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Cell, ISSN 0092-8674, 07/2015, Volume 162, Issue 2, pp. 391 - 402
Journal Article
BMC bioinformatics, 04/2016, Volume 17, p. 164
The adaptation of the CRISPR-Cas9 system to pooled library gene knockout screens in mammalian cells represents a major technological leap over RNA... 
Computational Biology - methods | Epithelial Cells - metabolism | Gene Library | HCT116 Cells | Humans | Gene Knockout Techniques | Genes, Essential | Machine Learning | Genetic Fitness | Glioblastoma - genetics | RNA Interference | Sensitivity and Specificity | Cell Line, Tumor | Models, Genetic | HeLa Cells
Journal Article
Genome Biology, ISSN 1474-7596, 12/2006, Volume 7, Issue 11, pp. 120 - 120
Journal Article
Computational and Structural Biotechnology Journal, ISSN 2001-0370, 2019, Volume 17, pp. 1318 - 1325
Chemogenetic profiling enables the identification of genes that enhance or suppress the phenotypic effect of chemical compounds. Using this approach in cancer... 
Chemogenetic screens | CRISPR | Drug-gene interactions
Journal Article
Molecular Systems Biology, ISSN 1744-4292, 07/2014, Volume 10, Issue 7, pp. 733 - n/a
Journal Article
BMC Bioinformatics, ISSN 1471-2105, 04/2016, Volume 17, Issue 1
Background: The adaptation of the CRISPR-Cas9 system to pooled library gene knockout screens in mammalian cells represents a major technological leap over RNA... 
CRISPR | Essential genes | Genetic screens | Functional genomics | Cancer | CELLS | RNAI | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | IDENTIFICATION | WIDE CRISPR SCREEN | Research | Gene expression | Genomics | Cells
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 60 - 68
Forward genetic screens with CRISPR-Cas9 genome editing enable high-resolution detection of genetic vulnerabilities in cancer cells. We conducted genome-wide... 
Medicine(all) | Biochemistry, Genetics and Molecular Biology(all) | Journal Article | MEDICINE, RESEARCH & EXPERIMENTAL | RNF43 | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | CANCER | CELL BIOLOGY | ESSENTIAL GENES | INHIBITION | GROWTH | MUTATIONAL LANDSCAPE | WNT | RECEPTORS | Frizzled Receptors - antagonists & inhibitors | Neoplasm Transplantation | Oncogene Proteins - genetics | Pancreatic Neoplasms - metabolism | Colorectal Neoplasms - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Molecular Targeted Therapy | RNA, Messenger - metabolism | Carcinoma, Pancreatic Ductal - genetics | Adenocarcinoma - metabolism | Flow Cytometry | Organoids - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Adenocarcinoma - genetics | Real-Time Polymerase Chain Reaction | Colorectal Neoplasms - metabolism | Frizzled Receptors - metabolism | Pancreatic Neoplasms - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Antibodies - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Cell Cycle Checkpoints - drug effects | Fluorescent Antibody Technique | Organoids - drug effects | Cell Line, Tumor | Mice | Care and treatment | Pancreatic cancer | Innovations | Development and progression | Genotype | Genetic engineering | Cellular signal transduction | Genetic aspects | Health aspects | Proteins | Viral antibodies | Genomics | Colorectal cancer | Antibodies | Genomes | Genetic screening | Cell proliferation | Adenocarcinoma | CRISPR | Therapy | Immunoglobulins | Wnt protein | Frizzled protein | Xenotransplantation | Colorectal carcinoma | Cell surface | Signaling | Receptors | Organoids | Xenografts | Inhibition | Mutation | Pancreas | Tumors | Recombinant
Journal Article
BMC Genomics, ISSN 1471-2164, 11/2013, Volume 14, Issue 1, pp. 778 - 778
Background: Early application of second-generation sequencing technologies to transcript quantitation (RNA-seq) has hinted at a vast mammalian transcriptome,... 
CELLS | HUMAN GENOME | TRANSCRIPTOME | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | QUANTIFICATION | GENETICS & HEREDITY | Animals | Humans | RNA, Messenger - genetics | Transcriptome | Genome | High-Throughput Nucleotide Sequencing - methods | Chromatin - genetics | RNA sequencing | Gene expression | Research | Chromatin | Cells | Studies | Proteins | Genomes
Journal Article
Nature, ISSN 0028-0836, 2018, Volume 560, Issue 7716, pp. 117 - 121
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7713, pp. 285 - 289
The observation that BRCA1-and BRCA2-deficient cells are sensitive to inhibitors of poly(ADP-ribose) polymerase (PARP) has spurred the development of cancer... 
RNASE H2 | CELLS | REPLICATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | DNA-DAMAGE | ANTIANDROGEN RESISTANCE | LINEAGE PLASTICITY | GENES | TRANSCRIPTION | TOPOISOMERASE-I | Humans | Genome - genetics | Male | Synthetic Lethal Mutations | DNA Repair - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Ribonucleotides - genetics | Neoplasms - genetics | Poly (ADP-Ribose) Polymerase-1 - deficiency | Female | Genes, BRCA1 | BRCA1 Protein - deficiency | Prostatic Neoplasms - drug therapy | Ribonuclease H - genetics | DNA Damage - drug effects | Cell Line | Prostatic Neoplasms - pathology | DNA Topoisomerases, Type I - metabolism | Ribonuclease H - deficiency | Neoplasms - enzymology | DNA Replication | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - pharmacology | Gene Editing | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Animals | CRISPR-Cas Systems | Prostatic Neoplasms - enzymology | Mice | HeLa Cells | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Neoplasms - pathology | Poly (ADP-Ribose) Polymerase-1 - genetics | Ribonuclease H - metabolism | DNA polymerases | Physiological aspects | Ribonucleotides | Genetic aspects | Ionizing radiation | DNA replication | Genes | Genomics | Development and progression | Ribonuclease | Health aspects | Prostate cancer | Sugars | Monosaccharides | Toxicity | Leukemia | Homologous recombination | DNA damage | Poly(ADP-ribose) | Cytotoxicity | Homology | Genomes | Kinases | ADP | Metastases | Ribonuclease H2 | Proteins | Dwarfism | Genotype & phenotype | Clonal deletion | Ribose | Cell cycle | Deletion | Inhibition | Lesions | Repair | Deoxyribonucleic acid--DNA | Adducts | BRCA2 protein | CRISPR | Enzymes | Chronic lymphatic leukemia | BRCA1 protein | Anemia | Hypersensitivity | Poly(ADP-ribose) polymerase | Breast cancer | Screens | Substrates | Polymerase | DNA biosynthesis | Poly(ADP-ribose) Polymerase 1 | Trapping | Inhibitors | Mutation | DNA adducts | Prostate | Cancer
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2011, Volume 706, pp. 83 - 95
Journal Article
Nature Methods, ISSN 1548-7091, 05/2013, Volume 10, Issue 5, pp. 397 - 399
  Hart and Moffat comment on three recent studies introducing different approaches, all based on RNA interference (RNAi), to genetic interaction assays in... 
HUMAN GENOME | OVARIAN-CANCER | CELL | BIOCHEMICAL RESEARCH METHODS | RNA Interference | Humans | Animals | Biotechnology | Genetics | Ribonucleic acid--RNA | Biological assays | Mammals
Journal Article