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The New England Journal of Medicine, ISSN 0028-4793, 06/2016, Volume 374, Issue 23, pp. 2209 - 2221
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2013, Volume 369, Issue 2, pp. 111 - 121
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2017, Volume 377, Issue 5, pp. 454 - 464
Midostaurin, an oral multitargeted kinase inhibitor, is active in patients with a FLT3 mutation. Among patients with acute myeloid leukemia and this mutation,... 
TRIAL | INTERNAL TANDEM DUPLICATION | WILD-TYPE | MEDICINE, GENERAL & INTERNAL | FAVORABLE PROGNOSIS | ACUTE MYELOGENOUS LEUKEMIA | DISTINCT | TYROSINE KINASE INHIBITOR | SORAFENIB | PHASE-I | YOUNGER | Humans | Middle Aged | Kaplan-Meier Estimate | Staurosporine - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Staurosporine - analogs & derivatives | Protein Kinase Inhibitors - adverse effects | Cytarabine - administration & dosage | Leukemia, Myeloid, Acute - mortality | Young Adult | fms-Like Tyrosine Kinase 3 - genetics | Protein Kinase Inhibitors - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Mutation | Daunorubicin - administration & dosage | Leukemia, Myeloid, Acute - genetics | Staurosporine - administration & dosage | Chemotherapy | Care and treatment | Myelocytic leukemia | Nonlymphoid leukemia | Research | Drug therapy | Cancer | Tyrosine | Medical research | Inhibitor drugs | Myeloid leukemia | Leukemia | Clinical trials | Oncology | Transplantation | Kinases | Patients | Cancer therapies | Survival | Cytarabine | Daunorubicin | Medical prognosis | Point mutation | Death | Remission | Acute myeloid leukemia | Protein-tyrosine kinase | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2016, Volume 22, Issue 7, pp. 792 - 799
Journal Article
Molecular Cancer, ISSN 1476-4598, 03/2013, Volume 12, Issue 1, pp. 19 - 19
Background: Activating mutations of class III receptor tyrosine kinases (RTK) FLT3, PDGFR and KIT are associated with multiple human neoplasms including... 
PDGFR | Quizartinib | FLT3 | AC220 | Leukemia | KIT | WILD-TYPE | GASTROINTESTINAL STROMAL TUMOR | LIGAND-INDEPENDENT ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-KIT | ACUTE MYELOID-LEUKEMIA | MYELODYSPLASTIC SYNDROME | SYSTEMIC MASTOCYTOSIS | ONCOLOGY | FLT3 GENE | INTERNAL TANDEM DUPLICATIONS | MAST-CELL LEUKEMIA | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Phosphorylation | Apoptosis - drug effects | Humans | Apoptosis - genetics | Leukemia - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Dose-Response Relationship, Drug | fms-Like Tyrosine Kinase 3 - genetics | Receptor, Platelet-Derived Growth Factor alpha - antagonists & inhibitors | Inhibitory Concentration 50 | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Gastrointestinal Stromal Tumors - genetics | Leukemia - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Benzothiazoles - pharmacology | fms-Like Tyrosine Kinase 3 - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Protein Isoforms | Cell Line, Tumor | Gastrointestinal Stromal Tumors - metabolism | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Mutation | Tyrosine | Medical research | Platelet-derived growth factor | Codon | Analysis | Medicine, Experimental | Phenols | Pediatrics | Hematology | Software | Kinases | Experiments | Drug dosages | Manuscripts | Index Medicus
Journal Article
Haematologica, ISSN 0390-6078, 03/2012, Volume 97, Issue 3, pp. 393 - 401
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 1, pp. 33 - 38
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2008, Volume 358, Issue 18, pp. 1909 - 1918
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2016, Volume 48, Issue 12, pp. 1551 - 1556
Journal Article