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PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, p. e0148764
VTX-2337 (USAN: motolimod) is a selective toll-like receptor 8 (TLR8) agonist, which is in clinical development as an immunotherapy for multiple oncology... 
HEAD | ENHANCE | NK CELLS | CANCER CELLS | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | CRYSTALS | GENERATION | TUMORS | CD8(+) T-CELLS | NALP3 INFLAMMASOME | Neoplasms - metabolism | Leukocytes, Mononuclear - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Macaca fascicularis | Caspase 1 - metabolism | Male | Receptors, IgG - metabolism | Carrier Proteins - agonists | Lymphocyte Activation - immunology | Neoplasms - genetics | Leukocytes, Mononuclear - immunology | Killer Cells, Natural - immunology | Female | Interleukin-1beta - biosynthesis | Disease Models, Animal | Toll-Like Receptor 8 - agonists | Leukocytes, Mononuclear - drug effects | Benzazepines - pharmacology | Cell Degranulation - immunology | Interleukin-18 - biosynthesis | Animals | Benzazepines - therapeutic use | Lymphocyte Activation - drug effects | Neoplasms - immunology | K562 Cells | Cell Line, Tumor | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Cytotoxicity, Immunologic - immunology | Cell Degranulation - drug effects | Physiological aspects | Toll-like receptors | Killer cells | Genetic aspects | Research | Immunotherapy | Toxicity | Cytotoxicity | Stimulation | Activation | Lymphocytes T | Monkeys | Cancer therapies | Caspase-1 | Metastases | NKG2 antigen | Cell activation | Epidermal growth factor | Lymphocytes | Rodents | Biocompatibility | Neck | Natural killer cells | Antibody-dependent cell-mediated cytotoxicity | Squamous cell carcinoma | Cytokines | Dendritic cells | Tumor cells | Caspase | T cell receptors | Tumor necrosis factor-α | Patients | Interleukin 18 | Medicine | Monocytes | Complement activation | Pyrin protein | Womens health | γ-Interferon | Monoclonal antibodies | Ligands | Lymphomas | Pharmaceuticals
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2018, Volume 200, Issue 9, pp. 3244 - 3258
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e58164
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 07/2006, Volume 24, Issue 19, pp. 3089 - 3094
Purpose Sipuleucel-T (APC8015) is an investigational immunotherapy product designed to stimulate T-cell immunity against prostatic acid. phosphatase. A phase... 
SURVIVAL | PREDNISONE | MITOXANTRONE | ACID | DENDRITIC CELLS | ONCOLOGY | IMMUNOTHERAPY | MEN | DOCETAXEL | Prognosis | Humans | Middle Aged | Tissue Extracts - adverse effects | Drug Resistance, Neoplasm | Male | Treatment Outcome | Tissue Extracts - therapeutic use | Prostatic Neoplasms - therapy | Immunotherapy | Survival Analysis | Aged, 80 and over | Placebos | Aged
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2017, Volume 23, Issue 10, pp. 2442 - 2450
Purpose: As Toll-like receptors (TLR) are key mediators of immune responses, TLR agonists may be important for augmenting the efficacy of therapies for... 
HEAD | II MULTICENTER | SOLID TUMORS | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | OPEN-LABEL | TOXICITY | ANTIBODY CETUXIMAB | NECK-CANCER | EGFR | CHEMOTHERAPY | Carcinoma, Squamous Cell - blood | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Benzazepines - adverse effects | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Drug-Related Side Effects and Adverse Reactions - pathology | Neoplasm Recurrence, Local - pathology | Neoplasm Metastasis | Squamous Cell Carcinoma of Head and Neck | Antibodies, Monoclonal, Humanized - administration & dosage | Head and Neck Neoplasms - blood | Adult | Female | Antibodies, Monoclonal, Humanized - adverse effects | Head and Neck Neoplasms - drug therapy | Disease-Free Survival | Carcinoma, Squamous Cell - drug therapy | Toll-Like Receptor 8 - genetics | Cetuximab - administration & dosage | Head and Neck Neoplasms - genetics | Aged | Benzazepines - administration & dosage | Killer Cells, Natural - metabolism | Drug-Related Side Effects and Adverse Reactions - classification | Toxicity | Metastasis | Metastases | Anticancer properties | Proteins | Receptors | Safety engineering | Design standards | Toll-like receptors | Bioindicators | Neck | Natural killer cells | Immune system | Squamous cell carcinoma | Head | Statistical analysis | Immune response | Cytokines | Dendritic cells | Pharmacology | Disease control | Patients | Monocytes | Experimental design | Biomarkers | Antitumor activity | Cancer | Index Medicus
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 8/2013, Volume 62, Issue 8, pp. 1347 - 1357
Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody that prolongs survival in the treatment for head and neck cancer (HNC), but... 
Immunology | Medicine & Public Health | VTX-2337 | Immunotherapy | Oncology | Cancer Research | TLR8 | Head and neck cancer | Cetuximab | ADCC | IMMUNITY | IFN-GAMMA PRODUCTION | MECHANISMS | IMMUNOLOGY | IMIQUIMOD | BLIND | TOLL-LIKE | NK CELLS | ONCOLOGY | CARCINOMA | AGONIST | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | Immunoglobulins - immunology | Membrane Glycoproteins - metabolism | Coculture Techniques | Dendritic Cells - immunology | Humans | Antibody-Dependent Cell Cytotoxicity - immunology | Interferon-gamma - metabolism | Head and Neck Neoplasms - metabolism | Antigens, CD - metabolism | Immunoglobulins - metabolism | Toll-Like Receptor 8 - immunology | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Antibodies, Monoclonal, Humanized - pharmacology | Benzazepines - immunology | Tumor Necrosis Factor-alpha - immunology | CD8-Positive T-Lymphocytes - metabolism | Killer Cells, Natural - immunology | Antineoplastic Agents - pharmacology | Interleukin-12 Subunit p40 - immunology | Membrane Glycoproteins - immunology | B7-2 Antigen - immunology | Dendritic Cells - metabolism | Toll-Like Receptor 8 - agonists | Interleukin-12 Subunit p40 - metabolism | Receptor, Epidermal Growth Factor - immunology | Enzyme-Linked Immunosorbent Assay | Antineoplastic Agents - immunology | B7-1 Antigen - immunology | Cells, Cultured | B7-1 Antigen - metabolism | Benzazepines - pharmacology | Head and Neck Neoplasms - pathology | B7-2 Antigen - metabolism | Head and Neck Neoplasms - immunology | Cross-Priming - immunology | Interferon-gamma - immunology | Cell Line, Tumor | Killer Cells, Natural - metabolism | Antibodies, Monoclonal, Humanized - immunology | Antibody-Dependent Cell Cytotoxicity - drug effects | CD8-Positive T-Lymphocytes - immunology | Toll-Like Receptor 8 - metabolism | Index Medicus | Head and Neck Cancer
Journal Article
The American Journal of Gastroenterology, ISSN 0002-9270, 02/2006, Volume 101, Issue 2, pp. 360 - 367
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2017, Volume 23, Issue 8, pp. 1955 - 1966
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. TPS3092 - TPS3092
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2004, Volume 113, Issue 9, pp. 1296 - 1306
Chronic intestinal inflammation, as seen in inflammatory bowel disease (IBD), results from an aberrant and poorly understood mucosal immune response to the... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | HLA CLASS-II | INFLAMMATORY-BOWEL-DISEASE | FLORA | TOLL-LIKE RECEPTORS | CD4(+) T-CELLS | NOD2 | COLITIC C3H/HEJBIR MICE | EXPRESSION | INTESTINAL EPITHELIAL-CELLS
Journal Article