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Journal of Clinical Investigation, ISSN 0021-9738, 07/2010, Volume 120, Issue 7, pp. 2406 - 2413
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 22, pp. 10208 - 10213
PIK3CA mutations are reported to be present in approximately 25% of breast cancer (BC), particularly the estrogen receptor—positive (ER+) and... 
Datasets | Health outcomes | Prognosis | Cell lines | Breast cancer | Signatures | Gene expression | Genetic mutation | Tumors | Cancer | Gene expression profiling | PI3 kinase | MOLECULAR SUBTYPES | TYROSINE PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PTEN | 3-KINASE MUTATIONS | AKT | EXPRESSION PROFILES | TUMORS | INSULIN-RECEPTOR | PATHWAY | POOR-PROGNOSIS | gene expression profiling | Neoplasms, Hormone-Dependent - metabolism | Receptors, Estrogen - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Multiprotein Complexes | Receptor, ErbB-2 - metabolism | DNA Primers - genetics | Gene Expression Profiling | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Neoplasms, Hormone-Dependent - genetics | Proteins | Antineoplastic Agents, Hormonal - therapeutic use | Base Sequence | Female | Sirolimus - therapeutic use | Signal Transduction | Breast Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - genetics | Transcription Factors - metabolism | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Antibiotics, Antineoplastic - therapeutic use | Tamoxifen - therapeutic use | Cell Line, Tumor | TOR Serine-Threonine Kinases | Mutation | Neoplasms, Hormone-Dependent - drug therapy | Receptors | Analysis | Estrogen | Genetic aspects | Research | Properties | Tamoxifen | Protein kinases | Health aspects | Genotype & phenotype | Oncology | Kinases | Clinical outcomes | Index Medicus | TOR protein | Transformation | Exons | Estrogens | AKT protein | Data processing | 1-Phosphatidylinositol 3-kinase | Signal transduction | Biological Sciences
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2007, Volume 12, Issue 4, pp. 395 - 402
A large-scale RNA interference screen to discover genes involved in trastuzumab resistance in breast cancer identified only as a modulator of drug sensitivity.... 
CELLCYCLE | CELLS | OVEREXPRESSION | PIK3CA MUTATIONS | INHIBITION | EFFICACY | ONCOLOGY | HERCEPTIN | MONOCLONAL-ANTIBODY | RECEPTORS | CHEMOTHERAPY | P53 | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Breast Neoplasms - metabolism | Patient Selection | Antibodies, Monoclonal, Humanized | Breast Neoplasms - enzymology | RNA Interference | Biomarkers, Tumor - metabolism | Adult | Female | Antineoplastic Agents - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | PTEN Phosphohydrolase - genetics | Transduction, Genetic | Antibodies, Monoclonal - pharmacology | Kaplan-Meier Estimate | PTEN Phosphohydrolase - metabolism | Gene Expression Profiling - methods | Treatment Outcome | Signal Transduction - genetics | Breast Neoplasms - drug therapy | Disease Progression | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Signal Transduction - drug effects | Cell Line, Tumor | Breast Neoplasms - mortality | Aged | Biomarkers, Tumor - genetics | Mutation | Trastuzumab | Cohort Studies | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 2724 - 2729
Journal Article
Cancer Microenvironment, ISSN 1875-2292, 4/2015, Volume 8, Issue 1, pp. 15 - 21
Angiogenesis or new vessel formation is essential for tumour growth and progression. Therefore, targeting angiogenesis has been an attractive strategy in the... 
Biochemistry, general | Biomedicine | Immunology | Immunomodulation | Antiangiogenesis | Cancer Research | Oncology | Biomedicine general | Tumour microenvironment | Cell Biology | Bevacizumab | Vascular endothelial growth factor | Immunoglobulin G | Angiogenesis inhibitors
Journal Article
Journal Article