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1. Full Text AMPK: Guardian of metabolism and mitochondrial homeostasis
by Herzig, Sébastien and Shaw, Reuben J
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 01/2018, Volume 19, Issue 2, pp. 121 - 135
Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient availability. Eukaryotes have evolved a very sophisticated system to... 
GAMMA-SUBUNIT ISOFORMS | ENERGY STRESS | GLUCOSE-HOMEOSTASIS | ACTIVATED PROTEIN-KINASE | FATTY-ACID OXIDATION | TUMOR-CELL-SURVIVAL | ACETYL-COA CARBOXYLASE | STARVATION-INDUCED AUTOPHAGY | MAMMALIAN-CELLS | HUMAN SKELETAL-MUSCLE | CELL BIOLOGY | Type 2 diabetes | Glucose metabolism | Enzymes | Physiological aspects | Homeostasis | Glucose | Protein kinases | Dextrose | Energy metabolism | AMP | Threonine | AMP-activated protein kinase | Metabolism | Kinases | Autophagy | Substrates | Eukaryotes | Mitochondria | Nutrient availability | Catabolism | Protein-serine/threonine kinase | Lipid metabolism | ATP | Phagocytosis
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2. Full Text SLP-2 is required for stress-induced mitochondrial hyperfusion
by Martinou, Jean-Claude and Mattenberger, Yves and Youle, Richard and Herzig, Sébastien and Tondera, Daniel and Bauer, Christoph and Karbowski, Mariusz and Raschke, Ines and Merkwirth, Carsten and Ehses, Sarah and Langer, Thomas and Da Cruz, Sandrine and Clerc, Pascaline and Krause, Frank and Jourdain, Alexis and Alexander, Christiane and Chan, David C and Grandemange, Stéphanie
The EMBO Journal, ISSN 0261-4189, 06/2009, Volume 28, Issue 11, pp. 1589 - 1600
Mitochondria are dynamic organelles, the morphology of which results from an equilibrium between two opposing processes, fusion and fission. Mitochondrial... 
fusion | stress | ATP | mitochondria | survival | Mitochondria | Fusion | Survival | Stress | PROTEOLYTIC CLEAVAGE | OUTER-MEMBRANE | APOPTOSIS | INNER MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN-CELLS | CELL BIOLOGY | DOMINANT OPTIC ATROPHY | OPA1 | ACTINOMYCIN-D | DYNAMIN-RELATED PROTEIN | Fibroblasts - physiology | GTP Phosphohydrolases - physiology | Cells, Cultured | Stress, Physiological | Mitochondria - metabolism | Mitochondria - drug effects | Dactinomycin - toxicity | Animals | Ultraviolet Rays | Fibroblasts - radiation effects | Membrane Proteins - physiology | Adenosine Triphosphate - metabolism | Fibroblasts - drug effects | Mitochondria - radiation effects | Mice | Mitochondria - physiology | Proteins | Mitochondrial DNA | Oxidation | Cellular biology | Molecular biology | Gene expression | Index Medicus | Life Sciences | Cellular Biology | Biochemistry, Molecular Biology
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3. Full Text Mitocellular communication: Shaping health and disease
by Mottis, Adrienne and Herzig, Sébastien and Auwerx, Johan
Science, ISSN 0036-8075, 11/2019, Volume 366, Issue 6467, pp. 827 - 832
Throughout the animal kingdom, mitochondria are the only organelles that retain their own genome and the transcription and translation machineries that are all... 
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4. Full Text AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
by Toyama, EQ and Herzig, S and Courchet, J and Lewis, TL and Loson, OC and Hellberg, K and Young, NP and Chen, H and Polleux, F and Chan, DC and Shaw, RJ
SCIENCE, ISSN 0036-8075, 01/2016, Volume 351, Issue 6270, pp. 275 - 281
Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons and mitochondrial DNA-linked disease mutations, yet how these stimuli... 
PROTEOLYTIC CLEAVAGE | APOPTOSIS | FUSION | OPA1 | STRUCTURAL BASIS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DYNAMICS | AUTOPHAGY | MAMMALIAN-CELLS | DRP1 | Energy metabolism | Bioenergetics | Physiological aspects | Mitochondrial DNA | Genetic aspects | Adenylic acid | Protein kinases | Mitochondria | Cellular biology | Metabolism | Cytoplasm
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5. Full Text Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
by Sébastien Herzig and Etienne Raemy and Sylvie Montessuit and Jean-Luc Veuthey and Nicola Zamboni and Benedikt Westermann and Edmund R. S. Kunji and Jean-Claude Martinou
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6090, pp. 93 - 96
The transport of pyruvate, the end product of glycolysis, into mitochondria is an essential process that provides the organelle with a major oxidative fuel.... 
Essential amino acids | Yeasts | Lactates | Cell growth | Mitochondria | Dehydrogenases | REPORTS | Mitochondrial membranes | Amino acids | Keto acids | Implementation maturity model | CATABOLISM | TRANSPORT | SPECIFICITY | LIPOIC ACID | MEMBRANE | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | LACTOCOCCUS-LACTIS | DEHYDROGENASE | Proprotein Convertase 2 | Proprotein Convertase 1 - genetics | Saccharomyces cerevisiae - genetics | Thioctic Acid - biosynthesis | Molecular Sequence Data | Lactococcus lactis - metabolism | Anion Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - genetics | Thioctic Acid - metabolism | Saccharomyces cerevisiae - metabolism | Biological Transport | Culture Media | Pyruvic Acid - metabolism | Proprotein Convertase 1 - chemistry | Lactococcus lactis - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Leucine - metabolism | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Proprotein Convertase 1 - metabolism | Biosynthetic Pathways | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Anion Transport Proteins - metabolism | Mitochondrial Membranes - metabolism | Animals | Valine - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Mice | Anion Transport Proteins - genetics | Saccharomyces cerevisiae - growth & development | Saccharomyces cerevisiae Proteins - chemistry | Plant mitochondria | Genetic aspects | Research | Plant molecular biology | Proteins | Glycoproteins | Yeast | Mutagenesis
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6. Full Text Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet
by Vanderperre, Benoît and Herzig, Sébastien and Krznar, Petra and Hörl, Manuel and Ammar, Zeinab and Montessuit, Sylvie and Pierredon, Sandra and Zamboni, Nicola and Martinou, Jean-Claude
PLoS Genetics, ISSN 1553-7390, 05/2016, Volume 12, Issue 5, p. e1006056
Mitochondrial import of pyruvate by the mitochondrial pyruvate carrier (MPC) is a central step which links cytosolic and mitochondrial intermediary metabolism.... 
TRANSPORT | STIMULATED INSULIN-SECRETION | METABOLISM | GLUCONEOGENESIS | GENETICS & HEREDITY | LACTIC-ACIDOSIS | MICE | DIFFERENTIATION | RAT-LIVER MITOCHONDRIA | MASS-SPECTROMETRY | DEHYDROGENASE DEFICIENCY | Pyruvates | Embryonic development | Genetic aspects | Health aspects | Ketogenic diet | Brain | Genotype & phenotype | Phosphorylation | Dehydrogenases | Metabolites | Diet | Funding | Metabolism | Mammals | Labeling | Experiments | Embryos
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7. Full Text Feasibility of neurochemically profiling mouse embryonic brain and its development in utero using 1H MRS at 14.1 T
by Lei, Hongxia and Montessuit, Sylvie and Herzig, Sébastien and Martinou, Jean‐Claude
NMR in Biomedicine, ISSN 0952-3480, 11/2019, Volume 32, Issue 11, p. n/a
We aimed to evaluate the feasibility of neurochemical profiling of embryonic mouse brain developments in utero and to seek potential in vivo evidence of an... 
in utero | lactate | neurochemical profile | mitochondrial pyruvate carrier 1 | embryonic mouse brain | Brain | Phosphorylation | Profiling | Feasibility studies | Pyruvic acid | Metabolism | Embryonic growth stage | Embryogenesis | Mitochondria | Magnetic resonance imaging | Metabolites | Oxidative phosphorylation | Energy | Developmental stages | Echo surveys | Glycolysis | Lactic acid
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8. Full Text Metabolism: AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
by Toyama, Erin Quan and Herzig, Sébastien and Courchet, Julien and Lewis, Tommy L and Losón, Oliver C and Hellberg, Kristina and Young, Nathan P and Chen, Hsiuchen and Polleux, Franck and Chan, David C and Shaw, Reuben J
Science, ISSN 0036-8075, 01/2016, Volume 351, Issue 6270, pp. 275 - 281
Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons and mitochondrial DNA-linked disease mutations, yet how these stimuli... 
Mitochondrial Dynamics | Mitochondria - enzymology | AMP-Activated Protein Kinases - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Stress, Physiological | Molecular Sequence Data | Mitochondrial Proteins - genetics | Mitochondrial Proteins - metabolism | Rotenone - pharmacology | Cytoplasm - enzymology | Adenosine Monophosphate - metabolism | Mitochondria - drug effects | AMP-Activated Protein Kinases - chemistry | Amino Acid Motifs | GTP Phosphohydrolases - metabolism | Energy Metabolism | GTP Phosphohydrolases - genetics | Dactinomycin - analogs & derivatives | Cell Line, Tumor | Enzyme Activation | Mitochondria - physiology | Dactinomycin - pharmacology | AMP-Activated Protein Kinases - genetics | Index Medicus
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9. Full Text Mitochondrial dynamics and cancer
by Grandemange, Stéphanie and Herzig, Sébastien and Martinou, Jean-Claude
Seminars in Cancer Biology, ISSN 1044-579X, 2008, Volume 19, Issue 1, pp. 50 - 56
Abstract Mitochondrial morphology is regulated by continuous fusion and fission events that are essential for maintaining a normal mitochondrial function. If... 
Hematology, Oncology and Palliative Medicine | Mitochondria | Metabolism | Fusion | Fission | Cancer | GTPASE ACTIVITY | MARIE-TOOTH-DISEASE | INNER MEMBRANE | BUDDING YEAST | APOPTOTIC CELL-DEATH | DEPENDENT PROTEIN-KINASE | CRISTAE MORPHOLOGY | SACCHAROMYCES-CEREVISIAE | MAMMALIAN-CELLS | ATP SYNTHASE | ONCOLOGY | Neoplasms - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Mitochondrial Proteins - metabolism | Humans | Cell Cycle - physiology | Autophagy - physiology | Apoptosis - physiology | Energy Metabolism - physiology | Mitochondria - physiology | Mitochondrial DNA | Life Sciences | Cellular Biology | Biochemistry, Molecular Biology
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10. Full Text Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
by Giri, Ayush and Hellwege, Jacklyn N and Keaton, Jacob M and Park, Jihwan and Qiu, Chengxiang and Warren, Helen R and Torstenson, Eric S and Kovesdy, Csaba P and Sun, Yan V and Wilson, Otis D and Robinson-Cohen, Cassianne and Roumie, Christianne L and Chung, Cecilia P and Birdwell, Kelly A and Damrauer, Scott M and DuVall, Scott L and Klarin, Derek and Cho, Kelly and Wang, Yu and Evangelou, Evangelos and Cabrera, Claudia P and Wain, Louise V and Shrestha, Rojesh and Mautz, Brian S and Akwo, Elvis A and Sargurupremraj, Muralidharan and Debette, Stephanie and Boehnke, Michael and Scott, Laura J and Luan, Jian'an and Zhao, Jing-Hua and Willems, Sara M and Theriault, Sebastien and Shah, Nabi and Oldmeadow, Christopher and Almgren, Peter and Li-Gao, Ruifang and Verweij, Niek and Boutin, Thibaud S and Mangino, Massimo and Ntalla, Ioanna and Feofanova, Elena and Surenan, Praveen and Cook, James P and Karthikeyan, Savita and Lahrouchi, Najim and Liu, Chunyu and Sepulveda, Nuno and Richardson, Tom G and van der Harst, Pim and Million Vet Program and Int Consortium Blood Pressure and Understanding Soc Sci Grp and Blood Pressure-Int Consortium and International Consortium for Blood Pressure and Blood Pressure-International Consortium of Exome Chip Studies and Understanding Society Scientific Group and Million Veteran Program and Cardiovascular Research - Hypertension and Kardiovaskulär forskning - hypertoni and Lund University and EpiHealth: Epidemiology for Health and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden
Nature Genetics, ISSN 1061-4036, 01/2019, Volume 51, Issue 1, pp. 51 - 62
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts... 
GLOBAL BURDEN | MEAN ARTERIAL | SOLUBLE GUANYLYL CYCLASE | PARTITIONING HERITABILITY | GENE | LOCI | AUTOSOMAL-DOMINANT HYPERTENSION | PULSE PRESSURE | IDENTIFIES 8 | GENOME-WIDE ASSOCIATION | GENETICS & HEREDITY | Blood Pressure - genetics | Gene Expression - genetics | Humans | Kidney Tubules - physiology | Middle Aged | Male | Up-Regulation - genetics | Transcriptome - genetics | Animals | Ethnic Groups - genetics | Adolescent | Polymorphism, Single Nucleotide - genetics | Female | Mice | Genome-Wide Association Study - methods | Kidneys | Disease | Genes | Homeostasis | Principal components analysis | Genomes | Single-nucleotide polymorphism | Gene expression | Tissues | Ribonucleic acid--RNA | Data bases | Gene sequencing | Meta-analysis | Studies | Consortia | Blood pressure | Bioinformatics | Hispanics | Clear cell-type renal cell carcinoma | Native North Americans | Kardiologi | Medicinsk genetik | Basic Medicine | Medical Genetics | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin
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11. Full Text Life without the mitochondrial calcium uniporter
by Herzig, Sébastien and Herzig, Sébastien and Maundrell, Kinsey and Maundrell, Kinsey and Martinou, Jean-Claude and Martinou, Jean-Claude
Nature Cell Biology, ISSN 1465-7392, 2013, Volume 15, Issue 12, pp. 1398 - 1400
Calcium enters mitochondria through a dedicated channel referred to as the mitochondrial calcium uniporter (MCU), whose molecular identity has long remained... 
MCU | PERMEABILITY TRANSITION | CELL-DEATH | CELL BIOLOGY | Female | Male | Animals | Calcium - physiology | Calcium Channels - genetics | Mitochondria, Muscle - metabolism | Physiological aspects | Mitochondria | Genetic aspects | Cellular signal transduction | Research | Calcium ions
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12. Full Text Daptomycin resistance mechanisms in clinically derived Staphylococcus aureus strains assessed by a combined transcriptomics and proteomics approach
by Fischer, Adrien and Yang, Soo-Jin and Bayer, Arnold S and Vaezzadeh, Ali R and Herzig, Sébastien and Stenz, Ludwig and Girard, Myriam and Sakoulas, George and Scherl, Alexander and Yeaman, Michael R and Proctor, Richard A and Schrenzel, Jacques and François, Patrice
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 8/2011, Volume 66, Issue 8, pp. 1696 - 1711
Objectives The development of daptomycin resistance in Staphylococcus aureus is associated with clinical treatment failures. The mechanism(s) of such... 
Biofilms | Quantitative proteomics | Microarrays | Oleic acid | Virulence | Antibiotic resistance | δ-haemolysis | Cell wall metabolism | METHICILLIN RESISTANCE | INFECTIOUS DISEASES | delta-haemolysis | REDUCED SUSCEPTIBILITY | oleic acid | cell wall metabolism | OLEIC-ACID | 2-COMPONENT SYSTEM | VANCOMYCIN RESISTANCE | MICROBIOLOGY | CELL-WALL BIOSYNTHESIS | microarrays | VIRULENCE DETERMINANTS | GLYCOPEPTIDE-RESISTANCE | virulence | antibiotic resistance | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | biofilms | quantitative proteomics | BIOFILM FORMATION | Recurrence | Nucleic Acid Hybridization | Staphylococcus aureus - isolation & purification | Humans | Drug Resistance, Bacterial | Gene Expression Profiling | Proteome - analysis | Reverse Transcriptase Polymerase Chain Reaction | Daptomycin - pharmacology | Microarray Analysis | Endocarditis, Bacterial - microbiology | Anti-Bacterial Agents - pharmacology | Staphylococcal Infections - microbiology | Staphylococcus aureus - drug effects | Original Research
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