics | Cohort Studies | Brain | Medical colleges | Medical research | Genetic research | Medicine, Experimental | Development and progression | b-Site APP cleaving enzyme 1 | Neuropathology | Herpes simplex | Viruses | Gene expression | Neuromodulation | Protein turnover | Proteins | Brain research | Neurodegeneration | Autopsy | Data collection
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4. Full Text SIMILARITIES IN THE GENE AND PROTEIN EXPRESSION SUBSTRATES OF SCHIZOPHRENIA AND BIPOLAR DISORDER
by Haroutunian, Vahram
Schizophrenia research, ISSN 0920-9964, 2012, Volume 136, pp. S8 - S8
Psychiatry
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5. Full Text Dysfunction of the ubiquitin proteasome and ubiquitin-like systems in schizophrenia
by Rubio, María D and Wood, Krista and Haroutunian, Vahram and Meador-Woodruff, James H
Neuropsychopharmacology (New York, N.Y.), ISSN 0893-133X, 09/2013, Volume 38, Issue 10, pp. 1910 - 1920
polyubiquitination | E3 ligase | Nedd8ylation | SUMOylation | E1 activase | Ufmylation | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Psychology. Psychoanalysis. Psychiatry | Psychoses | Adult and adolescent clinical studies | Psychopathology. Psychiatry | Schizophrenia | Biological and medical sciences | Medical sciences | Molecular Chaperones - metabolism | Humans | Middle Aged | Ubiquitin - metabolism | Male | Protein Inhibitors of Activated STAT - metabolism | Case-Control Studies | Ubiquitination - drug effects | Aged, 80 and over | Female | Nedd4 Ubiquitin Protein Ligases | Schizophrenia - enzymology | Temporal Lobe - enzymology | Haloperidol - pharmacology | Ubiquitins - metabolism | NEDD8 Protein | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Rats | Ubiquitin-Activating Enzymes - metabolism | Animals | Ubiquitin-Protein Ligase Complexes - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Sumoylation | Aged | Protein Processing, Post-Translational | Index Medicus | biological psychiatry | psychiatry & behavioral sciences | schizophrenia | ubiquitination | molecular & cellular neurobiology | antipsychotics | Original
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6. Full Text Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
by Lunnon, Katie and Smith, Rebecca and Hannon, Eilis and De Jager, Philip L and Srivastava, Gyan and Volta, Manuela and Troakes, Claire and Al-Sarraj, Safa and Burrage, Joe and Macdonald, Ruby and Condliffe, Daniel and Harries, Lorna W and Katsel, Pavel and Haroutunian, Vahram and Kaminsky, Zachary and Joachim, Catharine and Powell, John and Lovestone, Simon and Bennett, David A and Schalkwyk, Leonard C and Mill, Jonathan
Nature neuroscience, ISSN 1097-6256, 09/2014, Volume 17, Issue 9, pp. 1164 - 1170
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Genome-Wide Association Study | Humans | Middle Aged | Cerebral Cortex - pathology | Transcriptome | Male | DNA Methylation - genetics | Alzheimer Disease - pathology | Prefrontal Cortex - pathology | Epigenesis, Genetic - genetics | Ankyrins - genetics | Aged, 80 and over | Alzheimer Disease - epidemiology | Cerebral Cortex - physiology | Female | Aged | Temporal Lobe - physiology | Alzheimer Disease - genetics | Entorhinal Cortex - pathology | Temporal Lobe - pathology | Prefrontal Cortex - physiology | Entorhinal Cortex - physiology | Cerebellum | Entorhinal cortex | Patient outcomes | Development and progression | Genetic aspects | Research | Methylation | Alzheimer's disease | Risk factors | Index Medicus
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7. Full Text Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
by Min, Sang-Won and Cho, Seo-Hyun and Zhou, Yungui and Schroeder, Sebastian and Haroutunian, Vahram and Seeley, William W and Huang, Eric J and Shen, Yong and Masliah, Eliezer and Mukherjee, Chandrani and Meyers, David and Cole, Philip A and Ott, Melanie and Gan, Li
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2010, Volume 67, Issue 6, pp. 953 - 966
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Phosphorylation - physiology | Sirtuin 1 - metabolism | p300-CBP Transcription Factors - physiology | Tauopathies - genetics | Humans | tau Proteins - metabolism | Cerebral Cortex - cytology | Sirtuin 1 - genetics | Tauopathies - etiology | Transfection - methods | Ubiquitination - drug effects | tau Proteins - genetics | Time Factors | Neurons - metabolism | Phosphorylation - drug effects | Protein Synthesis Inhibitors - pharmacology | Neurons - drug effects | Disease Models, Animal | Animals, Newborn | Immunoprecipitation - methods | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Mice, Transgenic | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods | Mutation - genetics | Rats, Sprague-Dawley | Cycloheximide - pharmacology | Gene Expression Regulation - drug effects | Acetylation - drug effects | Tauopathies - metabolism | Animals | Analysis of Variance | Models, Biological | Mice | Carbazoles - pharmacology | Viral antibodies | Nervous system diseases | Neurons | Analysis | Antibodies | Histones | Acetates | Alzheimer's disease | Proteins | Enzymes | Amino acids | Grants | Neurodegeneration | Rodents | Index Medicus | Acetylation | proteasome-mediated degradation | tauopathy | sirtuin | ubiquitine | FTDP-17 | post-translational modification | deacetylase | tau phosphorylation | acetyltransferase | protein degradation
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8. Full Text Gene Expression Alterations in the Sphingolipid Metabolism Pathways during Progression of Dementia and Alzheimer’s Disease: A Shift Toward Ceramide Accumulation at the Earliest Recognizable Stages of Alzheimer’s Disease?
by Katsel, Pavel and Li, Celeste and Haroutunian, Vahram
Neurochemical research, ISSN 0364-3190, 4/2007, Volume 32, Issue 4, pp. 845 - 856
Biochemistry, general | Brain regions | Neurosciences | Alzheimer’s disease | Postmortem | Gene expression | Microarray | Neurology | Biomedicine | Glycosphingolipid | Sphingolipid metabolism | Ceramide | Dementia | Alzheimer's disease | Biochemistry & Molecular Biology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Oligonucleotide Array Sequence Analysis | Humans | tau Proteins - metabolism | Male | Dementia - genetics | Alzheimer Disease - pathology | RNA - genetics | Dementia - metabolism | Gene Expression - physiology | Aged, 80 and over | Female | Lipid Metabolism - genetics | Ceramides - metabolism | Dementia - pathology | Plaque, Amyloid - pathology | Sphingolipids - metabolism | Disease Progression | Neurites - pathology | RNA - biosynthesis | Sphingolipids - genetics | Sphingosine - biosynthesis | Homeostasis - physiology | Alzheimer Disease - metabolism | Glycosphingolipids - metabolism | Aged | Sphingomyelins - biosynthesis | Alzheimer Disease - genetics | Early Diagnosis | Lipid Metabolism - physiology | Development and progression | Index Medicus
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9. Full Text Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains
by Huynh, Jimmy L and Garg, Paras and Thin, Tin Htwe and Yoo, Seungyeul and Dutta, Ranjan and Trapp, Bruce D and Haroutunian, Vahram and Zhu, Jun and Donovan, Michael J and Sharp, Andrew J and Casaccia, Patrizia
Nature neuroscience, ISSN 1097-6256, 01/2014, Volume 17, Issue 1, pp. 121 - 130
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Epigenesis, Genetic | Humans | Cell Cycle Proteins - metabolism | DNA Methylation - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Oligodendrocyte Transcription Factor 2 | Apoptosis Regulatory Proteins - metabolism | Brain - metabolism | Nerve Tissue Proteins - metabolism | Oligodendroglia - pathology | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Epigenomics - methods | Brain - pathology | CpG Islands - genetics | Multiple Sclerosis - pathology | HLA-DR Antigens - metabolism | Gene Ontology | Cohort Studies | Epigenetic inheritance | Multiple sclerosis | Nucleotide sequence | Physiological aspects | Genetic aspects | Research | Methylation | Health aspects | Index Medicus
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