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1. Full Text What’s Harder: Seeing a Doctor or Reducing Readmissions?
by Hernandez, Adrian F., MD, MHS and DeVore, Adam D., MD
JACC: Heart Failure, ISSN 2213-1779, 2015, Volume 3, Issue 10, pp. 774 - 776
Cardiovascular | heart failure | hospital readmission | Medicare | transitional care
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2. Full Text Biomarker-guided therapy in chronic heart failure: A meta-analysis of randomized controlled trials
by Felker, G. Michael, MD, MHS and Hasselblad, Vic, PhD and Hernandez, Adrian F., MD, MHS and O'Connor, Christopher M., MD
American Heart Journal, ISSN 0002-8703, 2009, Volume 158, Issue 3, pp. 422 - 430
Background Measurement of circulating natriuretic peptides has been shown to play an important role in diagnosis and prognosis in patients with chronic heart... 
Cardiovascular | MORTALITY | TIME-CHF | VAL-HEFT | DESIGN | CARDIAC & CARDIOVASCULAR SYSTEMS | BRAIN NATRIURETIC PEPTIDE | EMERGENCY-DEPARTMENT | MORBIDITY | SPIRONOLACTONE | ELDERLY-PATIENTS | STANDARD MEDICAL THERAPY | Natriuretic Peptide, Brain - analysis | Prognosis | Humans | Middle Aged | Male | Biomarkers - blood | Heart Failure - blood | Randomized Controlled Trials as Topic | Peptide Fragments - analysis | Heart Failure - therapy | Peptide Fragments - blood | Female | Aged | Heart Failure - diagnosis | Chronic Disease | Natriuretic Peptide, Brain - blood | Heart Failure - mortality | Heart failure | Analysis | Cardiac patients | Natriuretic peptides | Studies | Clinical trials | Hospitalization | Drug therapy | Mortality | Quality of life
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3. Full Text Outcomes in patients with heart failure with preserved, borderline, and reduced ejection fraction in the Medicare population
by Cheng, Richard K., MD, MS and Cox, Margueritte, MS and Neely, Megan L., PhD and Heidenreich, Paul A., MD, MS and Bhatt, Deepak L., MD, MPH and Eapen, Zubin J., MD, MHS and Hernandez, Adrian F., MD, MHS and Butler, Javed, MD, MPH and Yancy, Clyde W., MD, MS and Fonarow, Gregg C., MD
American Heart Journal, ISSN 0002-8703, 2014, Volume 168, Issue 5, pp. 721 - 730.e3
Background Studies on outcomes among patients with heart failure (HF) with preserved left ventricular ejection fraction (HF p EF), borderline left ventricular... 
Cardiovascular | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | SYSTOLIC FUNCTION | PREVALENCE | TRENDS | ASSOCIATION | REGISTRY | Multivariate Analysis | Prognosis | Medicare | United States | Humans | Heart Failure - physiopathology | Proportional Hazards Models | Stroke Volume - physiology | Male | Ventricular Dysfunction - mortality | Aged, 80 and over | Female | Aged | Retrospective Studies | Patient Readmission - statistics & numerical data | Ventricular Dysfunction - physiopathology | Cohort Studies | Heart Failure - mortality | Heart failure | Care and treatment | Patient outcomes | Cardiac patients | Heart attacks | Review boards | Laboratories | Mortality | Cardiovascular disease | Hospitalization | Family medical history | Patients | Fractions | Studies | Variables | Hospitals | Chronic obstructive pulmonary disease | Rehabilitation | Drug therapy
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4. Full Text Linking inpatient clinical registry data to Medicare claims data using indirect identifiers
by Hammill, Bradley G., MS and Hernandez, Adrian F., MD, MHS and Peterson, Eric D., MD, MPH and Fonarow, Gregg C., MD and Schulman, Kevin A., MD and Curtis, Lesley H., PhD
American Heart Journal, ISSN 0002-8703, 2009, Volume 157, Issue 6, pp. 995 - 1000
Background Inpatient clinical registries generally have limited ability to provide a longitudinal perspective on care beyond the acute episode. We present a... 
Cardiovascular | HOSPITALIZED-PATIENTS | CARDIAC & CARDIOVASCULAR SYSTEMS | ORGANIZED PROGRAM | PERFORMANCE | HEART-FAILURE | FAILURE OPTIMIZE-HF | INITIATE LIFESAVING TREATMENT | ACUTE CORONARY SYNDROMES | LINKAGE | CARE | Medical Records Systems, Computerized | Medicare | Outcome Assessment (Health Care) | United States | Humans | Information Storage and Retrieval | Heart Failure | Registries | Hospitalization | Medical Record Linkage | Insurance Claim Reporting | Databases, Factual | Medical colleges | Studies | Heart failure | Hospitals | Research | Beneficiaries | Age | Data bases | Outcomes, Health Policy, and Managed Care
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5. Full Text The Changing Landscape of Randomized Clinical Trials in Cardiovascular Disease
by Jones, W. Schuyler, MD and Roe, Matthew T., MD, MHS and Antman, Elliott M., MD and Pletcher, Mark J., MD, MPH and Harrington, Robert A., MD and Rothman, Russell L., MD, MPP and Oetgen, William J., MD, MBA and Rao, Sunil V., MD and Krucoff, Mitchell W., MD and Curtis, Lesley H., PhD and Hernandez, Adrian F., MD, MHS and Masoudi, Frederick A., MD, MSPH
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 68, Issue 17, pp. 1898 - 1907
Abstract Large randomized clinical trials in cardiovascular disease have proliferated over the past 3 decades, with results that have influenced every aspect... 
Cardiovascular | Internal Medicine | coronary artery disease | aspirin | Patient-Centered Outcomes Research Institute | pragmatic clinical trial | CARDIAC & CARDIOVASCULAR SYSTEMS | OPPORTUNITIES | PERCUTANEOUS CORONARY INTERVENTION | HEART-DISEASE | ACCESS SITE | ENHANCEMENT | ACUTE MYOCARDIAL-INFARCTION | ASSOCIATION TASK-FORCE | OUTCOMES | HEALTH | SAFE-PCI | Randomized Controlled Trials as Topic - methods | United States | Humans | Pragmatic Clinical Trials as Topic | Cardiovascular Diseases - therapy | Registries | Randomized Controlled Trials as Topic - standards | Medical colleges | Aspirin | Low density lipoproteins | Clinical trials | Research institutes | Cardiovascular diseases | Cardiology | Epidemiology | Heart attacks | Funding | Pragmatism | Mortality | Cardiovascular disease | Patients | Blood clots | Studies | Womens health | Quality | Infrastructure | Data collection | Intubation | Clinical medicine | Pharmaceutical industry | Research centers
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6. Full Text Highlights of this issue
CMAJ : Canadian Medical Association Journal, ISSN 0820-3946, 5/2008, Volume 178, Issue 10, pp. 1249 - 1251
Highlights of This Issue
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7. Full Text Potential impact of optimal implementation of evidence-based heart failure therapies on mortality
by Fonarow, Gregg C., MD and Yancy, Clyde W., MD and Hernandez, Adrian F., MD, MHS and Peterson, Eric D., MD, MPH and Spertus, John A., MD, MPH and Heidenreich, Paul A., MD, MS
American Heart Journal, ISSN 0002-8703, 2011, Volume 161, Issue 6, pp. 1024 - 1030.e3
Background Although multiple therapies have been shown to lower mortality in patients with heart failure (HF) and reduced left ventricular ejection fraction,... 
Cardiovascular | VENTRICULAR SYSTOLIC DYSFUNCTION | RANDOMIZED CONTROLLED-TRIALS | COST-EFFECTIVENESS | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | CLINICAL EFFECTIVENESS | ISOSORBIDE DINITRATE | IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS | CARDIAC-RESYNCHRONIZATION THERAPY | CONVERTING ENZYME-INHIBITORS | PRIMARY PREVENTION | Stroke Volume | Heart Failure - therapy | Guideline Adherence - statistics & numerical data | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Outcome Assessment (Health Care) | Humans | Heart Failure - physiopathology | Evidence-Based Medicine | Angiotensin Receptor Antagonists - therapeutic use | Heart Failure - mortality | Practice Guidelines as Topic | Heart failure | Health aspects | Evidence-based medicine | Cardiac patients | Mortality | Heart attacks | Sensitivity analysis | Meetings | Comorbidity | Clinical trials | Cardiovascular disease | Statistical methods | Drug therapy | Cardiology
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8. Translating Evidence into Practice: Use of Statins in Real-World Patients with Heart Failure
by Hernandez, Adrian F and Fonarow, Gregg C
Heart Failure Clinics, ISSN 1551-7136, 04/2008, Volume 4, Issue 2, pp. 217 - 223
Heart failure is a common and serious disorder affecting more than 5 million patients in the United States. Although clinical trials have shown that several... 
Clinical Trials as Topic | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Quality of Health Care | Heart Failure - drug therapy
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9. Full Text Trajectory of Congestion Metrics by Ejection Fraction in Patients with Acute Heart Failure (From the Heart Failure Network)
by Ambrosy, Andrew P., MD and Bhatt, Ankeet S., MD and Gallup, Dianne, MS and Anstrom, Kevin J., PhD and Butler, Javed, MD, MPH, MBA and DeVore, Adam D., MD, MHS and Felker, G. Michael, MD, MHS and Fudim, Marat, MD and Greene, Stephen J., MD and Hernandez, Adrian F., MD, MHS and Kelly, Jacob P., MD, MHS and Samsky, Marc D., MD and Mentz, Robert J., MD
American Journal of Cardiology, The, ISSN 0002-9149, 2017, Volume 120, Issue 1, pp. 98 - 105
Abstract Differences in the clinical course of congestion by underlying ejection fraction (EF) have not been well-characterized in acute heart failure (AHF). A... 
Cardiovascular | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | TASK-FORCE | CARDIORENAL RESCUE | OUTCOMES | PRESERVED SYSTOLIC FUNCTION | HOSPITALIZATION | STRATEGIES | AHF | Severity of Illness Index | Risk Assessment - methods | United States - epidemiology | Acute Disease | Prognosis | Prospective Studies | Survival Rate - trends | Double-Blind Method | Humans | Middle Aged | Heart Failure - physiopathology | Stroke Volume - physiology | Male | Systole | Hospitalization - trends | Peptide Fragments - blood | Cause of Death - trends | Female | Aged | Heart Failure - diagnosis | Natriuretic Peptide, Brain - blood | Heart Failure - mortality | Heart failure | Heart | Care and treatment | Lung diseases, Obstructive | Analysis | Cardiac patients | Diuretics | Development and progression | Natriuretic peptides | Peptides | Syngeneic grafts | Self evaluation | Body weight | Clinical trials | Beta blockers | Optimization | Visual perception | Dyspnea | Fibrillation | Ischemia | Etiology | Risk assessment | Failure analysis | Xenografts | Flutter | Chronic obstructive pulmonary disease | Diagnosis | Heart diseases | Age | Brain natriuretic peptide | Edema | Evaluation | Signs and symptoms | Vibration | Kidneys | Adjustment | Mortality | Lung diseases | Markers | Hospitalization | Trajectories | Regression analysis | Congestion | Patients | Medical prognosis | Obstructive lung disease | Renal failure | Death | Ejection | Kidney transplantation | acute heart failure | ejection fraction | outcomes | congestion | signs and symptoms
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10. Full Text Rationale and design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) trial
by Holman, Rury R., FRCP, FMedSci and Bethel, Mary Angelyn, MD and George, Jyothis, MRCPE, MRCP (UK), PhD and Sourij, Harald, MD and Doran, Zoë, RN and Keenan, Joanne, BA and Khurmi, Nardev S., MD and Mentz, Robert J., MD and Oulhaj, Abderrahim, PhD and Buse, John B., MD, PhD and Chan, Juliana C., MD and Iqbal, Nayyar, MD and Kundu, Sudeep, PhD and Maggioni, Aldo P., MD and Marso, Steven P., MD and Öhman, Peter, MD, PhD and Pencina, Michael J., PhD and Poulter, Neil, FMedSci and Porter, Lisa E., MD and Ramachandran, Ambady, MD and Zinman, Bernard, MD and Hernandez, Adrian F., MD, MHS
American Heart Journal, ISSN 0002-8703, 2016, Volume 174, pp. 103 - 110
Exenatide once-weekly is an extended release formulation of exenatide, a glucagon-like peptide–1 receptor agonist, which can improve glycemic control, body... 
Cardiovascular | DIABETES-MELLITUS | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | GLUCAGON-LIKE PEPTIDE-1 | MYOCARDIAL-INFARCTION | SAFETY | RECEPTOR AGONISTS | GLUCOSE | CLINICAL-TRIALS | DISEASE | INCRETIN-BASED THERAPIES | Risk Assessment - methods | United States - epidemiology | Glucagon-Like Peptide 1 | Prognosis | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Male | Peptides - administration & dosage | Incidence | Dose-Response Relationship, Drug | Microspheres | Hypoglycemic Agents - administration & dosage | Time Factors | Injections, Subcutaneous | Cardiovascular Diseases - epidemiology | Venoms - administration & dosage | Adult | Female | Diabetes Mellitus, Type 2 - complications | Cardiovascular Diseases - etiology | Survival Rate - trends | Double-Blind Method | Drug Administration Schedule | Risk Factors | China - epidemiology | Diabetes Mellitus, Type 2 - blood | Ontario - epidemiology | Italy - epidemiology | Aged | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | United Kingdom - epidemiology | Type 2 diabetes | Hypoglycemic agents | Glucagon | Cardiac patients | Heart attack | Corporate sponsorship | Heart attacks | Research & development--R&D | Pragmatism | Cardiovascular disease | Diabetes | Pharmaceutical industry | Patients | Cholesterol
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11. Full Text Precipitating Clinical Factors, Heart Failure Characterization, and Outcomes in Patients Hospitalized With Heart Failure With Reduced, Borderline, and Preserved Ejection Fraction
by Kapoor, John R., MD, PhD and Kapoor, Roger, MD, MBA and Ju, Christine, MS and Heidenreich, Paul A., MD, MS and Eapen, Zubin J., MD, MHS and Hernandez, Adrian F., MD, MHS and Butler, Javed, MD, MPH, MBA and Yancy, Clyde W., MD, MBA and Fonarow, Gregg C., MD
JACC: Heart Failure, ISSN 2213-1779, 2016, Volume 4, Issue 6, pp. 464 - 472
Abstract Objectives This study assessed the comparative frequency of precipitating clinical factors leading to hospitalization among heart failure (HF)... 
Cardiovascular | heart failure | outcomes | precipitating factors | Heart failure | Outcomes | Precipitating factors | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | ADMISSION | ASSOCIATION | WORSENING RENAL-FUNCTION | Arrhythmias, Cardiac - epidemiology | Length of Stay | Medication Adherence - statistics & numerical data | Hospital Mortality | Pneumonia - epidemiology | Humans | Middle Aged | Heart Failure - physiopathology | Male | Hospitalization | Precipitating Factors | Stroke Volume | Kidney Diseases - epidemiology | Aged, 80 and over | Female | Aged | Weight Gain | Heart Failure - epidemiology | Index Medicus
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12. Full Text End Points for Clinical Trials in Acute Heart Failure Syndromes
by Allen, Larry A., MD, MHS and Hernandez, Adrian F., MD, MHS and O'Connor, Christopher M., MD and Felker, G. Michael, MD, MHS
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2009, Volume 53, Issue 24, pp. 2248 - 2258
Acute heart failure syndromes (AHFS) remain a major cause of morbidity and mortality, in part because the development of new therapies for these disorders has... 
Cardiovascular | Internal Medicine | randomized controlled trial design | end points | acute heart failure syndromes/acute decompensated heart failure | RANDOMIZED CONTROLLED-TRIALS | CARDIAC & CARDIOVASCULAR SYSTEMS | DYSPNEA | TOLVAPTAN | RISK | DEATH | NESIRITIDE | HOSPITALIZATION | DISEASE | NATIONAL REGISTRY ADHERE | OUTCOMES | Length of Stay | Acute Disease | Randomized Controlled Trials as Topic - methods | United States | Humans | Disease Progression | Syndrome | Heart Failure - drug therapy | Cardiotonic Agents - therapeutic use | Endpoint Determination | Hemodynamics | United States Food and Drug Administration | Heart Failure - mortality | Heart failure | Clinical trials | Mortality | Hospitals | Pulmonary arteries | Drug therapy | Acute coronary syndromes | Patients | Public health | Regulatory approval | acute decompensated heart failure | acute heart failure syndromes
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13. Full Text The design and rationale for the Acute Medically Ill Venous Thromboembolism Prevention with Extended Duration Betrixaban (APEX) study
by Cohen, Alexander T., MD and Harrington, Robert, MD and Goldhaber, Samuel Z., MD and Hull, Russell, MD and Gibson, C. Michael, MD and Hernandez, Adrian F., MD, MHS and Kitt, Michael M., MD and Lorenz, Todd J., MD
American Heart Journal, ISSN 0002-8703, 2014, Volume 167, Issue 3, pp. 335 - 341
Randomized clinical trials have identified a population of acute medically ill patients who remain at risk for venous thromboembolism (VTE) beyond the standard... 
Cardiovascular | ENOXAPARIN | HOSPITALIZED-PATIENTS | CARDIAC & CARDIOVASCULAR SYSTEMS | EVENTS | RISK | XA | PLACEBO-CONTROLLED TRIAL | THROMBOPROPHYLAXIS | Acute Disease | Prospective Studies | Pyridines - administration & dosage | Anticoagulants - administration & dosage | Double-Blind Method | Factor Xa Inhibitors | Humans | Middle Aged | Risk Factors | Treatment Outcome | Venous Thromboembolism - prevention & control | Benzamides - administration & dosage | Enoxaparin - administration & dosage | Time Factors | Internationality | Aged, 80 and over | Adult | Aged | Pulmonary embolism | Prevention | Thromboembolism | Studies | Cardiac arrhythmia | Stroke | Surgery | Mortality | Hospitalization | Drug therapy | Drug dosages | Cancer
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14. Full Text Comparative Effectiveness of CRT-D Versus Defibrillator Alone in HF Patients With Moderate-to-Severe Chronic Kidney Disease
by Friedman, Daniel J., MD and Singh, Jagmeet P., MD, DPhil and Curtis, Jeptha P., MD and Tang, W.H. Wilson, MD and Bao, Haikun, PhD and Spatz, Erica S., MD, MHS and Hernandez, Adrian F., MD, MHS and Patel, Uptal D., MD and Al-Khatib, Sana M., MD, MHS
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 66, Issue 23, pp. 2618 - 2629
Abstract Background Patients with moderate-to-severe chronic kidney disease (CKD) are poorly represented in clinical trials of cardiac resynchronization... 
Cardiovascular | Internal Medicine | chronic kidney disease | pacemaker | cardiomyopathy | biventricular | MORTALITY | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | RENAL-FUNCTION | CARDIAC-RESYNCHRONIZATION THERAPY | Cardiac Resynchronization Therapy - methods | United States - epidemiology | Humans | Medicare - statistics & numerical data | Hospitalization - statistics & numerical data | Male | Electric Countershock - statistics & numerical data | Renal Insufficiency, Chronic - epidemiology | Heart Failure - therapy | Comparative Effectiveness Research | Aged, 80 and over | Female | Renal Insufficiency, Chronic - diagnosis | Heart Failure - diagnosis | Heart Failure - epidemiology | Electric Countershock - methods | Severity of Illness Index | Glomerular Filtration Rate | Comorbidity | Defibrillators, Implantable - statistics & numerical data | Proportional Hazards Models | Cardiac Resynchronization Therapy - statistics & numerical data | Treatment Outcome | Electric Countershock - instrumentation | Survival Analysis | Aged | Heart | Sects | Medical colleges | Heart beat | Chronic kidney failure | Defibrillators | Cardiovascular agents | Medical research | Implants, Artificial | Prosthesis | Medicine, Experimental | Development and progression | Comparative analysis | Confidence intervals | Heart failure | Codes | Medicare | Diagnosis related groups--DRGs | Mortality | Ulcers | Amputation | Population | Hospitalization | Kidney diseases | Dementia
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15. Full Text Diuretic response in acute heart failure—an analysis from ASCEND-HF
by ter Maaten, Jozine M., MD and Dunning, Allison M., MS and Valente, Mattia A.E., MD and Damman, Kevin, MD, PhD and Ezekowitz, Justin A., MBBCh, MSc and Califf, Robert M., MD and Starling, Randall C., MD, MPH and van der Meer, Peter, MD, PhD and O'Connor, Christopher M., MD and Schulte, Phillip J., PhD and Testani, Jeffrey M., MD, MTR and Hernandez, Adrian F., MD, MHS and Tang, W.H. Wilson, MD and Voors, Adriaan A., MD, PhD
American Heart Journal, ISSN 0002-8703, 2015, Volume 170, Issue 2, pp. 313 - 321.e4
Background Diuretic unresponsiveness often occurs during hospital admission for acute heart failure (AHF) and is associated with adverse outcome. This study... 
Cardiovascular | TRIAL | RESPONSIVENESS | TRANSPORT | CARDIAC & CARDIOVASCULAR SYSTEMS | DYSFUNCTION | LOW-DOSE NESIRITIDE | RENAL-ARTERY STENOSIS | PATHOPHYSIOLOGY | Furosemide - administration & dosage | United States - epidemiology | Acute Disease | Diuretics - administration & dosage | Survival Rate - trends | Double-Blind Method | Follow-Up Studies | Humans | Middle Aged | Heart Failure - physiopathology | Male | Treatment Outcome | Disease Progression | Heart Failure - drug therapy | Incidence | Dose-Response Relationship, Drug | Hospital Mortality - trends | Female | Aged | Patient Admission - statistics & numerical data | Retrospective Studies | Heart Failure - epidemiology | Heart failure | Diuretics | Analysis | Studies | Urine | Variables | Heart attacks | Mortality | Classification | Hospitalization | Diabetes
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