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by Wang, W and Hind, T and Lam, BWS and Herr, DR
FASEB JOURNAL, ISSN 0892-6638, 06/2019, Volume 33, Issue 6, pp. 7180 - 7191
Epithelial-mesenchymal transition (EMT) is a critical process implicated in the initial stage of cancer metastasis, which is the major cause of tumor... 
TRANSCRIPTION FACTORS | MRTF-A | SPHK1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE 1 | YAP | PROLIFERATION | INDUCTION | EMT | SLUG | RHOA | CELL BIOLOGY | PROTEIN-COUPLED RECEPTOR | SPHINGOSINE-1-PHOSPHATE | BIOLOGY | epithelial-mesenchymal transition
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 12/2018, Volume 841, p. 49
Lysophosphatidic acid receptor 1 (LPA.sub.1) is one of six G protein-coupled receptors (GPCRs) activated by the bioactive lipid, lysophosphatidic acid (LPA).... 
Enzymes | Medical colleges | Care and treatment | Carrageenin | Pain | Lubrication and lubricants | Analysis | Phospholipases | G proteins | Protein binding
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 12/2018, Volume 841, pp. 49 - 56
Lysophosphatidic acid receptor 1 (LPA ) is one of six G protein-coupled receptors (GPCRs) activated by the bioactive lipid, lysophosphatidic acid (LPA).... 
GPCR | Carrageenan | Phospholipase A2 (PLA2) | Lysophosphatidic acid (LPA) | Inflammatory pain | LPA1 | PLA | LPA | Phospholipase A | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 2016, Volume 340, pp. 91 - 100
Highlights • Treatment of mice with maprotiline resulted in modulation of inflammatory facial pain. • This effect was abolished by prefrontal cortical... 
Neurology | lipid mediators | pain | noradrenaline | antinociception | prefrontal cortex | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 01/2017, Volume 340, p. 91
* Treatment of mice with maprotiline resulted in modulation of inflammatory facial pain. * This effect was abolished by prefrontal cortical knockdown of iPLA2.... 
Phospholipases | Unsaturated fatty acids | Antidepressants | Analysis | Omega-3 fatty acids
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 02/2019, Volume 93, Issue 2, pp. 132 - 138
Compounds with activity at serotonin (5‐hydroxytryptamine) 5‐HT 2 and α 1 adrenergic receptors have potential for the treatment of central nervous system... 
partial agonist | functional studies | receptors | adrenergic α | enantiomers | aporphines | G protein‐coupled receptors | antagonist | serotonin 5‐HT | allosteric modulator | G protein-coupled receptors | serotonin 5-HT
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 02/2019, Volume 93, Issue 2, p. 132
Compounds with activity at serotonin (5-hydroxytryptamine) 5-HT.sub.2 and [alpha].sub.1 adrenergic receptors have potential for the treatment of central... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 2, pp. 751 - 756
Sphingosine 1-phosphate (S1P), a lysophospholipid, has gained relevance to multiple sclerosis through the discovery of FTY720 (fingolimod), recently approved... 
Receptors | Multiple sclerosis | Spinal cord | Astrocytes | Neurons | Lymphocytes | Central nervous system | Cell lines | Null condition | Mice | G protein-coupled receptor | Lysophospholipid | Neuroprotection | Knockout | knockout | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | ORAL FINGOLIMOD | WHITE-MATTER | MULTIDISCIPLINARY SCIENCES | LYMPHOCYTE EGRESS | AGONISTS | neuroprotection | FIBRILLARY ACIDIC PROTEIN | SPHINGOSINE-1-PHOSPHATE | IMMUNOSUPPRESSANT FTY720 | CENTRAL-NERVOUS-SYSTEM | lysophospholipid | Astrocytes - cytology | Lymphocytes - metabolism | Propylene Glycols - pharmacology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Gene Expression Regulation | Fingolimod Hydrochloride | Mice, Knockout | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Female | Receptors, Lysosphingolipid - metabolism | Immunosuppressive Agents - pharmacology | Disease Models, Animal | Multiple Sclerosis - drug therapy | Physiological aspects | Care and treatment | Studies | Prescription drugs | Phosphorylation | Immunology | Metabolites | Rodents | Lipids | Models | Gene expression | Index Medicus | Animal models | Cell lineage | Data processing | Neuromodulation | Experimental allergic encephalomyelitis | sphingosine 1-phosphate receptors | Sphingosine 1-phosphate | Signal transduction | Gliosis | Demyelination | FTY720 | Glia | Protein transport | Biological Sciences
Journal Article
ISSN 2040-2503, 3/2018, Volume 9, Issue 3, pp. 576 - 582
In this study, the ( S )-enantiomers of the aporphine alkaloids, nuciferine and roemerine, were prepared via a synthetic route involving catalytic asymmetric... 
Journal Article
MedChemComm, ISSN 2040-2503, 03/2018, Volume 9, Issue 3, p. 576
In this study, the ( )-enantiomers of the aporphine alkaloids, nuciferine and roemerine, were prepared a synthetic route involving catalytic asymmetric... 
Journal Article
MedChemComm, ISSN 2040-2503, 2018, Volume 9, Issue 3, pp. 593 - 594
Journal Article
Chemical biology & drug design, 02/2019, Volume 93, Issue 2, p. 132
Compounds with activity at serotonin (5-hydroxytryptamine) 5-HT and α adrenergic receptors have potential for the treatment of central nervous system... 
Journal Article
MedChemComm, 03/2018, Volume 9, Issue 3, p. 593
[This corrects the article DOI: 10.1039/C7MD00629B.]. 
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2017, Volume 12, Issue 10, pp. e0186334 - e0186334
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2004, Volume 45, Issue 1, pp. 54 - 62
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 37, pp. 15444 - 15449
Fetal hypoxia is a common risk factor that has been associated with a range of CNS disorders including epilepsy, schizophrenia, and autism. Cellular and... 
Lysophospholipids | Lysophosphatidic acid receptors | Receptors | Cerebral cortex | Fetal hypoxia | Neurons | Cell lines | Cerebral hemispheres | Hypoxia | Brain hypoxia | Cortical development | Ischemia | Sphingosine 1-phosphate | ANTAGONIST | MULTIDISCIPLINARY SCIENCES | DISORDERS | ischemia | ORGANIZATION | NEOCORTEX | PROGENITOR-CELL | lysophospholipids | GROWTH | RHO | cortical development | sphingosine 1-phosphate | PROTEINS | MORPHOLOGY | HIF-1-ALPHA SYNTHESIS | Receptors, Lysophosphatidic Acid - metabolism | Brain - embryology | Cerebral Cortex - enzymology | Signal Transduction | Mitosis | Cerebral Cortex - pathology | Fetus - metabolism | Fetus - pathology | G-Protein-Coupled Receptor Kinase 2 - metabolism | Neural Stem Cells - pathology | Hypoxia - metabolism | Brain - metabolism | G-Protein-Coupled Receptor Kinase 2 - antagonists & inhibitors | Animals | Cerebral Cortex - embryology | Hypoxia - pathology | Brain - pathology | Female | Mice | Neural Stem Cells - metabolism | Cell Movement | Physiological aspects | Brain damage | Care and treatment | Research | Sphingosine | Proteins | Brain | Signal transduction | Lipids | Fetuses | G protein-coupled receptors | Complications | Epilepsy | Central nervous system | Cortex | Schizophrenia | Data processing | Botulinum toxin | Risk factors | Autism | N-Cadherin | Cell migration | Injuries | Index Medicus | Biological Sciences
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 10/2017, Volume 54, Issue 8, pp. 6032 - 6045
Pain and anxiety have a complex relationship and pain is known to share neurobiological pathways and neurotransmitters with anxiety. Top-down modulatory... 
Neurology | Neurosciences | Biomedicine | Pain | Neurobiology | iPLA 2 | Depression | Lipoxins, resolvins, neuroprotectins | Anxiety | DHA | Cell Biology | iPLA | CONTROLLED-TRIAL | CENTRAL SENSITIZATION | PHOSPHOLIPASE A | FATTY-ACIDS | 15-LIPOXYGENASE | NEUROSCIENCES | NEUROPATHIC PAIN | MILD ALZHEIMERS-DISEASE | DOCOSAHEXAENOIC ACID | INFRAORBITAL NERVE | MODULATION | Docosahexaenoic Acids - therapeutic use | Analgesics - pharmacology | Analgesics - therapeutic use | Arachidonate 12-Lipoxygenase - metabolism | Anti-Anxiety Agents - pharmacology | Male | Anxiety - drug therapy | Arachidonate 15-Lipoxygenase - metabolism | Pain - metabolism | Docosahexaenoic Acids - pharmacology | Animals | Prefrontal Cortex - drug effects | Pain - drug therapy | Prefrontal Cortex - metabolism | Mice | Anti-Anxiety Agents - therapeutic use | Pain Measurement | Anxiety - metabolism | Dietary Supplements | Enzymes | Medical colleges | Unsaturated fatty acids | Care and treatment | Functional foods | Depression, Mental | Omega-3 fatty acids | Antianxiety agents | Hair | Cortex (prefrontal) | Brain | Pain perception | Stroke | Periaqueductal gray area | Central nervous system | Stimulation | Strokes | Neuropathy | Docosahexaenoic acid | Neurotransmitters | Pathways | Analgesics | Anxieties | Rodents | Choline | Inhibition | Lipoxygenase | Functional foods & nutraceuticals | Index Medicus
Journal Article
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