X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
human necessities (43) 43
hygiene (43) 43
medical or veterinary science (43) 43
preparations for medical, dental, or toilet purposes (43) 43
chemistry (31) 31
index medicus (31) 31
investigating or analysing materials by determining theirchemical or physical properties (31) 31
measuring (31) 31
physics (31) 31
testing (31) 31
metallurgy (30) 30
humans (25) 25
biochemistry (18) 18
specific therapeutic activity of chemical compounds ormedicinal preparations (17) 17
beer (16) 16
compositions or test papers therefor (16) 16
condition-responsive control in microbiological orenzymological processes (16) 16
enzymology (16) 16
measuring or testing processes involving enzymes, nucleicacids or microorganisms (16) 16
microbiology (16) 16
mutation or genetic engineering (16) 16
processes of preparing such compositions (16) 16
spirits (16) 16
vinegar (16) 16
wine (16) 16
organic chemistry (15) 15
mice (14) 14
peptides (14) 14
animals (13) 13
cancer (13) 13
cell biology (13) 13
cell line, tumor (11) 11
tumors (11) 11
metabolism (10) 10
multidisciplinary sciences (9) 9
oncology (9) 9
phosphorylation (9) 9
physiological aspects (9) 9
cell line (8) 8
research (8) 8
signal transduction (8) 8
biochemistry & molecular biology (7) 7
cells (7) 7
enzymes (7) 7
kinases (7) 7
protein kinase inhibitors - pharmacology (7) 7
activation (6) 6
discovery (6) 6
female (6) 6
glucose (6) 6
growth (6) 6
molecular biology (6) 6
amino acid sequence (5) 5
antineoplastic agents - pharmacology (5) 5
b-raf (5) 5
glycolysis (5) 5
identification (5) 5
inhibitors (5) 5
map kinase signaling system - drug effects (5) 5
mutation (5) 5
proteins (5) 5
accessories, closures, or fittings therefor (4) 4
analysis (4) 4
apoptosis (4) 4
biological sciences (4) 4
cancer-cells (4) 4
cell proliferation (4) 4
containers for storage or transport of articles or materials,e.g. bags, barrels, bottles, boxes, cans, cartons, crates,drums, jars, tanks, hoppers, forwarding containers (4) 4
conveying (4) 4
enzyme inhibitors - pharmacology (4) 4
expression (4) 4
handling thin or filamentary material (4) 4
health aspects (4) 4
kinase (4) 4
lipids (4) 4
machines, apparatus or devices for, or methods of, packagingarticles or materials (4) 4
mitogen-activated protein kinase kinases - antagonists & inhibitors (4) 4
mitogen-activated protein kinase kinases - metabolism (4) 4
models, molecular (4) 4
molecular sequence data (4) 4
neoplasm proteins - antagonists & inhibitors (4) 4
neoplasm proteins - genetics (4) 4
neoplasm proteins - metabolism (4) 4
neoplasms - enzymology (4) 4
neoplasms - pathology (4) 4
packages (4) 4
packaging elements (4) 4
packing (4) 4
performing operations (4) 4
proto-oncogene proteins b-raf - genetics (4) 4
proto-oncogene proteins b-raf - metabolism (4) 4
storing (4) 4
structure-activity relationship (4) 4
transporting (4) 4
tumor metabolism (4) 4
unpacking (4) 4
akt (3) 3
amino acid substitution (3) 3
b-lymphocytes - pathology (3) 3
c-raf (3) 3
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (108) 108
French (17) 17
German (8) 8
Chinese (3) 3
Spanish (3) 3
Korean (2) 2
Portuguese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5930, pp. 1076 - 1080
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 431 - 435
Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours and 40% of melanoma, respectively, thus targeting this pathway could have... 
SELECTIVE INHIBITOR | POTENT | EFFICACY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-RAF | HETERODIMERIZATION | B-RAF | PROTEIN-KINASE KINASE | CANCER | Neoplasms - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | ras Proteins - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Cell Membrane - metabolism | raf Kinases - genetics | Cell Membrane - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Indenes - pharmacology | raf Kinases - chemistry | Proto-Oncogene Proteins c-raf - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Ras genes | Growth | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Mitogen-activated protein kinases | Competition | Clinical trials | Enzymes | Kinases | Index Medicus | Proteins | Cellular | Inhibitors | Pathways | Tumours | Signalling | Dimerization
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7466, pp. 232 - 236
KRAS and BRAF activating mutations drive tumorigenesis through constitutive activation of the MAPK pathway. As these tumours represent an area of high unmet... 
PATHWAYS | WILD-TYPE | ACTIVATION | PI3K | MULTIDISCIPLINARY SCIENCES | C-RAF | MAP KINASE KINASE-1 | B-RAF | MUTATIONS | TUMOR-GROWTH INHIBITION | RAF PROTEINS | Niacinamide - analogs & derivatives | Humans | Crystallography, X-Ray | Azetidines - pharmacology | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Piperidines - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Genes, ras - genetics | Allosteric Regulation - drug effects | Cell Survival - drug effects | HCT116 Cells | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Clinical Trials as Topic | Imidazoles - pharmacology | Enzyme Activation - drug effects | Phosphoserine - metabolism | Mitogen-Activated Protein Kinase Kinases - chemistry | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins B-raf - genetics | Feedback, Physiological - drug effects | Protein Kinase Inhibitors - pharmacology | Niacinamide - pharmacology | Neoplasms - pathology | Oncogene Protein p21(ras) - genetics | Gene mutations | Cancer cells | Cellular control mechanisms | Physiological aspects | Properties | Phosphotransferases | Mitogen-activated protein kinases | Studies | Phosphorylation | Hydrogen bonds | Melanoma | Kinases | Tumors | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 32, pp. E4410 - E4417
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 7/2003, Volume 162, Issue 1, pp. 59 - 69
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2008, Volume 105, Issue 42, pp. 16314 - 16319
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 10/2016, Volume 12, Issue 10, pp. 779 - 786
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, pp. e0164166 - e0164166
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 548 - 562
Although glycolysis is substantially elevated in many tumors, therapeutic targeting of glycolysis in cancer patients has not yet been successful, potentially... 
NOVO PYRIMIDINE SYNTHESIS | MTORC1 | ONCOLOGY | PATHWAY | GROWTH | 2-DEOXY-D-GLUCOSE | PROLIFERATION | CARBOXYLATION | CONTRIBUTES | DEHYDROGENASE | GLUTAMINE-METABOLISM | CELL BIOLOGY | Neoplasms - metabolism | Metabolomics | Pentose Phosphate Pathway - drug effects | Glutaminase - physiology | Humans | Neoplasm Proteins - physiology | Ovarian Neoplasms - pathology | Glutamine - metabolism | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - physiology | Adenosine Triphosphate - biosynthesis | Molecular Targeted Therapy | Glycolysis - drug effects | Glucose-6-Phosphate Isomerase - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Deoxyglucose - therapeutic use | TOR Serine-Threonine Kinases - antagonists & inhibitors | RNA Interference | Deoxyglucose - pharmacology | Everolimus - therapeutic use | Female | TOR Serine-Threonine Kinases - physiology | Carcinoma - pathology | Cytokines - genetics | Tumor Stem Cell Assay | Pentose Phosphate Pathway - physiology | Everolimus - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Combined Modality Therapy | Glutaminase - antagonists & inhibitors | Citric Acid Cycle | Hep G2 Cells | Multiprotein Complexes - physiology | Neoplasms - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | RNA, Small Interfering - therapeutic use | Glucose-6-Phosphate Isomerase - antagonists & inhibitors | Cell Line, Tumor | Mice | Cytokines - antagonists & inhibitors | Energy Metabolism - drug effects | Phosphates | Glucose metabolism | Cancer cells | Glucose | Molecular biology | Dextrose | Cancer | Index Medicus
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 01/2016, Volume 14, Issue 1 Supplement, pp. B02 - B02
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2014, Volume 111, Issue 39, pp. 14217 - 14222
Journal Article