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1. Full Text Management of organ motion in scanned ion beam therapy
by Bert, Christoph and Herfarth, Klaus
Radiation Oncology, ISSN 1748-717X, 11/2017, Volume 12, Issue 1, pp. 170 - 6
Scanned ion beam therapy has special demands for treatment of intra-fractionally moving tumors such as lesions in lung or liver. Interplay effects between beam... 
Beam scanning | Organ motion | Lon beam therapy | CARDIAC-ARRHYTHMIA ABLATION | FEASIBILITY | PROTON THERAPY | ADAPTIVE RADIOTHERAPY | PARTICLE BEAMS | ATRIAL-FIBRILLATION | CATHETER-FREE ABLATION | ONCOLOGY | OPTIMIZATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | INVASIVE BLADDER-CANCER | TARGET MOTION | Care and treatment | Usage | Arrhythmia | Radiotherapy | Ablation (Vaporization technology) | Tumors | Heart | Cardiac arrhythmia | Compression | Liver | Feasibility studies | Radiation | Radiation therapy | Management | Patients | Carbon | Catheters | Optimization | Ion beams | Mitigation | Quality assurance | Lungs | Planning | Charged particles | Cardiology | Lesions | Gating
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2. Full Text Carbon ion reirradiaton for patients with malignant gliomas: Toxicity and first results of the prospective dose-escalation phase I/II CINDERELLA trial
by Combs, Stephanie E and Bernhardt, Denise and Adeberg, Sebastian and Herfarth, Klaus K and Unterberg, Andreas and Wick, Wolfgang and Debus, Juergen and Rieken, Stefan
Journal of Clinical Oncology, ISSN 0732-183X, 05/2019, Volume 37, Issue 15_suppl, pp. 2059 - 2059
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3. Full Text PET and SPECT for Detection of Tumor Progression in Irradiated Low-Grade Astrocytoma: A Receiver-Operating-Characteristic Analysis
by Henze, Marcus and Mohammed, Ashour and Schlemmer, Heinz P and Herfarth, Klaus K and Hoffner, Simone and Haufe, Sabine and Mier, Walter and Eisenhut, Michael and Debus, Jurgen and Haberkorn, Uwe
The Journal of Nuclear Medicine, ISSN 0161-5505, 04/2004, Volume 45, Issue 4, pp. 579 - 586
Differentiation between tumor progression and radiation necrosis is one of the most difficult tasks in oncologic neuroradiology. Functional imaging of tumor... 
I-iodo-α-methyl-L-tyrosine | Tc(I)-hexakis(2-methoxyisobutylisonitrile) | Radiotherapy | F-FDG | Astrocytoma | PRIMARY BRAIN-TUMORS | ALPHA-METHYL TYROSINE | RECURRENT GLIOMAS | FOLLOW-UP | 3-I-123-iodo-alpha-methyl-L-tyrosine | TC-99M SESTAMIBI | RADIATION-THERAPY | IODINE-123-ALPHA-METHYL TYROSINE | Tc-99m(I)-hexakis(2-methoxyisobutylisonitrile) | POSITRON-EMISSION-TOMOGRAPHY | astrocytoma | F-18-FDG | radiotherapy | TC-99M-SESTAMIBI | DIFFERENTIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Astrocytoma - radiotherapy | Methyltyrosines | Predictive Value of Tests | Tomography, Emission-Computed, Single-Photon - methods | Neoplasm Invasiveness - diagnosis | Humans | Neoplasm Invasiveness - prevention & control | Neoplasm Invasiveness - diagnostic imaging | Male | Treatment Outcome | Neoplasm Recurrence, Local - diagnosis | Tomography, Emission-Computed - methods | Postoperative Care - methods | Astrocytoma - diagnostic imaging | Neoplasm Recurrence, Local - diagnostic imaging | Adult | Female | Fluorodeoxyglucose F18 | ROC Curve | Technetium Tc 99m Sestamibi | Radiopharmaceuticals | Astrocytoma - diagnosis
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4. Full Text High control rate in patients with chondrosarcoma of the skull base after carbon ion therapy: First report of long‐term results
by Uhl, Matthias and Mattke, Matthias and Welzel, Thomas and Oelmann, Jan and Habl, Gregor and Jensen, Alexandra D and Ellerbrock, Malte and Haberer, Thomas and Herfarth, Klaus K and Debus, Jürgen
Cancer, ISSN 0008-543X, 05/2014, Volume 120, Issue 10, pp. 1579 - 1585
BACKGROUND The current study was performed to evaluate the safety and effectiveness of irradiation with carbon ions using raster scanning as well as prognostic... 
carbon ion | proton therapy | chondrosarcoma | radiotherapy | heavy ion | particle therapy | skull base | Radiotherapy Dosage | Neoplasm Recurrence, Local - radiotherapy | Chondrosarcoma - diagnosis | Follow-Up Studies | Chondrosarcoma - mortality | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Treatment Outcome | Skull Base Neoplasms - mortality | Germany - epidemiology | Skull Base Neoplasms - diagnosis | Young Adult | Heavy Ion Radiotherapy | Skull Base Neoplasms - radiotherapy | Adolescent | Adult | Female | Surveys and Questionnaires | Aged | Neoplasm Recurrence, Local - epidemiology | Chondrosarcoma - radiotherapy | Complications and side effects | Chondrosarcoma | Care and treatment | Usage | Safety and security measures | Irradiation | Clinical trials | Radiotherapy | Index Medicus | Abridged Index Medicus
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5. Full Text A Multi-institutional Clinical Trial of Rectal Dose Reduction via Injected Polyethylene-Glycol Hydrogel During Intensity Modulated Radiation Therapy for Prostate Cancer: Analysis of Dosimetric Outcomes
by Song, Danny Y., MD and Herfarth, Klaus K., MD and Uhl, Matthias, MD and Eble, Michael J., MD and Pinkawa, Michael, MD and van Triest, Baukelien, MD, PhD and Kalisvaart, Robin, MSc and Weber, Damien C., MD and Miralbell, Raymond, MD and DeWeese, Theodore L., MD and Ford, Eric C., PhD
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2013, Volume 87, Issue 1, pp. 81 - 87
Purpose To characterize the effect of a prostate-rectum spacer on dose to rectum during external beam radiation therapy for prostate cancer and to assess for... 
Radiology | Hematology, Oncology and Palliative Medicine | TOXICITY | ONCOLOGY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CONFORMAL RADIOTHERAPY | Radiotherapy Dosage | Prostatic Neoplasms - pathology | Prostatic Neoplasms - radiotherapy | Prospective Studies | Radiotherapy Planning, Computer-Assisted - methods | Humans | Radiotherapy, Intensity-Modulated - methods | Organ Size | Male | Tomography, X-Ray Computed | Rectum - radiation effects | Rectum - anatomy & histology | Polyethylene Glycols - administration & dosage | Magnetic Resonance Imaging | Organ Sparing Treatments - methods | Regression Analysis | Pilot Projects | Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage | Radiation Injuries - prevention & control | Rectum - diagnostic imaging | Urinary Bladder - anatomy & histology | Urinary Bladder - diagnostic imaging | Prostatic Neoplasms - diagnostic imaging | Sects | Polyethylene | Care and treatment | Nuclear radiation | Clinical trials | Glycols | Radiotherapy | Health aspects | Prostate cancer | Cancer | PROSTATE | EXTERNAL BEAM RADIATION THERAPY | GELS | CLINICAL TRIALS | INJECTION | RECTUM | POLYETHYLENE GLYCOLS | RADIOLOGY AND NUCLEAR MEDICINE | RADIATION DOSES | BLADDER
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6. Full Text Stereotactic Single-Dose Radiation Therapy of Liver Tumors: Results of a Phase I/II Trial
by Klaus K. Herfarth and Jürgen Debus and Frank Lohr and Malte L. Bahner and Bernhard Rhein and Peter Fritz and Angelika Höss and Wolfgang Schlegel and Michael F. Wannenmacher
Journal of Clinical Oncology, ISSN 0732-183X, 01/2001, Volume 19, Issue 1, pp. 164 - 170
Purpose: To investigate the feasibility and the clinical response of a stereotactic single-dose radiation treatment for liver rumors. Patients and Methods:... 
HEPATIC METASTASES | LASER-INDUCED THERMOTHERAPY | RADIOTHERAPY | ONCOLOGY | REGIONAL CHEMOTHERAPY | CARCINOMA | Follow-Up Studies | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Stereotaxic Techniques | Liver Neoplasms - radiotherapy | Survival Analysis | Aged, 80 and over | Adult | Female | Aged | Radiotherapy Planning, Computer-Assisted
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7. Full Text Re-irradiation of adenoid cystic carcinoma: Analysis and evaluation of outcome in 52 consecutive patients treated with raster-scanned carbon ion therapy
by Jensen, Alexandra D and Poulakis, Melanie and Nikoghosyan, Anna V and Chaudhri, Naved and Uhl, Matthias and Münter, Marc W and Herfarth, Klaus K and Debus, Jürgen
Radiotherapy and Oncology, ISSN 0167-8140, 2015, Volume 114, Issue 2, pp. 182 - 188
Abstract Background Treatment of local relapse in adenoid cystic carcinoma (ACC) following prior radiation remains a challenge: without the possibility of... 
Hematology, Oncology and Palliative Medicine | Malignant salivary | Gland tumours | Re-irradiation | Carbon ions | Particle therapy | Adenoid cystic carcinoma | PHASE-II | RANDOMIZED-TRIAL | 2ND PRIMARY HEAD | LOCALLY RECURRENT | NECK-CANCER | RADIATION-THERAPY | SALVAGE REIRRADIATION | ONCOLOGY | CONCURRENT CHEMOTHERAPY | RECURRENT HEAD | SQUAMOUS-CELL CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neoplasm Recurrence, Local - radiotherapy | Carbon - therapeutic use | Heavy Ion Radiotherapy - adverse effects | Heavy Ion Radiotherapy - methods | Humans | Middle Aged | Male | Carbon - chemistry | Young Adult | Head and Neck Neoplasms - radiotherapy | Adult | Female | Aged | Retrospective Studies | Carcinoma, Adenoid Cystic - radiotherapy | Salvage Therapy - methods | Chemotherapy | Care and treatment | Carcinoma | Analysis | Patient outcomes | Cancer | Index Medicus
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8. Full Text Single-dose radiosurgical treatment for hepatic metastases - therapeutic outcome of 138 treated lesions from a single institution
by Habermehl, Daniel and Herfarth, Klaus K and Bermejo, Justo Lorenzo and Hof, Holger and Rieken, Stefan and Kuhn, Sabine and Welzel, Thomas and Debus, Jürgen and Combs, Stephanie E
Radiation Oncology, ISSN 1748-717X, 07/2013, Volume 8, Issue 1, pp. 175 - 175
Background: Local ablative therapies such as stereotactically guided single-dose radiotherapy or helical intensity-modulated radiotherapy (tomotherapy) with... 
SET-UP | PROGNOSTIC-FACTORS | ONCOLOGY | PHASE-I/II TRIAL | BODY RADIATION-THERAPY | COLORECTAL LIVER METASTASES | RADIOTHERAPY | NATURAL-HISTORY | CANCER | TUMORS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | RADIOFREQUENCY ABLATION | Humans | Middle Aged | Radiotherapy, Intensity-Modulated - methods | Kaplan-Meier Estimate | Proportional Hazards Models | Liver Neoplasms - surgery | Male | Treatment Outcome | Disease-Free Survival | Liver Neoplasms - radiotherapy | Aged, 80 and over | Adult | Female | Aged | Liver Neoplasms - secondary | Radiosurgery - methods | Metastasis | Research | Radiation | Radiosurgery | Studies | Hospitals | Medical imaging | Surgery | Clinical trials | Breast cancer | Radiation therapy | Cancer therapies | Tumors
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9. Full Text Stereotactic single-dose radiotherapy of stage I non–small-cell lung cancer (NSCLC)
by Hof, Holger and Herfarth, Klaus K and Münter, Marc and Hoess, Angelika and Motsch, Johann and Wannenmacher, Michael and Debus, J.ürgen
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2003, Volume 56, Issue 2, pp. 335 - 341
Purpose: The treatment of early-stage lung cancers is a primary domain of thoracic surgery, leading to persuasive results. In patients with medical... 
Single-dose treatment | Lung cancer | Stereotactic radiotherapy | BREATH-HOLD TECHNIQUE | RADIOSURGERY | IMMOBILIZATION | RADIATION-THERAPY | ACCURACY | lung cancer | single-dose treatment | stereotactic radiotherapy | ONCOLOGY | TUMOR MOVEMENT | LIVER | LIMITED FIELD IRRADIATION | CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Carcinoma, Non-Small-Cell Lung - pathology | Radiotherapy Dosage | Carcinoma, Non-Small-Cell Lung - radiotherapy | Adenocarcinoma - pathology | Follow-Up Studies | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Lung Neoplasms - radiotherapy | Carcinoma, Squamous Cell - surgery | Lung Neoplasms - pathology | Male | Remission Induction | Stereotaxic Techniques | Carcinoma, Large Cell - surgery | Aged, 80 and over | Aged | Neoplasm Staging | Adenocarcinoma - surgery
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10. Full Text Combined treatment of nonsmall cell lung cancer NSCLC stage III with intensity‐modulated RT radiotherapy and cetuximab
by Jensen, Alexandra D and Münter, Marc W and Bischoff, Helge G and Haselmann, Renate and Haberkorn, Uwe and Huber, Peter E and Thomas, Michael and Debus, Jürgen and Herfarth, Klaus K
Cancer, ISSN 0008-543X, 07/2011, Volume 117, Issue 13, pp. 2986 - 2994
BACKGROUND: The aim of this study was to evaluate efficacy and toxicity of radioimmunotherapy with intensity‐modulated radiation (IMRT) and cetuximab in stage... 
cetuximab | radioimmunotherapy | IMRT | NSCLC | elderly | ONCOLOGY-GROUP | PHASE-III | CHEMORADIOTHERAPY | COMBINATION | RADIATION-THERAPY IMRT | TRIAL | ONCOLOGY | CONFORMAL RADIATION | INDUCTION-CHEMOTHERAPY | CARCINOMA | PET
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11. Full Text 8 Gy TBI/cyclophosphamide (TBI8/CY) as conditioning regimen for allogeneic transplantation in patients with advanced multiple myeloma
by Schmitt, Thomas and Schoenland, Stefan and Bondong, Andrea and Goldschmidt, Hartmut and Neben, Kai and Herfarth, Klaus K and Ho, Anthony D and Dreger, Peter and Hegenbart, Ute
Journal of Clinical Oncology, ISSN 0732-183X, 05/2014, Volume 32, Issue 15_suppl, pp. e19562 - e19562
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12. Full Text Active-Scanned Protons and Carbon Ions in Cancer Treatment of Patients With Cardiac Implantable Electronic Devices: Experience of a Single Institution
by Seidensaal, K and Ben Harrabi, S and Scholz, E and Ellerbrock, M and Haberer, T and Weykamp, F and Mattke, M and Welte, SE and Herfarth, K and Debus, J and Uhl, M
FRONTIERS IN ONCOLOGY, ISSN 2234-943X, 08/2019, Volume 9, p. 798
Background: Ionizing radiation was shown to be able to influence the function of cardiac implantable electronic devices (CIED's) leading to malfunctions with... 
proton radiotherapy | beam scanning | THERAPY | ONCOLOGY | particle therapy | carbon ion radiotherapy | RADIOTHERAPY | PACEMAKERS | cardiac implantable electronic device | CIED malfunction | Usage | Cancer patients | Care and treatment | Proton beam radiotherapy | Implantable cardioverter-defibrillators
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13. Full Text Carbon-ion radiotherapy in accelerated hypofractionated active raster-scanning technique for malignant lacrimal gland tumors: Feasibility and safety
by Akbaba, Sati and Lang, Kristin and Held, Thomas and Herfarth, Klaus and Rieber, Juliane and Plinkert, Peter and Auffarth, Gerd U and Rieken, Stefan and Debus, Juergen and Adeberg, Sebastian
Cancer Management and Research, ISSN 1179-1322, 2019, Volume 11, pp. 1155 - 1166
Introduction: We evaluated treatment outcomes of CIRT in an active raster-scanning technique alone or in combination with IMRT for lacrimal gland tumors.... 
Carbon-ion radiotherapy | Local control | Malignant lacrimal gland tumor | Bimodal rt | Adenoid cystic carcinoma | malignant lacrimal gland tumor | HEAD | MANAGEMENT | local control | INTENSITY-MODULATED RADIOTHERAPY | adenoid cystic carcinoma | EPITHELIAL MALIGNANCIES | LOCATED CHOROIDAL MELANOMA | bimodal RT | carbon-ion radiotherapy | ONCOLOGY | NECK | OUTCOMES | PROTON RADIATION-THERAPY | SKULL BASE | Medical imaging | Otolaryngology | Oncology | Systematic review | Radiation therapy | Patients | Cancer therapies | Carbon | Medical prognosis | Surgery | Planning | Head & neck cancer | Tumors | carbon ion radiotherapy
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14. Full Text Linac-Based Radiosurgery of Cerebral Melanoma Metastases
: Analysis of 122 Metastases Treated in 64 Patients
by Herfarth, Klaus K and Izwekowa, Oxana and Thilmann, Christoph and Pirzkall, Andrea and Delorme, Stefan and Hofmann, Udo and Schadendorf, Dirk and Zierhut, Dietmar and Wannenmacher, Michael and Debus, Jürgen
Strahlentherapie und Onkologie, ISSN 0179-7158, 6/2003, Volume 179, Issue 6, pp. 366 - 371
Stereotactic radiosurgery is an alternative option to neurosurgical excision in the management of patients with brain metastases. We retrospectively analyzed... 
Radiotherapie | Schlüsselwörter: Malignes Melanom | Hirnmetastasen | Brain metastases | Prognostische Faktoren | Radiotherapy | Survival | Prognostic factors | Überleben | Key Words: Radiation | Strahlentherapie | Radiation | GAMMA-KNIFE RADIOSURGERY | brain metastases | survival | prognostic factors | WHOLE-BRAIN RADIOTHERAPY | MALIGNANT-MELANOMA | TUMORS | IRRADIATION | STEREOTACTIC RADIOSURGERY | ONCOLOGY | radiation | DISEASE | radiotherapy | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neoplasm Metastasis - radiotherapy | Humans | Middle Aged | Melanoma - radiotherapy | Male | Survival Rate | Treatment Outcome | Combined Modality Therapy | Melanoma - pathology | Brain Neoplasms - surgery | Brain Neoplasms - secondary | Time Factors | Female | Retrospective Studies | Brain Neoplasms - mortality | Melanoma - surgery | Radiosurgery - methods | Particle Accelerators | Melanoma - mortality | Care and treatment | Metastasis | Analysis | Surgery
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15. Full Text IMRT and carbon ion boost for malignant salivary gland tumors: Interim analysis of the COSMIC trial
by Jensen, Alexandra D and Nikoghosyan, Anna V and Lossner, Karen and Herfarth, Klaus K and Debus, Jürgen and Münter, Marc W
BMC Cancer, ISSN 1471-2407, 05/2012, Volume 12, Issue 1, pp. 163 - 163
Background: The COSMIC trial is designed to evaluate toxicity in dose-escalated treatment with intensity-modulated radiotherapy (IMRT) and carbon ion boost for... 
SURGERY | HEAD | NEUTRON | PROGNOSTIC-FACTORS | ONCOLOGY | CHEMORADIOTHERAPY | ADENOID CYSTIC CARCINOMA | RADIOTHERAPY | NECK | POSTOPERATIVE RADIATION-THERAPY | PHOTON IRRADIATION | Radiotherapy Dosage | Heavy Ion Radiotherapy - adverse effects | Humans | Middle Aged | Salivary Gland Neoplasms - radiotherapy | Adult | Treatment Outcome | Aged | Neoplasm Staging | Salivary Gland Neoplasms - pathology | Radiotherapy, Intensity-Modulated - adverse effects | Iontophoresis | Usage | Care and treatment | Salivary gland tumors | Patient outcomes | Intensity-modulated radiotherapy | Research | Analysis | Radiotherapy | Deglutition disorders | Tumors
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16. Full Text High control rate in patients with chondrosarcoma of the skull base after carbon ion therapy: First report of long-term results
: Carbon Ion Therapy in Skull Base Chondrosarcoma
by Uhl, Matthias and Mattke, Matthias and Welzel, Thomas and Oelmann, Jan and Habl, Gregor and Jensen, Alexandra D and Ellerbrock, Malte and Haberer, Thomas and Herfarth, Klaus K and Debus, Jürgen
Cancer, ISSN 0008-543X, 05/2014, Volume 120, Issue 10, pp. 1579 - 1585
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17. Full Text Evaluating target coverage and normal tissue sparing in the adjuvant radiotherapy of malignant pleural mesothelioma: Helical tomotherapy compared with step-and-shoot IMRT
by Sterzing, Florian and Sroka-Perez, Gabriele and Schubert, Kai and Münter, Marc W and Thieke, Christian and Huber, Peter and Debus, Jürgen and Herfarth, Klaus K
Radiotherapy and Oncology, ISSN 0167-8140, 2007, Volume 86, Issue 2, pp. 251 - 257
Abstract Purpose To evaluate the potential of helical tomotherapy in the adjuvant treatment of malignant pleural mesothelioma and compare target homogeneity,... 
Hematology, Oncology and Palliative Medicine | Step-and-shoot IMRT | Mesothelioma | MPM | Helical tomotherapy | MANAGEMENT | FEASIBILITY | PENCIL BEAM | step-and-shoot IMRT | NECK-CANCER | HEMITHORACIC RADIATION | helical tomotherapy | MODULATED RADIATION-THERAPY | LUNG-CANCER | ONCOLOGY | TREATMENT PLANS | EXTRAPLEURAL PNEUMONECTOMY | mesothelioma | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | HEIDELBERG EXPERIENCE | Radiotherapy Dosage | Mesothelioma - radiotherapy | Pleural Neoplasms - diagnostic imaging | Mesothelioma - diagnostic imaging | Humans | Radiotherapy, Intensity-Modulated - methods | Pleural Neoplasms - radiotherapy | Male | Treatment Outcome | Tomography, Spiral Computed | Radiotherapy, Adjuvant | Radiotherapy Planning, Computer-Assisted | Radiotherapy | Comparative analysis
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18. Full Text Assessment of focal liver reaction by multiphasic CT after stereotactic single-dose radiotherapy of liver tumors
by Herfarth, Klaus K and Hof, Holger and Bahner, Malte L and Lohr, Frank and Höss, Angelika and van Kaick, Gerhard and Wannenmacher, Michael and Debus, Jürgen
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2003, Volume 57, Issue 2, pp. 444 - 451
Purpose: To characterize and quantitatively assess focal radiation reactions in the liver after stereotactic single-dose radiotherapy for liver malignancies.... 
Normal tissue reaction | Veno-occlusive disease (VOD) | Radiosurgery | RADIATION HEPATITIS | INDUCED HEPATIC-INJURY | IRRADIATION | veno-occlusive disease (VOD) | THERAPY | ONCOLOGY | APPEARANCE | DISEASE | radiosurgery | normal tissue reaction | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiotherapy Dosage | Humans | Middle Aged | Liver - radiation effects | Male | Tomography, X-Ray Computed | Liver Neoplasms - diagnostic imaging | Stereotaxic Techniques | Time Factors | Liver - diagnostic imaging | Liver Neoplasms - radiotherapy | Aged, 80 and over | Adult | Female | Aged
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