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1. Full Text Immune attack: The role of inflammation in Alzheimer disease
by Heppner, Frank L and Ransohoff, Richard M and Becher, Burkhard
Nature reviews. Neuroscience, ISSN 1471-003X, 06/2015, Volume 16, Issue 6, pp. 358 - 372
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Inflammation - pathology | Inflammation - immunology | Animals | Alzheimer Disease - immunology | Humans | Alzheimer Disease - pathology | Care and treatment | Analysis | Development and progression | Inflammation | Research | Alzheimer's disease | Health aspects | Immune system | Dementia | Index Medicus
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2. Full Text DNA methylation-based classification of central nervous system tumours
by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Aiana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Henik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Roiguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, J. rgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Aneas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and ever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Guun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature (London), ISSN 0028-0836, 2018, Volume 555, Issue 7697, pp. 469 - 474
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Central Nervous System Neoplasms - classification | Reproducibility of Results | Central Nervous System Neoplasms - genetics | Humans | Middle Aged | Child, Preschool | Infant | Male | Unsupervised Machine Learning | Young Adult | Central Nervous System Neoplasms - pathology | DNA Methylation | Adolescent | Aged, 80 and over | Adult | Female | Aged | Central Nervous System Neoplasms - diagnosis | Child | Cohort Studies | Genetic aspects | Nucleotide sequencing | Diagnosis | Methylation | Observations | Methods | DNA sequencing | Tumors | Cancer | Analysis | DNA | Machine learning | Central nervous system | Classifiers | Brain cancer | Standardization | Clinical trials | Probability | Data processing | Nervous system | Genomes | Gene expression | Generalized linear models | Learning algorithms | Classification | Diagnostic software | DNA methylation | Diagnostic systems | Bioinformatics | Deoxyribonucleic acid--DNA | Index Medicus
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3. Full Text Microglia as Dynamic and Essential Components of the Amyloid Hypothesis
by Gandy, Sam and Heppner, Frank L
Neuron (Cambridge, Mass.), ISSN 0896-6273, 05/2013, Volume 78, Issue 4, pp. 575 - 577
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Sialic Acid Binding Ig-like Lectin 3 - genetics | Microglia - metabolism | Animals | Alzheimer Disease - genetics | Humans | Amyloid beta-Peptides - metabolism | Alzheimer's disease | Amyloidosis | Amyloid beta-protein | Drugs | Studies | Pathology | Hypotheses | Neurotoxicity | Brain research | Neurodegeneration | Pathogenesis | Rodents | Immunotherapy | Alzheimers disease | Immune system | Index Medicus
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4. Full Text Microglia actions in Alzheimer’s disease
by Prokop, Stefan and Miller, Kelly R and Heppner, Frank L
Acta neuropathologica, ISSN 0001-6322, 10/2013, Volume 126, Issue 4, pp. 461 - 477
Pathology | Neurosciences | Medicine & Public Health | Alzheimer’s disease | Cellular senescence | Activation | Phagocytosis | Microglia | Alzheimer's disease | Macrophage Activation - physiology | Microglia - metabolism | Humans | Myeloid Cells - physiology | Cellular Senescence - physiology | Alzheimer Disease - pathology | Phenotype | Animals | Microglia - immunology | Microglia - physiology | Alzheimer Vaccines - therapeutic use | Alzheimer Disease - metabolism | Amyloid beta-Peptides - immunology | Alzheimer Disease - genetics | Alzheimer Disease - immunology | Development and progression | Amyloid beta-protein | Index Medicus
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5. Full Text Neuroprotective function for ramified microglia in hippocampal excitotoxicity
by Vinet, Jonathan and van Weering, Hilmar R. J and Heinrich, Annette and Kaelin, Roland E and Wegner, Anja and Brouwer, Nieske and Heppner, Frank L and van Rooijen, Nico and Boddeke, Henikus W. G. M and Biber, Knut
Journal of neuroinflammation, ISSN 1742-2094, 01/2012, Volume 9, Issue 1, pp. 27 - 27
KAINATE NEUROTOXICITY | Organotypic hippocampal slice cultures | UMCG Approved | Microglia | CELL-DEATH | FACTOR-ALPHA | SLICE CULTURES | Ganciclovir | TUMOR-NECROSIS-FACTOR | Excitotoxicity | NEURONAL DEATH | NMDA | NITRIC-OXIDE | RAT HIPPOCAMPUS | DENTATE GYRUS | Clodronate | NERVOUS-TISSUE | Nmda | Neurosciences | Immunology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Microglia - cytology | Microglia - drug effects | Mice, Inbred C57BL | Mice, Transgenic | Neurotoxins - toxicity | Phosphopyruvate Hydratase - metabolism | Hippocampus - drug effects | Glial Fibrillary Acidic Protein - metabolism | Hippocampus - cytology | Nerve Degeneration - pathology | Dose-Response Relationship, Drug | CD11b Antigen - genetics | Animals | Microglia - physiology | Clodronic Acid - toxicity | Mice | Cell Death - drug effects | Neurons - drug effects | Organ Culture Techniques | N-Methylaspartate - toxicity | Nerve Degeneration - therapy | Prevention | Methyl aspartate | Complications and side effects | Cell culture | Nervous system | Degeneration | Research | Methods | Proteins | Neurology | Medical research | Brain | Nitric oxide | Colleges & universities | Experiments | Manuscripts | Index Medicus
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6. Full Text An unconventional role for miRNA: Let-7 activates Toll-like receptor 7 and causes neurodegeneration
by Lehmann, Sabrina M and Krüger, Christina and Park, Boyoun and Derkow, Katja and Rosenberger, Karen and Baumgart, Jan and Trimbuch, Thorsten and Eom, Gina and Hinz, Michael and Kaul, David and Habbel, Piet and Kälin, Roland and Franzoni, Eleonora and Rybak, Agnieszka and Nguyen, Duong and Veh, Rüdiger and Ninnemann, Olaf and Peters, Oliver and Nitsch, Robert and Heppner, Frank L and Golenbock, Douglas and Schott, Eckart and Ploegh, Hidde L and Wulczyn, F Gregory and Lehnardt, Seija
Nature neuroscience, ISSN 1097-6256, 06/2012, Volume 15, Issue 6, pp. 827 - 835
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Toll-Like Receptor 7 - metabolism | Membrane Glycoproteins - metabolism | Humans | Mice, Inbred C57BL | MicroRNAs - metabolism | Alzheimer Disease - cerebrospinal fluid | Nerve Degeneration - metabolism | Mice, Knockout | Brain - metabolism | Microscopy, Confocal | Animals | In Situ Hybridization | HEK293 Cells | Signal Transduction - physiology | Electrophoretic Mobility Shift Assay | Mice | Neurons - metabolism | Apoptosis - physiology | Alzheimer Disease - genetics | Real-Time Polymerase Chain Reaction | MicroRNA | Physiological aspects | Toll-like receptors | Nervous system | Degeneration | Genetic aspects | Research | Risk factors | Index Medicus
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7. Full Text The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
by Krasemann, Susanne and Madore, Charlotte and Cialic, Ron and Baufeld, Caroline and Calcagno, Narghes and El Fatimy, Rachid and Beckers, Lien and O’Loughlin, Elaine and Xu, Yang and Fanek, Zain and Greco, David J and Smith, Scott T and Tweet, George and Humulock, Zachary and Zrzavy, Tobias and Conde-Sanroman, Patricia and Gacias, Mar and Weng, Zhiping and Chen, Hao and Tjon, Emily and Mazaheri, Fargol and Hartmann, Kristin and Madi, Asaf and Ulrich, Jason D and Glatzel, Markus and Worthmann, Anna and Heeren, Joerg and Budnik, Bogdan and Lemere, Cynthia and Ikezu, Tsuneya and Heppner, Frank L and Litvak, Vladimir and Holtzman, David M and Lassmann, Hans and Weiner, Howard L and Ochando, Jordi and Haass, Christian and Butovsky, Oleg
Immunity (Cambridge, Mass.), ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | Life Sciences & Biomedicine | Immunology | Science & Technology | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Myeloid cells | Disease | Transcription | Neurodegenerative diseases | Genes | Homeostasis | Microglia | Neurological diseases | Proteins | Molecular modelling | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | β-Amyloid | Plaques | Phagocytosis | Apoptosis | Index Medicus
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