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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 37, pp. 13451 - 13456
Inflammatory diseases are characterized by dysregulated cytokine production. Altered functions for most risk loci, including the inflammatory bowel disease and... 
T lymphocytes | Myeloid cells | Inflammatory bowel diseases | Cytokines | Secretion | Small interfering RNA | Leprosy | Gene expression regulation | Physiological regulation | Intestinal diseases | TL1A TNFSF15 | CYTOKINE SECRETION | ACTIVATION | DR3 | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | NOD2 | T-CELL | HUMAN MONOCYTES | Crohn disease | genetics | INFLAMMATORY-BOWEL-DISEASE | ulcerative colitis | TLR | TNF-ALPHA | ADAM17 Protein | Humans | Caspase 8 - metabolism | Receptors, Tumor Necrosis Factor, Member 25 - metabolism | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Mycobacterium - metabolism | Receptors, Pattern Recognition - metabolism | Tissue Inhibitor of Metalloproteinase-3 - metabolism | Myeloid Cells - drug effects | Tumor Necrosis Factor Ligand Superfamily Member 15 - genetics | Interleukin-1 - metabolism | Genetic Predisposition to Disease | Cells, Cultured | Solubility | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | ADAM Proteins - metabolism | Macrophages - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Myeloid Cells - metabolism | Polymorphism, Single Nucleotide - genetics | Ligands | Macrophages - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Interleukins | Inflammation | Genetic aspects | Research | Health aspects | Genetic polymorphisms | Inflammatory bowel disease | Signal transduction | Homeostasis | Gene loci | T cell receptors | Polymorphism | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2014, Volume 111, Issue 37, pp. 13451 - 13456
Journal Article
Gut, ISSN 0017-5749, 05/2019, p. gutjnl-2018-316830
The interleukin (IL)23 pathway contributes to IBD pathogenesis and is being actively studied as a therapeutic target in patients with IBD. Unexpected outcomes... 
Journal Article
Cell Reports, ISSN 2211-1247, 08/2016, Volume 16, Issue 9, pp. 2442 - 2455
Interferon regulatory factor 5 (IRF5) regulates inflammatory M1 macrophage polarization, and disease-associated genetic variants regulate... 
RESPONSES | SYSTEMIC-LUPUS-ERYTHEMATOSUS | PROTEIN-KINASE | INFLAMMATION | TOLL-LIKE RECEPTORS | B-CELL ADAPTER | GENE-EXPRESSION | INNATE | IKK-BETA | INDUCTION | CELL BIOLOGY | Interleukin-1 Receptor-Associated Kinases - metabolism | Adjuvants, Immunologic - pharmacology | Interleukin-1 Receptor-Associated Kinases - genetics | Humans | Interferon Regulatory Factors - metabolism | Nod2 Signaling Adaptor Protein - genetics | Interferon Regulatory Factors - deficiency | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Glycolysis - drug effects | Proto-Oncogene Proteins c-akt - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Glycolysis - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Cell Differentiation | TNF Receptor-Associated Factor 6 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Macrophages - cytology | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Macrophages - metabolism | Animals | Nod2 Signaling Adaptor Protein - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Protein Binding | Macrophages - drug effects | Mice | Mutation | Primary Cell Culture | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 11/2012, Volume 491, Issue 7423, pp. 259 - 263
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2017, Volume 127, Issue 6, pp. 2192 - 2205
Inflammatory bowel disease (IBD) is characterized by dysregulation in both cytokines and responses to intestinal microbes, and proper regulation of pattern... 
MEDICINE, RESEARCH & EXPERIMENTAL | CYTOKINE SECRETION | ACTIVATION | CROHNS-DISEASE | DENDRITIC CELLS | OXIDASE COMPLEX | 14-3-3 PROTEINS | MACROPHAGES | SUSCEPTIBILITY LOCI | NOD2 | AUTOPHAGY | Gene Expression | Genetic Predisposition to Disease | Cytokines - metabolism | Genetic Association Studies | Staphylococcus aureus - physiology | Humans | Risk Factors | Cytokines - secretion | Case-Control Studies | MAP Kinase Signaling System | Carrier Proteins - genetics | Receptors, Pattern Recognition - metabolism | Macrophages - metabolism | Myeloid Cells - secretion | HEK293 Cells | Inflammatory Bowel Diseases - genetics | Heterozygote | Polymorphism, Single Nucleotide | Active Transport, Cell Nucleus | Primary Cell Culture | Enterococcus faecalis - physiology | Macrophages - microbiology | Cytokines | RNA | Gastrointestinal diseases | Genes | Genetic aspects | Genetic transcription | Risk factors | Cells | Inflammatory bowel diseases | Genetic variation | Pattern recognition | Object recognition (Computers) | Health aspects | Genetic screening | Methods | Transcription | Immune clearance | Homeostasis | Intracellular signalling | Kinases | Macrophages | Autophagy | Proteins | Genotype & phenotype | Signal transduction | Cell activation | Intestine | Gastroenterology | Myeloid cells | Dendritic cells | Secretion | MAP kinase | Ribonucleic acid--RNA | Crohns disease | Inflammatory bowel disease | Ligands | Intracellular | Phagocytosis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2007, Volume 104, Issue 49, pp. 19440 - 19445
Journal Article
Nature Communications, ISSN 2041-1723, 06/2017, Volume 8, Issue 1, pp. 15614 - 15614
Functional consequences for most inflammatory disease-associated loci are incompletely defined, including in the LACC1 (C13orf31) region. Here we show that... 
MITOCHONDRIAL ROS | INFLAMMATORY-BOWEL-DISEASE | BACTERIAL CLEARANCE | CROHNS-DISEASE | DENDRITIC CELLS | CRYSTAL-STRUCTURE | GENOMEWIDE ASSOCIATION | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | COMPLEX II | KAPPA-B | Index Medicus
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 6/2012, Volume 188, Issue 11, pp. 5348 - 5356
Monocyte-derived cells display highly variable cytokine secretion upon pattern-recognition receptor (PRR) stimulation across individuals; such variability... 
pattern-recognition receptors | human | dendritic cells
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 11/2016, Volume 197, Issue 9, pp. 3695 - 3704
JAK2 genetic variants are associated with inflammatory bowel disease (IBD) and JAK inhibitors are being evaluated for therapy targeting immune-mediated... 
monocytes | macrophages | cytokines | genetics | signal transduction
Journal Article
by Jostins, Luke and Ripke, Stephan and Weersma, Rinse K and Duerr, Richard H and McGovern, Dermot P and Hui, Ken Y and Lee, James C and Schumm, L. Philip and Sharma, Yashoda and Anderson, Carl A and Essers, Jonah and Mitrovic, Mitja and Ning, Kaida and Cleynen, Isabelle and Theatre, Emilie and Spain, Sarah L and Raychaudhuri, Soumya and Goyette, Philippe and Wei, Zhi and Abraham, Clara and Achkar, Jean-Paul and Ahmad, Tariq and Amininejad, Leila and Ananthakrishnan, Ashwin N and Andersen, Vibeke and Anews, Jane M and Baidoo, Leonard and Balschun, Tobias and Bampton, Peter A and Bitton, Alain and Boucher, Gabrielle and Brand, Stephan and Büning, Carsten and Cohain, Ariella and Cichon, Sven and D'Amato, Mauro and de Jong, Dirk and Devaney, Kathy L and Dubinsky, Marla and Edwards, Cathryn and Ellinghaus, David and Ferguson, Lynnette R and Franchimont, Denis and Fransen, Karin and Gearry, Richard and Georges, Michel and Gieger, Christian and Glas, Jürgen and Haritunians, Talin and Hart, Ailsa and Hawkey, Chris and Hedl, Matija and Hu, Xinli and Karlsen, Tom H and Kupcinskas, Limas and Kugathasan, Subra and Latiano, Anna and Laukens, Debby and Lawrance, Ian C and Lees, Charlie W and Louis, Edouard and Mahy, Gillian and Mansfield, John and Morgan, Angharad R and Mowat, Craig and Newman, William and Palmieri, Orazio and Ponsioen, Cyriel Y and Potocnik, Uros and Prescott, Natalie J and Regueiro, Miguel and Rotter, Jerome I and Russell, Richard K and Sanderson, Jeremy D and Sans, Miquel and Satsangi, Jack and Schreiber, Stefan and Simms, Lisa A and Sventoraityte, Jurgita and Targan, Stephan R and Taylor, Kent D and Tremelling, Mark and Verspaget, Hein W and de Vos, Martine and Wijmenga, Cisca and Wilson, David C and Winkelmann, Juliane and Xavier, Ramnik J and Zeissig, Sebastian and Zhang, Bin and Zhang, Clarence K and Zhao, Hongyu and Silverberg, Mark S and Annese, Vito and Hakonarson, Hakon and Brant, Steven R and Radford-Smith, Graham and Mathew, Christopher G and Rioux, John D and Schadt, Eric E and ... and Int IBD Genetics Consortium IIBDGC and International IBD Genetics Consortium (IIBDGC) and The International IBD Genetics Consortium (IIBDGC) and Region Örebro län and Örebro universitet and Institutionen för medicinska vetenskaper
Nature, ISSN 0028-0836, 2012, Volume 491, Issue 7422, pp. 119 - 124
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with... 
HYPER-IGE SYNDROME | RISK LOCI | NETWORK | NUMBER | METAANALYSIS | TUBERCULOSIS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | MUTATIONS | EXPRESSION | Crohn Disease - genetics | Humans | Inflammatory Bowel Diseases - immunology | Colitis, Ulcerative - genetics | Mycobacterium tuberculosis - immunology | Inflammatory Bowel Diseases - physiopathology | Colitis, Ulcerative - immunology | Host-Pathogen Interactions - immunology | Mycobacterium tuberculosis - pathogenicity | Haplotypes - genetics | Mycobacterium - pathogenicity | Mycobacterium Infections - genetics | Inflammatory Bowel Diseases - genetics | Crohn Disease - microbiology | Mycobacterium Infections - microbiology | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Reproducibility of Results | Mycobacterium - immunology | Crohn Disease - immunology | Genome, Human - genetics | Phenotype | Colitis, Ulcerative - microbiology | Host-Pathogen Interactions - genetics | Polymorphism, Single Nucleotide - genetics | Inflammatory Bowel Diseases - microbiology | Crohn Disease - physiopathology | Colitis, Ulcerative - physiopathology | Inflammatory bowel disease | Candidates | Tuberculosis | Architecture | Genetics | Genomes | Diabetes | Gene expression | Health risk assessment | Immune system | Index Medicus | Rheumatology and Autoimmunity | Basic Medicine | Medical Genetics | Medicinsk genetik | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin
Journal Article