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Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 2335 - 8
Insulin-degrading enzyme (IDE) functions in the catabolism of bioactive peptides. Established roles include degrading insulin and the amyloid beta peptide (A... 
AMYLOID BETA-PROTEIN | ALZHEIMER-DISEASE | ENDOSOMES | EXTRACELLULAR LEVELS | PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | SURFACE | DEGRADATION | ASTROCYTES | BRAIN | Exosomes - metabolism | Insulysin - metabolism | Cell Survival | Humans | Secretory Pathway | HEK293 Cells | Enzymes | Peptides | Secretion | Diabetes mellitus | Insulysin | β-Amyloid | Lovastatin | Lactic acid | Cytosol | Insulin | L-Lactate dehydrogenase
Journal Article
Cell, ISSN 0092-8674, 2005, Volume 120, Issue 5, pp. 701 - 713
Cerebral deposition of β-amyloid (Aβ) peptides is an invariant pathological hallmark in brains of patients with Alzheimer’s disease (AD) and transgenic mice... 
MEMORY CONSOLIDATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | IN-VIVO | GENE-EXPRESSION | PHYSICAL-ACTIVITY | PRECURSOR PROTEIN | DENTATE GYRUS | SYNAPTIC PLASTICITY | AGING BRAIN | CELL BIOLOGY
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2017, Volume 114, Issue 14, p. E2826
  Insulin-degrading enzyme (IDE) hydrolyzes bioactive peptides, including insulin, amylin, and the amyloid β peptides. Polyanions activate IDE toward some... 
Phosphates | Enzymes | Peptides | Insulin | Substrates | Binding sites
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 03/2007, Volume 100, Issue 5, pp. 1387 - 1396
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2011, Volume 12, Issue 1, pp. 45 - 53
Journal Article
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 06/2016, Volume 53, Issue 1, pp. 259 - 272
Amylin is a hormone synthesized and co-secreted with insulin by pancreatic β-cells that crosses the blood-brain barrier and regulates satiety. Amylin from... 
amylin | malondialdehyde | Alzheimer’s disease | neuroinflammation | type-2 diabetes | 4-hydroxynonenal
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2018, Volume 38, Issue 1, pp. 154 - 163
Objective Pulmonary artery smooth muscle cells (PASMCs) from neprilysin (NEP) null mice exhibit a synthetic phenotype and increased activation of Rho GTPases... 
phenotype | pulmonary artery | neprilysin | calponin | phosphorylation | KINASE | INHIBITION | PROTEIN-COUPLED RECEPTOR | DEGRADATION | PERIPHERAL VASCULAR DISEASE | DIFFERENTIATION | HYPERTENSION | HEMATOLOGY | VASOCONSTRICTION
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2003, Volume 23, Issue 6, pp. 1992 - 1996
Journal Article