Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (25) 25
animals (18) 18
humans (10) 10
mice (9) 9
cell biology (8) 8
drosophila (7) 7
slit diaphragm (7) 7
biology (6) 6
drosophila melanogaster (5) 5
endocytosis (5) 5
male (5) 5
mutations (5) 5
phenotypes (5) 5
proteins (5) 5
analysis (4) 4
animal models (4) 4
drosophila proteins - genetics (4) 4
female (4) 4
genetics & heredity (4) 4
insects (4) 4
kidneys (4) 4
morphogenesis (4) 4
proteinuria (4) 4
research article (4) 4
urology & nephrology (4) 4
adhesion (3) 3
basic research (3) 3
biochemistry & molecular biology (3) 3
cell (3) 3
cells, cultured (3) 3
clonal deletion (3) 3
deletion (3) 3
disease (3) 3
gene (3) 3
gene expression (3) 3
genetic aspects (3) 3
irrec-rst protein (3) 3
kidney diseases (3) 3
lining machines (3) 3
mammals (3) 3
medicine (3) 3
mice, knockout (3) 3
models, biological (3) 3
multidisciplinary sciences (3) 3
neurosciences (3) 3
performing operations (3) 3
phenotype (3) 3
podocyte (3) 3
podocytes (3) 3
printing (3) 3
printing machines or presses (3) 3
protein binding (3) 3
protein kinase c - metabolism (3) 3
stamps (3) 3
transporting (3) 3
typewriters (3) 3
zebrafish (3) 3
actin (2) 2
actomyosin (2) 2
adolescent (2) 2
adult (2) 2
anatomy (2) 2
article (2) 2
articles (2) 2
autophagy (2) 2
axonal projections (2) 2
blasting (2) 2
brain (2) 2
brakes (2) 2
cell adhesion molecules, neuronal - genetics (2) 2
cellular types (2) 2
chemistry, medicinal (2) 2
chronic kidney failure (2) 2
cilia (2) 2
cilia - metabolism (2) 2
class iii phosphatidylinositol 3-kinases - deficiency (2) 2
clutches (2) 2
congenital nephrotic syndrome (2) 2
couplings for transmitting rotation (2) 2
cysts (2) 2
diabetes (2) 2
drosophila - genetics (2) 2
drosophila melanogaster - cytology (2) 2
drosophila proteins - physiology (2) 2
drosophila-melanogaster (2) 2
dysfunction (2) 2
electron microscopy (2) 2
engineering elements and units (2) 2
epithelial cells (2) 2
experiments (2) 2
eye proteins - genetics (2) 2
fibroblasts (2) 2
filtration (2) 2
garland cell (2) 2
gene knockdown techniques (2) 2
gene mutations (2) 2
general measures for producing and maintaining effectivefunctioning of machines or installations (2) 2
genetics (2) 2
genomics (2) 2
health aspects (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3
by Hoff, S and Halbritter, J and Epting, D and Frank, V and Nguyen, T.M and Reeuwijk, J. van and Boehlke, C and Schell, C and Yasunaga, T and Helmstadter, M and Mergen, M and Filhol, E and Boldt, K and Horn, N and Ueffing, M and Otto, E.A and Eisenberger, T and Elting, M.W and Wijk, J.A. van and Bockenhauer, D and Sebire, N.J and Rittig, S and Vyberg, M and Ring, T and Pohl, M and Pape, L and Neuhaus, T.J and Elshakhs, N.A and Koon, S.J and Harris, P.C and Grahammer, F and Huber, T.B and Kuehn, E.W and Kramer-Zucker, A and Bolz, H.J and Roepman, R and Saunier, S and Walz, G and Hildebrandt, F and Bergmann, C and Lienkamp, S.S
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 8, pp. 951 - 956
Nephronophthisis is an autosomal recessive cystic kidney disease that leads to renal failure in childhood or adolescence. Most NPHP gene products form... 
CILIARY | NEPHROCYSTIN-3 | TANDEM AFFINITY PURIFICATION | ZEBRAFISH | PRONEPHROS | CILIOPATHIES | POLYCYSTIC KIDNEY-DISEASE | GENES | GENETICS & HEREDITY | PROTEIN COMPLEXES | MUTATIONS | Polycystic Kidney Diseases - genetics | Protein Kinases - metabolism | Protein Kinases - genetics | Exons | Humans | Xenopus - embryology | Gene Knockdown Techniques | Protein Interaction Maps | Kidney Diseases, Cystic - genetics | Kinesin - genetics | Nuclear Proteins - genetics | Introns | Zebrafish Proteins - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Cilia - metabolism | Zebrafish - genetics | Kinesin - metabolism | Protein Transport | Transcription Factors - metabolism | Kidney Diseases, Cystic - metabolism | Phenotype | Animals | Xenopus - metabolism | Zebrafish - metabolism | Protein Binding | Consanguinity | Mice | Mutation | Zebrafish Proteins - genetics | NIMA-Related Kinases | Physiological aspects | Genetic aspects | Research | Kidney diseases | Gene mutations | Proteins | Cysts | Proteomics | State government | Defects
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Using Drosophila nephrocytes in genetic kidney disease
by Helmstädter, Martin and Simons, Matias
Cell and Tissue Research, ISSN 0302-766X, 07/2017, Volume 369, Issue 1, pp. 119 - 126
Renal diseases are a growing health burden, and innovative models to study their pathomechanisms are greatly needed. Here, we highlight how the fruit fly... 
Podocytes | Proximal tubules | Drosophila | Kidney | Renal genetics | VARIANTS | SEQUENCE | TUBULE | DYSFUNCTION | CELL | CELL BIOLOGY | Genetic research | Genetic aspects | Chronic kidney failure | Fruit-flies | Analysis | Animal models | Filtration | Nephropathy | Insects | Tools | Reabsorption | Kidney diseases | Fruits | Diseases
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies
by Gonçalves, Sara and Patat, Julie and Guida, Maria Clara and Lachaussée, Noelle and Arrondel, Christelle and Helmstädter, Martin and Boyer, Olivia and Gribouval, Olivier and Gubler, Marie-Claire and Mollet, Geraldine and Rio, Marlène and Charbit, Marina and Bole-Feysot, Christine and Nitschke, Patrick and Huber, Tobias B and Wheeler, Patricia G and Haynes, Devon and Juusola, Jane and Billette de Villemeur, Thierry and Nava, Caroline and Afenjar, Alexandra and Keren, Boris and Bodmer, Rolf and Antignac, Corinne and Simons, Matias
PLoS Genetics, ISSN 1553-7390, 05/2018, Volume 14, Issue 5, p. e1007386
Recent evidence suggests that the presence of more than one pathogenic mutation in a single patient is more common than previously anticipated. One of the... 
ADDUCIN | DROSOPHILA-MELANOGASTER | SLIT DIAPHRAGM | ACETYLATION | GENETICS & HEREDITY | DIGENIC INHERITANCE | MUTATIONS | NEPHROTIC SYNDROME | PCAF | CELL | ACETYLTRANSFERASES | Calmodulin-Binding Proteins - genetics | Cell Line | Humans | Cells, Cultured | Male | Kidney Failure, Chronic - genetics | Homozygote | Phenotype | Animals | p300-CBP Transcription Factors - genetics | DNA Mutational Analysis | Pedigree | Adolescent | Adult | Female | Drosophila Proteins - genetics | Mutation | Calmodulin-Binding Proteins - deficiency | Abnormalities, Multiple - genetics | Heart Diseases - genetics | Drosophila - genetics | Genetic aspects | Disease susceptibility | Kidney diseases | Gene mutations | Heart diseases | Drosophila | Gene expression | Health aspects | Cataracts | Pediatrics | Animal models | Nephrology | Laboratories | Funding | Cardiomyopathy | Genomics | Biology | Fibroblasts | Genetics | Acetyltransferase | Supervision | Phenotypes | Kidneys | Adducin | Cardiomyocytes | Nephrotic syndrome | Coronary artery disease | Medicine | Microencephaly | Lysine | Point mutation | Alzheimers disease
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Modeling monogenic human nephrotic syndrome in the drosophila garland cell nephrocyte
by Hermle, Tobias and Braun, Daniela A and Helmstädter, Martin and Huber, Tobias B and Hildebrandt, Friedhelm
Journal of the American Society of Nephrology, ISSN 1046-6673, 05/2017, Volume 28, Issue 5, pp. 1521 - 1533
Steroid-resistant nephrotic syndrome is characterized by podocyte dysfunction. Drosophila garland cell nephrocytes are podocyte-like cells and thus provide a... 
APOPTOSIS | MUTANT | STEROID-RESISTANT | RHO | UROLOGY & NEPHROLOGY | SNS | CUBILIN | VANILLIC ACID | DYSFUNCTION | ENDOCYTOSIS | ONSET | Drosophila Proteins - physiology | Nerve Tissue Proteins - physiology | Animals | Models, Biological | Humans | Drosophila - cytology | Nephrotic Syndrome - genetics | COQ2 | SRNS | garland cell | Drosophila | nephrocyte | nephrotic syndrome | Basic Research
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Podocyte-specific deletion of murine CXADR does not impair podocyte development, function or stress response
by Schell, Christoph and Kretz, Oliver and Bregenzer, Andreas and Rogg, Manuel and Helmstädter, Martin and Lisewski, Ulrike and Gotthardt, Michael and Tharaux, Pierre-Louis and Huber, Tobias B and Grahammer, Florian
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0129424 - e0129424
The coxsackie-and adenovirus receptor (CXADR) is a member of the immunoglobulin protein superfamily, present in various epithelial cells including glomerular... 
CONGENITAL NEPHROTIC SYNDROME | COXSACKIEVIRUS | ADHESION MOLECULE | SESTRIN 2 | GLOMERULAR PROTEIN | MULTIDISCIPLINARY SCIENCES | CELL-ADHESION | ADENOVIRUS RECEPTOR CAR | TIGHT JUNCTION | FOOT PROCESSES | TRANSGENIC MICE | Gene Expression | Podocytes - metabolism | Kidney - embryology | Stress, Physiological | Coxsackie and Adenovirus Receptor-Like Membrane Protein - metabolism | Gene Knockout Techniques | Mice, Knockout | Kidney Glomerulus - ultrastructure | Kidney - metabolism | Animals | Gene Deletion | Kidney Glomerulus - metabolism | Kidney Glomerulus - embryology | Mice | Coxsackie and Adenovirus Receptor-Like Membrane Protein - genetics | Kidney Glomerulus - cytology | Genetic engineering | Pattern formation | Neurosciences | Animal models | Epithelial cells | Transgenic | Viruses | Biology | Lethality | Experiments | Proteins | Clonal deletion | Rodents | Deletion | Physiology | Stress response | Injuries | Urine | Phenotypes | Kidneys | Zebrafish | Mammals | Embryos | Medicine | Brain research | Molecular modelling | Microscopy | Adenoviruses | Laboratory animals | Cellular stress response | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes
by Rinschen, Markus M and Gödel, Markus and Grahammer, Florian and Zschiedrich, Stefan and Helmstädter, Martin and Kretz, Oliver and Zarei, Mostafa and Braun, Daniela A and Dittrich, Sebastian and Pahmeyer, Caroline and Schroder, Patricia and Teetzen, Carolin and Gee, HeonYung and Daouk, Ghaleb and Pohl, Martin and Kuhn, Elisa and Schermer, Bernhard and Küttner, Victoria and Boerries, Melanie and Busch, Hauke and Schiffer, Mario and Bergmann, Carsten and Krüger, Marcus and Hildebrandt, Friedhelm and Dengjel, Joern and Benzing, Thomas and Huber, Tobias B
Cell Reports, ISSN 2211-1247, 05/2018, Volume 23, Issue 8, pp. 2495 - 2508
Damage to and loss of glomerular podocytes has been identified as the culprit lesion in progressive kidney diseases. Here, we combine mass spectrometry-based... 
systems biology | hereditary nephrotic syndrome | kinase | proteinuria | pulse SILAC | slit diaphragm | metabolism | end-stage renal disease | focal segmental glomerulosclerosis | proteostasis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney
by Viau, Amandine and Bienaimé, Frank and Lukas, Kamile and Todkar, Abhijeet P and Knoll, Manuel and Yakulov, Toma A and Hofherr, Alexis and Kretz, Oliver and Helmstädter, Martin and Reichardt, Wilfried and Braeg, Simone and Aschman, Tom and Merkle, Annette and Pfeifer, Dietmar and Dumit, Verónica I and Gubler, Marie‐Claire and Nitschke, Roland and Huber, Tobias B and Terzi, Fabiola and Dengjel, Jörn and Grahammer, Florian and Köttgen, Michael and Busch, Hauke and Boerries, Melanie and Walz, Gerd and Triantafyllopoulou, Antigoni and Kuehn, E Wolfgang
The EMBO Journal, ISSN 0261-4189, 08/2018, Volume 37, Issue 15, p. n/a
Polycystic kidney disease (PKD) and other renal ciliopathies are characterized by cysts, inflammation, and fibrosis. Cilia function as signaling centers, but a... 
macrophages | cilia | nephronophthisis | polycystic kidney disease | MIGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | PLANAR CELL POLARITY | CELL BIOLOGY | NEPHROCYSTIN-4 | GENE | DISEASE | MUTATIONS | CYST GROWTH | CC chemokine receptors | Phenotypes | Kidneys | Polycystic kidney | Epithelial cells | Homeostasis | Polycystic kidney disease 1 protein | Leukocytes (mononuclear) | Inflammation | Macrophages | Renal tubules | Proteins | LKB1 protein | Phagocytes | Signaling | Clonal deletion | CCR2 protein | Cysts | Fibrosis | Deletion | Chemokines | Monocyte chemoattractant protein 1 | Cilia | Immune system | Immunology | Cell Adhesion, Polarity & Cytoskeleton | Molecular Biology of Disease
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text The polarity protein inturned links NPHP4 to daam1 to control the subapical actin network in multiciliated cells
by Yasunaga, Takayuki and Hoff, Sylvia and Schell, Christoph and Helmstädter, Martin and Kretz, Oliver and Kuechlin, Sebastian and Yakulov, Toma A and Engel, Christina and Müller, Barbara and Bensch, Robert and Ronneberger, Olaf and Huber, Tobias B and Lienkamp, Soeren S and Walz, Gerd
Journal of Cell Biology, ISSN 0021-9525, 2015, Volume 211, Issue 5, pp. 963 - 973
Motile cilia polarization requires intracellular anchorage to the cytoskeleton; however, the molecular machinery that supports this process remains elusive. We... 
SITUS-INVERSUS | DISEASE GENES | LOCALIZES | NEPHROCYSTIN-4 | TRANSITION ZONE | ROLES | BASAL BODIES | FUZZY | CILIOGENESIS | CILIA | CELL BIOLOGY | Protein Structure, Tertiary | Epidermis - metabolism | Green Fluorescent Proteins - metabolism | Oligonucleotides - chemistry | Actin Cytoskeleton - metabolism | Immunoprecipitation | Humans | Actins - metabolism | Molecular Sequence Data | Basal Bodies - metabolism | Cilia - metabolism | Gene Knockdown Techniques | Animals | Proteins - metabolism | Xenopus laevis - metabolism | HEK293 Cells | Protein Binding | Xenopus Proteins - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Drosophila melanogaster | Muscle proteins | Actin | Analysis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis
by Bechtel, Wibke and Helmstädter, Martin and Balica, Jan and Hartleben, Björn and Kiefer, Betina and Hrnjic, Fatima and Schell, Christoph and Kretz, Oliver and Liu, Shuya and Geist, Felix and Kerjaschki, Dontscho and Walz, Gerd and Huber, Tobias B
Journal of the American Society of Nephrology, ISSN 1046-6673, 04/2013, Volume 24, Issue 5, pp. 727 - 743
The molecular mechanisms that maintain podocytes and consequently, the integrity of the glomerular filtration barrier are incompletely understood. Here, we... 
AMINONUCLEOSIDE NEPHROSIS | PROTEIN | PERMEABILITY | MEMBRANE | UROLOGY & NEPHROLOGY | AUTOPHAGOSOME FORMATION | ELECTRON MICROSCOPY | GLOMERULAR CAPILLARY WALL | SACCHAROMYCES-CEREVISIAE | FERRITIN TRANSFER | CELL BIOLOGY | Mice, Inbred C57BL | Homeostasis | Kidney Glomerulus - pathology | Autophagy | Endosomes - metabolism | Sclerosis | Class III Phosphatidylinositol 3-Kinases - deficiency | Endocytosis | Animals | Podocytes - physiology | Mice | Drosophila melanogaster | Class III Phosphatidylinositol 3-Kinases - physiology | Proteinuria - etiology | Basic Research
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text The BAR Domain Protein PICK1 Regulates Cell Recognition and Morphogenesis by Interacting with Neph Proteins
by Martin Höhne and Johannes Lorscheider and Anna von Bardeleben and Matthias Dufner and M. Antonia Scharf and Markus Gödel and Martin Helmstädter and Eva-Maria Schurek and Sibylle Zank and Peter Gerke and Christine Kurschat and Sema Hayriye Sivritas and Elke Neumann-Haefelin and Tobias B. Huber and H. Christian Reinhardt and Astrid C. Schauss and Bernhard Schermer and Karl-Friedrich Fischbach and Thomas Benzing
Molecular and Cellular Biology, ISSN 0270-7306, 08/2011, Volume 31, Issue 16, pp. 3241 - 3251
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
IMMUNOGLOBULIN SUPERFAMILY | ADHESION | AMPA RECEPTOR TRAFFICKING | DEVELOPING DROSOPHILA RETINA | SLIT DIAPHRAGM | BIOCHEMISTRY & MOLECULAR BIOLOGY | LONG-TERM DEPRESSION | MEMBRANE CURVATURE | IRREC-RST PROTEIN | SURFACE EXPRESSION | PKC PHOSPHORYLATION | CELL BIOLOGY | Carrier Proteins - physiology | Protein Structure, Tertiary | Drosophila | Humans | Protein Multimerization | Cell Communication | Eye - cytology | Morphogenesis | Animals | PDZ Domains | Protein Binding | Membrane Proteins - metabolism | Nuclear Proteins - physiology | Protein Stability | Drosophila melanogaster | Protein Kinase C
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Using the drosophila nephrocyte to model podocyte function and disease
by Helmstädter, Martin and Huber, Tobias B and Hermle, Tobias
Frontiers in Pediatrics, ISSN 2296-2360, 12/2017, Volume 5, p. 262
Glomerular disorders are a major cause of end-stage renal disease and effective therapies are often lacking. Nephrocytes are considered to be part of the... 
Podocyte | Endocytosis | Drosophila | Glomerular disease | Renal disease | Garland cell | Nephrocyte | HEREDITARY MEGALOBLASTIC-ANEMIA | KIDNEY-DISEASE | PERICARDIAL CELLS | PROTEIN REABSORPTION | CONGENITAL NEPHROTIC SYNDROME | SLIT DIAPHRAGM | glomerular disease | renal disease | garland cell | podocyte | endocytosis | PEDIATRICS | MUTATIONS | MELANOGASTER | nephrocyte | Chronic kidney failure | Analysis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text A Brief Overview on IRM Function Across Evolution
by Helmstädter, Martin and Höhne, Martin and Huber, Tobias B
Journal of Neurogenetics, ISSN 0167-7063, 12/2014, Volume 28, Issue 3-4, pp. 264 - 269
Abstract The description of the Rst protein by Karl-Friedrich Fischbach and colleagues was a milestone in the discovery of the irre cell recognition module... 
IRM proteins | Neph1 | nephrin | nephrocytes | podocytes | Podocytes | Nephrin | Nephrocytes | IMMUNOGLOBULIN-LIKE PROTEIN | SLIT DIAPHRAGM | DROSOPHILA-MELANOGASTER | AXONAL PROJECTIONS | MYOBLAST FUSION | NEUROSCIENCES | CELL-DEATH | CHIASM-C-ROUGHEST | GENE | GENETICS & HEREDITY | IRREC-RST PROTEIN | Biological Evolution | Animals | Drosophila Proteins - genetics | Eye Proteins - genetics | Cell Adhesion Molecules, Neuronal - genetics | Drosophila - genetics
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Biallelic loss of function variants in PPP1R21 cause a neurodevelopmental syndrome with impaired endocytic function
by Rehman, Atteeq U and Najafi, Maryam and Kambouris, Marios and Al-Gazali, Lihadh and Makrythanasis, Periklis and Rad, Abolfazl and Bakey, Z and Wu, K.M and Yang, Yaping and Schmidts, M
Human Mutation, ISSN 1059-7794, 2019, Volume 40, Issue 3, pp. 267 - 280
Next‐generation sequencing (NGS) has been instrumental in solving the genetic basis of rare inherited diseases, especially neurodevelopmental syndromes.... 
early endosome | endo‐lysosome | storage disease | neurodevelopmental syndrome | PPP1R21 | PP1 | RAB5 | GENETICS & HEREDITY | endo-lysosome | PP2A | MUTATIONS | SNX14 CAUSE | CATHEPSIN-D DEFICIENCY | Medicine, Experimental | Medical research | Nucleotide sequencing | Genomics | DNA sequencing | Brain | Transferrin | Phenotypes | Immunoprecipitation | Congenital defects | Genomes | Substantia alba | Neurodevelopmental disorders | Corpus callosum | Hereditary diseases | Storage diseases | Alleles | Proteomics | Fibroblasts | Localization | Index Medicus | Rapid Communications | Rapid Communication
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights