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1. Full Text Molecular mediators of macrophage fusion
by Helming, Laura and Gordon, Siamon
Trends in cell biology, ISSN 0962-8924, 2009, Volume 19, Issue 10, pp. 514 - 522
Pathology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Fusion | Macrophages - metabolism | Matrix Metalloproteinase 9 - metabolism | Animals | Giant Cells - metabolism | Humans | Giant Cells - cytology | Macrophages - cytology | Osteoclasts - cytology | Osteoclasts - metabolism | Phagocytosis | Macrophages - enzymology | Macrophages | Index Medicus
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2. Full Text Inflammation: Cell Recruitment versus Local Proliferation
by Helming, Laura
Current biology, ISSN 0960-9822, 07/2011, Volume 21, Issue 14, pp. R548 - R550
Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Proliferation | Mitomycin | Ifosfamide | Monocytes - cytology | Filariasis - immunology | Antineoplastic Combined Chemotherapy Protocols | Inflammation - immunology | Monocytes - immunology | Th2 Cells - immunology | Macrophages - cytology | Blood | Cisplatin | Macrophage Activation | Interleukin-4 - immunology | Animals | Filarioidea - immunology | Macrophages - immunology | Inflammation | Index Medicus
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3. Full Text Alternative activation of macrophages: An immunologic functional perspective
by Martinez, Fernando O and Helming, Laura and Gordon, Siamon
Annual review of immunology, ISSN 0732-0582, 2009, Volume 27, Issue 1, pp. 451 - 483
IL-4 | Allergy | Parasite infection | IL-13 | Macrophage polarization | T-Lymphocyte Subsets - immunology | Macrophage Activation - immunology | Humans | Interleukin-13 - immunology | Interferon-gamma - metabolism | Antigen Presentation - immunology | Immunity, Innate | Interleukin-4 - immunology | Signal Transduction - immunology | Interleukin-13 - genetics | Animals | Natural Killer T-Cells - metabolism | Interferon-gamma - immunology | Interleukin-4 - genetics | Macrophages - immunology | Natural Killer T-Cells - immunology | Physiological aspects | Cell receptors | Immune response | Macrophages | Properties | Immunological research | Index Medicus
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4. Full Text Macrophage fusion induced by IL‐4 alternative activation is a multistage process involving multiple target molecules
by Helming, Laura and Gordon, Siamon
European journal of immunology, ISSN 0014-2980, 01/2007, Volume 37, Issue 1, pp. 33 - 42
Multinucleated giant cell | Interleukin‐4 | Macrophage | Interleukin-4 | Life Sciences & Biomedicine | Immunology | Science & Technology | Macrophage Activation - immunology | Giant Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Macrophages, Peritoneal - immunology | Giant Cells - cytology | Macrophages, Peritoneal - cytology | Mice, Knockout | Cell Adhesion - immunology | Cell Fusion | Animals | Giant Cells - immunology | Thioglycolates - pharmacology | Cell Line, Tumor | Mice | Macrophages, Peritoneal - metabolism | Interleukin-4 - physiology | Cell Line, Transformed | Index Medicus
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5. Full Text The molecular basis of macrophage fusion
by Helming, Laura and Gordon, Siamon
Immunobiology (1979), ISSN 0171-2985, 2007, Volume 212, Issue 9, pp. 785 - 793
Allergy and Immunology | Advanced Basic Science | Granuloma | Cellular fusion | Multinucleated giant cell | Macrophage | Macrophages - physiology | Humans | Interleukin-4 - metabolism | Receptors, Chemokine - metabolism | Glycosylation | Granuloma - physiopathology | Cell Adhesion Molecules - metabolism | Receptors, Purinergic P2X7 | Cell Fusion | ADAM Proteins - metabolism | Animals | Receptors, Purinergic P2 - metabolism | Giant Cells - physiology | Fusion Regulatory Protein-1 - metabolism | Membrane Proteins - metabolism | Osteoclasts - physiology | Macrophage colony stimulating factor | Macrophages | Mitogens | Growth factors | Index Medicus
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6. Full Text Genetic screen in myeloid cells identifies TNF-α autocrine secretion as a factor increasing MDSC suppressive activity via Nos2 up-regulation
by Schröder, Matthias and Krötschel, Marit and Conrad, Lena and Naumann, Svenja Kerstin and Bachran, Christopher and Rolfe, Alex and Umansky, Viktor and Helming, Laura and Swee, Lee Kim
Scientific reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 13399 - 12
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CRISPR | Myeloid cells | Limiting factors | Genes | Effector cells | Lymphocytes T | Tumor necrosis factor-α | Gene expression | Suppressor cells | Macrophages | Immunosuppressive agents | Genetic screening | Hemopoiesis | Autocrine signalling | Retinoic acid | Tumors | Cancer | Index Medicus
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7. Full Text Genetic basis of cell–cell fusion mechanisms
by Aguilar, Pablo S and Baylies, Mary K and Fleissner, Andre and Helming, Laura and Inoue, Naokazu and Podbilewicz, Benjamin and Wang, Hongmei and Wong, Melissa
Trends in genetics, ISSN 0168-9525, 2013, Volume 29, Issue 7, pp. 427 - 437
Medical Education | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Macrophages - physiology | Saccharomyces cerevisiae - physiology | Humans | Placenta - physiology | Fertilization - genetics | Membrane Fusion - genetics | Cytoplasm - physiology | Cell Membrane - physiology | Germ Cells - physiology | Pregnancy | Caenorhabditis elegans - physiology | Cell Fusion | Plants - metabolism | Animals | Fertilization - physiology | Gene Expression Regulation, Developmental | Female | Mice | Neurospora crassa - physiology | Membrane Fusion - physiology | Cell Differentiation - physiology | Myoblasts - physiology | Index Medicus | Life Sciences
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8. Full Text Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction
by Milde, Ronny and Ritter, Julia and Tennent, Glenys A and Loesch, Andrzej and Martinez, Fernando O and Gordon, Siamon and Pepys, Mark B and Verschoor, Admar and Helming, Laura
Cell reports (Cambridge), ISSN 2211-1247, 12/2015, Volume 13, Issue 9, pp. 1937 - 1948
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Tetradecanoylphorbol Acetate - pharmacology | Humans | Receptors, IgG - metabolism | CD11c Antigen - metabolism | Integrin alphaXbeta2 - metabolism | Interleukin-4 - pharmacology | Complement C3 - deficiency | Amyloid - metabolism | Macrophage Colony-Stimulating Factor - pharmacology | Bone Marrow Cells - drug effects | Complement C3 - genetics | Cricetinae | Phagocytosis - drug effects | Bone Marrow Cells - cytology | Complement C3 - metabolism | Giant Cells - metabolism | Mice, Inbred C57BL | Rats | Mice, Transgenic | Macrophages - cytology | Mice, Knockout | CD18 Antigens - metabolism | Up-Regulation - drug effects | Macrophages - metabolism | Animals | Giant Cells - immunology | Macrophages - drug effects | Mice | Bone Marrow Cells - metabolism | Index Medicus
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9. Full Text Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences
by Martinez, Fernando O and Helming, Laura and Milde, Ronny and Varin, Auey and Melgert, Barbro N and ijer, Christina and Thomas, Benjamin and Fabbri, Marco and Crawshaw, Anjali and Ho, Ling Pei and ten Hacken, Nick H and Cobos Jiménez, Viviana and Kootstra, Neeltje A and Hamann, Jörg and Greaves, David R and Locati, Massimo and Mantovani, Alberto and Gordon, Siamon
Blood, ISSN 0006-4971, 2013, Volume 121, Issue 9, pp. E57 - E69
Life Sciences & Biomedicine | Hematology | Science & Technology | Macrophages - physiology | Macrophage Activation - genetics | Species Specificity | Humans | Mice, Inbred C57BL | Cells, Cultured | Transcriptome | Proteome - drug effects | Gene Expression Profiling | Proteome - analysis | Interleukin-4 - pharmacology | Macrophages - metabolism | Animals | Models, Biological | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Macrophage Activation - drug effects | Macrophages - immunology | Cluster Analysis | Index Medicus | Abridged Index Medicus
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10. Full Text The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion
by Helming, Laura and Winter, Julia and Gordon, Siamon
Journal of cell science, ISSN 0021-9533, 02/2009, Volume 122, Issue 4, pp. 453 - 459
IL-4 | Macrophage fusion | CD36 | Mouse | Multinucleated giant cell | Life Sciences & Biomedicine | Science & Technology | Cell Biology | CD36 Antigens - deficiency | Membrane Fusion | Mice, Inbred C57BL | Phosphatidylserines - metabolism | Cells, Cultured | Giant Cells, Foreign-Body - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Antibodies, Monoclonal | Osteoclasts - metabolism | Cell Fusion | Interleukin-4 - pharmacology | Animals | CD36 Antigens - metabolism | Mice | Giant Cells, Langhans - metabolism | Macrophages, Peritoneal - metabolism | Macrophages, Peritoneal - drug effects | Index Medicus
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11. Full Text The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent
by Bachran, Christopher and Schröder, Matthias and Conrad, Lena and Cragnolini, Juan J and Tafesse, Fikadu G and Helming, Laura and Ploegh, Hidde L and Swee, Lee Kim
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 17916 - 10
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Proliferation | Monocytes - metabolism | Monocytes - immunology | Immunotoxins - pharmacology | Exotoxins - metabolism | Single-Domain Antibodies - immunology | Epitopes - immunology | Granulocytes - drug effects | Myeloid Cells - immunology | Female | Myeloid Cells - drug effects | Cell Differentiation | Granulocytes - metabolism | ADP Ribose Transferases - metabolism | CD11b Antigen - immunology | Mice, Inbred C57BL | Cells, Cultured | Organ Specificity | Monocytes - drug effects | Bacterial Toxins - metabolism | Animals | Antigens, Ly - immunology | Myeloid Cells - metabolism | Virulence Factors - metabolism | Mice | Granulocytes - immunology | Myeloid cells | CD11b antigen | Cell survival | Antibodies | Exotoxin A | Immunotoxins | Monocytes | Granulocytes | Ly-6 antigen | Autoimmune diseases | Leukocytes (granulocytic) | Apoptosis | Cancer
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