Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 1772 - 1772
Introduction: While the molecular target of immunomodulators such as pomalidomide (POM) and lenalidomide (LEN) has been identified, the mechanisms underlying...
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3070 - 3070
Introduction: Recent advancements in the treatment of multiple myeloma (MM) have centered on engaging the immune system to target multiple myeloma cells....
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3061 - 3061
Introduction: High-risk multiple myeloma can be defined by the presence of specific cytogenetic abnormalities (structural) or by characteristic changes in bone...
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2012, Volume 366, Issue 21, pp. 1987 - 1997
This trial assessed the utility of preoperative urodynamic testing in women with uncomplicated stress–predominant urinary incontinence. Women having office...
WOMEN | MEDICINE, GENERAL & INTERNAL | PELVIC ORGAN PROLAPSE | STANDARDIZATION | BURCH COLPOSUSPENSION | GUIDELINES | VALIDATION | TERMINOLOGY | HEALTH | DYSFUNCTION | URINARY-INCONTINENCE | Severity of Illness Index | Urologic Surgical Procedures | Office Visits | Humans | Middle Aged | Treatment Outcome | Urinary Incontinence, Stress - classification | Urinary Incontinence, Stress - physiopathology | Urinary Incontinence, Stress - diagnosis | Urodynamics | Intention to Treat Analysis | Female | Urinary Incontinence, Stress - surgery | Women | Care and treatment | Surgery | Diagnosis, Surgical | Health aspects | Methods | Urinary stress incontinence | Urinary organs | Research | Preoperative care | Patient outcomes | Surgical outcomes | Studies | Urinary incontinence | Diabetes mellitus | Older people | Bladder | Diagnosis | Patients | Quality of life
WOMEN | MEDICINE, GENERAL & INTERNAL | PELVIC ORGAN PROLAPSE | STANDARDIZATION | BURCH COLPOSUSPENSION | GUIDELINES | VALIDATION | TERMINOLOGY | HEALTH | DYSFUNCTION | URINARY-INCONTINENCE | Severity of Illness Index | Urologic Surgical Procedures | Office Visits | Humans | Middle Aged | Treatment Outcome | Urinary Incontinence, Stress - classification | Urinary Incontinence, Stress - physiopathology | Urinary Incontinence, Stress - diagnosis | Urodynamics | Intention to Treat Analysis | Female | Urinary Incontinence, Stress - surgery | Women | Care and treatment | Surgery | Diagnosis, Surgical | Health aspects | Methods | Urinary stress incontinence | Urinary organs | Research | Preoperative care | Patient outcomes | Surgical outcomes | Studies | Urinary incontinence | Diabetes mellitus | Older people | Bladder | Diagnosis | Patients | Quality of life
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 2928 - 2928
Abstract Abstract 2928 Multiple myeloma (MM) is caused by the clonal expansion of malignant plasma cells (PCs) producing high levels of monoclonal...
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2007, Volume 356, Issue 21, pp. 2143 - 2155
This multicenter, randomized clinical trial compared two surgical procedures — the Burch colposuspension and the autologous fascial pubovaginal sling — in...
UNITED-STATES | SURGERY | DEFINITION | WOMEN | MEDICINE, GENERAL & INTERNAL | STANDARDIZATION | IMPACT | FOLLOW-UP | TERMINOLOGY | INTERNATIONAL CONTINENCE SOCIETY | DYSFUNCTION | Reoperation | Urinary Retention - etiology | Humans | Middle Aged | Postoperative Complications - epidemiology | Urinary Retention - epidemiology | Patient Satisfaction | Urinary Incontinence, Urge - epidemiology | Urinary Tract Infections - epidemiology | Treatment Failure | Urinary Tract Infections - etiology | Female | Urinary Incontinence, Urge - etiology | Urinary Incontinence, Stress - surgery | Urologic Surgical Procedures - methods | Care and treatment | Usage | Research | Surgery | Urinary stress incontinence | Urinary organs | Urinary incontinence | Medical research
UNITED-STATES | SURGERY | DEFINITION | WOMEN | MEDICINE, GENERAL & INTERNAL | STANDARDIZATION | IMPACT | FOLLOW-UP | TERMINOLOGY | INTERNATIONAL CONTINENCE SOCIETY | DYSFUNCTION | Reoperation | Urinary Retention - etiology | Humans | Middle Aged | Postoperative Complications - epidemiology | Urinary Retention - epidemiology | Patient Satisfaction | Urinary Incontinence, Urge - epidemiology | Urinary Tract Infections - epidemiology | Treatment Failure | Urinary Tract Infections - etiology | Female | Urinary Incontinence, Urge - etiology | Urinary Incontinence, Stress - surgery | Urologic Surgical Procedures - methods | Care and treatment | Usage | Research | Surgery | Urinary stress incontinence | Urinary organs | Urinary incontinence | Medical research
Journal Article
Blood, ISSN 0006-4971, 11/2011, Volume 118, Issue 21, pp. 470 - 470
Abstract Abstract 470 Multiple myeloma (MM) is an incurable and fatal neoplasm characterized by the accumulation of clonal plasma cells (PC) that results in...
Journal Article
Cell, ISSN 0092-8674, 04/2018, Volume 173, Issue 2, pp. 355 - 370.e14
We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389...
cancer predisposition | LOH | variant pathogenicity | germline and somatic genomes | GENOMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GUIDELINES | SITES | RISK | MUTATIONS | BRCA1 | DISCOVERY | CELL BIOLOGY | Genetic Predisposition to Disease | Gene Frequency | Humans | Databases, Genetic | Genotype | Mutation, Missense | DNA Copy Number Variations | Loss of Heterozygosity - genetics | Proto-Oncogene Proteins c-met - genetics | Neoplasms - genetics | Gene Deletion | Tumor Suppressor Proteins - genetics | Germ-Line Mutation | Germ Cells - cytology | Polymorphism, Single Nucleotide | Germ Cells - metabolism | Neoplasms - pathology | Proto-Oncogene Proteins c-ret - genetics | Cancer predisposition
cancer predisposition | LOH | variant pathogenicity | germline and somatic genomes | GENOMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GUIDELINES | SITES | RISK | MUTATIONS | BRCA1 | DISCOVERY | CELL BIOLOGY | Genetic Predisposition to Disease | Gene Frequency | Humans | Databases, Genetic | Genotype | Mutation, Missense | DNA Copy Number Variations | Loss of Heterozygosity - genetics | Proto-Oncogene Proteins c-met - genetics | Neoplasms - genetics | Gene Deletion | Tumor Suppressor Proteins - genetics | Germ-Line Mutation | Germ Cells - cytology | Polymorphism, Single Nucleotide | Germ Cells - metabolism | Neoplasms - pathology | Proto-Oncogene Proteins c-ret - genetics | Cancer predisposition
Journal Article
Blood, ISSN 0006-4971, 11/2009, Volume 114, Issue 22, pp. 2817 - 2817
Abstract Abstract 2817 Poster Board II-793 Abnormal plasma cells (PC) present in patients with multiple myeloma (MM) and its precursor condition, monoclonal...
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4832 - 13
The gut microbiota has been causally linked to cancer, yet how intestinal microbes influence progression of extramucosal tumors is poorly understood. Here we...
ACTIVATION | MEPOLIZUMAB | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | MOUSE MODEL | GROWTH | DISEASE | IL-17 | MICE | SUPPRESSION | PROMOTES | Eosinophils - metabolism | Bone Marrow - immunology | Humans | Mice, Inbred C57BL | Interleukin-17 - immunology | Interleukin-17 - genetics | Mice, Transgenic | Multiple Myeloma - immunology | Multiple Myeloma - metabolism | Eosinophils - immunology | Disease Progression | Mice, Knockout | Cell Movement - immunology | Cell Differentiation - immunology | Interleukin-17 - metabolism | Multiple Myeloma - pathology | Prevotella - immunology | Animals | Th17 Cells - metabolism | Bone Marrow - metabolism | Th17 Cells - immunology | Gastrointestinal Microbiome - immunology | Phosphorylation | Interleukin | Helper cells | Multiple myeloma | Microbiomes | Antibodies | Paracrine signalling | Innate immunity | Lymphocytes T | Myc protein | Immunity | Synergism | Microbiota | Interleukin 5 | Intestine | Smoldering | Bone marrow | Digestive tract | Digestive system | Leukocytes (eosinophilic) | Transgenic mice | Stat3 protein | Interleukin 17 | Plasma cells | Mice | Cancer | Tumors | Eosinophils
ACTIVATION | MEPOLIZUMAB | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | MOUSE MODEL | GROWTH | DISEASE | IL-17 | MICE | SUPPRESSION | PROMOTES | Eosinophils - metabolism | Bone Marrow - immunology | Humans | Mice, Inbred C57BL | Interleukin-17 - immunology | Interleukin-17 - genetics | Mice, Transgenic | Multiple Myeloma - immunology | Multiple Myeloma - metabolism | Eosinophils - immunology | Disease Progression | Mice, Knockout | Cell Movement - immunology | Cell Differentiation - immunology | Interleukin-17 - metabolism | Multiple Myeloma - pathology | Prevotella - immunology | Animals | Th17 Cells - metabolism | Bone Marrow - metabolism | Th17 Cells - immunology | Gastrointestinal Microbiome - immunology | Phosphorylation | Interleukin | Helper cells | Multiple myeloma | Microbiomes | Antibodies | Paracrine signalling | Innate immunity | Lymphocytes T | Myc protein | Immunity | Synergism | Microbiota | Interleukin 5 | Intestine | Smoldering | Bone marrow | Digestive tract | Digestive system | Leukocytes (eosinophilic) | Transgenic mice | Stat3 protein | Interleukin 17 | Plasma cells | Mice | Cancer | Tumors | Eosinophils
Journal Article
Blood, ISSN 0006-4971, 10/2005, Volume 106, Issue 8, pp. 2837 - 2840
Fluorescence in situ hybridization (FISH) is more sensitive than conventional cytogenetics for recognizing chromosomal changes. Several FISH-detected...
MULTIPLE-MYELOMA | TRANSLOCATION | MMSET | T(4/14) | T(11/14) | HEMATOLOGY | FGFR3 | EXPRESSION | CHEMOTHERAPY | MORPHOLOGY | Prognosis | Chromosomes, Human - genetics | Humans | Middle Aged | In Situ Hybridization, Fluorescence | Male | Survival Rate | Treatment Outcome | Disease Progression | Tumor Suppressor Protein p53 - genetics | Multiple Myeloma - drug therapy | Adult | Female | Aged | Multiple Myeloma - genetics | Translocation, Genetic - genetics | Neoplasia
MULTIPLE-MYELOMA | TRANSLOCATION | MMSET | T(4/14) | T(11/14) | HEMATOLOGY | FGFR3 | EXPRESSION | CHEMOTHERAPY | MORPHOLOGY | Prognosis | Chromosomes, Human - genetics | Humans | Middle Aged | In Situ Hybridization, Fluorescence | Male | Survival Rate | Treatment Outcome | Disease Progression | Tumor Suppressor Protein p53 - genetics | Multiple Myeloma - drug therapy | Adult | Female | Aged | Multiple Myeloma - genetics | Translocation, Genetic - genetics | Neoplasia
Journal Article
Blood, ISSN 0006-4971, 06/2003, Volume 101, Issue 11, pp. 4569 - 4575
Nonrandom recurrent chromosomal abnormalities are ubiquitous in multiple myeloma (MM) and include, among others, translocations of the immunoglobulin heavy...
MULTIPLE-MYELOMA | CYTOGENETIC ABNORMALITIES | T(11/14)(Q13,Q32) | INTERPHASE FISH | TRANSLOCATIONS | PROGNOSIS | HEAVY-CHAIN GENE | CHROMOSOME-13 ABNORMALITIES | UNDETERMINED SIGNIFICANCE | MONOCLONAL GAMMOPATHY | HEMATOLOGY | Chromosome Deletion | Recurrence | Translocation, Genetic | Prognosis | Follow-Up Studies | Multiple Myeloma - diagnosis | Multiple Myeloma - mortality | Humans | Middle Aged | In Situ Hybridization, Fluorescence | Male | Chromosome Aberrations | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Immunoglobulin Heavy Chains - genetics | Multiple Myeloma - genetics
MULTIPLE-MYELOMA | CYTOGENETIC ABNORMALITIES | T(11/14)(Q13,Q32) | INTERPHASE FISH | TRANSLOCATIONS | PROGNOSIS | HEAVY-CHAIN GENE | CHROMOSOME-13 ABNORMALITIES | UNDETERMINED SIGNIFICANCE | MONOCLONAL GAMMOPATHY | HEMATOLOGY | Chromosome Deletion | Recurrence | Translocation, Genetic | Prognosis | Follow-Up Studies | Multiple Myeloma - diagnosis | Multiple Myeloma - mortality | Humans | Middle Aged | In Situ Hybridization, Fluorescence | Male | Chromosome Aberrations | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Immunoglobulin Heavy Chains - genetics | Multiple Myeloma - genetics
Journal Article
Blood, ISSN 0006-4971, 05/2002, Volume 99, Issue 10, pp. 3735 - 3741
The t(11;14)(q13;q32) results In up-regulation of cyclin D1 and is the most common translocation detected in multiple myeloma, where it is also associated with...
MULTIPLE-MYELOMA | MANTLE CELL LYMPHOMA | TRANSLOCATIONS | IN-SITU HYBRIDIZATION | CYCLIN D1 PROTEIN | UNDETERMINED SIGNIFICANCE | MONOCLONAL GAMMOPATHY | SWITCH REGIONS | HEMATOLOGY | EXPRESSION | CLINICAL-SIGNIFICANCE | Translocation, Genetic | Prognosis | Multiple Myeloma - diagnosis | Multiple Myeloma - mortality | Humans | Middle Aged | In Situ Hybridization, Fluorescence | Male | Genes, Immunoglobulin | Multiple Myeloma - drug therapy | Ploidies | Chromosome Aberrations | Survival Analysis | Adult | Chromosomes, Human, Pair 14 | Female | Aged | Chromosomes, Human, Pair 11 | Multiple Myeloma - genetics | Cohort Studies
MULTIPLE-MYELOMA | MANTLE CELL LYMPHOMA | TRANSLOCATIONS | IN-SITU HYBRIDIZATION | CYCLIN D1 PROTEIN | UNDETERMINED SIGNIFICANCE | MONOCLONAL GAMMOPATHY | SWITCH REGIONS | HEMATOLOGY | EXPRESSION | CLINICAL-SIGNIFICANCE | Translocation, Genetic | Prognosis | Multiple Myeloma - diagnosis | Multiple Myeloma - mortality | Humans | Middle Aged | In Situ Hybridization, Fluorescence | Male | Genes, Immunoglobulin | Multiple Myeloma - drug therapy | Ploidies | Chromosome Aberrations | Survival Analysis | Adult | Chromosomes, Human, Pair 14 | Female | Aged | Chromosomes, Human, Pair 11 | Multiple Myeloma - genetics | Cohort Studies
Journal Article