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Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 4056 - 4056
Abstract Background: Acute myeloid leukemia (AML) is a disease for which there is an urgent need for therapy that is more effective and less toxic. Antibody... 
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 07/2019, Volume 25, Issue 20, pp. 6260 - 6273
Aberrant Myc expression is a major factor in the pathogenesis of aggressive lymphoma, and these lymphomas, while clinically heterogeneous, often are resistant... 
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 4065 - 4065
Mantle cell lymphoma (MCL) is an incurable B-cell malignancy characterized by genetic dysregulation of cyclin D1 and activation of signaling pathways driving... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3931 - 3931
Abstract Acute Myeloid Leukemia (AML) is a heterogeneous disease that is characterized by an accumulation of neoplastic myeloid precursor cells in the bone... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2019, Volume 129, Issue 1, p. 122
Targeted therapy with small molecules directed at essential survival pathways in leukemia represents a major advance, including the... 
Molecular targeted therapy | Care and treatment | Usage | Lymphocytic leukemia | Development and progression | Research | T cells | Immune system
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 08/2019, Volume 60, Issue 10, pp. 2498 - 2507
Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy for which novel therapeutics with improved efficacy are greatly needed. To provide support for... 
LAG3 | Mantle cell lymphoma | PD-L1 | PD-L2 | CTLA-4 | immune checkpoint molecules | PD-1 | CD200
Journal Article
Cancer discovery, ISSN 2159-8274, 10/2018, Volume 8, Issue 10, pp. 1300 - 1315
Targeted inhibition of Bruton’s tyrosine kinase (BTK) with the irreversible inhibitor ibrutinib has improved outcomes for patients with hematologic... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 2908 - 2908
Abstract Background: Signaling through the B-cell receptor (BCR) results in cell survival and proliferation, and this pathway is critical for the progression... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 3941 - 3941
Abstract Background: Acute myeloid leukemia (AML) has very poor long-term survival with traditional therapies. AML has a diverse pathogenesis and likely... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 2920 - 2920
Abstract Introduction: BTK is involved in B-cell receptor (BCR) signal transduction and is an established target for the treatment of chronic lymphocytic... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2014, Volume 124, Issue 11, pp. 4867 - 4867
Chronic graft-versus-host disease (cGVHD) is a life-threatening impediment to allogeneic hematopoietic stem cell transplantation, and current therapies do not... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 318 - 318
Abstract Chronic Lymphocytic Leukemia (CLL) is a B-cell malignancy with aberrant activation of the B-cell receptor (BCR) pathway. Despite durable remissions... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2014, Volume 124, Issue 11, pp. 4867 - 4876
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0159607
Acalabrutinib (ACP-196) is a second-generation inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK) with increased target selectivity and potency... 
SURVIVAL | CLL | ACTIVATION | BRUTON TYROSINE KINASE | ONCOLOGY | MULTIDISCIPLINARY SCIENCES | IBRUTINIB | PCI-32765 | CHRONIC LYMPHOCYTIC-LEUKEMIA | GERMINAL CENTER | ANTIGEN | Lethargy - physiopathology | Protein-Tyrosine Kinases - metabolism | Diarrhea - physiopathology | Humans | Pyrazines - administration & dosage | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Weight Loss - drug effects | Diarrhea - chemically induced | Anorexia - physiopathology | Benzamides - administration & dosage | Protein-Tyrosine Kinases - genetics | Antineoplastic Agents - adverse effects | Female | B-Lymphocytes - pathology | Drug Evaluation, Preclinical | Benzamides - adverse effects | Disease Models, Animal | Lymphoma, Large B-Cell, Diffuse - drug therapy | Drug Administration Schedule | Lymphoma, Large B-Cell, Diffuse - enzymology | Lethargy - chemically induced | Lymphoma, Large B-Cell, Diffuse - mortality | B-Lymphocytes - drug effects | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Vomiting - chemically induced | Animals | B-Lymphocytes - immunology | Agammaglobulinaemia Tyrosine Kinase | Dogs | Pyrazines - adverse effects | Cell Line, Tumor | Anorexia - chemically induced | Lymphoma, Large B-Cell, Diffuse - veterinary | Vomiting - physiopathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Antimitotic agents | Care and treatment | Safety and security measures | Dosage and administration | Non-Hodgkin's lymphomas | Research | Antineoplastic agents | Cell proliferation | Cell culture | Flow cytometry | Veterinary colleges | Anorexia | Leukemia | Cytotoxicity | Malignancy | Kinases | Veterinary medicine | Vomiting | Quality | Inhibition | Protein-tyrosine kinase | Tyrosine | Internal medicine | Hematology | Agammaglobulinemia | Diarrhea | Gene expression | Lymphoma | Bruton's tyrosine kinase | Inhibitors | Lymphocytes B | Lethargy | Lymphomas | Cancer | B-cell lymphoma
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