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Investigational New Drugs, ISSN 0167-6997, 10/2018, Volume 36, Issue 5, pp. 895 - 902
Background DFP-10917 is a cytotoxic deoxycytidine analogue that causes DNA fragmentation, G2/M–phase arrest, and apoptosis. This agent has been shown to have... 
Medicine & Public Health | DFP-10917 | Colorectal cancer | Oncology | Phase II | Pharmacology/Toxicology | Chemotherapy-refractory | Pharmacogenomics | COMET ASSAY | NUCLEOSIDES | TUMOR | ANTITUMOR-ACTIVITY | CYTOSINE | TRIAL | NUCLEOTIDES | ONCOLOGY | IN-VIVO | PHARMACOLOGY & PHARMACY | Colorectal Neoplasms - genetics | Deoxycytidine - administration & dosage | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Anemia - chemically induced | Male | Fatigue - chemically induced | Antineoplastic Agents - administration & dosage | Disease-Free Survival | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Leukopenia - chemically induced | Adult | Deoxycytidine - adverse effects | Female | Aged | DNA Damage | Infusions, Intravenous | Deoxycytidine - analogs & derivatives | Pharmacogenetics | Chemotherapy | Genetic aspects | Research | Drug therapy | Cancer | Slopes | Intravenous administration | Toxicity | DNA damage | Colorectal carcinoma | Cytotoxicity | Comet assay | Anticancer properties | Confidence intervals | Infusion | DNA fragmentation | Safety | Intravenous infusion | Deoxyribonucleic acid--DNA | Neutropenia | Damage assessment | Bioassay | Leukopenia | Anemia | Bioassays | Fatigue | Pharmacology | Survival | Patients | Studies | Damage detection | Antitumor activity | Apoptosis | phase II | chemotherapy-refractory | colorectal cancer | pharmacogenomics
Journal Article
Oncogene, ISSN 0950-9232, 01/2003, Volume 22, Issue 3, pp. 319 - 329
Expression of vascular endothelial growth factor (VEGF), a key angiogenic protein, has been linked with pancreatic cancer progression. However, the molecular... 
Stat3 | Angiogenesis | Tumor | Metastasis | Pancreas | TRANSCRIPTION FACTORS | CELLS | FACTOR GENE-EXPRESSION | PERMEABILITY FACTOR | angiogenesis | CONSTITUTIVE ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC MYOCYTES | FACTOR MESSENGER-RNA | FACTOR-I | CELL BIOLOGY | ENHANCED EXPRESSION | ONCOLOGY | metastasis | tumor | pancreas | GENETICS & HEREDITY | UP-REGULATION | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Vascular Endothelial Growth Factors | Humans | Neovascularization, Pathologic | Pancreas - blood supply | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Adenocarcinoma - metabolism | Cell Nucleus - metabolism | Lymphokines - genetics | Genes, Dominant | Trans-Activators - genetics | Lymphokines - metabolism | Female | Adenocarcinoma - genetics | Tumor Cells, Cultured | Liver Neoplasms - secondary | Promoter Regions, Genetic | Signal Transduction | Down-Regulation | Pancreatic Neoplasms - pathology | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Pancreatic Neoplasms - genetics | DNA-Binding Proteins - genetics | Carcinogenicity Tests | Animals | Endothelial Growth Factors - genetics | Trans-Activators - metabolism | Mice | Mice, Inbred BALB C | STAT3 Transcription Factor
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 03/2006, Volume 24, Issue 7, pp. 1145 - 1151
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2016, Volume 34, Issue 15_suppl, pp. e15707 - e15707
Journal Article
Antimicrobial agents and chemotherapy, 07/2019, Volume 63, Issue 7
Endovascular infections caused by methicillin-resistant (MRSA) are a major health care concern, especially infective endocarditis (IE). Standard antimicrobial... 
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 04/2006, Volume 66, Issue 7, pp. 3802 - 3812
The epidermal growth factor receptor (EGFR) is considered an important therapeutic target in pancreatic cancer, but it is currently impossible to identify... 
LUNG-CANCER | SINGLE-AGENT | PHASE-II TRIAL | THERAPY | ONCOLOGY | METASTATIC BREAST-CANCER | KINASE | ERBB SIGNALING NETWORK | TUMOR-CELLS | EGF RECEPTOR | FACTOR-ALPHA
Journal Article
Investigational New Drugs, ISSN 0167-6997, 11/2004, Volume 22, Issue 4, pp. 459 - 466
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 07/2019, Volume 63, Issue 7
Journal Article