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Current Topics in Medicinal Chemistry, ISSN 1568-0266, 02/2007, Volume 7, Issue 4, pp. 391 - 403
Crystal structures of seven phosphodiesterase families (PDE1-5, 7, 9) show a conserved core catalytic domain that contains about 300 amino acids and fourteen... 
PDE4D5 splicing | cGMP | Metal binding | AMP binding residues | Catalytic domains | CGMP-SPECIFIC PHOSPHODIESTERASE | COMPLEX | CHEMISTRY, MEDICINAL | CAMP-SPECIFIC PHOSPHODIESTERASE | MECHANISM | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | CATALYTIC DOMAIN | BINDING | NEXT-GENERATION | PDE4 INHIBITORS | ROLIPRAM
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2007, Volume 104, Issue 45, pp. 17668 - 17673
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2007, Volume 104, Issue 14, pp. 5782 - 5787
Phosphodiesterases (PDEs) hydrolyze the second messengers cAMP and cGMP. It remains unknown how individual PDE families selectively recognize cAMP and cGMP.... 
Phosphates | Molecules | Hydrogen bonds | Active sites | Substrate specificity | Crystals | Atoms | Amino acids | Zinc | Crystal structure | Cyclic nucleotides cAMP and cGMP | INHIBITOR SELECTIVITY | MECHANISM | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | CRYSTAL-STRUCTURE | IMMUNOHISTOCHEMICAL LOCALIZATION | MULTIDISCIPLINARY SCIENCES | SUBCELLULAR-LOCALIZATION | CATALYTIC DOMAIN | cyclic nucleotides cAMP and cGMP | STRIATUM-ENRICHED PHOSPHODIESTERASE | PDE10A | crystal structure | DRUG DEVELOPMENT | Amino Acid Sequence | Catalytic Domain | Metals, Heavy - metabolism | Phosphoric Diester Hydrolases - metabolism | Models, Chemical | Humans | Glutamine - metabolism | Models, Molecular | Molecular Sequence Data | Substrate Specificity | Crystallography, X-Ray | Phosphoric Diester Hydrolases - genetics | Phosphoric Diester Hydrolases - chemistry | Sequence Homology, Amino Acid | Phosphoric Diester Hydrolases - isolation & purification | Cyclic GMP - metabolism | Hydrogen Bonding | Cations, Divalent - metabolism | Protein Conformation | Glutamine - chemistry | Kinetics | Mutation | Binding Sites | Cyclic AMP - metabolism | Cyclic adenylic acid | Research | Nucleotides | Phosphodiesterases | Structure | GLUTAMINE | SPECIFICITY | SUBSTRATES | CONFIGURATION | 08 HYDROGEN | CRYSTAL STRUCTURE | national synchrotron light source | MATERIALS SCIENCE | HYDROGEN | MUTANTS | ALIGNMENT | AMINO ACIDS | PHOSPHODIESTERASES | Biological Sciences
Journal Article
Cell, ISSN 0092-8674, 02/2012, Volume 148, Issue 3, pp. 421 - 433
Journal Article
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2002, Volume 99, Issue 19, pp. 12037 - 12042
Journal Article