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JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 08/2019, Volume 62, Issue 16, pp. 7340 - 7382
New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide... 
BREAST-CANCER | ANTITUMOR ANTIBIOTICS | IN-VITRO | POTENT | CHEMISTRY, MEDICINAL | VENOUS THROMBOEMBOLISM | ALPHA | LETERMOVIR | TYROSINE-KINASE-INHIBITOR | CYTOMEGALOVIRUS | DISCOVERY
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 08/1998, Volume 37, Issue 15, pp. 1986 - 2012
High enantioselectivity can be achieved when chiral oxazaborolidines are used as catalysts in the reduction of ketones by borane. In the transition state on... 
Reductions | Boron | Ketones | Asymmetric catalysis | Total synthesis
Journal Article
ACS Combinatorial Science, ISSN 2156-8952, 11/2017, Volume 19, Issue 11, pp. 675 - 680
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2010, Volume 51, Issue 45, pp. 5859 - 5860
2,3-Azaisoindoline ( ) was prepared via reaction of dichloride with 2,4-dimethoxybenzyl amine followed by deprotection with trifluoroacetic acid and... 
SUBSTITUTED OXAZOLIDINONES | CHEMISTRY, ORGANIC | ANTIBACTERIAL ACTIVITY | Tetrahedrons | Synthesis (chemistry) | Amines | Dichlorides | Conversion
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2018, Volume 61, Issue 3, pp. 1001 - 1018
Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor 1 with an imidazotriazine core... 
PDE5 | DESIGN | CHEMISTRY, MEDICINAL | MEMORY | CGMP | DISORDERS | CENTRAL-NERVOUS-SYSTEM | DISCOVERY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 7, pp. 3008 - 3026
Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway... 
SERINE HYDROLASES | SYSTEM | CHEMISTRY, MEDICINAL | MULTIPLE-SCLEROSIS | METABOLISM | ALIGNMENT | MONOGLYCERIDE LIPASE | MOUSE MODEL | DISEASE | OPTIMIZATION | TOOL
Journal Article
Journal Article
Journal Article
Organic Letters, ISSN 1523-7060, 02/2018, Volume 20, Issue 3, pp. 812 - 815
The design, synthesis, and application of [4-(acetylamino)phenyl]imidodisulfuryl difluoride (AISF), a shelf-stable, crystalline reagent for the synthesis of... 
PALLADIUM | POLYSULFATES | ARYL FLUOROSULFONATES | COUPLING REACTIONS | ACIDS | PHENOLS | CHEMISTRY | CHEMISTRY, ORGANIC | SUFEX
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2017, Volume 60, Issue 13, pp. 5673 - 5698
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2015, Volume 58, Issue 6, pp. 2678 - 2702
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2012, Volume 341, Issue 2, pp. 396 - 409
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9055 - 9068
Journal Article
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