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up-regulates filaggrin (3) 3
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International Journal of Molecular Sciences, ISSN 1661-6596, 09/2017, Volume 18, Issue 9, p. 1948
The Japanese mugwort, Artemisia princeps (yomogi in Japanese), has anti-inflammatory and antioxidant effects. Skin care products containing Artemisia princeps... 
Aryl hydrocarbon receptor | Artemisia princeps extract | Filaggrin | OVO-like 1 | Loricrin | Nuclear factor-erythroid 2-related factor-2 | UP-REGULATES FILAGGRIN | HOMEOSTASIS | EPIDERMAL DIFFERENTIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARRIER | MECHANISMS | nuclear factor-erythroid 2-related factor-2 | DEPENDENT MANNER | CHEMISTRY, MULTIDISCIPLINARY | HUMAN KERATINOCYTES | aryl hydrocarbon receptor | ATOPIC-DERMATITIS | NORMAL MURINE SKIN | ARYL-HYDROCARBON RECEPTOR | filaggrin | loricrin | Cell Line | Cytochrome P-450 CYP1A1 - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Artemisia - chemistry | NADPH Dehydrogenase - metabolism | Membrane Proteins - genetics | Plant Extracts - pharmacology | Humans | Receptors, Aryl Hydrocarbon - genetics | NADPH Dehydrogenase - genetics | Antioxidants - pharmacology | Transcription Factors - genetics | Cytochrome P-450 CYP1A1 - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Keratinocytes - drug effects | Keratinocytes - metabolism | Intermediate Filament Proteins - genetics | Receptors, Aryl Hydrocarbon - metabolism | Membrane Proteins - metabolism | Intermediate Filament Proteins - metabolism | Low concentrations | Cytochrome P450 | Quinone | Keratinocytes | Cytotoxicity | Inflammation | Maintenance | Gene expression | Dermatitis | Nuclear transport | Antioxidants | Proteins | NAD | Oxygenase | Aromatic compounds | NAD(P)H dehydrogenase | Atopic dermatitis | Skin care products | Heme | Skin
Journal Article
Journal of Dermatological Science, ISSN 0923-1811, 10/2019, Volume 96, Issue 1, pp. 53 - 56
Journal Article
The Journal of Dermatology, ISSN 0385-2407, 02/2015, Volume 42, Issue 2, pp. 171 - 180
Journal Article
Journal of Dermatological Science, ISSN 0923-1811, 07/2018, Volume 91, Issue 1, pp. 97 - 103
Scleroderma is caused by aberrant transforming growth factor-ß signaling. The degradation of extracellular matrix proteins is regulated by matrix... 
Extracellular signal-regulated kinase (ERK) | Matrix metalloproteinase-1 (MMP1) | Aryl hydrocarbon receptor | Scleroderma | 6-Formylindolo[3,2-b]carbazole (FICZ) | Tryptophan | Systemic scleroderma | Mitogens | Scleroderma (Disease) | Radiation | Phototherapy
Journal Article
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 07/2019, Volume 20, Issue 13, p. 3324
The vicious itch-scratch cycle is a cardinal feature of atopic dermatitis (AD), in which IL-13 signaling plays a dominant role. Keratinocytes express two... 
scratch injury | IL-13Rα1 | IL-13Rα2 | keratinocyte | atopic dermatitis | IL-13 | involucrin | IL-4Rα
Journal Article
Journal Article
Journal of Dermatological Science, ISSN 0923-1811, 01/2018, Volume 89, Issue 1, pp. 19 - 26
Persistent ultraviolet (UV) radiation in the form of sunlight causes photo-aging of the skin by reducing the production of type I collagen, the major... 
6-Formylindolo[3,2-b]carbazole | Aryl hydrocarbon receptor | Dermal fibroblast | FICZ | Ultraviolet | Photo-aging | OXIDATIVE STRESS | HUMAN-CELLS | MYOFIBROBLAST | INDUCED SIGNAL-TRANSDUCTION | HUMAN KERATINOCYTES | DERMATOLOGY | INDUCED CYP1A1 | ARYL-HYDROCARBON RECEPTOR | HUMAN SKIN FIBROBLASTS | ULTRAVIOLET-B | EXPRESSION
Journal Article
Oxidative medicine and cellular longevity, ISSN 1942-0900, 2018, Volume 2018, pp. 9298052 - 10
Ultraviolet B (UVB) irradiation activates the aryl hydrocarbon receptor (AHR), generates the reactive oxygen species (ROS), and induces the production of... 
ACTIVATION | ARYL-HYDROCARBON RECEPTOR | HUMAN-CELLS | CYP1A1 GENE-EXPRESSION | ULTRAVIOLET-B | AH RECEPTOR | CELL BIOLOGY | Cytochrome | Signal transduction | Flow cytometry | Cell culture | Ultraviolet radiation | Cytokines | Dermatology | Hydrocarbons | Science | Ligands | Skin | Metabolism
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1661-6596, 08/2019, Volume 20, Issue 16, p. 4053
Severe pruritus is a characteristic feature of atopic dermatitis (AD) and is closely related to its activity. Recent studies have shown that IL-31 is a key... 
ACTIVATION | Ccl 17 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | atopic dermatitis | INTERLEUKIN-31 | Ccl 22 | CHEMISTRY, MULTIDISCIPLINARY | IL-31 | IL-31 receptor alpha | CHEMOKINE | EXPRESSION | dendritic cell
Journal Article
Cell death & disease, ISSN 2041-4889, 07/2017, Volume 8, Issue 7, pp. e2931 - e2931
Filaggrin (FLG) mutation is a well-confirmed genetic aberration in atopic dermatitis (AD). Genome-wide association studies on AD have revealed other... 
POPULATION | HAIR | SUSCEPTIBILITY LOCI | MECHANISMS | DIFFERENTIATION | EPIDERMAL PROGENITOR CELLS | PROTEINS | SKIN BARRIER | GENOME-WIDE ASSOCIATION | AXIS | CELL BIOLOGY | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Humans | Transglutaminases - genetics | DNA-Binding Proteins - metabolism | Interleukin-4 - pharmacology | Cell Nucleus - metabolism | RNA Interference | Intermediate Filament Proteins - genetics | Receptors, Aryl Hydrocarbon - metabolism | Membrane Proteins - metabolism | Cell Culture Techniques | Cell Line | DNA-Binding Proteins - antagonists & inhibitors | Protein Precursors - genetics | Membrane Proteins - genetics | Receptors, Aryl Hydrocarbon - genetics | Transcription Factors - antagonists & inhibitors | Dermatitis, Atopic - pathology | Keratinocytes - cytology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Tars - pharmacology | Protein Precursors - metabolism | Receptors, Aryl Hydrocarbon - agonists | Transcription Factors - metabolism | Up-Regulation - drug effects | Keratinocytes - metabolism | Transglutaminases - metabolism | Carbazoles - pharmacology | Dermatitis, Atopic - metabolism | Intermediate Filament Proteins - metabolism | RNA, Small Interfering - metabolism | Tar | Hydrocarbons | Keratinocytes | Genomes | Filaggrin | Gene expression | Dermatitis | Carbazole | Nuclear transport | Interleukin 4 | Cellular biology | Atopic dermatitis | Ligands | Skin | Receptor mechanisms | Mutation | Original
Journal Article
Nutrients, ISSN 2072-6643, 03/2017, Volume 9, Issue 3, p. 223
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, p. e0149285
Journal Article
Journal of Dermatological Science, ISSN 0923-1811, 01/2018, Volume 89, Issue 1, p. 19
Persistent ultraviolet (UV) radiation in the form of sunlight causes photo-aging of the skin by reducing the production of type I collagen, the major... 
Collagen | Tryptophan | Bone morphogenetic proteins | Transforming growth factors
Journal Article
Toxicology Letters, ISSN 0378-4274, 04/2015, Volume 234, Issue 2, pp. 74 - 80
Due to its antioxidant and anti-inflammatory activities, ( ) has been used as folk medicine to treat various diseases. Cynaropicrin (Cyn), a sesquiterpene... 
Nqo1 | Cynaropicrin | AhR | Antioxidant | Nrf2 | Ultraviolet B | ACTIVATION | CANCER | HUMAN KERATINOCYTES | DAMAGE | CYNARA-SCOLYMUS L | SIGNALING PATHWAY | TOXICOLOGY | NF-KAPPA-B | EXPRESSION | SKIN INFLAMMATION | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Keratinocytes - radiation effects | Humans | NAD(P)H Dehydrogenase (Quinone) - genetics | RNA, Messenger - metabolism | Lactones - pharmacology | Dose-Response Relationship, Drug | Transfection | Basic Helix-Loop-Helix Transcription Factors - metabolism | RNA Interference | Inflammation Mediators - metabolism | Receptors, Aryl Hydrocarbon - metabolism | NF-E2-Related Factor 2 - genetics | Oxidative Stress - radiation effects | Active Transport, Cell Nucleus | Basic Helix-Loop-Helix Transcription Factors - drug effects | Interleukin-6 - metabolism | Keratinocytes - enzymology | Cytoprotection | Basic Helix-Loop-Helix Transcription Factors - genetics | Cells, Cultured | Receptors, Aryl Hydrocarbon - genetics | Receptors, Aryl Hydrocarbon - drug effects | Antioxidants - pharmacology | Ultraviolet Rays - adverse effects | Keratinocytes - drug effects | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | Oxidative Stress - drug effects | Sesquiterpenes - pharmacology | Antioxidants | Skin | Index Medicus | Pathways | Cytokines | Artichokes | Biocompatibility | Activation | Ultraviolet | Diseases
Journal Article