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Journal Article
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 04/2007, Volume 115, Issue 13, pp. 1777 - 1788
Background-Constriction of the ductus arteriosus (DA) is initiated at birth by inhibition of O-2-sensitive K+ channels in DA smooth muscle cells. Subsequent... 
Oxygen | Calcium | Prematurity | Congenital heart disease | Cardiovascular diseases | Muscle, smooth | Ductus arteriosus, patent | CA2+ SENSITIZATION | GTP-BINDING PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | calcium | prematurity | muscle, smooth | ductus arteriosus, patent | CLOSURE | cardiovascular diseases | SIGNAL-TRANSDUCTION | INHIBITION | NONMUSCLE MYOSIN-II | INFANTS | congenital heart disease | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | oxygen | K+ CHANNELS | CALCIUM SENSITIZATION | Oxygen - pharmacology | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Calcium Signaling - physiology | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Male | rhoA GTP-Binding Protein - metabolism | Mitochondria, Heart - drug effects | Vasoconstriction - physiology | Phenylephrine - pharmacology | rho-Associated Kinases | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Superoxides - metabolism | Enzyme Induction - drug effects | Female | rhoB GTP-Binding Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Infant, Newborn | Organ Culture Techniques | Amides - pharmacology | Animals, Newborn | Fetal Heart - physiology | Rabbits | Nifedipine - pharmacology | Oxidation-Reduction | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Calcium Channels, L-Type - physiology | rhoB GTP-Binding Protein - biosynthesis | Calcium Channel Blockers - pharmacology | Enzyme Activation - drug effects | Gestational Age | rhoA GTP-Binding Protein - drug effects | Oxygen - blood | Hydrogen Peroxide - metabolism | Ductus Arteriosus - enzymology | Protein-Serine-Threonine Kinases - biosynthesis | Feedback, Physiological | Animals | Hypoplastic Left Heart Syndrome - pathology | Calcium Signaling - drug effects | Partial Pressure | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Calcium Channels, L-Type - drug effects | Ductus Arteriosus - drug effects | Pyridines - pharmacology | Physiological aspects | Oxygen consumption | Care and treatment | Patent ductus arteriosus | Protein kinases
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 06/2002, Volume 90, Issue 12, pp. 1307 - 1315
Renal arteries (RAs) dilate in response to hypoxia, whereas the pulmonary arteries (PAs) constrict. In the PA, O2 tension is detected by an unidentified redox... 
Oxygen sensor | Redox | Pulmonary circulation | channels | Rotenone | NADPH OXIDASE | CARDIAC & CARDIOVASCULAR SYSTEMS | RAT LUNGS | pulmonary circulation | POTASSIUM CHANNELS | rotenone | RADICAL PRODUCTION | SENSOR | CHEMORECEPTION | redox | TONE | K+ channels | oxygen sensor | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | SUPEROXIDE-DISMUTASE | SMOOTH-MUSCLE CELLS | HYPOXIC PULMONARY VASOCONSTRICTION | Electron Transport - drug effects | Kidney - blood supply | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Culture Techniques | Humans | Potassium Channels - physiology | Renal Circulation - physiology | Mitochondria - ultrastructure | Cell Hypoxia | Pulmonary Circulation - physiology | Kidney - metabolism | Rotenone - pharmacology | Lung - ultrastructure | Renal Circulation - drug effects | Lung - metabolism | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Renal Artery - cytology | Muscle, Smooth, Vascular - ultrastructure | Oxidation-Reduction | Cells, Cultured | Rats | Vasoconstriction - drug effects | Kidney - ultrastructure | Hydrogen Peroxide - metabolism | Pulmonary Artery - cytology | Pulmonary Artery - physiology | Renal Artery - physiology | Animals | Pulmonary Circulation - drug effects | Vasodilation - drug effects | Lung - blood supply | Mitochondria - physiology
Journal Article
CIRCULATION, ISSN 0009-7322, 04/2003, Volume 107, Issue 15, pp. 2037 - 2044
Background-Alveolar hypoxia acutely elicits pulmonary vasoconstriction (HPV). Chronic hypoxia (CH), despite attenuating HPV, causes pulmonary hypertension... 
hypoxia | LUNG | CARDIAC & CARDIOVASCULAR SYSTEMS | ARTERY MYOCYTES | TRANSCRIPTION | catheterization | gene therapy | SENSORS | cardiac output | INHIBITION | GATED K+ CHANNELS | PERIPHERAL VASCULAR DISEASE | AGENTS | HEMATOLOGY | oxygen | EXPRESSION | SMOOTH-MUSCLE CELLS
Journal Article
Journal Article
Journal Article
CIRCULATION RESEARCH, ISSN 0009-7330, 09/2002, Volume 91, Issue 6, pp. 478 - 486
Functional closure of the human ductus arteriosus (DA) is initiated within minutes of birth by 0, constriction. It occurs by an incompletely understood... 
CARDIAC & CARDIOVASCULAR SYSTEMS | RAT LUNGS | CHEMORECEPTOR CELLS | POTASSIUM CHANNELS | ARTERY MYOCYTES | mitochondrial membrane potential | hydrogen peroxide | I CELLS | redox | OXYGEN | MOLECULAR-IDENTIFICATION | VASCULATURE | PERIPHERAL VASCULAR DISEASE | Kv1.5 | CAROTID-BODY | HEMATOLOGY | Kv2.1 | HYPOXIC PULMONARY VASOCONSTRICTION
Journal Article
Circulation, ISSN 0009-7322, 09/2004, Volume 110, Issue 11, pp. 1372 - 1379
Journal Article
Pediatric Research, ISSN 0031-3998, 2002, Volume 52, Issue 1, pp. 19 - 24
Journal Article
Circulation, ISSN 0009-7322, 04/2007, Volume 115, Issue 13, pp. 1777 - 1788
BACKGROUND: Constriction of the ductus arteriosus (DA) is initiated at birth by inhibition of O sub(2)-sensitive K super(+) channels in DA smooth muscle cells.... 
Journal Article
Circulation, ISSN 0009-7322, 10/2005, Volume 112, Issue 16, pp. 2477 - 2486
BACKGROUND: Bronchopulmonary dysplasia (BPD) and pulmonary emphysema, both significant global health problems, are characterized by a loss of alveoli. Vascular... 
Journal Article
Circulation, ISSN 0009-7322, 09/2004, Volume 110, Issue 11, pp. 1372 - 1379
BACKGROUND: Oxygen (O sub(2))-sensitive K super(+) channels mediate acute O sub(2) sensing in many tissues. At birth, initial functional closure of the ductus... 
Journal Article
Circulation Research, ISSN 0009-7330, 08/2004, Volume 95, Issue 3, pp. 308 - 318
Journal Article
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