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Methods in Molecular Biology, ISSN 1064-3745, 2015, Volume 1285, pp. 17 - 30
RNA-seq uses next-generation sequencing technology to determine the transcription profile of an organism in a quantitative manner. With respect to microarrays,... 
RNA extraction | Library preparation | RNA-seq | Illumina | Transcriptome | Computational Biology - methods | Gene Library | Gene Expression Profiling | High-Throughput Nucleotide Sequencing | Genomics - methods | Mycobacterium tuberculosis - genetics
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2014, Volume 58, Issue 5, pp. 2979 - 2981
The antileprosy drug clofazimine is also of interest for the treatment of multidrug-resistant tuberculosis. To understand possible resistance mechanisms,... 
MICROBIOLOGY | PHARMACOLOGY & PHARMACY | DRUG-RESISTANCE | ATP SYNTHASE | Clofazimine - pharmacology | Diarylquinolines - pharmacology | Mycobacterium tuberculosis - drug effects | Drug Resistance, Multiple, Bacterial | Antitubercular Agents - pharmacology | Mechanisms of Resistance
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2015, Volume 1285, pp. 1 - 16
Next-generation sequencing technologies for whole-genome sequencing of mycobacteria are rapidly becoming an attractive alternative to more traditional... 
Resistance | Whole genome | Next-generation sequencing | SNP | HiSeq | Llumina | Bioinformatics | MiSeq | Sequencing | Assembly | PacBio | MIRA | Computational Biology - methods | Genome, Bacterial | Genomic Library | High-Throughput Nucleotide Sequencing | Mutation | Genome | Genomics - methods | Mycobacterium tuberculosis - genetics | Index Medicus
Journal Article
Molecular Microbiology, ISSN 0950-382X, 04/2014, Volume 92, Issue 1, p. 194
  In Mycobacterium tuberculosis the decaprenyl-phospho-d-arabinofuranose (DPA) pathway is a validated target for the drugs ethambutol and benzothiazinones. To... 
Enzymes | Genotype & phenotype | Gram-positive bacteria | Mutation | Cells
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 04/2012, Volume 194, Issue 8, p. 2001
In Mycobacterium tuberculosis the alternative sigma factor SigF controls the expression of a particular subset of genes by altering RNA polymerase specificity.... 
Proteins | Chromatin | Bacteria | RNA polymerase | Gene expression | Binding sites
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2010, Volume 54, Issue 10, pp. 4150 - 4158
Journal Article
Embo Molecular Medicine, ISSN 1757-4676, 2014, Volume 6, Issue 3, pp. 372 - 383
The benzothiazinone lead compound, BTZ043, kills Mycobacterium tuberculosis by inhibiting the essential flavo-enzyme DprE1, decaprenylphosphoryl-beta-D-ribose... 
DprE1 | combination regimens | benzothiazinones | tuberculosis | Benzothiazinones | Tuberculosis | Combination regimens | MYCOBACTERIUM-TUBERCULOSIS | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | PA-824 | GRANULOMA-FORMATION | BTZ043 | Antitubercular Agents - chemical synthesis | Thiazines - therapeutic use | Humans | Bacterial Proteins - chemistry | Crystallography, X-Ray | Spiro Compounds - therapeutic use | Piperazines - chemistry | Embryo, Nonmammalian - drug effects | Mycobacterium tuberculosis - drug effects | Tuberculosis - drug therapy | Thiazines - pharmacology | Lung - metabolism | Binding Sites | Spiro Compounds - chemistry | Antitubercular Agents - therapeutic use | Disease Models, Animal | Thiazines - pharmacokinetics | Catalytic Domain | Antitubercular Agents - pharmacology | Alcohol Oxidoreductases - metabolism | Piperazines - therapeutic use | Piperazines - pharmacology | Thiazines - chemistry | Zebrafish - growth & development | Molecular Dynamics Simulation | Spiro Compounds - pharmacokinetics | Hep G2 Cells | Animals | Spleen - metabolism | Alcohol Oxidoreductases - chemistry | Bacterial Proteins - metabolism | Mice | Spiro Compounds - pharmacology | Chronic diseases | Enzymes | Analysis | Sugars | Monosaccharides | Drugs | Animal models | Acquired immune deficiency syndrome--AIDS | Ribose | Piperazine | New combinations | Clinical trials | Pyrazinamide | Epimerase | Crystal structure
Journal Article
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 10/2012, Volume 4, Issue 10, pp. 1032 - 1042
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 10/2010, Volume 192, Issue 20, pp. 5472 - 5479
The tolerance of Mycobacterium tuberculosis to antituberculosis drugs is a major reason for the lengthy therapy needed to treat a tuberculosis infection.... 
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 10/2010, Volume 192, Issue 20, p. 5472
  The tolerance of Mycobacterium tuberculosis to antituberculosis drugs is a major reason for the lengthy therapy needed to treat a tuberculosis infection.... 
Enzymes | Tuberculosis | Bacteria | RNA polymerase | Gene expression | Drug resistance | Bacteriology
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2018, Volume 13, Issue 9, pp. e0202749 - e0202749
Journal Article
Nature chemical biology, ISSN 1552-4450, 2014, Volume 10, Issue 2, pp. 96 - 98
Pyridomycin, a natural product with potent antituberculosis activity, inhibits a major drug target, the InhA enoyl reductase. Here, we unveil the co-crystal... 
NAD - chemistry | Antitubercular Agents - chemistry | Bacterial Proteins - chemistry | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Binding Sites | Oligopeptides - chemistry | Oxidoreductases - chemistry | Biosynthesis | Inhibitor drugs | Fatty acids | Substrates | Binding sites | Crystal structure
Journal Article
Antimicrobial Agents & Chemotherapy, ISSN 0066-4804, 01/2010, Volume 54, Issue 10, pp. 4150 - 4158
Nonreplicating or dormant cells of Mycobacterium tuberculosis constitute a challenge to tuberculosis (TB) therapy because of their tolerance or phenotypic... 
Journal Article
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