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1. Full Text Drugs and bugs: turning on the heat through UCP1 and UCP3
: Perspectives
by Harper, Mary-Ellen
The Journal of Physiology, ISSN 0022-3751, 12/2016, Volume 594, Issue 24, pp. 7151 - 7152
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2. Full Text Uncoupling proteins and the control of mitochondrial reactive oxygen species production
by Mailloux, Ryan J and Harper, Mary-Ellen
Free Radical Biology and Medicine, ISSN 0891-5849, 2011, Volume 51, Issue 6, pp. 1106 - 1115
Reactive oxygen species (ROS), natural by-products of aerobic respiration, are important cell signaling molecules, which left unchecked can severely impair... 
Oxidative stress | Mitochondria | Proton leak | UCP | Free radicals | ROS | Glutathionylation | SUPEROXIDE-PRODUCTION | BOVINE HEART-MITOCHONDRIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-KETOGLUTARATE DEHYDROGENASE | ELECTRON-TRANSPORT CHAIN | SKELETAL-MUSCLE | FATTY-ACID OXIDATION | COMPLEX-I | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | NADH-UBIQUINONE OXIDOREDUCTASE | Reactive Oxygen Species - metabolism | Oxidative Stress | Glutathione - metabolism | Antioxidants - metabolism | Humans | Mitochondria - metabolism | Feedback, Physiological | Animals | Ion Channels - metabolism | Mitochondrial Proteins - metabolism | Protein Processing, Post-Translational | Uncoupling Protein 2 | Uncoupling Protein 1 | Uncoupling Protein 3 | Proteins | Free radicals (Chemistry) | Mitochondrial DNA
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3. Full Text Effects of cobalt and chromium ions on oxidative stress and energy metabolism in macrophages in vitro
: OXIDATIVE STRESS AND ENERGY METABOLISM IN MACROPHAGES
by Salloum, Zeina and Lehoux, Eric A and Harper, Mary-Ellen and Catelas, Isabelle
Journal of Orthopaedic Research, ISSN 0736-0266, 12/2018, Volume 36, Issue 12, pp. 3178 - 3187
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4. Full Text Cellular redox dysfunction in the development of cardiovascular diseases
by Kanaan, Georges N and Harper, Mary-Ellen
BBA - General Subjects, ISSN 0304-4165, 11/2017, Volume 1861, Issue 11, pp. 2822 - 2829
To meet its exceptionally high energy demands, the heart relies largely on fatty acid oxidation, which then drives the oxidative phosphorylation system in... 
Heart | Oxidative stress | Mitochondria | Reactive oxygen species | Oxidative phosphorylation | Redox | Cardiac pathologies | Glutathione | MITOCHONDRIAL FUSION | ENDOTHELIAL DYSFUNCTION | SUPEROXIDE-PRODUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | CARDIAC MYOCYTES | ISCHEMIA-REPERFUSION INJURY | REACTIVE OXYGEN | BIOPHYSICS | OXIDE-MEDIATED DILATION | NITRIC-OXIDE | Heart failure | Nitric oxide | Atherosclerosis | Superoxide | Nitrogen | Nitrogen dioxide | Fatty acids | Antioxidants | Hypertension | Hydrogen peroxide | Thiols
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5. Full Text In utero Undernutrition Programs Skeletal and Cardiac Muscle Metabolism
by Beauchamp, Brittany and Harper, Mary-Ellen
Frontiers in physiology, ISSN 1664-042X, 2015, Volume 6, p. 401
In utero undernutrition is associated with increased risk for insulin resistance, obesity, and cardiovascular disease during adult life. A common phenotype... 
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6. Full Text Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics
by Mailloux, Ryan J and McBride, Skye L and Harper, Mary-Ellen
Trends in Biochemical Sciences, ISSN 0968-0004, 12/2013, Volume 38, Issue 12, pp. 592 - 602
During the cellular oxidation of fuels, electrons are used to power the proton pumps of the mitochondrial electron transport chain (ETC) and ultimately drive... 
redox signaling | glutathionylation | oxidative stress | oxidative phosphorylation | reactive oxygen species | Oxidative stress | Reactive oxygen species | Glutathionylation | Oxidative phosphorylation | Redox signaling | PERMEABILITY TRANSITION PORE | UNCOUPLING PROTEINS UCP2 | BOVINE HEART-MITOCHONDRIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXYGEN SPECIES GENERATION | ALPHA-KETOGLUTARATE DEHYDROGENASE | ELECTRON-TRANSPORT CHAIN | STIMULATED INSULIN-SECRETION | REACTIVE OXYGEN | HYDROGEN-PEROXIDE | Electron Transport | Reactive Oxygen Species - metabolism | Energy Metabolism | Glutathione - metabolism | Antioxidants - metabolism | Mitochondria - metabolism | Adenosine Triphosphate - biosynthesis | Proteins | Mitochondrial DNA
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7. Full Text Genome-wide identification of circulating-miRNA expression quantitative trait loci reveals the role of several miRNAs in the regulation of Cardiometabolic phenotypes
by Nikpay, Majid and Beehler, Kaitlyn and Valsesia, Armand and Hager, Jorg and Harper, Mary-Ellen and Dent, Robert and McPherson, Ruth
Cardiovascular research, ISSN 0008-6363, 01/2019, Volume 115, Issue 11, pp. 1629 - 1645
To identify genetic variants that have a regulatory impact on circulating miRNAs and to connect genetic risk to blood traits/biomarkers through the circulating... 
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8. Full Text Reactive Oxygen Species and Oxidative Stress in Obesity-Recent Findings and Empirical Approaches
: ROS and Oxidative Stress in Obesity
by McMurray, Fiona and Patten, David A and Harper, Mary-Ellen
Obesity, ISSN 1930-7381, 11/2016, Volume 24, Issue 11, pp. 2301 - 2310
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9. Full Text Mitochondrial proticity and ROS signaling: lessons from the uncoupling proteins
by Mailloux, Ryan J and Harper, Mary-Ellen
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 2012, Volume 23, Issue 9, pp. 451 - 458
Fifty years since Peter Mitchell proposed the theory of chemiosmosis, the transformation of cellular redox potential into ATP synthetic capacity is still a... 
Endocrinology & Metabolism | SKELETAL-MUSCLE | OXYGEN SPECIES PRODUCTION | OXIDATIVE-STRESS | OXIDOREDUCTASE COMPLEX-I | SUPEROXIDE-PRODUCTION | BOVINE HEART-MITOCHONDRIA | REVERSIBLE OXIDATION | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | ALPHA-KETOGLUTARATE DEHYDROGENASE | S-GLUTATHIONYLATION | Animals | Reactive Oxygen Species - metabolism | Ion Channels - metabolism | Mitochondrial Proteins - metabolism | Humans | Mitochondria - metabolism | Uncoupling Protein 1 | Proteins | Mitochondrial DNA | Cells | Index Medicus
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10. Full Text Reactive Oxygen Species and Oxidative Stress in Obesity—Recent Findings and Empirical Approaches
by McMurray, Fiona and Patten, David A and Harper, Mary‐Ellen
Obesity, ISSN 1930-7381, 11/2016, Volume 24, Issue 11, pp. 2301 - 2310
Objective High levels of reactive oxygen species (ROS) are intricately linked to obesity and associated pathologies, notably insulin resistance and type 2... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | ELECTRON-TRANSPORT CHAIN | HYPOXIA-INDUCIBLE FACTOR | NUTRITION & DIETETICS | MITOFLASH PROBE CPYFP | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | INTRACELLULAR HYDROGEN-PEROXIDE | NF-KAPPA-B | MITOCHONDRIAL COMPLEX-III | HUMAN SKELETAL-MUSCLE | MASS-SPECTROMETRY | Animals | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Obesity - diagnosis | Mitochondria - metabolism | Antioxidants - analysis | Empirical Research | Disease Models, Animal | Obesity - metabolism | Obesity | Oxidative stress | Enzymes | Oxygen | Disease | Lipids | Mitochondrial DNA | Proteins | Mitochondria | Phenols | Hypoxia | Physiology | Mutation | Diabetes | Metabolic disorders
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11. Full Text Maternal diet–induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity
by McMurray, Fiona and MacFarlane, Megan and Kim, Kijoo and Patten, David A and Wei-LaPierre, Lan and Fullerton, Morgan D and Harper, Mary-Ellen
The FASEB Journal, ISSN 0892-6638, 12/2019, Volume 33, Issue 12, pp. 13515 - 13526
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12. Full Text Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3
by Mailloux, Ryan J and Seifert, Erin L and Bouillaud, Frédéric and Aguer, Céline and Collins, Sheila and Harper, Mary-Ellen
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 24, pp. 21865 - 21875
The mitochondrial uncoupling proteins 2 and 3 (UCP2 and -3) are known to curtail oxidative stress and participate in a wide array of cellular functions,... 
SKELETAL-MUSCLE | CELLS | OVEREXPRESSION | OXIDATIVE STRESS | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYDROGEN-PEROXIDE | ENERGY-METABOLISM | EXPRESSION | S-GLUTATHIONYLATION | MITOCHONDRIAL PROTON LEAK | Reactive Oxygen Species | Oxidative Stress | Glutathione - metabolism | Cells, Cultured | Thymus Gland - cytology | Ion Channels - genetics | Mice, Transgenic | Mitochondrial Proteins - genetics | Cysteine - chemistry | Mice, Knockout | Animals | Models, Biological | Myoblasts - cytology | Glutathione - chemistry | Mice | Protein Processing, Post-Translational | Uncoupling Protein 2 | Thymus Gland - metabolism | Uncoupling Protein 3 | Mitochondria | Reactive Oxygen Species (ROS) | UCP | Post-translational Modification | Glutathionylation | Metabolism | Proton Leak | Mitochondrial Metabolism
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13. Full Text Drugs and bugs: turning on the heat through UCP1 and UCP3
by Harper, Mary‐Ellen
The Journal of Physiology, ISSN 0022-3751, 12/2016, Volume 594, Issue 24, pp. 7151 - 7152
THERMOGENESIS | PHYSIOLOGY | NEUROSCIENCES | UNCOUPLING PROTEINS | Membrane Proteins | Proteins | Ion Channels | Adipose Tissue, Brown | Humans | Membrane Transport Proteins | Hot Temperature | Uncoupling Protein 1 | Mitochondrial Proteins | RNA, Messenger | Carrier Proteins | Thermoregulation | Skeletal Muscle
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