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1. Full Text Microglia actions in Alzheimer's disease
by Prokop, Stefan and Miller, Kelly R and Heppner, Frank L
Acta Neuropathologica, ISSN 0001-6322, 2013, Volume 126, Issue 4, pp. 461 - 477
  The identification of microglia-associated, neurological disease-causing mutations in patients, combined with studies in mouse models has highlighted... 
Activation | Alzheimer's disease | Phagocytosis | Cellular senescence | Microglia | Development and progression | Amyloid beta-protein
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2. Full Text Inhibition of IL-12/IL-23 signaling reduces Alzheimer's diseasea-like pathology and cognitive decline
by Vom Berg, Johannes and Prokop, Stefan and Miller, Kelly R and Obst, Juliane and Kälin, Roland E and Lopategui-Cabezas, Ileana and Wegner, Anja and Mair, Florian and Schipke, Carola G and Peters, Oliver and Winter, York and Becher, Burkhard and Heppner, Frank L
Nature Medicine, ISSN 1078-8956, 12/2012, Volume 18, Issue 12, pp. 1812 - 1819
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3. Full Text Immune attack: The role of inflammation in Alzheimer disease
by Heppner, Frank L and Ransohoff, Richard M and Becher, Burkhard
Nature Reviews Neuroscience, ISSN 1471-003X, 06/2015, Volume 16, Issue 6, pp. 358 - 372
The past two decades of research into the pathogenesis of Alzheimer disease (AD) have been driven largely by the amyloid hypothesis; the neuroinflammation that... 
NEURODEGENERATIVE DISEASE | MICROGLIAL ACTIVATION | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PROTEIN TRANSGENIC MICE | AMYLOID-BETA-PEPTIDE | IN-VIVO | AD MOUSE MODELS | CENTRAL-NERVOUS-SYSTEM | MILD COGNITIVE IMPAIRMENT | REVERSE DEFICITS | NEUROSCIENCES | Inflammation - pathology | Inflammation - immunology | Animals | Alzheimer Disease - immunology | Humans | Alzheimer Disease - pathology | Care and treatment | Analysis | Development and progression | Inflammation | Research | Alzheimer's disease | Health aspects | Immune system | Dementia
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4. Full Text Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP 3
by Houtman, Judith and Freitag, Kiara and Gimber, Niclas and Schmoranzer, Jan and Heppner, Frank L and Jendrach, Marina
The EMBO Journal, ISSN 0261-4189, 02/2019, Volume 38, Issue 4
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5. Full Text CNS myeloid cells critically regulate heat hyperalgesia.(central nervous system)
by Kalin, Stefanie and Miller, Kelly R and Kalin, Roland E and Jendrach, Marina and Witzel, Christian and Heppner, Frank L
Journal of Clinical Investigation, ISSN 0021-9738, 07/2018, Volume 128, Issue 7, p. 2774
Physiological aspects | Research | Gene expression | Central nervous system
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6. Full Text THERAPEUTIC OPPORTUNITIES FOR THE MODULATION OF MYELOID CELLS FOR THE TREATMENT OF ALZHEIMER’S DISEASE
by Heppner, Frank L
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2016, Volume 12, Issue 7, pp. P366 - P366
Neurology
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7. Full Text THERAPEUTIC OPPORTUNITIES FOR THE MODULATION OF MYELOID CELLS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
by Heppner, Frank L
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2016, Volume 12, Issue 7, p. P366
Drug therapy | Alzheimer's disease | Health aspects
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8. Full Text Rorγt + innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice
by Pantelyushin, Stanislav and Haak, Stefan and Ingold, Barbara and Kulig, Paulina and Heppner, Frank L and Navarini, Alexander A and Becher, Burkhard
Journal of Clinical Investigation, ISSN 0021-9738, 06/2012, Volume 122, Issue 6, pp. 2252 - 2256
Psoriasis is a common, relapsing inflammatory skin disease characterized by erythematous scaly plaques. Histological manifestations of psoriasis include... 
Adjuvants, Immunologic - pharmacology | Dendritic Cells - immunology | Humans | Interleukin-17 - immunology | Dendritic Cells - pathology | Receptors, Antigen, T-Cell, gamma-delta - genetics | Interleukins - genetics | Psoriasis - genetics | Psoriasis - pathology | Interleukins - immunology | T-Lymphocytes - pathology | Aminoquinolines - pharmacology | Macrophages - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Skin - pathology | Disease Models, Animal | Neutrophils - pathology | Skin - immunology | Psoriasis - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | Psoriasis - drug therapy | Macrophages - pathology | Neutrophils - immunology | Interleukin-17 - genetics | Receptors, Antigen, T-Cell, gamma-delta - immunology | Mice, Knockout | Animals | T-Lymphocytes - immunology | Mice | Administration, Topical | Brief Report
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9. Full Text High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia
by Baufeld, Caroline and Osterloh, Anja and Prokop, Stefan and Miller, Kelly R and Heppner, Frank L
Acta neuropathologica, 09/2016, Volume 132, Issue 3, p. 361
Diets high in fat (HFD) are known to cause an immune response in the periphery as well as the central nervous system. In peripheral adipose tissue, this immune... 
Microglia - metabolism | Animals | Central Nervous System - metabolism | Obesity - complications | Diet, High-Fat | Gliosis - metabolism | Mice, Inbred C57BL | Male | Neurons - metabolism | Animal Feed | Astrocytes - metabolism
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10. Full Text Microglia as Dynamic and Essential Components of the Amyloid Hypothesis
by Gandy, Sam and Heppner, Frank L
Neuron, ISSN 0896-6273, 05/2013, Volume 78, Issue 4, pp. 575 - 577
In this issue of , investigate the Alzheimer’s disease risk gene, CD33. AD brains have increased CD33 and CD33-positive microglia. Mice lacking CD33 have less... 
MICE | PATHOLOGY | VARIANTS | ONSET ALZHEIMERS-DISEASE | NEUROSCIENCES | Sialic Acid Binding Ig-like Lectin 3 - genetics | Microglia - metabolism | Animals | Alzheimer Disease - genetics | Humans | Amyloid beta-Peptides - metabolism | Alzheimer's disease | Amyloidosis | Amyloid beta-protein | Drugs | Studies | Pathology | Hypotheses | Neurotoxicity | Brain research | Neurodegeneration | Pathogenesis | Rodents | Immunotherapy | Alzheimers disease | Immune system
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11. Full Text Conserved size and periodicity of pyramidal patches in layer 2 of medial/caudal entorhinal cortex
: Comparative entorhinal pyramidal patches
by Naumann, Robert K and Ray, Saikat and Prokop, Stefan and Las, Liora and Heppner, Frank L and Brecht, Michael
Journal of Comparative Neurology, ISSN 0021-9967, 03/2016, Volume 524, Issue 4, pp. 783 - 806
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12. Full Text Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology
by Krabbe, Grietje and Halle, Annett and Matyash, Vitali and Rinnenthal, Jan L and Eom, Gina D and Bernhardt, Ulrike and Miller, Kelly R and Prokop, Stefan and Kettenmann, Helmut and Heppner, Frank L
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e60921
Microglial cells closely interact with senile plaques in Alzheimer's disease and acquire the morphological appearance of an activated phenotype. The... 
CLEARANCE | MAINTENANCE | PHAGOCYTOSIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DISEASE | A-BETA | SENESCENCE | PLAQUES | BRAIN | TRANSGENIC MICE | Plaque, Amyloid - pathology | Protein Structure, Secondary | Humans | Protein Multimerization | Male | Mice, Transgenic | Alzheimer Disease - pathology | Animals | Amyloid beta-Peptides - genetics | Microglia - pathology | Female | Spatio-Temporal Analysis | Mice | Amyloid beta-Peptides - chemistry | Mutation | Phagocytosis | Cell Movement | Disease Models, Animal | Genetically modified animals | Animal genetic engineering | Alzheimer's disease | Brain | Animal models | Senescence | Cytokines | Neuropathology | Brain slice preparation | Vaccination | Impairment | Experiments | Microglia | Studies | Pathology | Signal transduction | Phagocytes | Senile plaques | Microscopy | Transgenic animals | Rodents | Morphology | Microglial cells | β-Amyloid | Deposition
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13. Full Text Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice
by Wagner, Lisa K and Gilling, Kate E and Schormann, Eileen and Kloetzel, Peter M and Heppner, Frank L and Krüger, Elke and Prokop, Stefan
Acta neuropathologica communications, ISSN 2051-5960, 06/2017, Volume 5, Issue 1, p. 52
The immunoproteasome (iP) represents a specialized type of proteasomes, which plays an important role in the clearance of oxidant-damaged proteins under... 
Inflammation | Alzheimer’s disease | Immunoproteasome | Microglia | Proteasome | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | OLDER PERSONS | INTERFERON-GAMMA | MOUSE MODEL | UBIQUITIN PROTEASOME SYSTEM | NEUROPATHOLOGY | PROTEINS | Alzheimer's disease | NF-KAPPA-B | SUBUNIT | BRAINS | Humans | Brain - enzymology | Male | Cognitive Dysfunction - enzymology | Alzheimer Disease - pathology | Aging - immunology | Cognitive Dysfunction - immunology | Microglia - immunology | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Microglia - pathology | Female | Alzheimer Disease - immunology | Alzheimer Disease - psychology | Disease Models, Animal | Peptide Fragments - metabolism | Cytokines - metabolism | Cells, Cultured | Microglia - enzymology | Mice, Transgenic | Alzheimer Disease - enzymology | Cognitive Dysfunction - pathology | Aging - pathology | Proteasome Endopeptidase Complex - genetics | Proteasome Endopeptidase Complex - deficiency | Amyloid beta-Protein Precursor - genetics | Animals | Brain - pathology | Brain - immunology | Advertising executives | Interferon | Biological response modifiers | Proteins | Brain | Pathology | Disease | Cytokines | Neuropathology | Rodents | Cell cycle | Homeostasis | Mutation | Gene expression | Animal cognition
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14. Full Text The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
by Krasemann, Susanne and Madore, Charlotte and Cialic, Ron and Baufeld, Caroline and Calcagno, Narghes and El Fatimy, Rachid and Beckers, Lien and O’Loughlin, Elaine and Xu, Yang and Fanek, Zain and Greco, David J and Smith, Scott T and Tweet, George and Humulock, Zachary and Zrzavy, Tobias and Conde-Sanroman, Patricia and Gacias, Mar and Weng, Zhiping and Chen, Hao and Tjon, Emily and Mazaheri, Fargol and Hartmann, Kristin and Madi, Asaf and Ulrich, Jason D and Glatzel, Markus and Worthmann, Anna and Heeren, Joerg and Budnik, Bogdan and Lemere, Cynthia and Ikezu, Tsuneya and Heppner, Frank L and Litvak, Vladimir and Holtzman, David M and Lassmann, Hans and Weiner, Howard L and Ochando, Jordi and Haass, Christian and Butovsky, Oleg
Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Myeloid cells | Disease | Transcription | Neurodegenerative diseases | Genes | Homeostasis | Microglia | Neurological diseases | Proteins | Molecular modelling | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | β-Amyloid | Plaques | Phagocytosis | Apoptosis
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15. Full Text Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients (vol 7, 89, 2019)
Acta Neuropathologica Commun
ACTA NEUROPATHOLOGICA COMMUNICATIONS, ISSN 2051-5960, 08/2019, Volume 7, Issue 1
NEUROSCIENCES
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16. Full Text Novel γ‐sarcoglycan‐mutation affects cardiac function and N‐terminal dystrophin expression
by Schröder, Nicolas W.J and Grieben, Ulrike and Prokop, Stefan and Dekomien, Gabriele and Epplen, Jörg T and Heppner, Frank. L and Goebel, Hans H and Stenzel, Werner
Muscle & Nerve, ISSN 0148-639X, 01/2014, Volume 49, Issue 1, pp. 144 - 145
MUSCULAR-DYSTROPHY | COMPLEX | GLYCOPROTEIN | PROTEINS | NEUROSCIENCES | CLINICAL NEUROLOGY | Cardiomyopathy, Dilated - genetics | Sarcoglycans - genetics | Dystrophin - genetics | Biopsy | Humans | Child, Preschool | Cardiomyopathy, Dilated - diagnosis | Male | Muscle, Skeletal - metabolism | Muscle, Skeletal - pathology | Mutation - genetics | Dystrophin - metabolism
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17. Full Text IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
by Haak, Stefan and Croxford, Andrew L and Kreymborg, Katharina and Heppner, Frank L and Pouly, Sandrine and Becher, Burkhard and Waisman, Ari
Journal of Clinical Investigation, ISSN 0021-9738, 01/2009, Volume 119, Issue 1, pp. 61 - 69
The clear association of Th17 cells with autoimmune pathogenicity implicates Th17 cytokines as critical mediators of chronic autoimmune diseases such as EAE.... 
ENCEPHALOMYELITIS | MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | MULTIPLE-SCLEROSIS | INTERLEUKIN-17 FAMILY | IFN-GAMMA | RECEPTOR COMPLEX | CENTRAL-NERVOUS-SYSTEM | T-CELLS | TH17 CELLS | CUTTING EDGE | Interleukins | Physiological aspects | Development and progression | Research | Autoimmune diseases | T cells | Health aspects | Risk factors
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