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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 06/2019, Volume 116, Issue 26, pp. 13067 - 13076
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3490 - 15
Altered pain sensations such as hyperalgesia and allodynia are characteristic features of various pain states, and remain difficult to treat. We have shown... 
CORD | ADENOSINE-DEAMINASE | RAT | MULTIDISCIPLINARY SCIENCES | RECEPTOR MESSENGER-RNA | CD26 | GLP-1 RECEPTOR | ILE-PRO-ILE | BINDING | MECHANICAL PAIN | Spinal cord | Pain perception | Peptidase | Narcotics | Astrocytes | Diabetes mellitus | Opioid receptors (type mu) | mRNA | Inflammation | Neuropathy | Microglia | Pain | Rodents | Dorsal horn
Journal Article
Journals of Gerontology - Series A Biological Sciences and Medical Sciences, ISSN 1079-5006, 2015, Volume 70, Issue 6, pp. 665 - 674
Aging impairs angiogenic capacity of cerebromicrovascular endothelial cells (CMVECs) promoting microvascular rarefaction, but the underlying mechanisms remain... 
Senescence | Vasculardementia | Ischemia | Vascular cognitive impairment | Capillary density | INDUCED RETINAL LESION | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | STRESS-INDUCED APOPTOSIS | LUNG-CANCER CELLS | GERIATRICS & GERONTOLOGY | MESSENGER-RNA | VASOACTIVE INTESTINAL POLYPEPTIDE | IN-VIVO | GERONTOLOGY | LONG-TERM POTENTIATION | GROWTH-FACTOR | Reactive Oxygen Species - metabolism | Rats, Inbred F344 | Caspase 3 - metabolism | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Gene Knockdown Techniques | Vascular Endothelial Growth Factor Receptor-2 - genetics | Brain - blood supply | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Signal Transduction | Endothelial Cells - metabolism | Down-Regulation | Cells, Cultured | Rats | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Recombinant Proteins - pharmacology | Cell Adhesion | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Animals | Aging - physiology | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Endothelial Cells - pathology | Neovascularization, Physiologic | Apoptosis | Cell Movement | Rattus | Physiological aspects | Aging | Development and progression | Cells | Endothelium | Genotype & phenotype | Neuropeptides | Gerontology | Collagen | Cell adhesion & migration | Index Medicus | Abridged Index Medicus | Original
Journal Article
Journal of Analytical Methods in Chemistry, ISSN 2090-8865, 2015, Volume 2015, pp. 102125 - 10
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2016, Volume 173, Issue 2, pp. 279 - 291
Journal Article
Neuropeptides, ISSN 0143-4179, 10/2017, Volume 65, pp. 131 - 131
PN6047 is a novel compound designed for treatment of chronic pain. The compound is a biased selective delta opioid receptor agonist. 1. Potent in vivo effect... 
Chronic pain | Safety and security measures | Toxicology | Pain | Drug tolerance | Morphine | Pharmacology | Bioavailability | Product safety | Constipation | Opioid receptors (type delta)
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e108164 - e108164
Transient Receptor Potential Ankyrin 1 (TRPA1) channels are localized on sensory nerves and several non-neural cells, but data on their functional significance... 
INFLAMMATORY-BOWEL-DISEASE | GENE-RELATED PEPTIDE | ACID-INDUCED COLITIS | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | INTESTINAL POLYPEPTIDE VIP | VANILLOID CAPSAICIN RECEPTORS | SODIUM-INDUCED COLITIS | SUBSTANCE-P | SENSORY NEURONS | TNBS-INDUCED COLITIS | Up-Regulation | Gene Expression | Nerve Tissue Proteins - physiology | Humans | Neuropeptides - metabolism | DNA Primers | Nerve Tissue Proteins - genetics | Colon - metabolism | Mice, Knockout | Calcium Channels - physiology | Animals | Colitis - physiopathology | Transient Receptor Potential Channels - genetics | Base Sequence | TRPA1 Cation Channel | Colitis - metabolism | Polymerase Chain Reaction | Transient Receptor Potential Channels - physiology | Mice | Calcium Channels - genetics | Immunohistochemistry | Inflammatory bowel diseases | Motility | Peptides | Disease | Epithelial cells | Interleukin | Capsaicin receptors | Neuropeptides | mRNA | Macrophages | Medical schools | Transient receptor potential proteins | Receptors | Neurokinin | Intestine | Vasoactive agents | Rodents | Nerves | Sensory neurons | Ion channels | Colon | Localization | Drug therapy | Cytokines | Internal medicine | Substance P | Inflammation | Pharmacology | Ganglia | Pituitary adenylate cyclase-activating polypeptide | Inflammatory bowel disease | Dextran | Crohn's Disease | Brain research | Lymphocytes B | Neurokinin NK1 receptors | γ-Interferon | Pituitary | Interferon | Ankyrin | Chemokines | Ulcerative colitis | Index Medicus
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 15916 - 8
Journal Article
Endocrinology, ISSN 0013-7227, 10/2017, Volume 158, Issue 10, pp. 3249 - 3258
Sex differences exist in chronic pain pathologies, and gonadal estradiol (E2) alters the pain sensation. The nocisensor transient receptor potential vanilloid... 
FEMALE RATS | TEMPOROMANDIBULAR-JOINT | MECHANICAL HYPERALGESIA | IN-VIVO | ENDOCRINOLOGY & METABOLISM | DORSAL-ROOT GANGLIA | PRIMARY SENSORY NEURONS | SEX-DIFFERENCES | TRPV1 RECEPTORS | OVARIECTOMIZED RATS | ESTROGEN-RECEPTOR | Gene Expression - drug effects | Capsaicin - pharmacology | Mechanoreceptors - physiology | Nociceptors - physiology | Proestrus - physiology | RNA, Messenger - analysis | Male | TRPV Cation Channels - drug effects | Sensory Receptor Cells - physiology | Female | Estradiol - pharmacology | TRPV Cation Channels - physiology | Ovariectomy | Mice, Inbred C57BL | Cells, Cultured | Drug Tolerance | Hot Temperature | Sex Characteristics | TRPV Cation Channels - genetics | Mice, Knockout | Up-Regulation - drug effects | Animals | Mechanoreceptors - drug effects | Pain - physiopathology | Estrus - physiology | Mice | Nociceptors - drug effects | Sensory Receptor Cells - chemistry | Capsaicin | Capsaicin receptors | Estrus cycle | Estradiol | Transient receptor potential proteins | Pain | Rodents | Gender aspects | Sensory neurons | TrkA protein | TrkA receptors | Pretreatment | Pain sensitivity | Pain perception | Estrus | Desensitization | Thresholds | Incubation | Neurons | Tropomyosin | Sex differences | Gene expression | Sex hormones | Ribonucleic acids | In vivo methods and tests | Receptor mechanisms | Index Medicus | Abridged Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2016, Volume 173, Issue 2, pp. 279 - 291
Journal Article