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1. Full Text Mass Cytometry
: Methods and Protocols
2019, Methods in Molecular Biology, ISBN 1493994530, Volume 1989
Life Sciences | Antibodies | Mass Spectrometry | Cell Biology
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2. Full Text Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses
by Andres-Terre, Marta and McGuire, Helen M and Pouliot, Yannick and Bongen, Erika and Sweeney, Timothy E and Tato, Cristina M and Khatri, Purvesh
Immunity, ISSN 1074-7613, 12/2015, Volume 43, Issue 6, pp. 1199 - 1211
Respiratory viral infections are a significant burden to healthcare worldwide. Many whole genome expression profiles have identified different respiratory... 
IMMUNE-RESPONSE | ACTIVATION | GENE | INFLUENZA | CD38 | INFECTION | EXPRESSION PROFILES | DRUG-RESISTANCE | IMMUNOLOGY | SYSTEMS BIOLOGY | REVEALS | Datasets as Topic | Virus Diseases - diagnosis | Humans | Transcriptome | Virus Diseases - genetics | Respiratory Tract Infections - diagnosis | Respiratory Tract Infections - genetics | Cohort Studies | Pneumonia | Bacterial infections | Analysis | Bacterial pneumonia | Influenza | Genomics | Genetic aspects | Genetic transcription | Health aspects | Influenza vaccines | Medical research | Medicine, Experimental | Studies | Datasets | Viral infections
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3. Full Text A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells
by Vogelzang, Alexis and McGuire, Helen M and Yu, Di and Sprent, Jonathan and Mackay, Charles R and King, Cecile
Immunity, ISSN 1074-7613, 2008, Volume 29, Issue 1, pp. 127 - 137
T cell help to B cells is a fundamental property of adaptive immunity, yet only recently have many of the cellular and molecular mechanisms of T cell help... 
MOLIMMUNO | CELLIMMUNO | CXC CHEMOKINE RECEPTOR-5 | B-CELLS | GERMINAL-CENTER DEVELOPMENT | IMMUNE-RESPONSES | IN-VIVO | IMMUNOGLOBULIN PRODUCTION | DEFICIENT MICE | IMMUNOLOGY | IL-21 | CUTTING EDGE | TH17 CELLS | Immunohistochemistry | Inducible T-Cell Co-Stimulator Protein | T-Lymphocyte Subsets - immunology | T-Lymphocyte Subsets - cytology | Germinal Center - immunology | Immunoglobulin Class Switching - immunology | Lymphocyte Cooperation - immunology | Interleukins - metabolism | Lymphocyte Activation - immunology | Flow Cytometry | Proto-Oncogene Proteins c-vav - immunology | Transfection | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | T-Lymphocytes, Helper-Inducer - cytology | Germinal Center - cytology | B-Lymphocytes - cytology | Antigens, Differentiation, T-Lymphocyte - immunology | Enzyme-Linked Immunosorbent Assay | Electrophoresis, Polyacrylamide Gel | Antigens, Differentiation, T-Lymphocyte - metabolism | Blotting, Western | Cell Differentiation - immunology | Microscopy, Confocal | Animals | B-Lymphocytes - immunology | Mice | Proto-Oncogene Proteins c-vav - metabolism | Interleukins | T cells | Lupus | Studies | Competition | Lymphocytes | Rodents | Software | Autoimmune diseases | Immune system
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4. Full Text CXCL13 is a plasma biomarker of germinal center activity
by Colin Havenar-Daughton and Madelene Lindqvist and Antje Heit and Jennifer E. Wu and Samantha M. Reiss and Kayla Kendric and Simon Bélanger and Sudhir Pai Kasturi and Elise Landais and Rama S. Akondy and Helen M. McGuire and Marcella Bothwell and Parsia A. Vagefi and Eileen Scully and Georgia D. Tomarasm and Mark M. Davis and Pascal Poignard and Rafi Ahmed and Bruce D. Walker and Bali Pulendran and M. Juliana McElrath and Daniel E. Kaufmann and Shane Crotty and IAVI Protocol C Principal Investga and IAVI Protocol C Principal Investigators
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 10, pp. 2702 - 2707
Significantly higher levels of plasma CXCL13 [chemokine (C-X-C motif) ligand 13] were associated with the generation of broadly neutralizing antibodies (bnAbs)... 
Antibodies | Vaccines | HIV | CXCL13 | Tfh | NEUTRALIZING ANTIBODIES | CD4 T-CELLS | DENDRITIC CELLS | vaccines | MULTIDISCIPLINARY SCIENCES | VACCINE | HELPER-CELL DIFFERENTIATION | BCL6 | SERUM-LEVELS | antibodies | ANTIBODY-RESPONSES | CHEMOKINE CXCL13 | LYMPHOID FOLLICLES | HIV Infections - blood | Enzyme-Linked Immunosorbent Assay | Germinal Center - immunology | Humans | Mice, Inbred C57BL | Vaccination | Biomarkers - blood | Lymph Nodes - immunology | Chemokine CXCL13 - blood | HIV Infections - immunology | Animals | Flow Cytometry | Macaca | Chemokine CXCL13 - immunology | Cohort Studies | Viral antibodies | Prevention | Host-virus relationships | Health aspects | HIV infection | Chemokines | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | Biological Sciences
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5. Full Text Staining of Phosphorylated Signalling Markers Protocol for Mass Cytometry
by Shinko, Diana and Ashhurst, Thomas M and McGuire, Helen M and Charles, Kellie A
Methods in molecular biology (Clifton, N.J.), 2019, Volume 1989, p. 139
Mass cytometry is a multi-parametric technique that offers insight into functional and biological systems at a single cell level (Tanner et al., Cancer Immunol... 
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6. Full Text Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells
by Rubelt, Florian and Bolen, Christopher R and McGuire, Helen M and Heiden, Jason A. Vander and Gadala-Maria, Daniel and Levin, Mikhail and Euskirchen, Ghia M and Mamedov, Murad R and Swan, Gary E and Dekker, Cornelia L and Cowell, Lindsay G and Kleinstein, Steven H and Davis, Mark M
Nature Communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, p. 11112
The adaptive immune system's capability to protect the body requires a highly diverse lymphocyte antigen receptor repertoire. However, the influence of... 
SEQUENCE-ANALYSIS | RESPONSES | V-SEGMENT FREQUENCIES | DEEP | MULTIDISCIPLINARY SCIENCES | V(D)J RECOMBINATION | VACCINATION | IDENTICAL-TWINS | DIVERSITY | EXPRESSION | REVEALS | V(D)J Recombination - genetics | Genes, Immunoglobulin - genetics | Twins, Monozygotic - genetics | Humans | CD4-Positive T-Lymphocytes - metabolism | Genes, T-Cell Receptor - genetics | CD8-Positive T-Lymphocytes - metabolism | Reverse Transcriptase Polymerase Chain Reaction | B-Lymphocytes - metabolism | Adaptive Immunity - genetics
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7. Full Text Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
by Mia C. Ã…kerfeldt and Jennifer Howes and Jeng Yie Chan and Veronica A. Stevens and Nacer Boubenna and Helen M. McGuire and Cecile King and Trevor J. Biden and D. Ross Laybutt
Diabetes, ISSN 0012-1797, 11/2008, Volume 57, Issue 11, pp. 3034 - 3044
Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling Mia C. Ã…kerfeldt 1 , Jennifer Howes 1 , Jeng Yie Chan 1 , Veronica A.... 
GLUCOSE-HOMEOSTASIS | UNFOLDED-PROTEIN RESPONSE | ER STRESS | MOUSE MODEL | FATTY-ACID | ENDOCRINOLOGY & METABOLISM | NITRIC-OXIDE | MAMMALIAN-CELLS | CHOP GADD153 | OXIDE-INDUCED APOPTOSIS | TRANSLATIONAL CONTROL | RNA, Small Interfering - genetics | Transcription Factor CHOP - genetics | Interleukin-1beta - pharmacology | Rats, Wistar | eIF-2 Kinase - metabolism | Endoplasmic Reticulum - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Insulin-Secreting Cells - metabolism | Palmitates - pharmacology | Endoplasmic Reticulum - drug effects | Eukaryotic Initiation Factor-2 - metabolism | Butyric Acid - pharmacology | Insulin-Secreting Cells - cytology | Stress, Physiological - drug effects | Cell Death - drug effects | Phosphorylation - drug effects | Stress, Physiological - physiology | Cells, Cultured | Rats | Blotting, Western | Animals | Activating Transcription Factor 4 - metabolism | Insulin-Secreting Cells - drug effects | Signal Transduction - drug effects | Mice, Inbred NOD | Mice | Transcription Factor CHOP - metabolism | Cytokines - pharmacology | Interferon-gamma - pharmacology | Islet Studies
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8. Full Text Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy
by Gide, Tuba N and Quek, Camelia and Menzies, Alexander M and Tasker, Annie T and Shang, Ping and Holst, Jeff and Madore, Jason and Lim, Su Yin and Velickovic, Rebecca and Wongchenko, Matthew and Yan, Yibing and Lo, Serigne and Carlino, Matteo S and Guminski, Alexander and Saw, Robyn P.M and Pang, Angel and McGuire, Helen M and Palendira, Umaimainthan and Thompson, John F and Rizos, Helen and Silva, Ines Pires da and Batten, Marcel and Scolyer, Richard A and Long, Georgina V and Wilmott, James S
Cancer Cell, ISSN 1535-6108, 02/2019, Volume 35, Issue 2, pp. 238 - 255.e6
Cancer immunotherapies provide survival benefits in responding patients, but many patients fail to respond. Identifying the biology of treatment response and... 
EOMES | predictive biomarkers | RNA-seq | immunotherapy | melanoma | combination therapy | immune checkpoint inhibitors | anti-CTLA-4 | anti-PD-1 | resistance mechanisms | CTLA-4 BLOCKADE | MASS-CYTOMETRY | DENDRITIC CELLS | ONCOLOGY | CARBONIC-ANHYDRASE IX | COMBINATION THERAPY | PD-L1 EXPRESSION | INDOLEAMINE 2,3-DIOXYGENASE | INHIBITORY RECEPTORS | CLINICAL-RESPONSE | CD8 T-CELLS | CELL BIOLOGY | RNA | T cells | Gene expression | Analysis | Immunotherapy | Melanoma
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9. Full Text Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes
by Withana, N.P and Ma, X.W and McGuire, H.M and Verdoes, M and Linden, W.A. van der and Ofori, L.O and Zhang, R.P and Li, H and Sanman, L.E and Wei, K and Yao, S.B and Wu, P.L and Li, F and Huang, H and Xu, Z.J and Wolters, P.J and Rosen, G.D and Collard, H.R and Zhu, Z.H and Cheng, Z and Bogyo, M
Scientific Reports, ISSN 2045-2322, 2016, Volume 6, Issue 1, p. 19755
Idiopathic pulmonary fibrosis (IPF) is a lethal, chronic, progressive disease characterized by formation of scar tissue within the lungs. Because it is a... 
MULTIDISCIPLINARY SCIENCES | CYSTATIN-C | INJURY | BLEOMYCIN | DEGRADATION | CYSTEINE CATHEPSINS | PREVALENCE | EMERGING-ROLES | CANCER | INDUCED LUNG FIBROSIS | MURINE | Optical Imaging | Lung - pathology | Idiopathic Pulmonary Fibrosis - chemically induced | Positron-Emission Tomography | Idiopathic Pulmonary Fibrosis - immunology | Disease Progression | Macrophage Activation | Diagnostic Imaging - methods | Molecular Probes - chemistry | Animals | Bleomycin | Idiopathic Pulmonary Fibrosis - diagnosis | Molecular Probes - metabolism | Cathepsins - metabolism | Gallium Radioisotopes | Idiopathic Pulmonary Fibrosis - pathology | Copper Radioisotopes | Disease Models, Animal | Cysteine | Animal models | Pulmonary fibrosis | Biopsy | Etiology | Lung diseases | Fibrosis | Cathepsins | Macrophages | Probes
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10. Full Text A Subset of Interleukin-21 + Chemokine Receptor CCR9 + T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity
by McGuire, Helen M and Vogelzang, Alexis and Ma, Cindy S and Hughes, William E and Silveira, Pablo A and Tangye, Stuart G and Christ, Daniel and Fulcher, David and Falcone, Marika and King, Cecile
Immunity, ISSN 1074-7613, 2011, Volume 34, Issue 4, pp. 602 - 615
This study describes a CD4 T helper (Th) cell subset marked by coexpression of the cytokine interleukin 21 (IL-21) and the gut-homing chemokine receptor CCR9.... 
B-LYMPHOCYTES | TERTIARY LYMPHOID STRUCTURES | NOD MICE | IMMUNE-SYSTEM | DENDRITIC CELLS | NONOBESE DIABETIC MICE | MOUSE | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | IL-21 | Autoimmunity | CD8-Positive T-Lymphocytes - cytology | Receptors, Interleukin-21 - immunology | Cell Survival | Humans | Islets of Langerhans - immunology | Sjogren's Syndrome - immunology | Mice, Knockout | Receptors, Interleukin-21 - deficiency | Animals | B-Lymphocytes - immunology | Receptors, CCR - immunology | Diabetes Mellitus - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | T-Lymphocytes, Helper-Inducer - cytology | Female | Mice | Interleukins - biosynthesis | CD8-Positive T-Lymphocytes - immunology | Cell Movement | Medical research | Disease | Research & development--R&D | Insulin | Proteins | Lymphocytes | Rodents | Population | Ligands | Software | Diabetes | Pancreas | Autoimmune diseases | Chemokines
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11. Full Text Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome
by Russo, Marc A and Fiore, Nathan T and Van Vreden, Caryn and Bailey, Dominic and Santarelli, Danielle M and McGuire, Helen M and Fazekas De St Groth, Barbara and Austin, Paul J
Journal of Neuroinflammation, ISSN 1742-2094, 03/2019, Volume 16, Issue 1, pp. 63 - 17
Background: Complex regional pain syndrome (CRPS) is a debilitating condition where trauma to a limb results in devastating persistent pain that is... 
Central memory T lymphocytes | Mass cytometry | NFkB | Complex regional pain syndrome | Myeloid dendritic cells | AUTOANTIBODIES | CYTOKINES | DIFFERENTIAL EXPRESSION | DENDRITIC CELLS | IMMUNOLOGY | CRPS | NEUROSCIENCES | PERIPHERAL-NERVE INJURY | IMMUNE-SYSTEM | AUTOIMMUNITY | INFLAMMATION | Phosphorylation | Disease | CD8 antigen | Memory | Lymphocytes T | Mental depression | Signal transduction | Cell activation | Pain | Lymphocytes | Human immunodeficiency virus--HIV | Stat1 protein | Gating | Immune system | NF-κB protein | Immunological memory | Memory cells | Autoantibodies | Cytokines | Dendritic cells | Mortality | Gender differences | Inflammation | Trauma | CD4 antigen | CD1c antigen | Cytometry | Brain research | Psychiatry
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12. Full Text Loss of Parity between IL-2 and IL-21 in the NOD Idd3 Locus
by Helen M. McGuire and Alexis Vogelzang and Natasha Hill and Malin Flodström-Tullberg and Jonathan Sprent and Cecile King
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2009, Volume 106, Issue 46, pp. 19438 - 19443
IL-2 and IL-21 are two cytokines with great potential to affect autoimmune infiltration of nonlymphoid tissue, and are contained within the strongest... 
T lymphocytes | Messenger RNA | Cytokines | Lymphocytes | Splenocytes | Alleles | Genetic loci | Diabetes | Pancreas | Type 1 diabetes mellitus | Promoter | Allele | Transcription factor | Type 1 diabetes | transcription factor | type 1 diabetes | ACTIVATION | MULTIDISCIPLINARY SCIENCES | MOUSE | RECEPTOR | GLYCOSYLATION | INTERLEUKIN-2 GENE | AUTOIMMUNITY | NONOBESE DIABETIC MICE | allele | DISEASE | REGULATORY T-CELLS | cytokines | promoter | ISLET BETA-CELLS | Promoter Regions, Genetic | Gene Expression Regulation | Autoimmunity - genetics | Sp1 Transcription Factor - metabolism | RNA Stability | RNA, Messenger - metabolism | Polymorphism, Genetic | Interleukin-2 - genetics | Interleukins - genetics | Animals | Mice, Inbred NOD | Mice | Autoimmunity | Allelomorphism | Transcription factors | Promoters (Genetics) | Development and progression | Genetic aspects | Properties | Identification and classification | Biological Sciences
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