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PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e82881
During mammalian development the fertilized zygote and primordial germ cells lose their DNA methylation within one cell cycle leading to the concept of active... 
CARCINOMA-IN-SITU | STEM-CELLS | METHYLATION | MAMMALIAN DNA | MULTIDISCIPLINARY SCIENCES | LINE | 5-HYDROXYMETHYLCYTOSINE | MOUSE PREIMPLANTATION DEVELOPMENT | ACTIVE DNA DEMETHYLATION | DIFFERENTIATION | TUMORS | Immunohistochemistry | Proto-Oncogene Proteins - metabolism | Cytosine - analogs & derivatives | Testis - metabolism | Oxidation-Reduction | Spermatogenesis | Down-Regulation | Humans | Male | Neoplasms, Germ Cell and Embryonal - metabolism | Proto-Oncogene Proteins - genetics | Neoplasms, Germ Cell and Embryonal - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | DNA Methylation | 5-Methylcytosine - metabolism | Cytosine - metabolism | Testis - enzymology | Proto-Oncogene Proteins - physiology | Cell Line, Tumor | Carcinoma - genetics | Carcinoma - metabolism | Germ Cells - metabolism | Oxidation-reduction reaction | Pyrimidines | Methyltransferases | Methylation | Gene expression | Genes | Biotechnology | Germ cells | Neuropathology | Sperm | DNA damage | DNA glycosylase | Genomes | Tissues | Base excision repair | Demethylation | Cell cycle | Xenografts | DNA methylation | Oxidation | Cytosine | Deoxyribonucleic acid--DNA | Tumor cell lines | Pathology | Seminoma | Correlation analysis | Cell lines | Epigenetics | Mutation | Cancer | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Modern Pathology, ISSN 0893-3952, 10/2016, Volume 29, Issue 10, pp. 1165 - 1172
Immunohistochemistry of the PD-L1 protein may be predictive for anti-PD-1 and anti-PD-L1 immunotherapy in pulmonary adenocarcinoma and in clinically unselected... 
SURVIVAL | LUNG-CANCER | MULTICENTER | PEMBROLIZUMAB | GASTRIC-CANCER | LONG-TERM SAFETY | DEATH-LIGAND 1 | ANTIBODY | PATHOLOGY | NIVOLUMAB | DOCETAXEL | Adenocarcinoma | Carcinoma, Squamous Cell | Immunohistochemistry - methods | Biomarkers, Tumor - analysis | Humans | B7-H1 Antigen - analysis | Lung Neoplasms | Observer Variation
Journal Article
by George, Julie and Lim, Jing Shan and Jang, Se Jin and Cun, Yupeng and Ozretia, Luka and Kong, Gu and Leenders, Frauke and Lu, Xin and Fernández-Cuesta, Lynnette and Bosco, Graziella and Müller, Christian and Dahmen, Ilona and Jahchan, Nadine S and Park, Kwon-Sik and Yang, Dian and Karnezis, Anthony N and Vaka, Dedeepya and Torres, Angela and Wang, Maia Segura and Korbel, Jan O and Menon, Roopika and Chun, Sung-Min and Kim, Deokhoon and Wilkerson, Matt and Hayes, Neil and Engelmann, David and Pützer, Brigitte and Bos, Marc and Michels, Sebastian and Vlasic, Ignacija and Seidel, Danila and Pinther, Berit and Schaub, Philipp and Becker, Christian and Altmüller, Janine and Yokota, Jun and Kohno, Takashi and Iwakawa, Reika and Tsuta, Koji and Noguchi, Masayuki and Muley, Thomas and Hoffmann, Hans and Schnabel, Philipp A and Petersen, Iver and Chen, Yuan and Soltermann, Alex and Tischler, Verena and Choi, Chang-Min and Kim, Yong-Hee and Massion, Pierre P and Zou, Yong and Jovanovic, Dragana and Kontic, Milica and Wright, Gavin M and Russell, Prudence A and Solomon, Benjamin and Koch, Ina and Lindner, Michael and Muscarella, Lucia A and La Torre, Annamaria and Field, John K and Jakopovic, Marko and Knezevic, Jelena and Castaños-Vélez, Esmeralda and Roz, Luca and Pastorino, Ugo and Brustugun, Odd-Terje and Lund-Iversen, Marius and Thunnissen, Erik and Köhler, Jens and Schuler, Martin and Botling, Johan and Sandelin, Martin and Sanchez-Cespedes, Montserrat and Salvesen, Helga B and Achter, Viktor and Lang, Ulrich and Bogus, Magdalena and Schneider, Peter M and Zander, Thomas and Ansén, Sascha and Hallek, Michael and Wolf, Jürgen and Vingron, Martin and Yatabe, Yasushi and Travis, William D and Nürnberg, Peter and Reinhardt, Christian and Perner, Sven and Heukamp, Lukas and Büttner, Reinhard and Haas, Stefan A and Brambilla, Elisabeth and Peifer, Martin and Sage, Julien and Thomas, Roman K and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Lungmedicin och allergologi and Uppsala universitet and Institutionen för medicinska vetenskaper
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7563, pp. 47 - 53
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic... 
NEUROENDOCRINE TUMORS | PATHWAY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | IN-VIVO | GENES | CYCLE ARREST | NOTCH | C-KIT | MUTATIONS | CARCINOMA | Neurosecretory Systems - pathology | Receptors, Notch - metabolism | Chromosome Breakpoints | Genomics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Receptors, Notch - genetics | Gene Expression Profiling | Tumor Suppressor Protein p53 - genetics | Small Cell Lung Carcinoma - metabolism | Tumor Suppressor Proteins - genetics | Neurosecretory Systems - metabolism | Female | Nuclear Proteins - genetics | Disease Models, Animal | Lung Neoplasms - genetics | Signal Transduction - genetics | Small Cell Lung Carcinoma - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Genome, Human - genetics | Small Cell Lung Carcinoma - pathology | Tumor Protein p73 | Animals | Cyclin D1 - genetics | Retinoblastoma Protein - genetics | Alleles | Cell Line, Tumor | Mice | Gene mutations | Analysis | Exome sequencing | Lung cancer, Small cell | Genetic aspects | Drug therapy | Cancer | Pathogenesis | Lung cancer | Genomes | Mutation | Kinases | Gene expression | Cancer therapies | Tumors | Clinical Medicine | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 16123 - 9
Interleukin-2 (IL-2) is a key regulator of adaptive immune responses but its regulation is incompletely understood. We previously found that PDL1-dependent... 
INTERLEUKIN-2 | RESPONSES | ACTIVATION | REGULATORY CELLS | AUTOCRINE IL-2 | SINUSOIDAL ENDOTHELIAL-CELLS | TOLERANCE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | EXPANSION | ANTIGEN | Phosphorylation | CD8 antigen | Secretion | Effector cells | AKT protein | Lymphocytes T | KLRG1 protein | Endothelial cells | Hepatocytes | Interleukin 2 | Lymphocytes | PD-L1 protein | Guanosinetriphosphatase
Journal Article
by Peifer, Martin and Fernández-Cuesta, Lynnette and Sos, Martin L and George, Julie and Seidel, Danila and Kasper, Lawryn H and Plenker, Dennis and Leenders, Frauke and Sun, Ruping and Zander, Thomas and Menon, Roopika and Koker, Mirjam and Dahmen, Ilona and Müller, Christian and Di Cerbo, Vincenzo and Schildhaus, Hans-Ulrich and Altmüller, Janine and Baessmann, Ingelore and Becker, Christian and De Wilde, Bram and Vandesompele, Jo and Böhm, Diana and Ansén, Sascha and Gabler, Franziska and Wilkening, Ines and Heynck, Stefanie and Heuckmann, Johannes M and Lu, Xin and Carter, Scott L and Cibulskis, Kristian and Banerji, Shantanu and Getz, Gad and Park, Kwon-Sik and Rauh, Daniel and Grütter, Christian and Fischer, Matthias and Pasqualucci, Laura and Wright, Gavin and Wainer, Zoe and Russell, Prudence and Petersen, Iver and Chen, Yuan and Stoelben, Erich and Ludwig, Corinna and Schnabel, Philipp and Hoffmann, Hans and Muley, Thomas and Brockmann, Michael and Engel-Riedel, Walburga and Muscarella, Lucia A and Fazio, Vito M and Groen, Harry and Timens, Wim and Sietsma, Hannie and Thunnissen, Erik and Smit, Egber and Heideman, Daniëlle A. M and Snijders, Peter J. F and Cappuzzo, Federico and Ligorio, Claudia and Damiani, Stefania and Field, John and Solberg, Steinar and Brustugun, Odd Terje and Lund-Iversen, Marius and Sänger, Jörg and Clement, Joachim H and Soltermann, Alex and Moch, Holger and Weder, Walter and Solomon, Benjamin and Soria, Jean-Charles and Validire, Pierre and Besse, Benjamin and Brambilla, Elisabeth and Brambilla, Christian and Lantuejoul, Sylvie and Lorimier, Philippe and Schneider, Peter M and Hallek, Michael and Pao, William and Meyerson, Matthew and Sage, Julien and Shendure, Jay and Schneider, Robert and Büttner, Reinhard and Wolf, Jürgen and Nürnberg, Peter and Perner, Sven and Heukamp, Lukas C and Brindle, Paul K and Haas, Stefan and Thomas, Roman K
Nature Genetics, ISSN 1061-4036, 10/2012, Volume 44, Issue 10, pp. 1104 - 1110
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 11/2017, Volume 12, Issue 11, pp. e186 - e188
Journal Article
Journal Article
Nature medicine, ISSN 1078-8956, 2014, Volume 20, Issue 9, pp. 1027 - 1034
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 8, pp. 872 - 877
Journal Article