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Molecular Imaging and Biology, ISSN 1536-1632, 2/2019, Volume 21, Issue 1, pp. 105 - 112
The imdazoline I2 receptor (I2R) has been found in the feeding centers of the brain, such as the hypothalamus, and certain I2R ligands have been reported to... 
Imidazoline receptor | Obesity | Medicine & Public Health | [ 11 C]BU99008 | I 2 | Imaging / Radiology | Zucker rats | Positron emission tomography | Binding | Neuroimaging | Brain | Parameter estimation | Medical imaging | Positron emission | Rats | Hypothalamus | Injection | Feeding | Metabolites | Food intake | Imidazoline | Rodents | Tomography | Radioactivity
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 05/2014, Volume 129, Issue 4, pp. 712 - 720
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 14945 - 9
Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial pharmacological target for several central nervous system disorders. In this study, we aimed to... 
HIPPOCAMPUS | CYTOKINES | MULTIDISCIPLINARY SCIENCES | MECHANISMS | C-11-ABP688 | MODEL | TYPE-1 | EXPRESSION | Lithium chloride | Epilepsy | Central nervous system | Forebrain | Lithium | Glutamic acid receptors | Pilocarpine | Inflammation | Rodents | Thalamus | Glutamic acid receptors (metabotropic) | Positron emission tomography | Hippocampus | Seizures
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 02/2019, Volume 27, Issue 3, p. 483
Metabotropic glutamate receptor 2 (mGluR2) has been suggested as a therapeutic target for treating schizophrenia-like symptoms arising from increased glutamate... 
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e45065
Purpose: The translocator protein (18 kDa) (TSPO) is highly expressed on the bronchial and bronchiole epithelium, submucosal glands in intrapulmonary bronchi,... 
RESPONSES | POSITRON-EMISSION-TOMOGRAPHY | LYMPHOID-TISSUE | MACROPHAGES | KINETICS | MULTIDISCIPLINARY SCIENCES | PERIPHERAL BENZODIAZEPINE-RECEPTOR | LIPOPOLYSACCHARIDE | INJURY | RATS | OUTCOMES | Isoquinolines - pharmacokinetics | Area Under Curve | Male | Lung - diagnostic imaging | Fluorine Radioisotopes - pharmacokinetics | Pneumonia - diagnosis | Pulmonary Alveoli - metabolism | Lung - metabolism | Pulmonary Alveoli - diagnostic imaging | Neutrophils - metabolism | Neutrophils - pathology | Lung - pathology | Tissue Distribution - drug effects | Pulmonary Alveoli - pathology | Radiopharmaceuticals - pharmacokinetics | Acetamides - pharmacokinetics | Macrophages - pathology | Carbon Radioisotopes - pharmacokinetics | Neutrophils - drug effects | Purines - pharmacokinetics | Rats | Positron-Emission Tomography - methods | Rats, Sprague-Dawley | Blotting, Western | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Fluorescent Antibody Technique | Lipopolysaccharides - pharmacology | Ligands | Macrophages - drug effects | Receptors, GABA-A - metabolism | Acute respiratory distress syndrome | Inflammation | PET imaging | Macrophages | Mitogens | Disease | Emission analysis | Glands | Bronchi | Lipopolysaccharides | Proteins | Rodents | Imaging | Tomography | Chronic obstructive pulmonary disease | Pretreatment | Alveoli | Trachea | Radioactivity | Medical imaging | Neutrophils | Positron emission | Bronchus | Fluorine isotopes | Leukocytes (neutrophilic) | Epithelium | Pneumocytes | Lungs | Laboratory animals | Positron emission tomography
Journal Article
ChemMedChem, ISSN 1860-7179, 08/2018, Volume 13, Issue 16, pp. 1723 - 1731
To introduce the 3‐[18F]fluoro‐2‐hydroxypropyl moiety into positron emission tomography (PET) radiotracers, we performed automated synthesis of (rac)‐, (R)‐,... 
[18F]epifluorohydrin | automated synthesis | translocator protein | imaging agents | 18F-fluoroalkylation | F]epifluorohydrin | F-fluoroalkylation | CHEMISTRY, MEDICINAL | HUMAN BRAIN | PERIPHERAL BENZODIAZEPINE-RECEPTORS | NO-CARRIER | BIODISTRIBUTION | TRACERS | [F-18]epifluorohydrin | PROTEIN 18 KDA | F-18 FLUOROMISONIDAZOLE | LIGANDS | RADIOSYNTHESIS | PHARMACOLOGY & PHARMACY | F-18-fluoroalkylation | BINDING | Hydrocarbons, Fluorinated - chemical synthesis | Radiopharmaceuticals - chemistry | Stereoisomerism | Hydrocarbons, Fluorinated - pharmacology | Hydrocarbons, Fluorinated - chemistry | Positron-Emission Tomography - methods | Propanols - pharmacology | Radiopharmaceuticals - chemical synthesis | Propanols - chemical synthesis | Propanols - metabolism | Brain - metabolism | Tissue Distribution | Propanols - chemistry | Radiopharmaceuticals - metabolism | Animals | Epoxy Compounds - chemical synthesis | Bone and Bones - metabolism | Epoxy Compounds - chemistry | Receptors, GABA - metabolism | Hydrocarbons, Fluorinated - metabolism | Mice | Molecular Structure | Fluorine Radioisotopes | Radiopharmaceuticals - pharmacology | Enantiomers | Distillation | Phenylacetamide | Automation | Radiolabelling | Liver | Positron emission | Oxazol | Fluorine isotopes | Radioactive tracers | Proteins | Synthesis | Chirality | Reagents | Phenols | Tomography | Positron emission tomography | Radioactivity
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e86625 - e86625
Liver damage induced by drug toxicity is an important concern for both medical doctors and patients. The aim of this study was to noninvasively visualize acute... 
APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | PERIPHERAL BENZODIAZEPINE-RECEPTOR | DISEASE | KUPFFER CELLS | MODEL | EXPRESSION | IL-10 | Cycloheximide - toxicity | Radiopharmaceuticals - pharmacokinetics | Acetamides - pharmacokinetics | Protein Synthesis Inhibitors - toxicity | Purines - pharmacokinetics | RNA, Messenger - genetics | Rats | Male | Positron-Emission Tomography | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Immunoenzyme Techniques | Protein Transport | Tissue Distribution | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Chemical and Drug Induced Liver Injury - metabolism | Receptors, GABA-A - genetics | Receptors, GABA-A - metabolism | Chemical and Drug Induced Liver Injury - pathology | Real-Time Polymerase Chain Reaction | Chemical and Drug Induced Liver Injury - etiology | Liver diseases | PET imaging | RNA | Liver | Cyclohexane | DNA polymerases | Inflammation | Apoptosis | Nuclear magnetic resonance--NMR | RNA-directed DNA polymerase | Toxicity | Emission analysis | Kupffer cells | Kinases | Macrophages | Proteins | Rodents | Hepatology | Tomography | Physiology | Damage | Radioactivity | Medical personnel | Enzymes | Damage assessment | Medical imaging | Cytokines | Neutrophils | Positron emission | Leukocytes (neutrophilic) | Injection | Gene expression | Doctors | Studies | Polymerase chain reaction | Cycloheximide | Hepatocytes | Biomarkers | Infiltration | Laboratory animals | Positron emission tomography | Index Medicus | Nuclear magnetic resonance | NMR
Journal Article
Molecular Imaging and Biology, ISSN 1536-1632, 02/2019, Volume 21, Issue 1, p. 105
The imdazoline I.sub.2 receptor ([I.sub.2]R) has been found in the feeding centers of the brain, such as the hypothalamus, and certain [I.sub.2]R ligands have... 
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2015, Volume 5, Issue 1, p. 16417
1-Methyl-tryptophan (1MTrp) is known as a specific inhibitor targeting the immune- checkpoint protein indoleamine-2,3-dioxygenase, in two stereoisomers of... 
Stereoisomers | Dioxygenase | Kidneys | Carbon dioxide | Tryptophan | Isomers | Immune checkpoint | Computed tomography | Immunotherapy | Pharmacokinetics | Pancreas | Probes | Radioactivity
Journal Article
Journal Article