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by Gerstein, Hertzel C and Bosch, Jackie and Dagenais, Gilles R and Díaz, Rafael and Jung, Hyejung and Maggioni, Aldo P and Pogue, Janice and Probstfield, Jeffrey and Ramachandran, Ambady and Riddle, Matthew C and Rydén, Lars E and Yusuf, Salim and Richardson, L and Diaz, R and Johnston, P and Vige, R and Birkeland, K and Budaj, A and Cardona, E and Chazova, I and Commerford, P and Danilova, L and Davies, M and Fernando, R and Fodor, G and Gilbert, R and Gomis, R and Hâncu, N and Hanefeld, M and Hildebrandt, P and Kacerovsky-Bielesz, G and Keltai, M and Kim, J.H and Krum, H and Kültürsay, H and Lanas, F and Lewis, B.S and Lonn, E and López-Jaramillo, P and Marin-Neto, J and Marre, M and McKelvie, R and McQueen, M and Mendoza, I and Morillo, C and Pan, C and Pīrāgs, V and Profozic, V and Ratner, R and Richardson, L and Rosenstock, J and Spinas, G.A and Sreenan, S and Stoel, I and Syvänne, M and Yale, J.F and Avezum, A and Bahit, M.C and Bogaty, P and Bordeleau, L and Chacόn, C and Corson, M and Harper, W.L and Halon, D and Magloire, P and Mann, J and Pavlova, V and Punthakee, Z and Silva, J and Tsang, B and Yakubovich, N and Abdallah, A and Ahmad, S and Chandra, J and Chandra, R and Cukierman-Yaffee, T and Dyal, L and Joldersma, L and MacRae, L and MacRae, S and Malik, S and Mead, A and Pasha, F and Pazmino-Canizares, J and Pohl, K and Sakalas, A and Tyrwhitt, J and Ahuad Guerrero, R and Alebuena, A and Alvarez, N and Alzogaray, M and Amuchastegui, M and Andres, M and Angos, M and Baglivo, H and Barbieri, M and Bassi, F and Bello, F and Bono, J and Bustamante Labarta, M and ... and The ORIGIN Trial Investigators and ORIGIN Trial Investigators and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Centrum för klinisk forskning, Västerås
The New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 4, pp. 319 - 328
In this study with a 2-by-2 factorial design, patients with cardiovascular risk factors and dysglycemia or type 2 diabetes received insulin glargine or... 
DIABETES-MELLITUS | MEDICINE, GENERAL & INTERNAL | GLYCEMIC CONTROL | THERAPY | GLARGINE | GLUCOSE CONTROL | DISEASE | RISK | PEOPLE | ENDOTHELIAL FUNCTION | BETA-CELL FUNCTION | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Cholesterol - blood | Humans | Middle Aged | Male | Incidence | Glucose Intolerance - drug therapy | Cardiovascular Diseases - epidemiology | Female | Drug Therapy, Combination | Hypoglycemia - chemically induced | Diabetes Mellitus, Type 2 - complications | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Fasting | Blood Glucose - analysis | Double-Blind Method | Proportional Hazards Models | Hospitalization | Glucose Intolerance - complications | Insulin, Long-Acting - adverse effects | Insulin Glargine | Insulin, Long-Acting - therapeutic use | Intention to Treat Analysis | Triglycerides - blood | Fatty Acids, Omega-3 - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Complications and side effects | Care and treatment | Insulin glargine | Patient outcomes | Causes of | Cardiovascular diseases | Risk factors | Myocardial infarction | Fees & charges | Cerebral infarction | Medical research | Stroke | Heart attacks | Statistical analysis | Diabetes mellitus | Glucose | Hypoglycemia | Fatty acids | Insulin | Glucose tolerance | Insulin resistance | Microvasculature | Diabetes | Diabetes mellitus (non-insulin dependent) | Heart diseases | Drug dosages | Cardiovascular Diseases | Insulin, Long-Acting | Blood Glucose | Triglycerides | Glucose Intolerance | Cholesterol | Life Sciences | Hypoglycemic Agents | Diabetes Mellitus, Type 2 | Fatty Acids, Omega-3 | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
by Bosch, Jackie and Gerstein, Hertzel C and Dagenais, Gilles R and Díaz, Rafael and Dyal, Leanne and Jung, Hyejung and Maggiono, Aldo P and Probstfield, Jeffrey and Ramachandran, Ambady and Riddle, Matthew C and Rydén, Lars E and Yusuf, Salim and Richardson, L and Diaz, R and Johnston, P and Vige, R and Birkeland, K and Budaj, A and Cardona, E and Chazova, I and Commerford, P and Danilova, L and Davies, M and Fernando, R and Fodor, G and Gilbert, R and Gomis, R and Hâncu, N and Hanefeld, M and Hildebrandt, P and Kacerovsky-Bielesz, G and Keltai, M and Kim, J.H and Krum, H and Kültürsay, H and Lanas, F and Lewis, B.S and Lonn, E and López-Jaramillo, P and Marin-Neto, J and Marre, M and McKelvie, R and McQueen, M and Mendoza, I and Morillo, C and Pan, C and Pīrāgs, V and Profozic, V and Ratner, R and Richardson, L and Rosenstock, J and Spinas, G.A and Sreenan, S and Stoel, I and Syvänne, M and Yale, J.F and Avezum, A and Bahit, M.C and Bogaty, P and Bordeleau, L and Chacόn, C and Corson, M and Harper, W.L and Halon, D and Magloire, P and Mann, J and Pavlova, V and Punthakee, Z and Silva, J and Tsang, B and Yakubovich, N and Abdallah, A and Ahmad, S and Chandra, J and Chandra, R and Cukierman-Yaffee, T and Dyal, Leanne and Joldersma, L and MacRae, L and MacRae, S and Malik, S and Mead, A and Pasha, F and Pazmino-Canizares, J and Pohl, K and Sakalas, A and Tyrwhitt, J and Ahuad Guerrero, R and Alebuena, A and Alvarez, N and Alzogaray, M and Amuchastegui, M and Andres, M and Angos, M and Baglivo, H and Barbieri, M and Bassi, F and Bello, F and Bono, J and Bustamante Labarta, M and ... and The ORIGIN Trial Investigators and ORIGIN Trial Investigators and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Centrum för klinisk forskning, Västerås
The New England Journal of Medicine, ISSN 0028-4793, 07/2012, Volume 367, Issue 4, pp. 309 - 318
Participants with impaired fasting glucose who were at risk for cardiovascular events were assigned to receive daily n−3 fatty acids or placebo and to receive... 
MEDICINE, GENERAL & INTERNAL | EVENTS | PREVENTION | FISH | RISK | CORONARY-HEART-DISEASE | OMEGA-3-FATTY-ACID INTAKE | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Cholesterol - blood | Humans | Middle Aged | Male | Incidence | Glucose Intolerance - drug therapy | Treatment Failure | Cardiovascular Diseases - mortality | Female | Drug Therapy, Combination | Diabetes Mellitus, Type 2 - complications | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Double-Blind Method | Proportional Hazards Models | Glucose Intolerance - complications | Insulin Glargine | Insulin, Long-Acting - therapeutic use | Intention to Treat Analysis | Triglycerides - blood | Fatty Acids, Omega-3 - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Prevention | Complications and side effects | Care and treatment | Patient outcomes | Dietary supplements | Causes of | Diabetes | Cardiovascular diseases | Fatty acids | Health aspects | Myocardial infarction | Arrhythmia | Diabetes mellitus | Lipids | Esters | Cardiovascular disease | Insulin | Glucose tolerance | Diet | Death | Supplementation | Diabetes mellitus (non-insulin dependent) | Heart diseases | Cardiovascular Diseases | Insulin, Long-Acting | Triglycerides | Glucose Intolerance | Cholesterol | Life Sciences | Hypoglycemic Agents | Diabetes Mellitus, Type 2 | Fatty Acids, Omega-3 | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
by Drake, Thomas M and Cheung, Lok Ka and Gaba, Fortis and Glasbey, James and Griffiths, Nathan and Helliwell, Rebecca J and Huq, Tausif and Khaw, Rachel and Mayes, Jonathan and Khan, Saif and Rafiq, Nasir and Woin, Evelina and Fitzgerald, J Edward and Harrison, Ewen M and Nepogodiev, Dmitri and Drake, TM and Drake, Thomas M and Glasbey, James and Bath, Mike and Borakati, Aditya and Burke, Joshua and Claireaux, Henry and Deekonda, Praveena and Gundogan, Buket and Joyce, Holly and Kamarajah, Sivesh and Khatri, Chetan and Kong, Chia and McLean, Kenneth A and Mcnamee, Lisa and Mohan, Midhun and Woin, Evelina and Fitzgerald, J Edward and Bhangu, Aneel and Harrison, Ewen M and Nepogodiev, Dmitri and Arulkumaran, Nishkantha and Bell, Samira and Duthie, Fiona and Hughes, Jeremy and Prowle, John and Richards, Toby and Dynes, K and Patel, P and Wigley, C and Suresh, R and Shaw, A and Klimach, S and Jull, P and Evans, D and Preece, R and Ibrahim, I and Manikavasagar, V and Brown, F S and Deekonda, P and Teo, R and Sim, D P Y and Borakati, A and Logan, A E and Barai, I and Amin, H and Suresh, S and Sethi, R and Bolton, W and Corbridge, O and Horne, L and Attalla, M and Morley, R and Hoskins, T and McAllister, R and Lee, S and Dennis, Y and Nixon, G and Heywood, E and Wilson, H and Ng, L and Samaraweera, S and Mills, A and Doherty, C and Woin, E and Belchos, J and Phan, V and Chouari, T and Gardner, T and Goergen, N and Hayes, J D B and MacLeod, C S and McCormack, R and McKinley, A and McKinstry, S and Milligan, W and Ooi, L and Rafiq, N M and Sammut, T and Sinclair, E and Smith, M and Baker, C and Boulton, A P R and Collins, J and Copley, H C and ... and STARSurg Collaborative
Anaesthesia, ISSN 0003-2409, 10/2018, Volume 73, Issue 10, pp. 1214 - 1222
Summary The peri‐operative use of angiotensin‐converting enzyme inhibitors or angiotensin‐2 receptor blockers is thought to be associated with an increased... 
postoperative complications | acute kidney injury | angiotensin‐converting enzyme inhibitors | angiotensin II receptor blockers | angiotensin-converting enzyme inhibitors | RISK | ANESTHESIOLOGY | DIURETICS | Prospective Studies | Humans | Middle Aged | Elective Surgical Procedures - adverse effects | Postoperative Complications - prevention & control | Male | Angiotensin-Converting Enzyme Inhibitors - adverse effects | Aged, 80 and over | Female | Acute Kidney Injury - chemically induced | Postoperative Complications - chemically induced | Drug Administration Schedule | Comorbidity | Risk Factors | Ireland - epidemiology | Postoperative Complications - epidemiology | Digestive System Surgical Procedures - adverse effects | Withholding Treatment | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Acute Kidney Injury - prevention & control | Perioperative Care - methods | Aged | Acute Kidney Injury - epidemiology | United Kingdom - epidemiology | Angiotensin Receptor Antagonists - administration & dosage | Angiotensin Receptor Antagonists - adverse effects | Heart | Enzymes | Kidneys | Heart surgery | Health risks | Risk reduction | Risk | Gastrointestinal tract | Patients | Matching | Injury prevention | Inhibitors | Enzyme inhibitors | Converting | Surgery | Gastrointestinal system | Angiotensin
Journal Article
Journal Article
by Chaisson, Mark J P and Sanders, Ashley D and Zhao, Xuefang and Malhotra, Ankit and Porubsky, David and Rausch, Tobias and Gardner, Eugene J and Roiguez, Oscar L and Guo, Li and Collins, Ryan L and Fan, Xian and Wen, Jia and Handsaker, Robert E and Fairley, Susan and Kronenberg, Zev N and Kong, Xiangmeng and Hormozdiari, Fereydoun and Lee, Dillon and Wenger, Aaron M and Hastie, Alex R and Antaki, Danny and Anantharaman, Thomas and Audano, Peter A and Brand, Harrison and Cantsilieris, Stuart and Cao, Han and Cerveira, Eliza and Chen, Chong and Chen, Xintong and Chin, Chen-Shan and Chong, Zechen and Chuang, Nelson T and Lambert, Christine C and Church, Deanna M and Clarke, Laura and Farrell, Anew and Flores, Joey and Galeev, Timur and Gorkin, David U and Gujral, Madhusudan and Guryev, Victor and Heaton, William Haynes and Korlach, Jonas and Kumar, Sushant and Kwon, Jee Young and Lam, Ernest T and Lee, Jong Eun and Lee, Joyce and Lee, Wan-Ping and Lee, Sau Peng and Li, Shantao and Marks, Patrick and Viaud-Martinez, Karine and Meiers, Sascha and Munson, Katherine M and Navarro, Fabio C P and Nelson, Bradley J and Nodzak, Conor and Noor, Amina and Kyriazopoulou-Panagiotopoulou, Sofia and Pang, Andy W C and Qiu, Yunjiang and Rosanio, Gabriel and Ryan, Mallory and Stütz, Aian and Spierings, Diana C J and Ward, Alistair and Welch, AnneMarie E and Xiao, Ming and Xu, Wei and Zhang, Chengsheng and Zhu, Qihui and Zheng-Bradley, Xiangqun and Lowy, Ernesto and Yakneen, Sergei and McCarroll, Steven and Jun, Goo and Ding, Li and Koh, Chong Lek and Ren, Bing and Flicek, Paul and Chen, Ken and Gerstein, Mark B and Kwok, Pui-Yan and Lansdorp, Peter M and Marth, Gabor T and Sebat, Jonathan and Shi, Xinghua and Bashir, Ali and Ye, Kai and Devine, Scott E and Talkowski, Michael E and Mills, Ryan E and Marschall, Tobias and Korbel, Jan O and Eichler, Evan E and Lee, Charles
Nature Communications, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1784 - 16
Journal Article
Geophysical Research Letters, ISSN 0094-8276, 11/2016, Volume 43, Issue 22, pp. 11,884 - 11,892
The effects of imposing at various altitudes in the stratosphere zonally symmetric circulation anomalies associated with a stratospheric sudden warming are... 
stratospheric sudden warming | stratosphere troposphere coupling | planetary waves | GEOSCIENCES, MULTIDISCIPLINARY | TROPOSPHERIC RESPONSE | NORTHERN-HEMISPHERE | SUDDEN WARMINGS | SOLAR | JET OSCILLATION EVENTS | MODEL | VORTEX | CYCLE | Stratosphere | Troposphere | Geophysics | Meteorology | Amplification | Planetary waves | Temperature | Wave propagation | Tropopause | Evolution | Fluxes | Waves | Circulation | Anomalies
Journal Article
by Liao, Hua-Xin and Lynch, Rebecca and Zhou, Tongqing and Gao, Feng and Munir Alam, S and Boyd, Scott D and Fire, Andrew Z and Roskin, Krishna M and Schramm, Chaim A and Zhang, Zhenhai and Zhu, Jiang and Shapiro, Lawrence and Mullikin, James C and Gnanakaran, S and Hraber, Peter and Wiehe, Kevin and Kelsoe, Garnett and Yang, Guang and Xia, Shi-Mao and Montefiori, David C and Parks, Robert and Lloyd, Krissey E and Scearce, Richard M and Soderberg, Kelly A and Cohen, Myron and Kamanga, Gift and Louder, Mark K and Tran, Lillian M and Chen, Yue and Cai, Fangping and Chen, Sheri and Moquin, Stephanie and Du, Xiulian and Gordon Joyce, M and Srivatsan, Sanjay and Zhang, Baoshan and Zheng, Anqi and Shaw, George M and Hahn, Beatrice H and Kepler, Thomas B and Korber, Bette T. M and Kwong, Peter D and Mascola, John R and Haynes, Barton F and Becker, Jesse and Benjamin, Betty and Blakesley, Robert and Bouffard, Gerry and Brooks, Shelise and Coleman, Holly and Dekhtyar, Mila and Gregory, Michael and Guan, Xiaobin and Gupta, Jyoti and Han, Joel and Hargrove, April and Ho, Shi-Ling and Johnson, Taccara and Legaspi, Richelle and Lovett, Sean and Maduro, Quino and Masiello, Cathy and Maskeri, Baishali and McDowell, Jenny and Montemayor, Casandra and Mulliki, James and Park, Morgan and Riebow, Nancy and Schandler, Karen and Schmidt, Brian and Sison, Christina and Stantripop, Mal and Thomas, James and Thomas, Pam and Vemulapalli, Meg and Young, Alice and NISC Comparative Sequencing Progra and NISC Comparative Sequencing Program
Nature, ISSN 0028-0836, 04/2013, Volume 496, Issue 7446, pp. 469 - 476
Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise... 
CRYSTALLIZATION | B-CELL RESPONSES | CONFORMATIONAL EPITOPE | POTENT NEUTRALIZATION | EVOLUTION | CD4 BINDING-SITE | MULTIDISCIPLINARY SCIENCES | ENVELOPE GLYCOPROTEIN | HUMAN MONOCLONAL-ANTIBODIES | SUBTYPE-B | IN-SITU PROTEOLYSIS | HIV Envelope Protein gp120 - genetics | Clone Cells - cytology | Humans | AIDS Vaccines - immunology | Molecular Sequence Data | Crystallography, X-Ray | Neutralization Tests | Phylogeny | HIV Envelope Protein gp120 - metabolism | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | HIV Envelope Protein gp120 - chemistry | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Protein Structure, Tertiary | Amino Acid Sequence | CD4 Antigens - immunology | Africa | Cells, Cultured | Models, Molecular | Antibodies, Neutralizing - genetics | Cross Reactions - immunology | HIV Antibodies - chemistry | HIV-1 - classification | Antibodies, Monoclonal - genetics | Cell Lineage | HIV-1 - immunology | CD4 Antigens - chemistry | Antibodies, Neutralizing - chemistry | Epitopes - chemistry | HIV Antibodies - genetics | Mutation | Evolution, Molecular | Monoclonal antibodies | AIDS vaccines | Genetic aspects | Research | HIV (Viruses) | Properties | Proteins | Plasma | Infections | Patients | Binding sites | Crystal structure
Journal Article