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European Journal of Organic Chemistry, ISSN 1434-193X, 08/2018, Volume 2018, Issue 27-28, pp. 3724 - 3734
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2018, Volume 61, Issue 22, pp. 10084 - 10105
Mechanistic target of rapamycin (mTOR) promotes cell proliferation, growth, and survival and is overactivated in many tumors and central nervous system... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2017, Volume 60, Issue 17, pp. 7524 - 7538
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2019, Volume 62, Issue 18, pp. 8609 - 8630
The mechanistic target of rapamycin (mTOR) plays a pivotal role in growth and tumor progression and is an attractive target for cancer treatment.... 
BREAST-CANCER | IN-VITRO | POTENT | CHEMISTRY, MEDICINAL | EVEROLIMUS | PQR309 | DOUBLE-BLIND | KINASE INHIBITOR | ANTITUMOR-ACTIVITY | PHOSPHOINOSITIDE 3-KINASE | PI3K/MTOR INHIBITOR
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 10/2011, Volume 52, Issue 41, pp. 5229 - 5233
Bromophenyl magnesium reagents generated via a Knochel type magnesium–halogen exchange of aryl iodides undergo regioselective ring opening of cyclic primary... 
Stereoselectivity | Cyclic sulfamidate | Knochel Grignard | Regioselectivity | Aziridine | EXCHANGE-REACTION | INDOLINES | CHEMISTRY, ORGANIC | ANTAGONISTS | AGONISTS | Heterocyclic compounds | Exchange | Iodides | Inversions | Tetrahedrons | Complement | Cleaning | Magnesium | Ring opening
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 10/2019, Volume 10, Issue 10, pp. 1473 - 1479
The phosphoinositide 3-kinase (PI3K)/mechanistic target of rapamycin (mTOR) pathway is a critical regulator of cell growth and is frequently hyperactivated in... 
ATP-competitive | CHEMISTRY, MEDICINAL | PQR309 | 4-(difluoromethyl)pyrimidin-2-amine | PI3K inhibitor | pharmacology | Phosphoinositide 3-kinase (PI3K) | cancer | clinical candidate | PHOSPHOINOSITIDE 3-KINASE | PI3K/MTOR INHIBITOR | mammalian or mechanistic target of rapamycin (mTOR)
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2010, Volume 8, Issue 4, pp. 758 - 760
A desymmetrization protocol has been used to develop a palladium catalyzed enantioselective carbonylation process. Achiral cyclic bis-alkenyltriflates are... 
HALIDES | COMPLEX | ALKYLATION | CONSTRUCTION | ESTERS | CHEMISTRY, ORGANIC | OLEFINS | ARYL | STEREOGENIC CENTERS | CYCLIZATION | Allyl Compounds - chemical synthesis | Polyenes - chemical synthesis | Models, Chemical | Stereoisomerism | Catalysis | Palladium - chemistry | Carbon - chemistry
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 2, pp. 594 - 599
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2004, Volume 47, Issue 6, pp. 1487 - 1513
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 13, pp. 6241 - 6261
The phosphoinositide 3-kinase (PI3K)/mechanistic target of rapamycin (mTOR) pathway is frequently overactivated in cancer, and drives cell growth,... 
NVP-BYL719 | CHEMISTRY, MEDICINAL | PQR309 | METABOLISM | 3-KINASE/MAMMALIAN TARGET | GROWTH | NVP-BEZ235 | IDENTIFICATION | PI3K/MTOR INHIBITOR | PHOSPHOINOSITIDE 3-KINASE | WORTMANNIN
Journal Article
ORGANIC PROCESS RESEARCH & DEVELOPMENT, ISSN 1083-6160, 11/2019, Volume 23, Issue 11, pp. 2416 - 2424
A new, scalable, rapid, high yielding, and practical synthesis of 4-(difluoromethyl)pyridin-2-amine provides a key intermediate for the preparation of numerous... 
RAPAMYCIN | EVEROLIMUS | CHEMISTRY, ORGANIC | pyridine ring closure | PHOSPHOINOSITIDE 3-KINASE | CANCER | WORTMANNIN | 4-(difluoromethyl)pyridin-2-amine | POTENT | difluoroacetic acid anhydride | GROWTH | chromatography-free process | telescope process | CHEMISTRY, APPLIED | upscaling
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 140 - 140
Journal Article
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