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1. Full Text Prion-like Propagation Model of Tau
by Hosokawa, Masato and Hasegawa, Masato
YAKUGAKU ZASSHI, ISSN 0031-6903, 07/2019, Volume 139, Issue 7, pp. 1021 - 1025
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2. Full Text Molecular mechanisms in the pathogenesis of alzheimer’s disease and Tauopathies-Prion-Like seeded aggregation and phosphorylation
by Hasegawa, Masato
Biomolecules, ISSN 2218-273X, 06/2016, Volume 6, Issue 2, p. 24
Neurofibrillary tau pathology (tangles and threads) and extracellular amyloid-β (Aβ) pathology are defining features of Alzheimer’s disease. For 25 years, most... 
Amyloid 3 | TDP-43 | Fibril 4 | MAPT | Synuclein | Prion 2 | APP 5 | fibril 4 | synuclein | prion 2 | amyloid 3
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3. Full Text FTLD-TDP-43 AND FTLD-FUS
by Hasegawa, Masato
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2017, Volume 13, Issue 7, pp. P892 - P892
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4. Full Text Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants
by Kimura, Taeko and Hosokawa, Tomohisa and Taoka, Masato and Tsutsumi, Koji and Ando, Kanae and Ishiguro, Koichi and Hosokawa, Masato and Hasegawa, Masato and Hisanaga, Shin-Ichi
Scientific Reports, ISSN 2045-2322, 09/2016, Volume 6, Issue 1, p. 33479
Tau is hyperphosphorylated in the brains of patients with tauopathies, such as Alzheimer's disease and frontotemporal dementia and parkinsonism linked to... 
ALZHEIMER-DISEASE | WILD-TYPE | SUBSTRATE-SPECIFICITY | PROTEIN | P35 | MULTIDISCIPLINARY SCIENCES | FRONTOTEMPORAL DEMENTIA | CASPASE-CLEAVAGE | CDK5 ACTIVITY | CYCLIN-DEPENDENT KINASE-5 | BRAIN | Frontotemporal Dementia - genetics | Amino Acid Sequence | Phosphorylation | Cercopithecus aethiops | tau Proteins - metabolism | Mutant Proteins - metabolism | Mutation - genetics | tau Proteins - chemistry | Cyclin-Dependent Kinase 5 - metabolism | Brain - metabolism | Frontotemporal Dementia - metabolism | Animals | Alanine - genetics | Models, Biological | Mutant Proteins - chemistry | Brain - pathology | Mice | COS Cells | Basal ganglia | Neurodegenerative diseases | Central nervous system diseases | Kinases | Cyclin-dependent kinase 5 | Banding | Isotypes | Tau protein | Dementia disorders | Frontotemporal dementia | Alzheimers disease | Alzheimer's disease | Movement disorders | Chromosome 17
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5. Full Text Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice
by Hosokawa, Masato and Arai, Tetsuaki and Masuda-Suzukake, Masami and Nonaka, Takashi and Yamashita, Makiko and Akiyama, Haruhiko and Hasegawa, Masato
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, p. e52389
In neurodegenerative disorders, abnormally hyperphosphorylated and aggregated tau accumulates intracellularly, a mechanism which is thought to induce neuronal... 
INHIBITION | PROTEIN | DYES | MULTIDISCIPLINARY SCIENCES | PHENOTHIAZINES | DRUGS | SEPTIC SHOCK | RATS | AGGREGATION | Immunohistochemistry | Mutant Proteins - genetics | Solubility | tau Proteins - metabolism | Immunoblotting | Mice, Transgenic | Mutant Proteins - metabolism | Methylene Blue - pharmacology | Subcellular Fractions - metabolism | tau Proteins - chemistry | Brain - metabolism | Animals | tau Proteins - genetics | Mutant Proteins - chemistry | Protein Structure, Quaternary | Brain - pathology | Mice | Sarcosine - analogs & derivatives | Phosphorylation - drug effects | Sarcosine - pharmacology | Amino Acid Substitution | Nervous system diseases | Genetic engineering | Neurons | Cell death | Analysis | Brain | Phosphorylation | Neurodegenerative diseases | Oral administration | Transgenic mice | Science | Biology | Metabolism | Experiments | Accumulation | Western blotting | Methylene blue | Proteins | Pathology | Tau protein | Transgenic animals | Rodents | Sepsis | Laboratory animals | Phenothiazine | Dementia | Animal cognition
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6. Full Text Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation
by Hosokawa, Masato and Kondo, Hiromi and Serrano, Geidy E and Beach, Thomas G and Robinson, Andrew C and Mann, David M and Akiyama, Haruhiko and Hasegawa, Masato and Arai, Tetsuaki
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1513 - 11
In 2006, mutations in the granulin gene were identified in patients with familial Frontotemporal Lobar Degeneration. Granulin transcript haploinsufficiency has... 
VARIABILITY | PROGRANULIN GENE | INCLUSIONS | EPITHELIN PRECURSOR | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | ALPHA-SYNUCLEIN PATHOLOGY | CORTICOBASAL SYNDROME | HOST-DEFENSE | TAU | BRAIN | Frontotemporal Lobar Degeneration - pathology | Phosphorylation | Humans | Middle Aged | Granulins - genetics | tau Proteins - metabolism | Male | DNA-Binding Proteins - genetics | Mutation - genetics | Amyloid beta-Peptides - metabolism | Female | Aged | Frontotemporal Lobar Degeneration - genetics | Temporal Lobe - pathology | alpha-Synuclein - metabolism | Transcription | Neurodegenerative diseases | Astrocytes | Transgenic mice | Neuropil | Synuclein | Neuronal-glial interactions | Haploinsufficiency | Proteins | Granulin | Tau protein | Neurodegeneration | Rodents | Oligodendrocytes | Isoforms | Mutation | Frontotemporal dementia
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7. Full Text TDP-43 stabilises the processing intermediates of mitochondrial transcripts
by Izumikawa, Keiichi and Nobe, Yuko and Yoshikawa, Harunori and Ishikawa, Hideaki and Miura, Yutaka and Nakayama, Hiroshi and Nonaka, Takashi and Hasegawa, Masato and Egawa, Naohiro and Inoue, Haruhisa and Nishikawa, Kouki and Yamano, Koji and Simpson, Richard J and Taoka, Masato and Yamauchi, Yoshio and Isobe, Toshiaki and Takahashi, Nobuhiro
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 7709 - 14
The 43-kDa trans-activating response region DNA-binding protein 43 (TDP-43) is a product of a causative gene for amyotrophic lateral sclerosis (ALS). Despite... 
MOTOR-NEURONS | SPLICING REGULATION | RNA | MULTIDISCIPLINARY SCIENCES | DISEASE | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | MUTATIONS | FRONTOTEMPORAL LOBAR DEGENERATION | EXPRESSION | TRANSGENIC MICE | Cell Line | Gene Expression | RNA Processing, Post-Transcriptional | Humans | Mitochondria - metabolism | DNA-Binding Proteins - genetics | RNA Stability | Genes, Mitochondrial | Mitochondria - ultrastructure | Protein Transport | DNA-Binding Proteins - metabolism | Mitochondria - genetics | Protein Binding | RNA, Transfer - genetics | Transcription, Genetic | Ribonuclease P | Mitochondria | DNA-binding protein | rRNA 16S | Homeostasis | Amyotrophic lateral sclerosis | Mitochondrial DNA | Electron transport | Intermediates
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8. Full Text Prion-like spreading of pathological α-synuclein in brain
by Masuda-Suzukake, Masami and Nonaka, Takashi and Hosokawa, Masato and Oikawa, Takayuki and Arai, Tetsuaki and Akiyama, Haruhiko and Mann, David M. A and Hasegawa, Masato
Brain, ISSN 0006-8950, 2013, Volume 136, Issue 4, pp. 1128 - 1138
alpha-Synuclein is the major component of filamentous inclusions that constitute the defining characteristic of neurodegenerative alpha-synucleinopathies.... 
Parkinson's disease | propagation | α-synuclein | Lewy bodies | DEMENTIA | INCLUSIONS | alpha-synuclein | NEUROSCIENCES | CLINICAL NEUROLOGY | TRANSMISSION | NEURODEGENERATIVE-DISEASES | MUTATION | DUPLICATION | FAMILIAL PARKINSONS-DISEASE | AGGREGATION | Prions - metabolism | alpha-Synuclein - administration & dosage | alpha-Synuclein - toxicity | Brain - physiopathology | Humans | Mice, Inbred C57BL | Injections, Intraventricular | Lewy Body Disease - pathology | Behavior, Animal - physiology | Administration, Intranasal | Recombinant Proteins - administration & dosage | Brain - metabolism | Lewy Body Disease - metabolism | Animals | Time Factors | Brain - pathology | Recombinant Proteins - toxicity | Female | Mice | alpha-Synuclein - metabolism | Disease Models, Animal | Lewy Body Disease - physiopathology | Original | Parkinson’s disease
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9. Full Text Fugine as Single-Point Compression Engine based on Supermulti-Jets Colliding with Pulse: Combustion Test of Second Prototype Engine with Strongly-Asymmetric Double-Piston System
by Naitoh, Ken, author and Shirai, Tomoya, author and Tanaka, Masato, author and Nojima, Yoshiyuki, author and Hashimoto, Taiki, author and Hasegawa, Kenya, author and Kojima, Kentaro, author and Kihara, Takahiro, author
SAE technical paper series, Volume 2015-01-1964.
We proposed a new compressive combustion principle for an inexpensive and relatively quiet engine reactor that has the potential to achieve incredible thermal... 
Pistons | Combustion and combustion processes
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10. Full Text Effects of Hydrogen Addition to Intake Mixture on Cyclic Variation of Diesel Engine
by Miyamoto, Toru, author and Hasegawa, Hirokazu, author and Yagenji, Takashi, author and Seo, Takehiko, author and Mikami, Masato, author and Kabashima, Hajime, author and Hashimoto, Tomoyuki, author
SAE technical paper series, Volume 2011-01-1964.
The present study experimentally investigated cyclic variation of combustion characteristics of a diesel engine with hydrogen added to the intake air in... 
Combustion and combustion processes | Diesel / Compression Ignition engines | Ignition timing | Hydrogen fuel
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11. Full Text Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice
by Hosokawa, Masato and Tanaka, Yoshinori and Arai, Tetsuaki and Kondo, Hiromi and Akiyama, Haruhiko and Hasegawa, Masato
Experimental Animals, ISSN 1341-1357, 2018, Volume 67, Issue 1, pp. 63 - 70
Granulin (Grn) mutations were identified in familial frontotemporal lobar degeneration (FTLD) patients with TAR DNA-binding protein of 43 kd (TDP-43)... 
progranulin | amyloid beta (Aβ) | haploinsufficiency | Alzheimer’s disease | granulin | Granulin | Progranulin | Amyloid beta (Aβ) | Haploinsufficiency | Transcription | Neurodegenerative diseases | Pathogenesis | Transgenic mice | Immunoblotting | Amyloid precursor protein | Accumulation | Proteins | Pathology | DNA-binding protein | Tau protein | Neurodegeneration | Transgenic animals | Rodents | Mice | Degeneration | Mutation | Frontotemporal dementia | Alzheimer's disease | Deoxyribonucleic acid--DNA | Original
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12. Full Text Reconsideration of amyloid hypothesis and tau hypothesis in Alzheimer's disease
by Kametani, Fuyuki and Hasegawa, Masato
Frontiers in Neuroscience, ISSN 1662-4548, 01/2018, Volume 12, p. 25
The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or fibrillar amyloid beta (A beta) peptide is the primary cause of... 
APP | Tau | Amyloid | Alzheimer's disease | PHF | tau | APP INTRACELLULAR DOMAIN | NEUROSCIENCES | A beta | amyloid | MOUSE MODEL | IN-VIVO | PAIRED HELICAL FILAMENTS | MULTIPLE SYSTEM TAUOPATHY | A-BETA | COGNITIVELY NORMAL INDIVIDUALS | PRECURSOR PROTEIN | GAMMA-SECRETASE | ALPHA-SECRETASE CLEAVAGE | Drug targeting | Care and treatment | Glycoproteins | Research
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13. Full Text The Art of Being Governed: Everyday Politics in Late Imperial China by Michael Szonyi (review)
by Hasegawa, Masato
China Review International, ISSN 1069-5834, 2017, Volume 24, Issue 3, pp. 232 - 236
1368-1644 | Szonyi, Michael, -- author | China | Politics and government
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14. Full Text Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation
by Hasegawa, M
BIOMOLECULES, ISSN 2218-273X, 06/2016, Volume 6, Issue 2
Neurofibrillary tau pathology (tangles and threads) and extracellular amyloid- (A) pathology are defining features of Alzheimer's disease. For 25 years, most... 
TAU-PROTEIN | prion 2 | amyloid 3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PICKS-DISEASE | MASS-SPECTROMETRIC ANALYSES | APP 5 | AMYLOID CASCADE HYPOTHESIS | MICROTUBULE-BINDING REGION | fibril 4 | synuclein | TDP-43 | NEURODEGENERATIVE-DISEASES | PAIRED HELICAL FILAMENTS | MULTIPLE SYSTEM TAUOPATHY | MAPT | PROGRESSIVE SUPRANUCLEAR PALSY | CORTICOBASAL DEGENERATION | Prions - metabolism | Phosphorylation | Dementia - pathology | Humans | Tauopathies - pathology | tau Proteins - metabolism | tau Proteins - chemistry | Brain - metabolism | Dementia - metabolism | Tauopathies - metabolism | Amyloid beta-Protein Precursor - genetics | Amyloid - metabolism | Amyloid beta-Protein Precursor - metabolism | Mutation
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15. Full Text Stellar mass dependence of the 21-cm signal around the first star and its impact on the global signal
by Tanaka, Toshiyuki and Hasegawa, Kenji and Yajima, Hidenobu and Kobayashi, Masato I.N and Sugiyama, Naoshi
Monthly Notices of the Royal Astronomical Society, ISSN 0035-8711, 10/2018, Volume 480, Issue 2, pp. 1925 - 1937
The 21-cm signal in the vicinity of the first stars is expected to reflect properties of the first stars. In this study, we pay special attention to tracing... 
First stars | Intergalactic medium -H II regions | Dark ages | Reionization | Hydrodynamics | Radiative transfer | Radio lines: general | CDM UNIVERSE | REIONIZATION | EARLY UNIVERSE | radiative transfer | intergalactic medium | hydrodynamics | COLD-DARK-MATTER | SMOOTHED PARTICLE HYDRODYNAMICS | dark ages, reionization, first stars | POPULATION-III | H II regions | EVOLUTION | TEMPERATURE | ASTRONOMY & ASTROPHYSICS | radio lines: general | ULTRAVIOLET-RADIATION
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16. Full Text C9ORF72 DIPEPTIDE REPEAT PROTEINS CAUSE INTRACELLULAR AGGREGATION OF PHOSPHORYLATED TDP-43
by Nonaka, Takashi and Hasegawa, Masato
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P1046 - P1046
Neurology
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17. Full Text Prion-like Propagation Model of Tau
by Hosokawa, Masato and Hasegawa, Masato
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, ISSN 0031-6903, 2019, Volume 139, Issue 7, pp. 1021 - 1025
Abnormal proteins such as tau or α-synuclein that accumulate in brains with dementia have been shown to propagate like prion proteins. However, the expression... 
Prion Proteins | Dementia - drug therapy | Humans | tau Proteins - metabolism | Drug Discovery | Gene Editing | Protein Aggregation, Pathological | Brain - metabolism | Tauopathies | Dementia - metabolism | Animals | Mice | Disease Models, Animal | TRANSMISSION | propagation | FIBRILS | tau | PHARMACOLOGY & PHARMACY | TAUOPATHY | MICE | ALPHA-SYNUCLEIN | PATHOLOGY | animal model | SPREAD
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18. Full Text Efficacy of corticosteroid and intravenous cyclophosphamide in acute exacerbation of idiopathic pulmonary fibrosis: A propensity score‐matched analysis
by Hozumi, Hironao and Hasegawa, Hirotsugu and Miyashita, Koichi and Yasui, Hideki and Suzuki, Yuzo and Kono, Masato and Karayama, Masato and Furuhashi, Kazuki and Hashimoto, Dai and Enomoto, Noriyuki and Fujisawa, Tomoyuki and Inui, Naoki and Nakamura, Yutaro and Yokomura, Koshi and Nakamura, Hidenori and Suda, Takafumi
Respirology, ISSN 1323-7799, 08/2019, Volume 24, Issue 8, pp. 792 - 798
A propensity score‐matched analysis demonstrated that in patients with idiopathic pulmonary fibrosis with a first episode of idiopathic acute exacerbation,... 
acute exacerbation | cyclophosphamide | idiopathic pulmonary fibrosis | corticosteroids | CYCLOSPORINE-A | RESPIRATORY SYSTEM | Respiratory tract diseases | Cyclophosphamide | Rankings | Corticosteroids | Pulmonary fibrosis | Analysis | Corticoids | Intravenous administration | Lung diseases | Fibrosis | Survival | Immunosuppressive agents
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