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The Journal of Pathology, ISSN 0022-3417, 05/2019, Volume 248, Issue 1, pp. 3 - 5
Lung cancer is the leading cause of cancer mortality worldwide, with adenocarcinomas of the non‐small cell lung carcinoma (NSCLC) subtype accounting for the... 
lung cancer | CDKN1B | NSCLC | p27 | Kip1 | RhoB | Lung cancer, Non-small cell | Mice | Genetically modified organisms | Small cell lung carcinoma | Lung | Lung cancer | Lung carcinoma | Proteins | Pathology | Chemotherapy | Biomarkers | Cyclin-dependent kinase inhibitor p27 | Bioindicators | Tumorigenesis | Genetic modification | Cancer | Guanosinetriphosphatase | Tumors | Index Medicus | p27Kip1 | Invited | Invited Commentaries
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 04/2018, Volume 46, Issue 6, pp. 3198 - 3210
Abstract The CDK inhibitor p27Kip1 plays a central role in controlling cell proliferation and cell-cycle exit. p27Kip1 protein levels oscillate during... 
RNA and RNA-protein complexes
Journal Article
The Journal of pathology, ISSN 0022-3417, 05/2019, Volume 248, Issue 1, pp. 3 - 5
Lung cancer is the leading cause of cancer mortality worldwide, with adenocarcinomas of the non-small cell lung carcinoma (NSCLC) subtype accounting for the... 
Journal Article
Journal of Pathology, ISSN 0022-3417, 05/2019, Volume 248, Issue 1, p. 3
Lung cancer is the leading cause of cancer mortality worldwide, with adenocarcinomas of the non-small cell lung carcinoma (NSCLC) subtype accounting for the... 
Lung cancer, Non-small cell | Mice | Genetically modified organisms
Journal Article
Nature Cell Biology, ISSN 1465-7392, 12/2004, Volume 6, Issue 12, pp. 1153 - 1155
  The cell cycle regulator p27Kip1 must be degraded to permit cell division. Degradation is moderate in G1 phase, but is enhanced in S-phase. Now, a novel... 
Physiological aspects | Research | Ubiquitin-proteasome system | Proteolysis | Protein kinases
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2012, Volume 11, Issue 10, pp. 1910 - 1917
Extracellular mitogen signal transduction is initiated by ligand binding to specific receptors of target cells. This causes a cellular response that frequently... 
growth factors | p27 | cytokines | JAK2 | Kip1 | tyrosine kinases | JAK2V617F | cyclin-dependent kinase inhibitor | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Tyrosine kinases | Cyclin-dependent kinase inhibitor | Cytokines | Growth factors
Journal Article
Nature Cell Biology, ISSN 1465-7392, 12/2004, Volume 6, Issue 12, pp. 1153 - 1155
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 12/2002, Volume 16, Issue 23, pp. 3087 - 3099
p27(Kip1) restrains cell proliferation by binding to and inhibiting cyclin-dependent kinases. To investigate the mechanisms of p27 translational regulation, we... 
Translation | HuR | IRES | HuD | ELAV | P27 Kip1 | Cell division cycle | p27 kip1 | DEVELOPMENTAL BIOLOGY | MESSENGER-RNA STABILITY | CYCLIN-DEPENDENT KINASES | 5'-UNTRANSLATED REGION | INTERNAL RIBOSOME ENTRY | RICH ELEMENT | HUMAN P27(KIP1) | GENETICS & HEREDITY | translation | cell division cycle | CELL-CYCLE | GROWTH-FACTOR | EXPRESSION | p27 Kip1 | Research Paper
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 07/2002, Volume 1, Issue 4, pp. 243 - 247
No Abstract Available Key Words: Proteasome, Rad23, UBA-domain, Ubiquitin 
Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Posttranslational modification | Ubiquitin | SUMO | p53 | CELL BIOLOGY
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 128, Issue 2, pp. 281 - 294
The kinase inhibitor p27 regulates the G cell cycle phase. Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through... 
GROWTH-FACTOR RECEPTOR | FACTOR-BETA | HUMAN-BREAST-CANCER | DEPENDENT-KINASE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE | CDK INHIBITOR | MEDIATED G ARREST | ESTROGEN-RECEPTOR | C-SRC | CELL BIOLOGY | Phosphorylation | Protein Binding - genetics | Humans | Cyclin E - genetics | Antineoplastic Agents, Hormonal - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - therapy | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cell Nucleus - metabolism | Cell Transformation, Neoplastic - genetics | Cell Cycle Proteins - genetics | Female | Tamoxifen - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Antineoplastic Agents, Hormonal - pharmacology | Cell Cycle Proteins - metabolism | Cyclin-Dependent Kinase 2 - genetics | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Cell Transformation, Neoplastic - metabolism | Down-Regulation - genetics | Drug Resistance, Neoplasm - genetics | Tyrosine - metabolism | Breast Neoplasms - genetics | Proto-Oncogene Proteins pp60(c-src) - genetics | Proto-Oncogene Proteins pp60(c-src) - metabolism | Feedback, Physiological - genetics | Tamoxifen - pharmacology | Cell Line, Tumor | Carcinoma - genetics | Carcinoma - therapy | Carcinoma - metabolism | Cyclin E - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Index Medicus
Journal Article
Haematologica, ISSN 0390-6078, 08/2017, Volume 102, Issue 8, pp. 1378 - 1389
P27 (p27) can prevent cell proliferation by inactivating cyclin-dependent kinases. This function is impaired upon phosphorylation of p27 at tyrosine residue... 
Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cell Cycle Checkpoints | Phosphorylation | Tyrosine - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Tandem Repeat Sequences | Tumor Cells, Cultured | fms-Like Tyrosine Kinase 3 - metabolism | Protein Kinase Inhibitors - metabolism
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2009, Volume 11, Issue 4, pp. 377 - 379
To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that akt - a major kinase that coordinates... 
CYCLIN A-CDK2 | COMPLEX | UBIQUITIN LIGASE | PHOSPHORYLATION | DEGRADATION | S-PHASE KINASE | PROTEOLYSIS | CANCER | CELL BIOLOGY
Journal Article
Science, ISSN 0036-8075, 3/1996, Volume 271, Issue 5257, pp. 1861 - 1864
Cell cycle phase transitions in eukaryotic cells are driven by regulation of the activity of protein kinases known as cyclin-dependent kinases (Cdks). A broad... 
Diploidy | Cell growth | Messenger RNA | Half lives | Cell cycle | Cell lines | HeLa cells | Fibroblasts | Reports | Gene expression regulation | Cell cycle proteins | TUMOR | MULTIDISCIPLINARY SCIENCES | KINASES
Journal Article
Haematologica, ISSN 0390-6078, 07/2017, Volume 102, Issue 8, pp. 1378 - 1389
P27 Kip1 (p27) can prevent cell proliferation by inactivating cyclin-dependent kinases. This function is impaired upon phosphorylation of p27 at tyrosine... 
Index Medicus
Journal Article
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