X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (154) 154
index medicus (137) 137
human necessities (128) 128
hygiene (128) 128
medical or veterinary science (128) 128
preparations for medical, dental, or toilet purposes (128) 128
chemistry (119) 119
metallurgy (115) 115
heterocyclic compounds (112) 112
organic chemistry (110) 110
animals (85) 85
specific therapeutic activity of chemical compounds ormedicinal preparations (82) 82
biochemistry (79) 79
biochemistry & molecular biology (77) 77
natural sciences (75) 75
naturvetenskap (75) 75
dna repair (74) 74
microbiology (74) 74
dna damage (73) 73
enzymes (72) 72
cancer (68) 68
enzymology (67) 67
beer (66) 66
compositions thereof (66) 66
culture media (66) 66
microorganisms or enzymes (66) 66
mutation or genetic engineering (66) 66
propagating, preserving or maintaining microorganisms (66) 66
spirits (66) 66
vinegar (66) 66
wine (66) 66
homologous recombination (62) 62
cell biology (54) 54
biological sciences (53) 53
mammalian-cells (53) 53
medicin och hälsovetenskap (53) 53
biologiska vetenskaper (51) 51
medical and health sciences (50) 50
dna (45) 45
double-strand breaks (44) 44
cell line (43) 43
cricetinae (43) 43
dna replication (43) 43
oncology (41) 41
cell line, tumor (36) 36
article (34) 34
recombination, genetic (33) 33
cells (32) 32
genetics & heredity (31) 31
dna-binding proteins - metabolism (29) 29
female (28) 28
cell cycle (27) 27
klinisk medicin (27) 27
male (27) 27
mice (27) 27
clinical medicine (25) 25
dna-binding proteins - genetics (25) 25
enzyme inhibitors - pharmacology (25) 25
research (25) 25
poly polymerase (24) 24
apparatus therefor (23) 23
biology (23) 23
damage (23) 23
general methods of organic chemistry (23) 23
multidisciplinary sciences (23) 23
mutation (23) 23
proteins (23) 23
toxicology (23) 23
dna breaks, double-stranded (22) 22
dna repair - genetics (22) 22
neoplasms - genetics (22) 22
phosphorylation (22) 22
cricetulus (20) 20
recombination; genetic (20) 20
repair (20) 20
cell cycle proteins - metabolism (19) 19
cho cells (19) 19
protein (19) 19
adult (18) 18
cancer och onkologi (18) 18
antineoplastic agents - pharmacology (17) 17
cell survival (17) 17
dna-damage (17) 17
dna-repair (17) 17
biochemistry and molecular biology (16) 16
biokemi och molekylärbiologi (16) 16
cancer and oncology (16) 16
dna replication - drug effects (16) 16
gene expression (16) 16
inhibition (16) 16
medicinska och farmaceutiska grundvetenskaper (16) 16
neoplasms - drug therapy (16) 16
physiological aspects (16) 16
tumors (16) 16
analysis (15) 15
dna repair - drug effects (15) 15
enzymes and coenzymes (15) 15
general tagging of cross-sectional technologies spanning over several sections of the ipc (15) 15
general tagging of new technological developments (15) 15
mth1 (15) 15
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (474) 474
French (38) 38
German (17) 17
Chinese (7) 7
Spanish (7) 7
Portuguese (6) 6
Norwegian (5) 5
Danish (4) 4
Korean (2) 2
Slovenian (2) 2
Swedish (2) 2
Greek (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular Oncology, ISSN 1574-7891, 2011, Volume 5, Issue 4, pp. 387 - 393
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 04/2017, Volume 15, Issue 4 Supplement, pp. IA12 - IA12
Journal Article
Nature, ISSN 0028-0836, 04/2005, Volume 434, Issue 7035, pp. 913 - 917
Journal Article
Annals of Oncology, ISSN 0923-7534, 03/2019, Volume 30, Issue 3, pp. 360 - 361
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 256 - 263
The cytostatic deoxycytidine analog cytarabine (ara-C) is the most active agent available against acute myelogenous leukemia (AML). Together with... 
MEDICINE, RESEARCH & EXPERIMENTAL | CYTOSINE-ARABINOSIDE | CELLS | ARA-C SENSITIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | CELL BIOLOGY | IN-VITRO | DNA | CHRONIC LYMPHOCYTIC-LEUKEMIA | MUTATIONS | EXPRESSION | Cytarabine - pharmacology | Prognosis | Apoptosis - drug effects | Cytarabine - therapeutic use | Humans | Leukemia, Myeloid, Acute - metabolism | SAM Domain and HD Domain-Containing Protein 1 | Child, Preschool | Infant | Male | Viral Regulatory and Accessory Proteins - pharmacology | Molecular Targeted Therapy | Monomeric GTP-Binding Proteins - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Antimetabolites, Antineoplastic - pharmacology | Female | Child | Disease Models, Animal | Arabinofuranosylcytosine Triphosphate - metabolism | Antimetabolites, Antineoplastic - therapeutic use | Animals | Monomeric GTP-Binding Proteins - metabolism | Adolescent | Aged | Mice | In Vitro Techniques | Cellular proteins | Molecular targeted therapy | Care and treatment | Cytarabine | Patient outcomes | Drug interactions | Innovations | Development and progression | Genetic aspects | Blood diseases | Health aspects | Biomarkers | Cytotoxicity | Chemotherapy | Gene expression | Leukemia | Biological Sciences | Clinical Medicine | Naturvetenskap | Medical and Health Sciences | Hematology | Hematologi | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
Journal Article
by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article